Fibromyalgia Symptom Severity and Psychosocial Outcomes in Fibromyalgia Patients with Hypovitaminosis D: A Prospective Questionnaire Study

Abstract Objective To evaluate the association between hypovitaminosis D and outcomes of symptom severity, mood disorders, fatigue, and quality of life in fibromyalgia (FM) patients. Methods Five hundred ninety-three FM patients were surveyed from May 2012 to November 2013. Patients with serum vitamin D <25 ng/mL were considered to have hypovitaminosis D. The primary outcome was FM symptom severity (FIQ-R questionnaire). Secondary outcomes included quality of life (SF-36), fatigue (MFI-20), anxiety (GAD-7), and depression (PHQ-9). Independent t tests and chi-square tests were performed for continuous and categorical variables, respectively. Regression analysis was performed adjusting for age, gender, body mass index, ethnicity, and season. A post hoc analysis examined for correlation between outcomes and serum vitamin D (ng/mL) as a continuous variable. Results One hundred twenty-two patients (20.6%) had hypovitaminosis D. In our adjusted regression analysis, the total FIQ-R score in patients with hypovitaminosis D was higher compared with control patients with adequate serum vitamin D (57.85 ± 18.09 vs 62.79 ± 18.10, P = 0.04). Adjusted regression analysis revealed higher total GAD-7 (P = 0.01) and higher total PHQ-9 scores (P = 0.04) in patients with hypovitaminosis D compared with control patients. There were no differences based on severity of depression or anxiety. No differences in fatigue or quality of life were identified. Unadjusted post hoc analysis revealed that as serum vitamin D increased, there was an association with lower total FIQ-R (β coefficient = –0.11, P = 0.02) and lower SF-36 subscale scores of role-physical (β coefficient = –0.10, P = 0.03). Adjusted post hoc analysis revealed no significant associations. Conclusions Hypovitaminosis D may be a risk factor for worse symptom severity, anxiety, and depression in FM patients.

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Serum vitamin D levels and survival of patients with colorectal cancer: Post-hoc analysis of a prospective cohort study

BMC Cancer ◽

10.1186/1471-2407-10-347 ◽

2010 ◽

Vol 10 (1) ◽

Cited By ~ 58

Author(s):

Hidetoshi Mezawa ◽

Tsutomu Sugiura ◽

Michiaki Watanabe ◽

Chihiro Norizoe ◽

Daisuke Takahashi ◽

...

Keyword(s):

Colorectal Cancer ◽

Vitamin D ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Serum Vitamin ◽

Post Hoc Analysis ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Post Hoc

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Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome

Journal of the American College of Nutrition ◽

10.1080/07315724.2018.1510349 ◽

2018 ◽

Vol 38 (4) ◽

pp. 327-333 ◽

Cited By ~ 7

Author(s):

Amir Abbasnezhad ◽

Reza Amani ◽

Amin Hasanvand ◽

Esmaeil Yousefi Rad ◽

Meysam Alipour ◽

...

Keyword(s):

Quality Of Life ◽

Vitamin D ◽

Irritable Bowel Syndrome ◽

Clinical Symptoms ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Irritable Bowel

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Quality of Life-Spasticity-Fatigue Score in Patients With Multiple Sclerosis and Serum Vitamin D Level

Journal of Neurology Research ◽

10.14740/jnr372e ◽

2016 ◽

Vol 6 (1) ◽

pp. 18-23

Author(s):

Yasemin Ozkan

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Vitamin D ◽

Serum Vitamin ◽

Fatigue Score ◽

Serum Vitamin D

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Vitamin D status and quality of life in people with Irritable Bowel Syndrome

Proceedings of The Nutrition Society ◽

10.1017/s0029665120006023 ◽

2020 ◽

Vol 79 (OCE2) ◽

Author(s):

Claire Williams ◽

Elizabeth Williams ◽

Bernard Corde

Keyword(s):

Quality Of Life ◽

Vitamin D ◽

Irritable Bowel Syndrome ◽

Clinical Diagnosis ◽

Symptom Severity ◽

Serum Vitamin ◽

Vitamin D Status ◽

Baseline Serum ◽

Irritable Bowel

AbstractIrritable Bowel Syndrome (IBS) is a chronic and debilitating functional disorder of the gastrointestinal tract with serious and detrimental impacts on quality of life. Its aetiology is largely unknown, and the identification of effective management strategies remains far from complete. Research suggests that people with IBS have a high prevalence of vitamin D deficiency, which may impact on symptom severity and quality of life.A double-blind, placebo-controlled, 2-arm, parallel-design study is underway to investigate the effect of a 12 week, 3,000IU vitamin D p.d. supplementation on symptom severity and quality of life in participants with a clinical diagnosis of IBS. This report assesses whether relationships exist between vitamin D status, IBS severity and quality of life in the baseline (cross-sectional) data.Eighty males and females with a clinical diagnosis of IBS were recruited in phase I of the trial in January-April 2018. Mixed-type IBS and constipation-predominant IBS were the more frequent subtypes (36% and 33%), while diarrhoea-predominant had a lower prevalence (23%). More females (n = 65) than males (n = 15) were recruited to the study which reflects the reported greater prevalence of IBS in women. Baseline serum 25(OH)D levels in participants were classified as deficient 23.1% (n = 18) (< 30nmol/L), insufficient 37.2% (n = 29) (31–49 nmol/L) and sufficient 39.7% (n = 31) (> 50 nmol/L) respectively. The sample median for serum vitamin D at baseline was 42.2 (± 28.3) nmol/L. Quality of Life was significantly associated with two IBS sub-symptoms: pain (p = 0.037, r = 0.233) and distension severity (p = 0.009, r = 0.291). Neither Quality of Life, nor IBS symptom severity score, correlated with vitamin D status in the sample.This study found no relationship between baseline vitamin D status and symptom severity or quality of life in this subsample. Two publications report vitamin D intervention improves quality of life in participants with IBS. It is possible that the unusual homogeneity of these studies enabled identification of these relationships.These initial observations agree with previous reports of widespread vitamin D insufficiency in people with IBS. Analysis of full trial outcomes (July 2019) will determine whether vitamin D supplementation is beneficial for either symptoms severity or quality of life in people with IBS.

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Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People

Nutrients ◽

10.3390/nu11112748 ◽

2019 ◽

Vol 11 (11) ◽

pp. 2748 ◽

Cited By ~ 2

Author(s):

Verde ◽

Giaquinta ◽

Sainz ◽

Ondina ◽

Araque

Keyword(s):

Quality Of Life ◽

Vitamin D ◽

Muscle Strength ◽

Serum Vitamin ◽

Self Report ◽

Three Dimensions ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Relationship

As the relationship between vitamin D and various diseases or health conditions has become known, interest in the contribution of vitamin D to overall health-related quality of life (QoL) has increased. We examined the relationship between vitamin D status and QoL in 273 participants aged 65 years and older. Serum levels of total calcium, phosphorus, intact parathyroid hormone, albumin, and 25-hydroxyvitaminD3 were analyzed. We also recruited data for QoL, physical activity, nutritional impairment, and muscular strength. Ninety percent of the subjects were classified as vitamin D deficient or insufficient. Participants with higher serum 25(OH)D3, calcium, phosphorous, and Alb levels were significantly less likely to self-report depression or anxiety after adjustment (p = 0.009, p = 0.005, p = 0.003, and p = 0.005, respectively). Additionally, we found an association between lower levels of albumin and self-reported problems with mobility or usual activities (p = 0.01). We also found associations between better muscle strength and higher levels of vitamin D, calcium, phosphorous, and albumin (p = 0.006, p = 0.003, p = 0.004 and p = 0.002, respectively). Overall, our data provide evidence that serum vitamin D and Alb levels are negatively related to self-reported anxiety or depression, usual activities, mobility, and three dimensions of QoL in older adults. Furthermore, vitamin D levels are positively related to hand grip strength in adults over 65 years old.

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Relationship between Serum Vitamin D Levels and Health-Related Quality of Life in Maintenance Hemodialysis Patients

Blood Purification ◽

10.1159/000497242 ◽

2019 ◽

Vol 48 (1) ◽

pp. 67-75 ◽

Cited By ~ 1

Author(s):

Ali Veysel Kara ◽

Mehmet Naci Aldemir ◽

Yasin Emrah Soylu ◽

Yusuf Kemal Arslan

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Vitamin D ◽

Kidney Disease ◽

Serum Vitamin ◽

Hemodialysis Patients ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Independent Risk Factors

Objectives: Aim of the study was investigating the effect of serum vitamin D levels on health-related quality of life in hemodialysis patients. Method: One-hundred and twenty-three maintenance hemodialysis patients were enrolled in this cross-sectional study. Patients divided into 2 groups according to serum vitamin D levels. A serum 25-hydroxyvitamin D (25[OH] D) level of < 20 ng/mL was identified as vitamin D deficiency (n = 78), and a serum level of ≥20 ng/mL was identified as normal (n = 45). Kidney Disease Quality of Life 36 (KDQOL-36) survey was used for quality of life measurement. Scores of the all of 5 subscales of KDQOL-36 were calculated. Multiple linear regression analyses were used to define independent risk factors affecting the survey. Results: Mean age of patients was 62 and 56% of patients were male. Mean 25(OH) D levels were 11.86 and 29.57 ng/mL, respectively, in 2 groups. There was statistically significant difference between age and Kt/V levels between 2 groups (p = 0.008 and p = 0.041). Age and gender were found as significant predictors of vitamin D deficiency (p = 0.026 and p = 0.021). In symptom and problem list subscale, gender and comorbidity were detected as independent risk factors (p = 0.050 and p = 0.032). Comorbidity was the only independent risk factor for effect of kidney disease subscale (p < 0.001). Independent risk factors associated with burden of kidney disease subscale were comorbidity and serum 25 (OH) D levels (p = 0.003 and p = 0.023). Serum 25(OH) D, gender, and comorbidity were independently associated with physical component summary (PCS) subscale (p < 0.001, p = 0.008, and p = 0.011). The only independently associated factor with mental component summary (MCS) was serum 25(OH) D (p < 0.001). Conclusion: We first showed the relationship between serum vitamin D levels and KDQOL-36 in hemodialysis patients. Lower serum vitamin D levels were negatively associated with burden of kidney disease, PCS, and MCS subscales.

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