scholarly journals P212 The effect of body weight in response to subcutaneous tocilizumab in patients with RA

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Rebecca Davies ◽  
Arani Vivekanantham ◽  
Mark Lunt ◽  
Kath Watson ◽  
Kimme L Hyrich ◽  
...  
Keyword(s):  
Body Weight ◽  
Linear Regression ◽  
Hospital Costs ◽  
Initial Response ◽  
Normal Weight ◽  
Separate Analysis ◽  
Das28 Score ◽  
Antibody Treatment ◽  
Monoclonal Antibody Treatment ◽  
The Relationship

Abstract Background Tocilizumab is an IL-6 receptor humanised monoclonal antibody treatment option in rheumatoid arthritis (RA) who have not responded or are intolerant of disease modifying anti-rheumatic drugs (DMARDs) or other biologics. Tocilizumab was available initially as an intravenous preparation, dosed according to weight, and more recently as a subcutaneous (SC) preparation given at 162mg/weekly irrespective of body weight. Obesity is highly prevalent in RA and there has been concern that starting or switching patients to SC tocilizumab could reduce its effectiveness in those patients with a higher body weight. The objective of the current study is to investigate the relationship between body weight and DAS28 response at 6 months in tocilizumab naïve RA patients starting SC tocilizumab. Methods The study population comprised RA subjects recruited to the BSRBR-RA up to 30/11/2018 commencing SC tocilizumab for the first time. Patients had to be tocilizumab naïve and have at least one six monthly study follow-ups recorded after starting tocilizumab. Baseline characteristics at point of starting tocilizumab are described. Linear regression, fully adjusted for relevant confounders, was used to investigate the relationship between change in DAS28 score from baseline to six months and body weight per ten kilograms (kg), and in a separate analysis, as BMI category. Multiple imputation was used to handle missing data. Results Three hundred and fifteen patients starting SC tocilizumab were eligible for analysis. The median age was 60 years, majority were female, and had median disease duration of 11 years at baseline. Seventy percent had prior biologic exposure. Median weight was 76kg, and the majority of patients were categorised as normal weight (37%) or pre-obesity (31%) according to BMI. Median DAS28 score was 5.5 at start of treatment with median improvement after 6-months of 2.0 units. The fully adjusted linear regression model showed no association between body weight or BMI and change in DAS28 score at six months (Table 1). Conclusion Data from this study show that body weight does not appear to affect initial response to SC tocilizumab. This is reassuring given that patients are likely to be given subcutaneous tocilizumab due to ease of administration and reduced hospital costs. Disclosures R. Davies None. A. Vivekanantham None. M. Lunt None. K. Watson None. K.L. Hyrich None. J. Bluett None.

Voluntary food intake in relation to body weight among British breeds of cattle

1986 ◽  
Vol 42 (1) ◽  
pp. 11-18 ◽  
Author(s):  
St C. S. Taylor ◽  
A. J. Moore ◽  
R. B. Thiessen
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Linear Regression ◽  
Regression Coefficient ◽  
Natural Logarithm ◽  
The Mean ◽  
Voluntary Intake ◽  
Relationship Of ◽  
The Relationship ◽  
Voluntary Food Intake

ABSTRACTVoluntary food intake and body weight were examined over 4-week intervals between 14 and 70 weeks of age in 306 females from 25 British breeds of cattle. At each age, the relationship of the natural logarithm of voluntary food intake to that of body weight was examined by linear regression both within and between breeds.Of the total variation in voluntary food intake, the proportion accounted for by body weight was extremely high between breeds (phenotypically, 0·80 or more; genetically 0·88 or more, at most ages) but phenotypically low within breeds (0·33 or less). The mean voluntary intake of a breed at any age could be predicted from its mean body weight at the same age with a coefficient of variation (CV) among breeds that declined with age from 0·08 to 0·04. Within breeds, the corresponding CV for individual intake was between 0·12 and 0·15 beyond 9 months of age, and even higher at early ages.Within breeds, the regression coefficient of log intake on log body weight was close to the value of 0·7 at all ages. Between breeds, it was over 0·8 at early ages, declining to about 0·7 beyond 1 year of age. Thus, genetically larger breeds voluntarily consumed relatively more food at early ages compared with later ages. Breed size should therefore be taken into account when recommending food intake requirements. Breed deviations for high and low appetite are discussed.

scholarly journals Association of gestational diabetes mellitus with offspring weight status across infancy: a prospective birth cohort study in China

2020 ◽  
Author(s):  
Jiajin Hu ◽  
Yilin Liu ◽  
Xiaotong Wei ◽  
Lin Li ◽  
Ming Gao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Linear Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Multiple Linear Regression ◽  
Normal Weight ◽  
Effect Estimate ◽  
Obese Women ◽  
Z Scores

Abstract Background: The association between gestational diabetes mellitus (GDM) and childhood body weight remains controversial, and additional study is needed, especially in Asian populations.Methods: This prospective study investigated the association between maternal glucose concentration, and GDM status and infant body weight from birth to 12 months of age. Linear mixed effects (LME) models and multiple linear regression were used to assess the longitudinal association of GDM with infant growth measured by weight-for-length z-scores (WFLZ), weight-for-age z-scores (WFAZ), and length-for-age z-scores (LFAZ) at birth, 1, 3, 6, 8, and 12 months of age.Results: Offspring born to mothers with GDM had higher WFLZ [β: 0.26 SD units (95% CI: 0.13–0.40)] across infancy than those of mothers without GDM. When stratified analysis by maternal pre-pregnancy body mass index (BMI) status, the association was pronounced in normal-weight [β:0.28 SD units (95% CI: 0.11–0.45)] and overweight/obese women [β: 0.34 SD units (95% CI: 0.09–0.58)] but not in underweight women (P for interaction <0.05). Multiple linear regression found that the effect estimate of GDM on infant WFLZ was highest at birth [β: 0.36 SD units (95% CI: 0.11– 0.61)], remained significant at 1 [β: 0.22 SD units (95% CI: 0.03–0.41)] and 3 [β:0.19 SD units (95% CI: 0.01–0.37)] months of age and decreased across infancy. Maternal GDM status was not associated with infant WFAZ or LFAZ.Conclusions: Maternal GDM status was associated with infant WFLZ, but not WFAZ or LFAZ. The association between GDM status and offspring WFLZ was more pronounced in early infancy or in normal-weight and overweight/obese women. Increased public health efforts to prevent GDM in normal-weight and overweight/obese pre-pregnancy mothers are recommended to control offspring overweight or obesity.

scholarly journals Association of gestational diabetes mellitus with offspring weight status across infancy: a prospective birth cohort study in China

2020 ◽  
Author(s):  
Jiajin Hu ◽  
Yilin Liu ◽  
Xiaotong Wei ◽  
Lin Li ◽  
Ming Gao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Linear Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Multiple Linear Regression ◽  
Weight Status ◽  
Normal Weight ◽  
Obese Women ◽  
Childhood Weight

Abstract Background: The association between gestational diabetes mellitus (GDM) and childhood body weight remains controversial, and additional study is needed, especially in Asian populations.Methods: This prospective study investigated the association between maternal glucose concentration, and GDM status and infant body weight from birth to 12 months of age. Linear mixed effects (LME) models and multiple linear regression were used to assess the longitudinal association of GDM with infant growth measured by weight-for-length (WFLZ), weight-for-age (WFAZ), and length-for-age (LFAZ) z-scores at birth, 1, 3, 6, 8, and 12 months of age.Results: Offspring born to mothers with GDM had higher WFLZ [β: 0.26 SD units (95% CI: 0.13–0.40)] across infancy than those of mothers without GDM. The association was more pronounced in normal-weight and overweight/obese women (P for interaction< 0.05). Multiple linear regression found that the effect estimate of GDM on infant WFLZ was highest at birth [β: 0.32 SD units (95% CI: 0.07– 0.57)], remained significant at 1 [β: 0.24 SD units (95% CI: 0.05–0.43)] and 3 [β:0.20 SD units (95% CI: 0.01–0.39)] months of age and decreased across infancy. Maternal GDM status was not associated with infant WFAZ or LFAZ.Conclusions: Maternal GDM status was associated with infant WFLZ, but not WFAZ or LFAZ. The association of GDM status with offspring WFLZ was more pronounced in early infancy or in normal-weight and overweight/obese women. The results may help to identify the critical period and specific GDM-risk groups for childhood weight status.

scholarly journals Relationship between binge-eating episodes and self-perception of body weight in a nonclinical sample of five Brazilian cities

2005 ◽  
Vol 27 (4) ◽  
pp. 290-294 ◽  
Author(s):  
Kamile S Siqueira ◽  
José C Appolinário ◽  
Rosely Sichieri
Keyword(s):  
Body Weight ◽  
Binge Eating ◽  
Demographic Variables ◽  
Normal Weight ◽  
Shopping Malls ◽  
Porto Alegre ◽  
Dsm Iv ◽  
The Relationship ◽  
Overweight Subjects ◽  
The Ideal

OBJECTIVE: To investigate the relationship between binge-eating episodes and a perception that body weight is above the ideal in a sample of customers interviewed at shopping malls in five Brazilian cities. METHODS: In 1999, data were collected over the course of one week (Monday-Friday only) at the largest shopping malls in the cities of Porto Alegre, Salvador, Fortaleza, Goiânia and Curitiba (two malls per city). A total of 2855 participants (917 men and 1938 women) were interviewed. Weight and height measurements were standardized. Binge-eating episodes were identified using a questionnaire including the following questions based on DSM-IV diagnostic criteria: "Have you ever eaten, in a period of two hours or less, an amount of food greater than that most people would eat?" and "If the answer was "yes", did you, during these episodes, feel unable to stop eating or to control how much you were eating?". RESULTS: The prevalence of binge-eating episodes was higher among overweight subjects (15.6%) compared with normal-weight subjects (9.9%) (p = 0.0001) and, among subjects who perceived their body weight to be above the ideal (men: 13.9%; women: 15.1%) compared with those who perceived their body weight to be ideal or below the ideal (men: 8%; women: 7%) (p < 0.0001). In the multivariate analysis adjusted for body mass index and demographic variables, binge-eating episodes were correlated with the perception that body weight is above the ideal only among women (OR: 1.8; 95% CI: 1.2-2.5). CONCLUSIONS: These findings suggest that the perception that body weight is above the ideal, regardless of overweight status, is associated with binge-eating episodes in women.

scholarly journals Prediction of Phenytoin Dosage in Epilepsy Using Multiple Linear Regression

1982 ◽  
Vol 19 (3) ◽  
pp. 141-144 ◽  
Author(s):  
S P Gray
Keyword(s):  
Body Weight ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Multiple Regression ◽  
Therapeutic Range ◽  
Drug Dosage ◽  
The Body ◽  
Clinical Value ◽  
Number Of Patients ◽  
The Relationship

Analysis of plasma phenytoin in a group of patients treated for epilepsy showed that only 36% had values in the therapeutic range. The relationship between plasma phenytoin, body weight, and daily dosage of the drug were explored, and the data were analysed by multiple regression. The resultant equation, relating all three factors, was used to optimise drug dosage, and the importance of using the body weight of the patient before starting a phenytoin regimen is emphasised. An increase in the number of patients with plasma phenytoin in the therapeutic range was achieved, and the clinical value of being in that range is shown.

scholarly journals Association of gestational diabetes mellitus with offspring weight status across infancy: a prospective birth cohort study in China

2020 ◽  
Author(s):  
Jiajin Hu ◽  
Yilin Liu ◽  
Xiaotong Wei ◽  
Lin Li ◽  
Ming Gao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Linear Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Multiple Linear Regression ◽  
Normal Weight ◽  
Effect Estimate ◽  
Obese Women ◽  
Z Scores

Abstract Background: The association between gestational diabetes mellitus (GDM) and childhood body weight remains controversial, and additional study is needed, especially in Asian populations.Methods: This prospective study investigated the association between maternal glucose concentration, and GDM status and infant body weight from birth to 12 months of age. Linear mixed effects (LME) models and multiple linear regression were used to assess the longitudinal association of GDM with infant growth measured by weight-for-length z-scores (WFLZ), weight-for-age z-scores (WFAZ), and length-for-age z-scores (LFAZ) at birth, 1, 3, 6, 8, and 12 months of age.Results: Offspring born to mothers with GDM had higher WFLZ [β: 0.26 SD units (95% CI: 0.13–0.40)] across infancy than those of mothers without GDM. When stratified analysis by maternal pre-pregnancy body mass index (BMI) status, the association was pronounced in normal-weight [β:0.28 SD units (95% CI: 0.11–0.45)] and overweight/obese women [β: 0.34 SD units (95% CI: 0.09–0.58)] but not in underweight women (P for interaction <0.05). Multiple linear regression found that the effect estimate of GDM on infant WFLZ was highest at birth [β: 0.36 SD units (95% CI: 0.11– 0.61)], remained significant at 1 [β: 0.22 SD units (95% CI: 0.03–0.41)] and 3 [β:0.19 SD units (95% CI: 0.01–0.37)] months of age and decreased across infancy. Maternal GDM status was not associated with infant WFAZ or LFAZ.Conclusions: Maternal GDM status was associated with infant WFLZ, but not WFAZ or LFAZ. The association between GDM status and offspring WFLZ was more pronounced in early infancy or in normal-weight and overweight/obese women. Increased public health efforts to prevent GDM in normal-weight and overweight/obese pre-pregnancy mothers are recommended to control offspring overweight or obesity.

scholarly journals Vybrané kondiční testy a jejich vztah k výkonu ve sportovním lezení

2011 ◽  
Vol 5 (1) ◽  
pp. 105-116 ◽  
Author(s):  
Ladislav Vomáčko ◽  
Jiří Baláš ◽  
Matouš Jindra
Keyword(s):  
Body Weight ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Body Height ◽  
Sport Climbing ◽  
Standing Long Jump ◽  
Dependent Variables ◽  
Long Jump ◽  
And Performance ◽  
The Relationship

Sport climbing is now seen as part of the climbing population fi tness interesting resource. Th is study clarifi es the relationship between selected conditioning tests, anamnetic data and performance in sport climbing in the climbing trips OS or RP and each points to a relationship between these ways of ascent climbing routes. Study describes the relation between the diff erent standardized tests selected from Eurofi t test set (standing long jump, full forward trunk bend, pull-up hold, manual dynamometry, „fl amingo“ exercise), anthropometric data (body height, body weight, body fat ratio in %) and anamnestic data (length of climbing experience, climbing performance in terms Red Point RP, and On sight OS). Th e dependency measure is expressed by a linear regression with two dependent variables. Th e dependent variables express climbing performance in terms of RP and OS. Th e signifi cant indicators for dependent variable RP in this given regressive model are length of climbing experience, pull-up hold, manual dynamometry and body weight; for the dependent variable OS, these are length of climbing experience, pull-up hold and manual dynamometry. Aft er the application of a linear regression analysis with two dependent variables, the dependency measure between the RP and OS performance was formulated as a partial correlation rp = 0,745.

scholarly journals Association of Gestational Diabetes Mellitus with Offspring Weight Status Across Infancy: A Prospective Birth Cohort Study in China

2020 ◽  
Author(s):  
Jiajin Hu ◽  
Yilin Liu ◽  
Xiaotong Wei ◽  
Lin Li ◽  
Ming Gao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Linear Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Multiple Linear Regression ◽  
Weight Status ◽  
Normal Weight ◽  
Obese Women ◽  
Study Results

Abstract Background: The association between gestational diabetes mellitus (GDM) and childhood body weight remains controversial, and additional study is needed, especially in Asian populations.Methods: This prospective study investigated the association between maternal glucose concentration, and GDM status and infant body weight from birth to 12 months of age. Linear mixed effects (LME) models and multiple linear regression were used to assess the longitudinal association of GDM with infant growth measured by weight-for-length (WFLZ), weight-for-age (WFAZ), and length-for-age (LFAZ) z-scores at birth, 1, 3, 6, 8, and 12 months of age.Results: Offspring born to mothers with GDM had higher WFLZ [β: 0.26 SD units (95% CI: 0.13–0.40)] across infancy than those of mothers without GDM. The association was more pronounced in normal-weight and overweight/obese women (P for interaction< 0.05). Multiple linear regression found that the effect estimate of GDM on infant WFLZ was highest at birth [β: 0.32 SD units (95% CI: 0.07– 0.57)], remained significant at 1 [β: 0.24 SD units (95% CI: 0.05–0.43)] and 3 [β:0.20 SD units (95% CI: 0.01–0.39)] months of age and decreased across infancy. Maternal GDM status were not associated with infant WFAZ or LFAZ.Conclusions: Maternal GDM status were associated with infant weight status, the association was more pronounced in normal-weight and overweight/obese women. The study results may contribute to the development interventions to prevent childhood obesity and to better define the target population.

scholarly journals Association of gestational diabetes mellitus with offspring weight status across infancy: a prospective birth cohort study in China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jiajin Hu ◽  
Yilin Liu ◽  
Xiaotong Wei ◽  
Lin Li ◽  
Ming Gao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Linear Regression ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Multiple Linear Regression ◽  
Normal Weight ◽  
Effect Estimate ◽  
Obese Women ◽  
Z Scores

Abstract Background The association between gestational diabetes mellitus (GDM) and childhood body weight remains controversial, and additional study is needed, especially in Asian populations. Methods This prospective study investigated the association between maternal glucose concentration, and GDM status and infant body weight from birth to 12 months of age. Linear mixed effects (LME) models and multiple linear regression were used to assess the longitudinal association of GDM with infant growth measured by weight-for-length z-scores (WFLZ), weight-for-age z-scores (WFAZ), and length-for-age z-scores (LFAZ) at birth, 1, 3, 6, 8, and 12 months of age. Results Offspring born to mothers with GDM had higher WFLZ [β: 0.26 SD units (95% CI: 0.13–0.40)] across infancy than those of mothers without GDM. When stratified analysis by maternal pre-pregnancy body mass index (BMI) status, the association was pronounced in normal-weight [β:0.28 SD units (95% CI: 0.11–0.45)] and overweight/obese women [β: 0.34 SD units (95% CI: 0.09–0.58)] but not in underweight women (P for interaction < 0.05). Multiple linear regression found that the effect estimate of GDM on infant WFLZ was highest at birth [β: 0.36 SD units (95% CI: 0.11–0.61)], remained significant at 1 [β: 0.22 SD units (95% CI: 0.03–0.41)] and 3 [β:0.19 SD units (95% CI: 0.01–0.37)] months of age and decreased across infancy. Maternal GDM status was not associated with infant WFAZ or LFAZ. Conclusions Maternal GDM status was associated with infant WFLZ, but not WFAZ or LFAZ. The association between GDM status and offspring WFLZ was more pronounced in early infancy or in normal-weight and overweight/obese women. Increased public health efforts to prevent GDM in normal-weight and overweight/obese pre-pregnancy mothers are recommended to control offspring overweight or obesity.

Normalization of Protein Equivalent of Nitrogen Appearance and Dialytic Adequacy in Capd

1996 ◽  
Vol 16 (1_suppl) ◽  
pp. 185-190 ◽  
Author(s):  
Giovambattista Virga ◽  
Giusto Viglino ◽  
Carmen Gandolfo ◽  
Elisabetta Aloi ◽  
Pier Luigi Cavalli
Keyword(s):  
Body Weight ◽  
Peritoneal Dialysis ◽  
Linear Regression ◽  
Life Insurance ◽  
Protein Intake ◽  
Actual Body Weight ◽  
Increased Risk ◽  
Total Body ◽  
Metropolitan Life Insurance ◽  
The Relationship

Caloric-proteic malnutrition is frequently encountered in peritoneal dialysis and is associated with an increased risk of morbidity and mortality. Our paper aims to assess any greater reliability of protein equivalent of nitrogen appearance (PNA) normalization to desirable body weight (dBW) compared to actual body weight (aBW) and resulting implications for the relationship between dialytic adequacy and protein intake in continuous ambulatory peritoneal dialysis (CAPD). We studied 36 patients on CAPD, 24 male and 12 female (aged 66.6±10.2 years, 24±29 months on dialysis), collecting dialysate and urine over 24 hours (126 samples) to calculate the PNA according to Randerson and the total weekly KT N. The total body muscle mass (TBMM) was calculated by anthropometry and the dBW according to Metropolitan Life Insurance tables. Finally, PNA was normalized to aBW (aPNA, g/kg/day) and to dBW (dPNA, g/kg/day). Average aBW proved to be higher than dBW (66.0±11.1 vs 59.8±6.9 kg, p < 0.0001) and aPNA lower than dPNA (0.96±0.31 vs 1.08±0.3 g/kg/day, p < 0.005). Compared to aPNA, dPNA correlates better with both blood urea nitrogen (BUN) (R2 = 0.702 vs 0.614) and KT/V (R2 = 0.348 vs 0.306). The TBMM is higher in the group with dPNA ≥ 1.0 vs < 1.0 g/kg/day (25.5±0.6 vs 23. 1±0. 7 kg, p < 0.02) while, paradoxically, it is lower in patients with aPNA≥ 1.0 vs < 1.0 g/kg/day (22.8±0.8 vs 25.4±0.6 kg, p < 0.01). The KT/V of the patients with dPNA < 0.8,0.8–1.2 and > 1.2 g/kg/day proved to be different (1.52±0.06 vs 1.80±0.03 vs 2.04±0.04, p < 0.005). On analysis of the linear regression, dPNA = 1.0 and 1.2 g/kg/day corresponds to KT/V values of 1.7 and 2.05, respectively. We consider dPNA to be more suitable then aPNA for the correct assessment of protein intake, and a weekly KT/V of 1.7 2.05 as being sufficient to guarantee satisfactory dPNA.

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