scholarly journals 100: Non-Dairy Milk Consumption is Associated with Lower Serum 25-Hydroxyvitamin D in Early Childhood

2014 ◽  
Vol 19 (6) ◽  
pp. e71-e71
Author(s):  
GJ Lee ◽  
CS Birken ◽  
PC Parkin ◽  
G Lebovic ◽  
Y Chen ◽  
...  
Keyword(s):  
Early Childhood ◽  
Milk Consumption ◽  
Lower Serum ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Dairy Milk

scholarly journals Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Bankole Peter Kuti ◽  
Alex Ifeoluwa Akinwumi ◽  
Demilade Kehinde Kuti ◽  
Kazeem Olanrewaju Amoo
Keyword(s):  
Vitamin D ◽  
Total Antioxidant Capacity ◽  
Serum Vitamin ◽  
Severe Pneumonia ◽  
Lower Serum ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Nigerian Children ◽  
Total Antioxidant ◽  
25 Hydroxyvitamin D

Abstract Background The pathologic basis of childhood community-acquired pneumonia (CAP) involves the generation of reactive oxygen species by immune cells leading to cellular damage and lung congestion. Serum antioxidants and vitamin D with immunomodulatory properties therefore hold prospects in the prevention and management of pneumonia in children. This case–control study set out to compare the serum 25-hydroxyvitamin D (25-OHD) and total antioxidant capacity (TAC) in Nigerian children with CAP and age- and sex-matched controls and to relate these parameters with pneumonia severity and outcome—length of hospital stay (LOH). Results A total of 160 children (80 each for CAP and controls) were recruited. The median (IQR) age was 1.8 (0.6–4.0) years, male:female 1.7:1, 63 (78.8%) and 11 (13.8%) of CAP group had severe pneumonia and parapneumonic effusions, respectively. Serum 25-OHD (33.8 (18.3) ng/ml vs. 41.9 (12.3) ng/ml; p = 0.010) and TAC (6.1 (4.4–8.1) ng/dl vs. 7.2 (4.7–17.5) ng/dl; p = 0.023) were lower in children with CAP than controls. Lower serum 25-OHD was observed in severe than non-severe pneumonia (30.5(17.1) ng/ml vs. 46.3 (17.6) ng/ml; p = 0.001) but LOH did not correlate with serum 25-OHD and TAC. Conclusion Children with CAP had lower serum vitamin D and antioxidants than controls, and severe pneumonia was significantly associated with suboptimal serum vitamin D. They however were not related to pneumonia outcome. Optimal serum vitamin D and antioxidants may play a role in reducing the incidence of childhood CAP in Nigerian children.

scholarly journals Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia

2019 ◽  
Vol 47 (10) ◽  
pp. 4673-4682 ◽  
Author(s):  
Xinhua Chen ◽  
Xuxia Xi ◽  
Fan Cui ◽  
Ming Wen ◽  
Aijuan Hong ◽  
...  
Keyword(s):  
Late Onset ◽  
Demographic Data ◽  
Rank Correlation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Lower Serum ◽  
Hydroxyvitamin D ◽  
Diagnosis And Prognosis ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
25 Hydroxyvitamin D

Objective To determine the association between levels of serum 25-hydroxyvitamin D (25[OH]D) and soluble fms-like tyrosine kinase 1 (sFlt-1) in patients with preeclampsia. Methods Clinical and demographic data were collected from patients with preeclampsia and healthy pregnant controls. Serum 25(OH)D and sFlt-1 levels were evaluated by enzyme-linked immunosorbent assay and their correlations were determined using Spearman’s rank correlation coefficient. Associations between serum 25(OH)D and sFlt-1 levels and disease severity and clinical parameters were evaluated. Results Significantly lower serum 25(OH)D and higher sFlt-1 levels were observed in patients with preeclampsia ( n = 100) versus controls ( n = 100), and 25(OH)D was inversely correlated with sFlt-1 in patients with preeclampsia. Serum 25(OH)D levels were reduced, while sFlt-1 concentration was increased in patients with severe versus mild preeclampsia. Serum 25(OH)D levels were reduced in late-onset versus early-onset severe preeclampsia. Patients with preeclampsia who had lower serum 25(OH)D or elevated sFlt-1 levels showed significantly higher blood pressure indexes versus those with higher 25(OH)D or lower sFlt-1. Conclusions Low serum 25(OH)D and high sFlt-1 may be candidate biomarkers for preeclampsia diagnosis and prognosis.

Goat’s Milk, Plant-based Milk, Cow’s Milk, and Serum 25-hydroxyvitamin D Levels in Early Childhood

Epidemiology ◽  
2016 ◽  
Vol 27 (4) ◽  
pp. e29-e31 ◽  
Author(s):  
Grace J. Lee ◽  
Catherine S. Birken ◽  
Patricia C. Parkin ◽  
Gerald Lebovic ◽  
Yang Chen ◽  
...  
Keyword(s):  
Early Childhood ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Hydroxyvitamin D ◽  
Goat’S Milk ◽  
25 Hydroxyvitamin D ◽  
Goat's Milk

Prospective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood

Autism ◽  
2018 ◽  
Vol 23 (3) ◽  
pp. 584-593 ◽  
Author(s):  
Yamna Ali ◽  
Laura N Anderson ◽  
Sharon Smile ◽  
Yang Chen ◽  
Cornelia M Borkhoff ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Early Childhood ◽  
Relative Risk ◽  
Confidence Interval ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Adjusted Relative Risk ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Several studies have suggested an association between vitamin D in childhood and autism spectrum disorder. No prospective studies have evaluated whether lower vitamin D levels precede ASD diagnoses – a necessary condition for causality. The objective of this study was to prospectively evaluate whether vitamin D serum levels in early childhood was associated with incident physician diagnosed ASD. A prospective cohort study was conducted using data from preschool-aged children in the TARGet Kids! practice-based research network in Toronto, Canada, from June 2008 to July 2015. 25-hydroxyvitamin D concentration was measured through blood samples and vitamin D supplementation from parent report. Autism spectrum disorder diagnosis was determined from medical records at follow-up visits. Covariates included age, sex, family history of autism spectrum disorder, maternal ethnicity, and neighborhood household income. Unadjusted and adjusted relative risks and 95% confidence intervals were estimated using Poisson regression with a robust error variance. In this study, 3852 children were included. Autism spectrum disorder diagnosis was identified in 41 children (incidence = 1.1%) over the observation period (average follow-up time = 2.5 years). An association between 25-hydroxyvitamin D concentration and autism spectrum disorder was not identified in the unadjusted (relative risk = 1.04, 95% confidence interval: 0.97, 1.11 per 10 nmol/L increase in 25-hydroxyvitamin D concentration) or adjusted models (adjusted relative risk = 1.06; 95% confidence interval: 0.95, 1.18). An association between vitamin D supplementation in early childhood and autism spectrum disorder was also not identified (adjusted relative risk = 0.86, 95% confidence interval: 0.46, 1.62). Vitamin D in early childhood may not be associated with incident physician diagnoses of autism spectrum disorder.

scholarly journals Lower Serum 25-Hydroxyvitamin D Level is Associated With 3 Types of Autoimmune Thyroid Diseases

Medicine ◽  
2015 ◽  
Vol 94 (39) ◽  
pp. e1639 ◽  
Author(s):  
Jie Ma ◽  
Di Wu ◽  
Chenyang Li ◽  
Chenling Fan ◽  
Nannan Chao ◽  
...  
Keyword(s):  
Thyroid Diseases ◽  
Lower Serum ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Regulation of serum 1,25-dihydroxyvitamin D3 in lactating rats

1990 ◽  
Vol 259 (5) ◽  
pp. E665-E671 ◽  
Author(s):  
B. Lobaugh ◽  
A. Boass ◽  
G. E. Lester ◽  
S. U. Toverud
Keyword(s):  
Bolus Injection ◽  
Basal Diet ◽  
Hydroxylase Activity ◽  
Lower Serum ◽  
Dihydroxyvitamin D3 ◽  
Hydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D3 ◽  
Supplemental Calcium ◽  
25 Hydroxyvitamin D ◽  
Hormone Biosynthesis

To characterize further the mechanism(s) underlying the increased serum 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] concentration associated with lactation in the rat, we examined hormone biosynthesis [i.e., renal 25-hydroxyvitamin D-1 alpha-hydroxylase (1 alpha-hydroxylase) activity] and hormone disappearance in groups of lactating Holtzman rats and age- and sex-matched nonlactating controls. 1 alpha-Hydroxylase activity was significantly greater in kidneys from lactating rats (4.0 +/- 0.42 fmol.mg-1.min-1) on a basal diet than in those from nonmated females (1.4 +/- 0.08 fmol.mg-1.min-1), an increment sufficient to account for the observed fourfold elevation of 1,25(OH)2D3 in the dams. The increase occurs despite the lower serum 1,25(OH)2D3 levels in lactating than in nonlactating rats at 12 and 24 h after a bolus injection of 1,25(OH)2D3 (2 ng/g body wt). Elevation of serum 1,25(OH)2D3 is not a requisite consequence of lactation, however, because dams receiving supplemental calcium from food (1.6%) and water (0.3%) exhibited no increase of either serum 1,25(OH)2D3 or 1 alpha-hydroxylase activity compared with controls. In contrast, lactating rats that received a diet with only 0.1% calcium had 5-fold higher serum 1,25(OH)2D3 levels and 20-fold higher 1 alpha-hydroxylase activity than nonlactating rats on the same diet. We conclude that other factors in conjunction with lactation, but not the lactating state per se, promote the changes in 1,25(OH)2D3 metabolism observed.

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