Relation between Circulating Vitamin k2 level and Osteoporosis in Post-Menopausal Women

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Dina M Abdel Aziz ◽  
Hala A Saleh ◽  
Neven M Taha ◽  
Mohga A Elbadawy
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Liver Function Tests ◽  
Thyroid Stimulating Hormone ◽  
Vitamin K2 ◽  
Mineral Density ◽  
Laboratory Assessment ◽  
Cross Sectional ◽  
Post Menopausal Osteoporosis ◽  
Post Menopausal

Abstract Objective We aimed to measure the serum level of vitamin k2 in postmenopausal osteoporotic patients to determine its role in the disease. Patients and Methods Our study was designed as a cross sectional study, with 15 postmenopausal osteoporotic patients (with reduced bone mineral density BMD), aged between 54-58 years old compared to 15 healthy controls (with normal BMD at all of lumbar spine, femoral neck and hip) matched in age with the patients. All participants were subjected to full medical history taking, physical examination and functional assessment of the activity of daily livings (ADL). Biochemical assays of thyroid stimulating hormone, parathyroid hormone, total calcium, phosphorus, alkaline phosphatase (ALP), 25-hydroxyvitamin D (25 (OH) D), erythrocyte sedimentation rate, Kidney and liver function tests and serum levels of vitamin k2 were performed. Results The patients showed highly significantly lower vitamin k2 levels (P < 0.05) and non-significant correlations between vitamin k2 and the activity of daily living (ADL) nor the other laboratory assessment parameters (P > 0.05) among the patient’s group. Conclusion Vitamin K deficiency is highly prevalent in the majority of our patients and should be considered an associating factor in the etiology of postmenopausal osteoporosis. Vitamin k2 deficiency could result in a decrease in the bone mineral density in postmenopausal women, so vitamin k2 levels should be checked in post-menopausal osteoporosis and any deficiency must be treated and corrected to improve the bone mineral density.

Hormone replacement therapy increases isometric muscle strength of adductor pollicis in post-menopausal women

1999 ◽  
Vol 96 (4) ◽  
pp. 357-364 ◽  
Author(s):  
D. A. SKELTON ◽  
S. K. PHILLIPS ◽  
S. A. BRUCE ◽  
C. H. NAYLOR ◽  
R. C. WOLEDGE
Keyword(s):  
Bone Mineral Density ◽  
Muscle Strength ◽  
Bone Mineral ◽  
Hormone Replacement ◽  
Treated Group ◽  
Control Group ◽  
Sectional Area ◽  
Mineral Density ◽  
Cross Sectional ◽  
Post Menopausal

A randomized open trial of hormone replacement therapy was used to assess changes in adductor pollicis muscle strength during 6–12 months of treatment with Prempak C 0.625® in comparison with an untreated control group. Muscle strength (maximal voluntary force; MVF), muscle cross-sectional area and bone mineral density were measured. Women entering the trial had oestrogen levels below 150 pmolċl-1, confirming their post-menopausal hormonal status. In the treated group, MVF increased by 12.4±1.0% (mean±S.E.M.) of initial MVF over the duration of treatment, while it declined slightly (2.9±0.9%) in the control group. This increase in strength could not be explained by an increase in muscle bulk, there being no significant increase in cross-sectional area during the study. Those subjects who were weakest at enrolment showed the greatest increases in muscle strength after treatment. Bone mineral density in total hip, Ward's triangle and total spine increased in the treated group, in agreement with previous studies. There was no correlation between the individual increases in bone mineral density and those in MVF.

scholarly journals Relation Between Circulating Vitamin K1 and Osteoporosis in the Lumbar Spine in Syrian Post-Menopausal Women

2018 ◽  
Vol 12 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Sawsan Jaghsi ◽  
Taghrid Hammoud ◽  
Shaden Haddad
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Serum Vitamin ◽  
Vitamin K1 ◽  
Mineral Density ◽  
Post Menopausal Osteoporosis ◽  
Menopausal Women ◽  
Healthy Control ◽  
Post Menopausal

Background: In the past two decades, Vitamin K has been receiving more attention due to its role in bone health and metabolism. The bone mineral density does not remain steady with age, particularly declining after menopause. Objective: This study is aimed to investigate the relationship between bone mineral density and serum vitamin K1 levels in post-menopausal women, and to evaluate serum vitamin K1 levels as a potential biomarker for postmenopausal osteoporosis. Methods: Serum levels of vitamin k1 were measured in 23 postmenopausal osteoporotic women, and in 15 postmenopausal healthy control women using a standardized Enzyme-Linked Immune Sorbent Assay (ELISA) kit. Bone mineral density BMD was assessed at the lumbar spine. Results: The mean serum vitamin k1 level was significantly lower in the postmenopausal osteoporotic women group than in the normal control group (mean=0.794 vs3.61ng/ml, P< 0.0001), and serum vitamin k1 concentration was positively correlated with lumbar spine BMD among postmenopausal osteoporotic women (R=0.533, p = 0.009), and in postmenopausal healthy control (R=0.563, p = 0.02). Diagnostic sensitivity and specificity of vitamin k1 for osteoporosis were 90% and 98%, respectively (cut-off value: 0.853 ng/ml). The area under the ROC curve (AUC) value for vitamin k1 was 0.984 the odd ratio result was 18.66. Conclusion: Our results suggest that vitamin K1 may contribute to maintain bone mineral density. Vitamin K1 may have a role in diagnosing post-menopausal osteoporosis. Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.

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