scholarly journals The Surgical White Matter Chassis: A Practical 3-Dimensional Atlas for Planning Subcortical Surgical Trajectories

2017 ◽  
Vol 14 (5) ◽  
pp. 469-482 ◽  
Author(s):  
Jonathan E Jennings ◽  
Amin B Kassam ◽  
Melanie B Fukui ◽  
Alejandro Monroy-Sosa ◽  
Srikant Chakravarthi ◽  
...  
Keyword(s):  
White Matter ◽  
Surgical Planning ◽  
Diffusion Tensor ◽  
Magnetic Resonance Images ◽  
Practical Implementation ◽  
Fiber Types ◽  
3.0 Tesla ◽  
3 Dimensional ◽  
White Matter Anatomy

AbstractBACKGROUNDThe imperative role of white matter preservation in improving surgical functional outcomes is now recognized. Understanding the fundamental white matter framework is essential for translating the anatomic and functional literature into practical strategies for surgical planning and neuronavigation.OBJECTIVETo present a 3-dimensional (3-D) atlas of the structural and functional scaffolding of human white matter—ie, a “Surgical White Matter Chassis (SWMC)”—that can be used as an organizational tool in designing precise and individualized trajectory-based neurosurgical corridors.METHODSPreoperative diffusion tensor imaging magnetic resonance images were obtained prior to each of our last 100 awake subcortical resections, using a clinically available 3.0 Tesla system. Tractography was generated using a semiautomated deterministic global seeding algorithm. Tract data were conceptualized as a 3-D modular chassis based on the 3 major fiber types, organized along median and paramedian planes, with special attention to limbic and neocortical association tracts and their interconnections.RESULTSWe discuss practical implementation of the SWMC concept, and highlight its use in planning select illustrative cases. Emphasis has been given to developing practical understanding of the arcuate fasciculus, uncinate fasciculus, and vertical rami of the superior longitudinal fasciculus, which are often-neglected fibers in surgical planning.CONCLUSIONA working knowledge of white matter anatomy, as embodied in the SWMC, is of paramount importance to the planning of parafascicular surgical trajectories, and can serve as a basis for developing reliable safe corridors, or modules, toward the goal of “zero-footprint” transsulcal access to the subcortical space.

Diffusion tensor imaging of cerebral white matter in patients with myotonic dystrophy

2005 ◽  
Vol 46 (1) ◽  
pp. 104-109 ◽  
Author(s):  
H. Fukuda ◽  
J. Horiguchi ◽  
C. Ono ◽  
T. Ohshita ◽  
J. Takaba ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Myotonic Dystrophy ◽  
Normal Control ◽  
Diffusion Tensor ◽  
Age At Onset ◽  
Mean Diffusivity ◽  
Magnetic Resonance Images ◽  
Microstructural Changes ◽  
Control Subjects

Purpose: To determine whether myotonic dystrophy (MyD) patients have diffusion tensor abnormalities suggestive of microstructural changes in normal‐appearing white matter (NAWM). Material and Methods: Conventional and diffusion tensor magnetic resonance images of the brain were obtained in 19 MyD patients and 19 age‐matched normal control subjects. Fractional anisotropy (FA) and mean diffusivity (MD) values were calculated in white matter lesions (WMLs) and NAWM in MyD patients and in the white matter of normal control subjects. Differences between WML and NAWM values and between MyD patient and control subject values were analyzed statistically. Results: Significantly lower FA and higher MD values were found in all regions of interest in the NAWM of MyD patients than in the white matter of control subjects ( P<0.01), as well as significantly lower FA and higher MD values in WMLs than in NAWM of MyD patients ( P<0.05). There was no significant correlation of mean FA or MD values in NAWM with patient age, age at onset, or duration of illness ( P>0.1). Conclusion: Diffusion tensor imaging analysis suggests the presence of diffuse microstructural changes in NAWM of MyD patients that may play an important role in the development of disability.

scholarly journals White matter abnormalities of corpus callosum in patients with bipolar disorder and suicidal ideation

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Ran Zhang ◽  
Xiaowei Jiang ◽  
Miao Chang ◽  
Shengnan Wei ◽  
Yanqing Tang ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Suicidal Ideation ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
The Body ◽  
Pathophysiological Mechanism ◽  
The Relationship ◽  
Diffusion Tensor Imaging Dti

Abstract Objective Although many studies have shown that the corpus callosum (CC) may play an important role in bipolar disorder (BD) and suicide, the pathophysiological mechanism of BD underlying suicidal behavior is still unclear. This study aimed to explore the relationship between the CC, and BD and suicidal ideation using diffusion tensor imaging (DTI). Method A total of 203 participants (47 BD patients with suicidal ideation, 59 with BD without suicidal ideation, and 97 healthy controls [HC]) underwent DTI scanning at a single site. We examined the white matter integrity of the CC in the three groups. Results A comparison among groups showed that BD patients with suicidal ideation had significant lower fractional anisotropy (FA) values than those of BD without suicidal ideation and HCs in the body and genu of the CC, and FA values of BD without suicidal ideation were significantly lower than those of HCs. However, in the splenium of corpus callosum, no difference was found between BD without suicidal ideation and HCs. Conclusions Our findings add to the evidence suggesting that the CC plays a key role in BD with suicidal ideation, especially with respect to the role of the genu and body of the CC subserving emotion regulation.

scholarly journals Correlation of neurochemical and imaging markers in migraine

Neurology ◽  
2018 ◽  
Vol 91 (12) ◽  
pp. e1166-e1174 ◽  
Author(s):  
Dániel Veréb ◽  
Nikoletta Szabó ◽  
Bernadett Tuka ◽  
János Tajti ◽  
András Király ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Magnetic Resonance Scanner ◽  
Left Posterior ◽  
Pituitary Adenylate Cyclase ◽  
Left Thalamus ◽  
Imaging Markers ◽  
Microstructural Integrity

ObjectiveTo examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine.MethodsInterictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB's Software Library.ResultsInterictal plasma PACAP38-LI showed significant correlation with mean diffusivity (p < 0.0179) mostly in the bilateral occipital white matter spreading into parietal and temporal white matter. Axial and radial diffusivity showed positive correlation with interictal PACAP38-LI (p < 0.0432 and p < 0.0418, respectively) in the left optic radiation and left posterior corpus callosum. Fractional anisotropy did not correlate significantly with PACAP38-LI. With disease duration as a nuisance regressor in the model, PACAP38-LI correlated with axial and mean diffusivity in the left thalamus (p < 0.01).ConclusionWe report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.

scholarly journals Relation Between Reading Performance and White-Matter Alteration and Reorganization in Neurosurgical Patients

2020 ◽  
Vol 11 ◽  
Author(s):  
Elisa Cargnelutti ◽  
Marta Maieron ◽  
Tamara Ius ◽  
Miran Skrap ◽  
Barbara Tomasino
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Clinical Importance ◽  
Reading Performance ◽  
Low Grade ◽  
Reading Impairment ◽  
Reading Abilities ◽  
Neurosurgical Patients ◽  
The Right

Reading abilities and diffusion tensor imaging (DTI) parameters were retrospectively analyzed in a group of neurosurgical patients to investigate (Study 1) the role of white matter—in particular the arcuate fasciculus (AF)—in preserved vs. impaired reading; 4 months after surgery, we explored the plasticity processes (Study 2). Study 1 involved 40 patients with brain glioma (23 low-grade and 17 high-grade gliomas). We compared preoperative DTI parameters of language-related fascicles between patients who developed a reading impairment after surgery (n = 23) and patients with preserved reading (n = 17). Besides lower fractional anisotropy (FA), patients with impaired reading also displayed lower number and density of streamlines of a direct (i.e., directly connecting temporal and frontal lobes) AF segment. In Study 2, we longitudinally tested at follow-up-when reading performance had generally improved-13 patients diagnosed with low-grade glioma. The most relevant finding was a significant increase in length of streamlines of the direct AF segments in both hemispheres. From a neurosurgical perspective, our preliminary findings suggest the clinical importance of sparing direct AF segments for the involvement they showed in reading; however, the results also suggest the reorganization potential of these segments, possibly compensating of the right homologs as well.

Abnormalities in the white matter tracts in patients with Parkinson disease and psychosis

Neurology ◽  
2020 ◽  
Vol 94 (18) ◽  
pp. e1876-e1884 ◽  
Author(s):  
Abhishek Lenka ◽  
Madhura Ingalhalikar ◽  
Apurva Shah ◽  
Jitender Saini ◽  
Shyam Sundar Arumugham ◽  
...  
Keyword(s):  
White Matter ◽  
Parkinson Disease ◽  
Diffusion Tensor ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Inferior Longitudinal Fasciculus ◽  
Microstructural Integrity ◽  
Tesla Scanner ◽  
Diffusion Tensor Imaging Dti

ObjectiveThe objective of the current study was to compare the microstructural integrity of the white matter (WM) tracts in patients having Parkinson disease (PD) with and without psychosis (PD-P and PD-NP) through diffusion tensor imaging (DTI).MethodsThis cross-sectional study involved 48 PD-NP and 42 PD-P who were matched for age, sex, and education. Tract-based spatial statistics (TBSS) was used to compare several DTI metrics from the diffusion-weighted MRIs obtained through a 3-Tesla scanner. A set of neuropsychological tests was used for the cognitive evaluation of all patients.ResultsThe severity and stage of PD were not statistically different between the groups. The PD-P group performed poorly in all the neuropsychological domains compared with the PD-NP group. TBSS analysis revealed widespread patterns of abnormality in the fractional anisotropy (FA) in the PD-P group, which also correlated with some of the cognitive scores. These tracts include inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, right parieto-occipital WM, body of the corpus callosum, and corticospinal tract.ConclusionThis study provides novel insights into the putative role of WM tract abnormalities in the pathogenesis of PD-P by demonstrating significant alterations in several WM tracts. Additional longitudinal studies are warranted to confirm the findings of our research.

Brain white matter anatomy of tumor patients evaluated with diffusion tensor imaging

2002 ◽  
Vol 51 (3) ◽  
pp. 377-380 ◽  
Author(s):  
Susumu Mori ◽  
Kim Frederiksen ◽  
Peter C. M. van Zijl ◽  
Bram Stieltjes ◽  
Michael A. Kraut ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Tumor Patients ◽  
Brain White Matter ◽  
White Matter Anatomy

Association of Superficial White Matter Alterations with Cerebrospinal Fluid Biomarkers and Cognitive Decline in Neurodegenerative Dementia

2021 ◽  
pp. 1-12
Author(s):  
Valeria Elisa Contarino ◽  
Silvia Siggillino ◽  
Andrea Arighi ◽  
Elisa Scola ◽  
Giorgio Giulio Fumagalli ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
White Matter ◽  
Cognitive Decline ◽  
Clinical Data ◽  
Parietal Lobe ◽  
Diffusion Tensor ◽  
Amyloid Β ◽  
Magnetic Resonance Images ◽  
Csf Biomarkers ◽  
Neurodegenerative Dementia

Background: Superficial white matter (SWM) alterations correlated with cognitive decline have been described in Alzheimer’s disease (AD). Objective: The study aims to extend the investigation of the SWM alterations to AD and non-AD neurodegenerative dementia (ND) and explore the relationship with cerebrospinal fluid (CSF) biomarkers and clinical data. Methods: From a database of 323 suspected dementia cases, we retrospectively recruited 55 ND with abnormal amyloid-β 42 (AD) and 38 ND with normal amyloid-β 42 (non-AD) and collected clinical data, CSF biomarkers, and magnetic resonance images. Ten healthy controls (HC) were recruited for imaging and Mini-Mental State Examination (MMSE). Diffusion tensor imaging (DTI) measurements were performed in the lobar SWM regions and Kruskal Wallis tests were used for among-group comparison. Spearman’s correlation tests were performed between DTI measures, CSF biomarkers, and clinical data. Results: AD and non-AD showed significant differences in the DTI measures across the SWM compared to HC. Significant differences between AD and non-AD were detected in the left parietal lobe. DTI measures correlated with amyloid-β 42 and MMSE diffusely in the SWM, less extensively with total-tau and phosphorylated tau, and with disease duration in the parietal lobe bilaterally. Conclusion: Widespread SWM alterations occur in both AD and non-AD ND and AD shows appreciably more severe alterations in the parietal SWM. Notably, the alterations in the SWM are strongly linked not only to the cognitive decline but also to the diagnostic CSF biomarkers. Further studies are encouraged to evaluate the DTI measures in the SWM as in vivo non-invasive biomarkers in the preclinical phase.

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