Substance

Author(s):  
Georges Dicker

Locke’s idea of a substance (e.g., a rock, a tree, or a swan) comprises (1) the ideas of the qualities that define its species, and (2) the idea of a substratum in which those qualities inhere. The proper interpretation of (2) is controversial. The traditional view is that substratum is an unperceivable component distinct from any and all of a thing’s qualities; the rival view is that substratum = real essence. This chapter examines three arguments for the traditional view: the argument from change traceable at least to Aristotle, the logico-linguistic argument discussed by J. L. Mackie, and a subtler argument, implicit in Leibniz, based on the division of labor between the referential words and descriptive words in subject-predicate sentences. It discuses the textual evidence that Locke held the traditional view. It argues that despite that view’s incompatibility with Locke’s Empiricism, he accepts it, albeit with misgivings, because of the latter argument.

Author(s):  
E.Y. Chi ◽  
M.L. Su ◽  
Y.T. Tien ◽  
W.R. Henderson

Recent attention has been directed to the interaction of the nerve and immune systems. The neuropeptide substance P, a tachykinnin which is a neurotransmitter in the central and peripheral nervous systems produces tissue swelling, augemntation of intersitial fibrin deposition and leukocyte infiltration after intracutaneous injection. There is a direct correlation reported between the extent of mast cell degranulation at the sites of injection and the tissue swelling or granulocyte infiltration. It has previously been demonstrated that antidromic electrical stimulation of sensory nerves induces degranulation of cutaneous mast cells, cutaneous vasodilation and augmented vascular permeability. Morphological studies have documented a close anatiomical association between mast cells and nonmyelinated nerves, that contain substance P and other neuropeptides. However, the presence of mast cells within nerve fasicles has not been previously examined ultrastructurally. In this study, we examined ultrastructurally the distribution of mast cells in the nerve fiber bundles located in the muscular connective tissue of rat tongues (n=20).


1997 ◽  
Vol 27 (4) ◽  
pp. 372-378 ◽  
Author(s):  
H. FUJISHIMA ◽  
M. TAKEYAMA ◽  
T. TAKEUCHI ◽  
I. SAITO ◽  
K. TSUBOTA

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