MRI Various Sequences in Evaluation of Hypervascular Hepatic Focal Lesions in Cirrhotic Patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Rania Aly Maarouf ◽  
Mohamed Khairy Mohamed Fayed ◽  
Mohamed Amr Farouk ◽  
Mai Mokhtar Kamal Barakat
Keyword(s):  
Contrast Material ◽  
Dynamic Mri ◽  
Management Plan ◽  
Response To Treatment ◽  
Disease Assessment ◽  
Radiology Department ◽  
Breath Hold ◽  
University Hospitals ◽  
Focal Lesions ◽  
Tissue Water

Abstract Background Hepatic focal lesions may be benign or malignant and some of the hypervascular focal lesions may be benign. Therapy requires an accurate diagnosis, which in turn relies primarily on appropriate imaging and image-guided biopsy. Objectives The purpose of this study is to study the role of MRI in characterization of hypervascular hepatic focal lesions in cirrhotic patient on unenhanced, dynamic contrastenhanced and diffusion weighted MR images for better patient management plan. Patients and Methods This study was conducted at Radiology department at Ain Shams University hospitals. About 70 patients were included (17 females & 53 males) and their age ranged from 14 to 87 years. Results DW MRI in the liver is a relative new and increasingly used imaging technique. It has the advantage that it can be obtained during a single breath-hold; it provides unique information that reflects tissue cellularity and organization. The ADC maps can also provide quantitative measurements of tissue water diffusibility, which can be used not only for disease assessment, but also for the evaluation of disease response to treatment. Conclusion Conventional MRI sequences combined with dynamic MRI and DWI provide further more accurate diagnoses for hepatic focal lesions, especially for hypervascular hepatic focal lesions which requires the necessity for injecting the contrast material and through the different pattern of enhancement and washout, we could be able to reach the definite diagnosis for these hepatic focal lesions and so stating management as early as possible which reflect on increasing the prognostic criteria for hepatic focal lesions.

scholarly journals Analysis of Personality Traits in Patients with Hodgkin Lymphoma

2021 ◽  
Vol 10 (8) ◽  
pp. 1631
Author(s):  
Fatima Roso-Bas ◽  
Maria Dolores Alonso-Llobregat ◽  
Leyre Bento ◽  
Blanca Sanchez-Gonzalez ◽  
Ines Herraez ◽  
...  
Keyword(s):  
Personality Traits ◽  
Hodgkin Lymphoma ◽  
Mental Illnesses ◽  
Response To Treatment ◽  
Personality Profiles ◽  
University Hospitals ◽  
Distribution Width ◽  
Potential Link ◽  
Proinflammatory Activity ◽  
Neo Five Factor Inventory

Hodgkin lymphoma (HL) is a highly-curable malignancy mostly affecting young people. As far as we know, there is no published study that has analyzed personality profiles in HL nor their potential role in lymphomagenesis, natural history, or response to treatment. We aim to explore the personality traits of HL patients, as well as the prevalence of mental disorders and suicide ideas. We retrospectively identified all alive HL patients from three centers (Son Espases and Son Llatzer University Hospitals and Hospital del Mar of Barcelona) for using NEO Five-Factor Inventory (NEO-FFI) and Personality Inventory for DSM-5 Brief Form. Patients with HL showed significantly higher neuroticism scores and lower conscientiousness, extraversion, and openness. Considering maladaptive personality traits, HL patients showed higher levels of detachment and psychoticism. All of these translated into the fact that HL patients showed more than double the prevalence of mental illnesses (41%) and more than triple the prevalence of suicidal ideation or attempts than the general population (15 and 6%, respectively). An exploratory analysis of biomarkers associated with HL personality traits showed that higher scores of neuroticism correlated with more elevated erythrocyte sedimentation rate (ESR) and red cell distribution width (RDW), suggesting a potential link between neuroticism and proinflammatory activity in HL.

Retrospective Analysis of the Prognostic Factors That Influence Treatment Response and Survival of Patients with Cancer of Unknown Primary

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Zeinab Abdlelhafeez ◽  
Dina Ragab ◽  
Nervana Hussien ◽  
Fatma El – Tabakh
Keyword(s):  
Prognostic Factors ◽  
Treatment Response ◽  
Retrospective Analysis ◽  
Clinical Oncology ◽  
Cancer Registries ◽  
Cancer Of Unknown Primary ◽  
Response To Treatment ◽  
Unknown Primary ◽  
University Hospitals ◽  
Patients With Cancer

Abstract Background Cancers of unknown primary site (CUPs) are heterogeneous group of metastatic tumors for which a standardized diagnostic work-up could not recognize the site of origin at the time of diagnosis. Cancer registries around the world report the incidence of CUP in the range of 3%–5% of all malignancies, worldwide the overall age-standardized incidence per 100.000 people per year is 4–19 cases. CUP therefore ranks among the top 10 commonest malignancies. CUP occurs equally in both males and females, at average age 60 years old. Incidence of CUP in Egypt is 6.1%in males and 5.5% in females. Aim of the Work to retrospectively identify the prognostic factors that influence treatment outcome and survival of patients diagnosed with cancer of unknown primary treated patients at Clinical Oncology departments at Ain Shams University Hospitals (ASUH) and Helwan University Hospitals by retrospective analysis. Patients and Methods At the department of clinical oncology, Ain Shams University, 102 patients with cancer of unknown primary were identified in the period between January 2012 and December 2017, all patients data was collected and reviewed. The primary end point of this study is to identify different prognostic factors that influence treatment response and OS in 102 patients with CUP in the period from January 2012 to December 2017. Results Patients with PS 1, with no comorbidities showed better treatment response, also Patients younger than 65year, presented with PS1, with no comorbidity had longer survival. Conclusion CUP has a poor prognosis. Some prognostic factors that affect response to treatment and survival in these patients, which may be identified.

Association of Mucoid Degeneration of the ACL with Medial Tibiofemoral Osteoarthritis Progression at MR Imaging

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Samer Mohamed Moustafa ◽  
Amany Moh. Rashad Abdel-Aziz ◽  
Mennatallah Hatem Shalaby
Keyword(s):  
Cartilage Damage ◽  
Strong Association ◽  
Pulse Sequences ◽  
Joint Damage ◽  
Radiology Department ◽  
Proton Density ◽  
Mucoid Degeneration ◽  
University Hospitals ◽  
Osteoarthritis Progression ◽  
And Cartilage

Abstract Background Using MRI, ACL mucoid degeneration is defined as a thickened ACL with increased signal intensity on all MR pulse sequences, with discrete fibers easily distinguished on fatsaturated T2-weighted or fat-saturated proton-density (PD)-weighted images but poorly differentiated on T1-weighted or non-fat-saturated PD-weighted images. Objective To assess the prevalence of ACL mucoid degeneration in a population of patients referred for routine knee MRI, and its association with age and structural joint damage. Patients and Methods Our study is a retrospective study conducted at the radiology department of Ain Shams University hospitals and Ain Shams University Specialized Hospital including 81 cases of knees with ACL mucoid degeneration by MRI and no sex predilection. Cases and controls were scored with respect to independent articular features: cartilage signal and morphology, subarticular bone marrow abnormality, subarticular cysts, subarticular bone attrition, marginal osteophytes and medial meniscal integrity. Results Patients with ACL mucoid degeneration were older than patients with a normal ACL, without statistically significant sex difference. Knees with ACL mucoid degeneration had statistically significant medial meniscal injuries and cartilage damage involving the central and posterior MTFC compared to control knees with a normal ACL frequency matched for age, sex and MR field strength. Conclusion Our study proved that there is a strong association between ACL mucoid degeneration and cartilage damage in MTFC.

scholarly journals Combination of Alvarado score and ultrasound findings in diagnosis of acute appendicitis in children

2017 ◽  
Vol 1 ◽  
pp. 1
Author(s):  
Tamer Fakhry ◽  
Mohamed Shawky
Keyword(s):  
Acute Appendicitis ◽  
Imaging Modality ◽  
Radiology Department ◽  
University Hospitals ◽  
Normal Appendix ◽  
Differential Leukocyte Count ◽  
Alvarado Score ◽  
Ultrasound Findings ◽  
Clinical Scoring ◽  
Us Findings

Appendicitis is the most common cause of emergency abdominal surgeries in children. Ultrasound (US) has been proven to be a helpful imaging modality in patient evaluation, especially in children suspected of appendicitis. The Alvarado score is a 10-point scoring system for the diagnosis of appendicitis based on clinical data and differential leukocyte count. The aim of the present study was to evaluate a combination of clinical scoring (Alvarado score) and US findings for accurate diagnosis of appendicitis in children. The study was done in Menoufia University Hospitals from March 2011 to January 2013. 322 children with abdominal pain clinically suspected of having appendicitis were included in the study and clinically assessed to calculate the Alvarado score. Patients were referred to the radiology department for abdominal US. Among the 153 of the 322 patients who were operated on, 149 patients were diagnosed pre-operatively with acute appendicitis and 4 girls were diagnosed with complex ovarian cysts. Of the 149 patients diagnosed with appendicitis, the percentage of appendicitis was 93% (139/149) and 10 (7%) patients had normal appendix. The prevalence of appendicitis among the patients of the study was 43% (139/322). In conclusion, a combination of Alvarado scores and abdominal US is a good approach for the diagnosis of appendicitis in children to reduce the number of laparotomies for normal appendix. In the case of normal appendix or nonvisualization of the appendix via abdominal US without a high Alvarado score, appendicitis can be safely ruled out. If it is proven as an inflamed appendix on US or a high Alvarado score, patient should be subjected for appendectomy without delay.

scholarly journals The Privilege of Proton Magnetic Resonance Spectroscopy in Evaluating Ovarian Tumors

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A A Hafez ◽  
M A Nasr ◽  
N L Salman
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Malignant Tumors ◽  
Radiology Department ◽  
Invasive Technique ◽  
Resonance Spectroscopy ◽  
Ovarian Mass ◽  
University Hospitals ◽  
Non Invasive

Abstract Background Exclusion of malignancy in ovarian mass is of paramount importance. It is the most crucial step after identification of a mass and it has a profound effect on the patient's management. So, a reliable method with which to differentiate a benign from a malignant ovarian mass would provide a basis for optimal preoperative planning and may also reduce the number of unnecessary laparotomies for patients undergoing treatment for benign disease. Objective The aim of our study is to highlight the role of magnetic resonance spectroscopy as a non-invasive technique which may effectively assist in differentiating benign from malignant ovarian masses. Patients and Methods This study included 20 patients with adnexal masses as suggested by preliminary pelvic ultrasound examination. referred from the Gynecology Department to the Radiology Department at Ain shams university hospitals. nine were benign, two were borderline, and six were malignant tumors and 3 were hemorrhagic cyst. Endometriosis, tubo-ovarian abscess. Results Our study revealed sharp choline peak in some benign as well as some malignant cases and so Cho peak could not help in the differential diagnosis between benign and malignant tumors, creatine, lipid and NAA were detected in both benign and malignant tumors, also Choline/Creatine Ratio fairly can differentiate between benign and malignant tumors with cut off point = 3.750 at sensitivity = 75.0% & specificity = 100.0% . Conclusion Our study had some factors that affect the results. First, the sample size were not enough to achieve a good results, second, diversity of samples and the complicated tumor histopathologic and morphologic features.

Reflectance confocal microscopy and Hailey-Hailey disease: Assessment of response to treatment after CO2laser ablation

2014 ◽  
Vol 12 (12) ◽  
pp. 1135-1137 ◽  
Author(s):  
Lisa-Lena Grönemeyer ◽  
Kai-Martin Thoms ◽  
Hans Peter Bertsch ◽  
Lars Hofmann ◽  
Michael P. Schön ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
Response To Treatment ◽  
Disease Assessment

scholarly journals Emergency imaging after a mass casualty incident: role of the radiology department during training for and activation of a disaster management plan

2016 ◽  
Vol 89 (1061) ◽  
pp. 20150984 ◽  
Author(s):  
Ferco H Berger ◽  
Markus Körner ◽  
Mark P Bernstein ◽  
Aaron D Sodickson ◽  
Ludo F Beenen ◽  
...  
Keyword(s):  
Disaster Management ◽  
Mass Casualty Incident ◽  
Management Plan ◽  
Mass Casualty ◽  
Radiology Department ◽  
Emergency Imaging

scholarly journals Use of gadobenate dimeglumine dynamic MRI for detection of early hepatocellular carcinoma in atypical hepatic focal lesions

2017 ◽  
Vol 3 (6) ◽  
Author(s):  
Mohamed F. El-Gazzar ◽  
Mohamed Ahmed Samy Kohla ◽  
Mahmoud M. El-Sakhawy ◽  
Mohamed M. Husseiny ◽  
Reda R. H. Yousef ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dynamic Mri ◽  
Gadobenate Dimeglumine ◽  
Focal Lesions ◽  
Early Hepatocellular Carcinoma

scholarly journals MR ENTEROGRAPHY: AN EMERGENT TECHNIQUE FOR CHARACTERIZATION OF SMALL BOWEL LESIONS IN ONCOLOGICAL AND NON-ONCOLOGY DISEASES

2018 ◽  
Vol 4 (4) ◽  
Author(s):  
Waqas Ahmad ◽  
Iram Zaheer ◽  
Imran Khalid Niazi ◽  
Khurram Aftab Mufti
Keyword(s):  
Small Bowel ◽  
Imaging Technique ◽  
Contrast Material ◽  
Three Dimensional ◽  
Mr Enterography ◽  
Breath Hold ◽  
Diffusion Weighted Images ◽  
Before And After ◽  
Computed Tomography Enterography

Small bowel is not easily accessed by endoscope and diagnosis of its pathology relies on clinical assessment and imaging. Traditional contrast studies have the disadvantage of not including the mural and extramural details. This is best seen with magnetic resonance enterography (MRE) which is rapidly replacing computed tomography enterography due to better soft tissue resolution and lack of ionizing radiation. Comprehensive MRE requires axial and coronal T1- and T2-WI, high-resolution diffusion-weighted images, fat-suppressed three-dimensional T1-W breath-hold gradient-echo images of the abdomen, and pelvis before and after intravenous gadolinium-based contrast material administration. MRE is the preferred imaging technique for small bowel pathology due to its ability to show mural and extramural details which allow differentiation in acute, active, and chronicity of changes. Being radiation free, there is no age limitation for its use.

scholarly journals P005 Regulators of the guanylate cyclase pathway are potential novel markers of mucosal healing in IBD

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S131-S132
Author(s):  
L E Jeffery ◽  
U N Shivaji ◽  
D Zardo ◽  
A Acharjee ◽  
O M Nardone ◽  
...  
Keyword(s):  
Guanylate Cyclase ◽  
Biologic Therapy ◽  
Statistical Significance ◽  
Mucosal Healing ◽  
Endoscopic Examination ◽  
Response To Therapy ◽  
Response To Treatment ◽  
University Hospitals ◽  
Therapy Assessment ◽  
The Difference

Abstract Background Intestinal guanylate cyclase C (GC-C) present in epithelial cells has been shown to have a role in gut homeostasis. The downstream effects of activation of GC-C are due to production of cyclic-GMP. GC-C is encoded by the gene GUCY2C, mutations in which are implicated in Familial Diarrhoea Syndrome and noted as risk factors for Crohn’s disease. GUCY2C and its activator, GUCA2A have been shown to be downregulated in IBD. We hypothesised that regulation of this pathway might be important in remission and response to therapy. Methods Forty-four patients with IBD and 7 patients with polyps (controls) at University Hospitals Birmingham, UK were recruited under ethical consent. Relevant demographic and clinical data were extracted from the hospital EMR. All patients had disease activity recorded on endoscopic examination of mucosa and intestinal biopsies collected for analysis. Mucosal healing was defined as MES = 0 (UC) and SES-CD <6 (CD). Of 44 patients, 14 had matched baseline and 12-week post-biologic therapy assessment and had tissues collected. Intestinal biopsies were analysed by 3’RNA-sequencing using the Illumina Nextseq sequencer. FASTQ files were generated through BaseSpace and reads de-multiplexed, trimmed, aligned, and quantified using the GeneGlobe (Qiagen) workflow. Expression was compared between groups using either Wilcoxon tests or Kruskal–Wallis with Dunn post-hoc analysis as appropriate. Results Expression of Guanylate cyclase activators GUCA2A and GUCA2B in patients who showed mucosal healing was equivalent to controls, but GUCA2A was down-regulated in those with active disease (non-healing) (p = 0.006). The same pattern was observed for transcriptional regulators of GUCY2C, including HNF4A (p = 0.0248) and CDX2 (0.0062). Correspondingly, GUCY2C was reduced in non-healing mucosa, although the difference was not significant (Figure 1). In patients who responded to biologic therapy, both GUCA2A (p = 0.0234) and GUCA2B (p = 0.0117) were increased at follow-up but no change was observed for those who did not respond. Change in GUCY2C expression did not reach statistical significance in either group, although an increase was observed for a large proportion of responders. Conclusion Our findings suggest that regulation of the Guanylate Cyclase pathway may be involved in the restoration of a stable mucosa in IBD and that expression of its regulators may be used to indicate response to treatment.

Sign in / Sign up

Export Citation Format

Share Document