A STUDY OF THE INFLUENCE OF VARIOUS ANTIRHEUMATIC DRUG REGIMENS ON SERUM ACUTE-PHASE PROTEINS, PLASMA TRYPTOPHAN, AND ERYTHROCYTE SEDIMENTATION RATE IN RHEUMATOID ARTHRITIS

Rheumatology ◽  
1975 ◽  
Vol 14 (2) ◽  
pp. 101-101 ◽  
Author(s):  
M. AYLWARD ◽  
J. MADDOCK ◽  
R. WHEELDON ◽  
R. J. PARKER
Author(s):  
Ravinder Nath Maini

Rheumatoid arthritis (RA) is a common, painful, and disabling disease affecting 0.8 to 1.0% of the adult population worldwide, with a female:male ratio of 3:1. The predominant feature of the disease is a deforming and destructive polyarthritis, with (less commonly) extra-articular manifestations such as subcutaneous nodule formation, serositis, vasculitis, fibrosing alveolitis, amyloidosis, and Felty’s syndrome. Patients also exhibit systemic features of inflammation, including fatigue, anaemia, weight loss, a raised erythrocyte sedimentation rate (ESR), and elevated concentrations of acute phase proteins....


1990 ◽  
Vol 94 (5) ◽  
pp. 637-640 ◽  
Author(s):  
Paul R. Katz ◽  
Jurgis Karuza ◽  
Steven I. Gutman ◽  
William Bartholomew ◽  
Gary Richman

2019 ◽  
Vol 32 (1) ◽  
pp. 47
Author(s):  
Lara Ali Nazar ◽  
Eiman AA.` Abass

   This study is planned to find relationship between interleukin-33 (IL-33) with its receptor interleukin-1 receptor 4 (IL-1R4), and assurance IL-33/IL-1R4 proportion as biomarker to atherosclerosisin rheumatoid arthritis (RA) Iraqi females patients with and without dyslipidemia. This study was attempted at Baghdad Teaching Hospital included 60 females patients with RA that were isolated into: 30 patients with dyslipidemia(G2), 30 patients without dyslipidemia(G3) and 30 individual as control group (G1) .Patients were experiencing treatment by methortexiene medication, analyzed by rheumatoid factor(RF) and erythrocyte sedimentation rate( ESR) tests. All patients and control groups age ranged from (30-55) years. The results show an increase in ESR, RF, IL-33, and IL-1R4 levels. In addition to decrease in IL-33/IL-1R4 ratio in the two patients groups when contrasted and control group. The momentum examine inferred that the level of ESR, and  IL-33 in RA Iraqi females  patients with dyslipidemia were higher than that in RA Iraqi females patients without dyslipidemia, while the level of IL-33/IL-1R4 ratio in RA Iraqi females patients with dyslipidemia was lower than that in RA Iraqi females patients without dyslipidemia patients; in this manner the IL-33/IL-1R4 ratio may be used as a biomarker in diagnostic early porn to atherosclerosis in RA females patients with dyslipidemia


2020 ◽  
Vol 68 (6) ◽  
pp. 1186-1192
Author(s):  
Bei Zhang ◽  
Yimeng Lei ◽  
Xin Li ◽  
Ziyu Gao ◽  
Liping Xia ◽  
...  

To measure the serum levels of anticarbamylated protein (CarP) antibodies in patients with rheumatoid arthritis (RA) in China and to evaluate the association of anti-CarP antibodies with clinical parameters and disease activity. 260 Chinese patients with RA, 40 patients with osteoarthritis (OA), 88 patients with spondyloarthritis (SpA) and 77 healthy controls were included. The serum levels of anti-CarP antibodies were detected by ELISA. Blood tests to detect the anticyclic citrullinated peptide (CCP) antibody level, rheumatoid factor (RF) level, erythrocyte sedimentation rate, C reactive protein level and Disease Activity Score in 28 joints using the erythrocyte sedimentation rate (DAS28-ESR) were performed by standard methods. Bone erosion was assessed by colour Doppler ultrasonography. A total of 18.8% of patients with RA and 9.4% of anti-CCP antibody and RF-double-negative patients were positive for anti-CarP antibody. The anti-CarP antibody level was significantly higher in patients with RA than in patients with OA or SpA and in healthy controls. Univariate and multivariate analyses showed that the level of anti-CarP antibody was positively correlated with DAS28-ESR; the higher a level of serum anti-CarP antibody, the higher the DAS28-ESR score. Anti-CarP-positive patients had higher disease activity scores than anti-CarP-negative patients. Moreover, anti-CarP-positive patients had a higher risk of developing bone erosion. The anti-CarP antibody was found to play an important role in the diagnosis of RA, especially in anti-CCP antibody and RF-double-negative patients. The anti-CarP antibody is a potential marker of disease activity and bone erosion in RA.


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