Transcranial magnetic stimulation (TMS) measures and voluntary motor function

Author(s):  
John Rothwell ◽  
Ricci Hannah

Transcranial magnetic stimulation (TMS) can be viewed as interacting with voluntary movement in two ways: it can used to probe the excitability of central nervous system (CNS) pathways before, during, and after a movement; alternatively, it can be used to interfere with movement and give information about the role of different cortical areas in different aspects of a task. This chapter concentrates on the role of single and paired pulse TMS methods that have been covered in detail in previous chapters. Long lasting effects of repetitive TMS (rTMS) are described in later chapters. Almost all of the TMS measures described in previous chapters differ in subjects at rest and during tonic voluntary activity.

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Mengchu Cui ◽  
Hongfei Ge ◽  
Hengli Zhao ◽  
Yongjie Zou ◽  
Yujie Chen ◽  
...  

Localized magnetic fields (MFs) could easily penetrate the scalp, skull, and meninges, thus inducing an electrical current in both the central and peripheral nervous systems, which is primarily used in transcranial magnetic stimulation (TMS) for inducing specific effects on different regions or cells that play roles in various brain activities. Studies of repetitive transcranial magnetic stimulation (rTMS) have led to novel attractive therapeutic approaches. Neural stem cells (NSCs) in adult human brain are able to self-renew and possess multidifferential ability to maintain homeostasis and repair damage after acute central nervous system. In the present review, we summarized the electrical activity of NSCs and the fundamental mechanism of electromagnetic fields and their effects on regulating NSC proliferation, differentiation, migration, and maturation. Although it was authorized for the rTMS use in resistant depression patients by US FDA, there are still unveiling mechanism and limitations for rTMS in clinical applications of acute central nervous system injury, especially on NSC regulation as a rehabilitation strategy. More in-depth studies should be performed to provide detailed parameters and mechanisms of rTMS in further studies, making it a powerful tool to treat people who are surviving with acute central nervous system injuries.


Author(s):  
John C. Rothwell

Transcranial magnetic stimulation (TMS) can be used to probe the excitability of central nervous system pathways before, during, and after a movement. In addition, it can be used to interfere with movement and give information about the role of different cortical areas in different aspects of a task. This article reviews the work that has been carried out using TMS measures to probe the excitability of central circuits before and after different types of contraction in healthy subjects. In some cases the results confirm previous work on animals, which means that the same measures can be used to investigate the pathophysiology in human neurological disease. However, many results reveal new information that had not previously been described in experiments on animals. Therefore, it is not wrong to say that TMS measures can be used to describe in humans what has already been described in animals; they can become drivers of new concepts as well.


2008 ◽  
Vol 119 ◽  
pp. S79
Author(s):  
Nuria Raguer ◽  
Karina Breitenbucher ◽  
Carlos Sanchez ◽  
Margarida Gratacos ◽  
Manolo Benito ◽  
...  

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