The bottom line

Author(s):  
Steven F. Perry ◽  
Markus Lambertz ◽  
Anke Schmitz

This chapter summarizes the most important aspects of the entire book. Writing an abstract of a summary can result in a ‘bouillon cube’ of information that is nearly incomprehensible, so this sticks to the most far-reaching observations and conclusions. The structure–function unit referred to here as the respiratory faculty did not just suddenly appear, but rather bits and pieces of it are recognizable even in most basally branching metazoan lineages. The use of mitochondria in an aerobic atmosphere to produce large amounts of energy-carrying molecules precipitated a kind of arms race, whereby the individuals that could compete better for food sources or become predatory could become part of an evolutionary cascade. These new animals moved into another realm, but the old ones did not necessarily disappear: they just did what they always did, maybe a little better. In the most diverse lineages of invertebrates and craniotes we see similar changes appearing: gills with counter-current exchange, highly specialized oxygen-carrying proteins, a partly or completely closed circulatory system that includes the gas exchange organs, lungs. The more extreme the grounds for specialization, the more similar are these structures and functions. Often the functional result remains unchanged or becomes improved while the anatomical cause changes dramatically, but just as often structures change little but minor functions become major ones: a phenomenon called exaptation. This book has looked at most major animal groups and these principles turn up everywhere. It talks about multidimensional forces at work in a multidimensional world, and respiration is the keystone to it all.

2020 ◽  
Vol 48 (2) ◽  
pp. 507-516 ◽  
Author(s):  
Pierre Hardouin ◽  
Adeline Goulet

Bacteriophages (phages) and their preys are engaged in an evolutionary arms race driving the co-adaptation of their attack and defense mechanisms. In this context, phages have evolved diverse anti-CRISPR proteins to evade the bacterial CRISPR–Cas immune system, and propagate. Anti-CRISPR proteins do not share much resemblance with each other and with proteins of known function, which raises intriguing questions particularly relating to their modes of action. In recent years, there have been many structure–function studies shedding light on different CRISPR–Cas inhibition strategies. As the anti-CRISPR field of research is rapidly growing, it is opportune to review the current knowledge on these proteins, with particular emphasis on the molecular strategies deployed to inactivate distinct steps of CRISPR–Cas immunity. Anti-CRISPR proteins can be orthosteric or allosteric inhibitors of CRISPR–Cas machineries, as well as enzymes that irreversibly modify CRISPR–Cas components. This repertoire of CRISPR–Cas inhibition mechanisms will likely expand in the future, providing fundamental knowledge on phage–bacteria interactions and offering great perspectives for the development of biotechnological tools to fine-tune CRISPR–Cas-based gene edition.


2020 ◽  
pp. 3937-3946
Author(s):  
Peter D. Wagner ◽  
Pallav L. Shah

The lung is the organ of gas exchange, providing the means of transferring oxygen (O2) from the air to the blood by passive diffusion for subsequent distribution to the tissues, and of similarly removing metabolically produced carbon dioxide (CO2) from the blood, which is then exhaled to the atmosphere. The lungs are enclosed within the thoracic cavity. Inspiration is driven by contraction of the intercostal muscles and the diaphragm, which expands the ribcage in both anteroposterior and lateral dimensions, such that the pressure inside the thoracic cavity but external to the lungs is reduced to below that of the air, which is thereby drawn in. Lung diseases of many types commonly affect each of the steps involved in gas exchange, and the clinical consequences can usually be readily understood if the structure–function relationships are known.


1988 ◽  
Vol 66 (1) ◽  
pp. 109-123 ◽  
Author(s):  
G. Shelton ◽  
P. C. Croghan

Control of breathing and gas exchange has been extensively investigated in unimodal animals, particularly mammals, in which ventilation is characteristically a regular and continuous process and gas exchange approximates to a steady-state system. Both static and dynamic models have been developed in control-theory analyses. Similar analyses are possible in unimodal fish, though few have been carried out. Control in bimodal animals, such as air-breathing fish and amphibians, is more difficult to understand and model. The evolutionary change from water to air breathing in vertebrates involves not only the adjustment of many control processes but also the development, in the early stages, of non steady states in gas exchangers, blood, and tissues. A simple control-system model, differing from mammalian counterparts in its greater emphasis on storage functions and its intermittently activated controller, is described for two suggested stages in the evolution of air breathing. The first of these stages is air gulping, in which a fixed and rather brief pattern of air breathing is activated by internal signals generated as a result of the inadequacy of the gills to provide sufficient oxygen for tissue metabolism. The second stage is that of burst breathing, in which lung ventilation is both begun and ended by internal signals so that burst duration is variable. The effects of adjusting parameters on variables of evolutionary importance, such as dive duration, burst duration, store renewal, and metabolic rate, can be examined in these two versions of the model. Refinements to incorporate arterial and venous compartments in the circulatory system, the shunting of venous and arterial blood streams in the heart, realistic oxygen dissociation curves, controller inputs from a wider range of sources, and the capacity to respond to some conditions with changes in ventilation rate as well as in burst and dive durations, are being developed. They should make the complex, non-steady-state interactions between gas exchangers, circulating blood, and tissues easier to understand and indicate the likely steps toward the evolution of steady-state systems seen in birds and mammals.


2004 ◽  
Vol 286 (2) ◽  
pp. H584-H601 ◽  
Author(s):  
K. Lu ◽  
J. W. Clark ◽  
F. H. Ghorbel ◽  
C. S. Robertson ◽  
D. L. Ware ◽  
...  

The goal of this work is to study the cerebral autoregulation, brain gas exchange, and their interaction by means of a mathematical model. We have previously developed a model of the human cardiopulmonary (CP) system, which included the whole body circulatory system, lung and peripheral tissue gas exchange, and the central nervous system control of arterial pressure and ventilation. In this study, we added a more detailed description of cerebral circulation, cerebrospinal fluid (CSF) dynamics, brain gas exchange, and cerebral blood flow (CBF) autoregulation. Two CBF regulatory mechanisms are included: autoregulation and CO2 reactivity. Central chemoreceptor control of ventilation is also included. We first established nominal operating conditions for the cerebral model in an open-loop configuration using data generated by the CP model as inputs. The cerebral model was then integrated into the larger CP model to form a new integrated CP model, which was subsequently used to study cerebral hemodynamic and gas exchange responses to test protocols commonly used in the assessment of CBF autoregulation (e.g., carotid artery compression and the thigh-cuff deflation test). The model can closely mimic the experimental findings and provide biophysically based insights into the dynamics of cerebral autoregulation and brain tissue gas exchange as well as the mechanisms of their interaction during test protocols, which are aimed at assessing the degree of autoregulation. With further refinement, our CP model may be used on measured data associated with the clinical evaluation of the cerebral autoregulation and brain oxygenation in patients.


Author(s):  
Steven F. Perry ◽  
Markus Lambertz ◽  
Anke Schmitz

This chapter introduces the ‘who has what’ in terms of water-breathing respiratory faculties for craniotes. A branchial basket and a ventral heart or hearts that perfuse the branchial region with deoxygenated internal fluid is part of the bauplan of all chordates, including craniotes. Cilia ventilate the branchial region of extant non-craniote chordates, which are also predominantly sessile or planktonic filter feeders. In craniotes, the gills are the main gas exchange organs. They are ventilated by muscular activity and perfused with blood that contains haemoglobin in erythrocytes and flows in the opposite direction to the ventilated water (counter-current model). In spite of major differences in the structure of gills and the ventilatory apparatus among jawless craniotes, cartilaginous fish, and bony fish, the basic push–pull, constant, unidirectional flow respiratory mechanism remains unchanged (of course, with a few notable exceptions). In addition, both the blood and the structure of the gills may reflect adaptations of the respiratory faculty to habitual living conditions.


1995 ◽  
Vol 58 (10) ◽  
pp. 1153-1170 ◽  
Author(s):  
JAMES L. SMITH

The most frequently identified cause of gastroenteritis in developed countries is Campylobacter jejuni. In the United States, dairy products are the food sources commonly associated with outbreaks; however, most cases of C. jejuni gastroenteritis are sporadic, with poultry as the major source. Diarrhea, malaise, fever, and abdominal pain are the usual symptoms of C. jejuni enteritis. Lasting only a few days, the illness is generally self-limiting; however, some cases may be more severe. Although several virulence factors have been identified in C. jejuni, their role in disease is currently unclear. C. jejuni has been linked to the acquisition of certain forms of sterile arthritides such as reactive arthritis and Reiter's syndrome and to acute generalized paralytic diseases such as Guillain-Barré syndrome, Miller-Fisher syndrome, and Chinese paralytic syndrome. In addition, C. jejuni may induce diseases affecting the nervous system, circulatory system, and various organs, particularly in immunocompromised individuals. Illnesses associated with C. jejuni have been estimated to cost the citizens of the United States several billion dollars annually.


The Lancet ◽  
1998 ◽  
Vol 351 (9096) ◽  
pp. 113 ◽  
Author(s):  
Noreen R Henig ◽  
Robb W Glenny ◽  
Moira L Aitken

2019 ◽  
Author(s):  
Benjamin J. I. Schellenberg ◽  
Patrick Gaudreau ◽  
Daniel Bailis

Obsessive passion predicts many different types of maladaptive intra- and inter-personal outcomes (Vallerand, 2015). Our aim in this research was to explore one potential force that might promote or sustain obsessive passion in the workplace: lay beliefs about the relationship between obsessive passion and work success. We hypothesized that people hold the lay belief that obsessive passion is ideal for achieving success in workplaces that focus on singular objectives (e.g., productivity) at the expense of competing goals (e.g., well-being) – that is, those work environments characterized by bottom-line mentalities (e.g., Greenbaum, Mawritz, & Eissa, 2012). In three studies we assessed lay beliefs about passion from different perspectives, including perceptions of others (Study 1, n = 138), the way people presented themselves and believed others should present themselves (Study 2, n = 355), and estimates of one’s own success in different workplace environments (Study 3, n = 418). In support of our hypothesis, participants believed that, in workplaces characterized by bottom-line mentalities, they and others would be more likely to achieve success with high levels of obsessive passion. This means that lay beliefs about passion may be a force that promotes and sustains obsessive passion in workplaces focused exclusively on bottom line outcomes. This finding has implications for the decisions that are made by both employers and employees, and reveals a process that could contribute to the value that workplaces put on being obsessed toward the job.


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