Substituted Benzenes: The Kirsch Synthesis of Cybrodol

2013 ◽  
Author(s):  
Douglass F. Taber
Keyword(s):  
Aryl Halide ◽  
Boronic Acids ◽  
Aryl Halides ◽  
Heck Coupling ◽  
Organic Transformations ◽  
University Of Alberta ◽  
Decarboxylative Coupling ◽  
Mcgill University ◽  
The University ◽  
Technological University

Stephen L. Buchwald of MIT established (J. Am. Chem. Soc. 2010, 132, 14076) a Pd-catalyzed protocol for conversion of an aryl triflate 1 to the halide 2. Jie Wu of Fudan University prepared (Tetrahedron Lett. 2010, 51, 6646) aromatic halides from the corresponding carboxylic acids. Yong-Chua Teo of Nanyang Technological University described (Tetrahedron Lett . 2010, 51, 3910) the Mn-mediated conversion of 3 to 5, suggesting a benzyne intermediate. Takanori Shibata of Waseda University effected (Synlett 2010, 2601) the direct Ru-mediated coupling of aryl halides with amines, and Paul Helquist of the University of Notre Dame prepared (J. Org. Chem. 2010, 75, 4887) anilines by coupling aryl halides with NaN3 . Chao-Jun Li of McGill University devised (Tetrahedron Lett. 2010, 51, 5486) the Pd-catalyzed decarbonylative Heck coupling of 6 with 7 to give 8. Mats Larhed of Uppsala University showed (Angew. Chem. Int. Ed. 2010, 49, 7733) that Pd could also catalyze the decarboxylative coupling of an aromatic acid 9 with a nitrile to give the ketone 10. Dennis G. Hall of the University of Alberta found (Tetrahedron Lett. 2010, 51, 4256) that an areneboronic acid could promote the Zr-catalyzed ortho condensation of a phenol 11 with an aldehyde, leading to 12, which could then be carried on to a range of other products. Professor Hall also showed (Angew. Chem. Int. Ed. 2010, 49, 2883) that areneboronic acids are stable to many standard organic transformations, and that the product boronic acids can be readily purified by extraction into sorbitol/Na2CO3. Professor Buchwald reported (J. Am. Chem. Soc. 2010, 132, 14073) an optimized source of Pd for the Suzuki-Miyaura coupling, allowing the room-temperature participation even of unstable boronic acids such as 13. Wing-Yiu Yu of the Hong Kong Polytechnic University observed (J. Am. Chem. Soc. 2010, 132, 12862) that 17 was an effective donor for the Pd-catalyzed ortho C-H amination of 16. Nicholas C. O. Tomkinson of Cardiff University uncovered (Synlett 2010, 2471) the facile rearrangement of 19 to 20. Professor Buchwald described (J. Am. Chem. Soc. 2010, 132, 9990) the coupling of 21, prepared from the aryl halide, with 22 to give the benzofuran 23.

James Bertram Collip, 1892-1965

1973 ◽  
Vol 19 ◽  
pp. 234-267 ◽  
Keyword(s):  
Family Life ◽  
Clinical Medicine ◽  
National Research Council ◽  
Pituitary Hormones ◽  
University Of Alberta ◽  
University Of Toronto ◽  
Mcgill University ◽  
Medical Importance ◽  
The University ◽  
Happy Family

James Bertram Collip was a pioneer in endocrine research, especially in its biochemical aspects. Following an excellent training in biochemistry under Professor A. B. Macallum, F.R.S., at the University of Toronto, he spent thirteen years at the University of Alberta in Edmonton. There was a momentous year at the University of Toronto about midway through the Edmonton period; this coincided with the discovery of insulin by Sir Frederick G. Banting, F.R.S., and Professor Charles S. Best, F.R.S., and the experience altered the course of his career. Henceforth, Professor Collip’s life was dominated by an urge to discover hormones that would be useful in clinical medicine. Success attended these efforts, first in the isolation of the parthyroid hormone, called parathormone, while he was at the University of Alberta and later in the identification of placental and pituitary hormones during particularly fruitful years at McGill University. There were other important facets to Professor Collip’s career. These included the training of young scientists, many of whom subsequently came to occupy positions of responsibility, work with the National Research Council of Canada, and in his latter years an important contribution as Dean of the Faculty of Medicine, University of Western Ontario. In addition to a life of fulfilment through accomplishments of scientific and medical importance, Professor Collip’s career was enriched by a happy family life and by the friendship of a host of individuals who were attracted to his brilliance as a scientist and his warm personality.

scholarly journals COMPARISON OF THE CIVIL ENGINEERING CURRICULUM AMONG SEVERAL CANADIAN UNIVERSITIES

2020 ◽  
Author(s):  
Mohammad Mehdi Ebadi ◽  
Michele Richards ◽  
Carol Brown ◽  
Samer Adeeb
Keyword(s):  
Environmental Sustainability ◽  
Civil Engineering ◽  
Modular Construction ◽  
University Of Alberta ◽  
University Of Toronto ◽  
University Of British Columbia ◽  
Mcgill University ◽  
Comprehensive Comparison ◽  
The University ◽  
New Generation

Growing attention to environmental sustainability, modular construction, and application of new generation of materials, accompanied with advanced data collection techniques and computer modeling, has revolutionized the area of Civil Engineering within the past few years. This demonstrates the necessity of continually reviewing the curriculum to assure that graduating engineers are knowledgeable enough to deal with complex problems in their area of specialty. This is also essential to satisfy the continual improvement process (CIP) requirements mandated by the Canadian Engineering Accreditation Board (CEAB). As a first step to design a rigorous CIP, a comprehensive comparison was made between the Civil Engineering curricula of the University of Alberta (UofA) and eight other major universities across Canada, including the University of Calgary, University of Toronto, McGill University, University of Windsor, University of Regina, University of British Columbia (UBC), University of Waterloo, and Polytechnic of Montreal. After categorizing the courses into twelve different streams, it was observed that some universities paid less attention to a specific stream in comparison with the average, which could be identified as a gap in the curriculum. A capstone design or group design project that is multidisciplinary and covers multiple areas of specialty is the predominant approach followed by most of the universities.

African Studies in Canada

1965 ◽  
Vol 8 (03) ◽  
pp. 71-75
Author(s):  
Donald L. Wiedner
Keyword(s):  
Social Science Research ◽  
Science Research ◽  
African Studies ◽  
International Studies ◽  
Canadian Universities ◽  
University Of Alberta ◽  
French And English ◽  
Mcgill University ◽  
The University ◽  
Research Councils

African studies in Canada are still relatively in their early stages, but university interest in the African continent is being developed by three types of approach: by the Comnnittee on International Studies of the National Conference of Canadian Universities and Colleges (an organization of university administrations), by the Committee on African Studies in Canada (an association of scholars and students, assisted by the Humanities Research and Social Science Research Councils of Canada), and by the efforts of individual universities across the dominion. The earliest coordinated effort was that of the Committee on African Studies in Canada, which was formed by some ten scholars from seven universities, meeting informally in Montreal in December 1962. A semiannual Bulletin, appearing simultaneously in French and English, business and academic meetings in June of each year, and affiliation, with assistance, to the research councils, were agreed upon. Dr. Ronald Cohen, then at McGill University, and Dr. Donald C. Savage of Loyola College were elected chairman and secretary-treasurer respectively. In 1963, Dr. Donald L. Wiedner, then of the University of Alberta at Edmonton, succeeded to the chair for two years and, with the help of that university and the councils, edited the Bulletin throughout that time. In 1964, Professeur Bernard Charles (Université de Montréal), M. Louis Bérubé (Collège Sainte-Marie), and Dr. E. Palmer Patterson (University of Waterloo) were added as vice-chairman, secretary, and treasurer respectively.

scholarly journals Descending the Mountain: Exploring the Impact of Research on Pedagogy and Practice

2021 ◽  
Vol 6 ◽  
pp. 010
Author(s):  
Jana Baumgaertner
Keyword(s):  
Higher Education ◽  
Physical Education ◽  
International Association ◽  
Conference Report ◽  
Scientific Conference ◽  
University Of Alberta ◽  
Mcgill University ◽  
The University ◽  
The Impact

Conference Report to the virtual Scientific conference of the International Association for Physical Education in Higher Education (AIESEP) 2021 hosted by the University of Alberta and McGill University (Banff, Canada).

Report on the Na+/H+ Exchanger Satellite Meeting at the 53rd Annual Meeting of the Canadian Society of Biochemistry, Molecular and Cellular Biology

2011 ◽  
Vol 89 (2) ◽  
pp. 85-86 ◽  
Author(s):  
R. T. Alexander ◽  
L. Fliegel
Keyword(s):  
Ph Homeostasis ◽  
New Developments ◽  
University Of Alberta ◽  
E Coli ◽  
University Of British Columbia ◽  
Hebrew University ◽  
Mcgill University ◽  
University Of Manitoba ◽  
And Function ◽  
The University

The Satellite Meeting on Na+/H+ Exchangers, held on 17 April 2010, covered a range of new developments in this field. The symposium was chaired by Dr. Larry Fliegel, University of Alberta, and the speakers were Dr. John Orlowski of McGill University, Dr. Jan Rainey of Dalhousie University, Dr. Etana Padan of The Hebrew University of Jerusalem, Dr. Masa Numata of The University of British Columbia, Dr. Pavel Dibrov from the University of Manitoba, Dr. Todd Alexander of the University of Alberta, and Grant Kemp of the University of Alberta. Talks ranged from organellar pH homeostasis to structure and function of Na+/H+ exchanger proteins. Highlights of the symposium included elucidation of the structure of transmembrane regions of the NHE1 isoform and development of a new model of the NHE1 protein based on the E. coli Na+/H+ exchanger. The symposium brought together scientists from different corners of the world. The discussions that followed were lively and many scientists received constructive comments from their peers.

Centres for Health Evidence Demonstration Project

2013 ◽  
Author(s):  
Tracy Stewart ◽  
Denise Koufogiannakis ◽  
Robert S.A. Hayward ◽  
Ellen Crumley ◽  
Michael E. Moffatt
Keyword(s):  
Evidence Based Practice ◽  
Demonstration Project ◽  
Evidence Based ◽  
Research Opportunities ◽  
University Of Alberta ◽  
Information Usage ◽  
University Of Manitoba ◽  
The University ◽  
Hospital Wards ◽  
Support Evidence

This paper will report on the establishment of the Centres for Health Evidence (CHE) Demonstration Project in both Edmonton at the University of Alberta and in Winnipeg at the University of Manitoba. The CHE Project brings together a variety of partners to support evidence-based practice using Internet-based desktops on hospital wards. There is a discussion of the CHE's cultural and political experiences. An overview of the research opportunities emanating from the CHE Project is presented as well as some early observations about information usage.

scholarly journals Is the Letter ‘t’ in the Word ‘gourmet’? Disruption in Task-Evoked Connectivity Networks in Adults with Impaired Literacy Skills

NeuroSci ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 75-94
Author(s):  
Kulpreet Cheema ◽  
William E. Hodgetts ◽  
Jacqueline Cummine
Keyword(s):  
Developmental Disorders ◽  
Brain Networks ◽  
Literacy Skills ◽  
Resting State Networks ◽  
Skilled Readers ◽  
University Of Alberta ◽  
Domain Specific ◽  
Probe Task ◽  
The University ◽  
General Networks

Much work has been done to characterize domain-specific brain networks associated with reading, but very little work has been done with respect to spelling. Our aim was to characterize domain-specific spelling networks (SpNs) and domain-general resting state networks (RSNs) in adults with and without literacy impairments. Skilled and impaired adults were recruited from the University of Alberta. Participants completed three conditions of an in-scanner spelling task called a letter probe task (LPT). We found highly connected SpNs for both groups of individuals, albeit comparatively more connections for skilled (50) vs. impaired (43) readers. Notably, the SpNs did not correlate with spelling behaviour for either group. We also found relationships between SpNs and RSNs for both groups of individuals, this time with comparatively fewer connections for skilled (36) vs. impaired (53) readers. Finally, the RSNs did predict spelling performance in a limited manner for the skilled readers. These results advance our understanding of brain networks associated with spelling and add to the growing body of literature that describes the important and intricate connections between domain-specific networks and domain-general networks (i.e., resting states) in individuals with and without developmental disorders.

scholarly journals Access to Healthcare for Immigrant Children in Canada

2020 ◽  
Vol 17 (9) ◽  
pp. 3320
Author(s):  
Bukola Salami ◽  
Alleson Mason ◽  
Jordana Salma ◽  
Sophie Yohani ◽  
Maryam Amin ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Service Providers ◽  
Social Determinant ◽  
Immigrant Children ◽  
Access To Healthcare ◽  
Cultural Barriers ◽  
Immigrant Parents ◽  
Financial Barriers ◽  
University Of Alberta ◽  
The University

Immigrants experience poorer health outcomes than nonimmigrants in Canada for several reasons. A central contributing factor to poor health outcomes for immigrants is access to healthcare. Previous research on access to healthcare for immigrants has largely focused on the experience of immigrant adults. The purpose of this study was to investigate how immigrants access health services for their children in Alberta, Canada. Our study involved a descriptive qualitative design. Upon receiving ethics approval from the University of Alberta Research Ethics Board, we invited immigrant parents to participate in this study. We interviewed 50 immigrant parents, including 17 fathers and 33 mothers. Interviews were audio recorded, transcribed, and analyzed according to the themes that emerged. Findings reveal that systemic barriers contributed to challenges in accessing healthcare for immigrant children. Participants identified several of these barriers—namely, system barriers, language and cultural barriers, relationship with health professionals, and financial barriers. These barriers can be addressed by policymakers and service providers by strengthening the diversity of the workforce, addressing income as a social determinant of health, and improving access to language interpretation services.

scholarly journals Success factors in the realization of large ice projects in education

2021 ◽  
Vol 36 (1) ◽  
pp. 4-12
Author(s):  
Arno Pronk ◽  
Peng Luo ◽  
Qingpeng Li ◽  
Fred Sanders ◽  
Marjolein overtoom ◽  
...  
Keyword(s):  
Success Factors ◽  
Learning Experience ◽  
Learning By Doing ◽  
University Of Alberta ◽  
The North ◽  
3D Printed ◽  
Good Learning ◽  
The University ◽  
Ice Shell ◽  
Motivation And Learning

There has been a long tradition in making ice structures, but the development of technical improvements for making ice buildings is a new field with just a handful of researchers. Most of the projects were realized by professors in cooperation with their students as part of their education in architecture and civil engineering. The following professors have realized ice projects in this setting: Heinz Isler realized some experiments since the 1950s; Tsutomu Kokawa created in the past three decades several ice domes in the north of Japan with a span up to 25 m; Lancelot Coar realized a number of fabric formed ice shell structures including fiberglass bars and hanging fabric as a mold for an ice shell in 2011 and in 2015 he produced an fabric-formed ice origami structure in cooperation with MIT (Caitlin Mueller) and VUB (Lars de Laet). Arno Pronk realized several ice projects such as the 2004 artificially cooled igloo, in 2014 and 2015 dome structures with an inflatable mold in Finland and in 2016–2019, an ice dome, several ice towers and a 3D printed gridshell of ice in Harbin (China) as a cooperation between the Universities of Eindhoven & Leuven (Pronk) and Harbin (Wu and Luo). In cooperation between the University of Alberta and Eindhoven two ice beams were realized during a workshop in 2020. In this paper we will present the motivation and learning experiences of students involved in learning-by-doing by realizing one large project in ice. The 2014–2016 projects were evaluated by Sanders and Overtoom; using questionnaires among the participants by mixed cultural teams under extreme conditions. By comparing the results in different situations and cultures we have found common rules for the success of those kinds of educational projects. In this paper we suggest that the synergy among students participating in one main project without a clear individual goal can be very large. The paper will present the success factors for projects to be perceived as a good learning experience.

Development of an agronomically superior blackleg resistant canola cultivar in Brassica napus L. using doubled haploidy

1995 ◽  
Vol 75 (2) ◽  
pp. 437-439 ◽  
Author(s):  
G. R. Stringam ◽  
V. K. Bansal ◽  
M. R. Thiagarajah ◽  
D. F. Degenhardt ◽  
J. P. Tewari
Keyword(s):  
Brassica Napus ◽  
Doubled Haploid ◽  
Leptosphaeria Maculans ◽  
Resistance Breeding ◽  
Breeding Method ◽  
Brassica Napus L ◽  
Breeding Lines ◽  
University Of Alberta ◽  
Blackleg Resistance ◽  
The University

The doubled haploid breeding method and greenhouse screening using cotyledon bio-assay were successfully applied to transfer blackleg resistance from the Australian cultivar Maluka (Brassicas napus), into susceptible advanced B. napus lines from the University of Alberta. This approach for blackleg resistance breeding was effective and efficient as several superior blackleg resistant breeding lines were identified within 4 yr from the initial cross. One of these lines (91–21864NA) was entered in the 1993 trials of the Western Canada Canola/Rapeseed Recommending Committee. Key words: Blackleg resistance, Leptosphaeria maculans, doubled haploid, Brassica napus

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