MISCELLANEOUS RHEUMATIC DISEASES272. BONE MARROW OEDEMA SYNDROME OF THE FOOT AND ANKLE: OUR CLINICAL EXPERIENCE USING A SINGLE DOSE OF INTRAVENOUS ZOLENDRONIC ACID

Purpose By means of a case series we wanted to describe and correlate the clinical and imaging features of bone marrow oedema syndrome (BMOS) of the foot and ankle in children. Methods A retrospective data study was performed on patients born on or after 01 January 2001 who underwent multiple MRI scans of the foot and ankle for pain symptoms. Six patients who presented with increased signal intensity on T2-weighted MR imaging without any underlying causes or concomitant pathology were included. Results All patients, three boys and three girls with a mean age of 11 years (8 to 14), displayed patchy areas of increased signal intensity on T2-weighted and turbo inversion recovery magnitude (TIRM) images. On average, six tarsal bones were involved (4 to 8). In all patients, treatment consisted of rest and/or protected weight-bearing. The mean time for symptoms to improve during treatment was 6 months (1 to 16). The mean duration of treatment was nine months (3 to 16). In all patients clinical and imaging symptoms were strongly correlated and regressed in time. Conclusion BMOS as a pathological entity should be considered in paediatric patients with foot and ankle pain without a clear underlying cause, and characteristic T2-weighted and TIRM signal intensity increase on MRI images. As BMOS is transient and self-limiting, conservative treatment is advised while the oedema regresses. An early diagnosis of this pathology could prevent unnecessary diagnostic investigations and invasive treatments. Level of Evidence IV

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High prevalence of vitamin D deficiency in patients with bone marrow oedema syndrom of the foot and ankle: Data from a single center analysis

10.26226/morressier.587e1051a874c6002655a372 ◽

2017 ◽

Author(s):

Konstantin Horas

Keyword(s):

Bone Marrow ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Bone Marrow Oedema ◽

Foot And Ankle ◽

Single Center ◽

High Prevalence

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Does adding the presence of MRI detected bone marrow oedema improve the accuracy of the 2010 EULAR/ACR criteria for rheumatoid arthritis?: Table 1

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-206930 ◽

2014 ◽

Vol 74 (3) ◽

pp. e29-e29 ◽

Cited By ~ 2

Author(s):

Wouter P Nieuwenhuis ◽

Monique Reijnierse ◽

Annette HM van der Helm-van Mil

Keyword(s):

Rheumatoid Arthritis ◽

Bone Marrow ◽

Bone Marrow Oedema ◽

Acr Criteria

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THU0492 MAGNETIC RESONANCE IMAGING OF THE SACROILIAC JOINTS IN PATIENTS WITH HYPERMOBILITY: A RETROSPECTIVE COHORT STUDY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.5686 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 482.4-483

Author(s):

A. Jones ◽

C. Ciurtin ◽

H. Kazkaz ◽

M. Hall-Craggs

Keyword(s):

Magnetic Resonance Imaging ◽

Bone Marrow ◽

Back Pain ◽

Lumbar Spine ◽

Magnetic Resonance ◽

Bone Marrow Oedema ◽

Resonance Imaging ◽

Sacroiliac Joints ◽

Fatty Change ◽

Subchondral Sclerosis

Background:The incidence of inflammatory and structural lesions on magnetic resonance imaging of sacroiliac joints (MRI SIJs) in patients with hypermobility related disorders has not been fully investigated. Hypermobile patients are more susceptible to pelvic instability and biomechanical stress of the SIJs, leading to MRI SIJ changes similar to those occurring in spondyloarthritis (SpA). Patients with hypermobility and suspected SpA pose a unique challenge owing to the high prevalence of back pain in the hypermobility cohort and the absence of spinal restriction on clinical examination.Objectives:In this study, we aim to investigate the incidence of MRI SIJ lesions in patients with hypermobility.Methods:We performed a retrospective study of all patients with a confirmed diagnosis of hypermobility related disorders (including hypermobility syndrome, hypermobility spectrum disorders and Ehlers-Danlos Syndromes) referred for an MRI lumbar spine and SIJ between 2011 and 2019 to investigate long-standing back pain. MRIs were examined by a musculoskeletal (MSK) radiologist with more than 25 years of experience, who was blinded to the clinical outcome of the patients. MRI SIJs were assessed for the presence of bone marrow oedema, subchondral sclerosis, erosion, fatty change, enthesitis, ankylosis, joint fluid and capsulitis.Results:51 patients with confirmed hypermobility related disorders were referred for MRI SIJ and lumbar spine between 2011 and 2019. 3 patients demonstrated clinical features in keeping with a diagnosis of SpA and were excluded from the study. 15/48 (31.3%) of patients with hypermobility and back pain (but no clinical picture of SpA) were found to have inflammatory and/or structural lesions on MRI SIJ. The most frequent lesions were small foci of bone marrow oedema (16.6%) followed by subchondral sclerosis (12.5%) and fatty change (10.4%). The incidence of erosions was 4.2%.Conclusion:There is a relatively high incidence of inflammatory and structural lesions on MRI SIJ of patients with hypermobility. The presence of hypermobility should be taken into consideration when interpreting MRI changes in patients with suspected SpA. Further research into long-term outcomes of MRI SIJs in patients with hypermobility and back pain is required to establish the clinical significance of these findings.Disclosure of Interests: :Alexis Jones: None declared, Coziana Ciurtin Grant/research support from: Pfizer, Consultant of: Roche, Modern Biosciences, Hanadi Kazkaz: None declared, Margaret Hall-Craggs: None declared

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Incidence of pubic bone marrow oedema in Australian rules football players: relation to groin pain

British Journal of Sports Medicine ◽

10.1136/bjsm.35.1.28 ◽

2001 ◽

Vol 35 (1) ◽

pp. 28-33 ◽

Cited By ~ 130

Author(s):

G M Verrall

Keyword(s):

Bone Marrow ◽

Groin Pain ◽

Bone Marrow Oedema ◽

Pubic Bone ◽

Football Players ◽

Australian Rules Football

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Is active sacroiliitis on MRI associated with radiographic damage in axial spondyloarthritis? Real-life data from the ASAS and DESIR cohorts

Rheumatology ◽

10.1093/rheumatology/key387 ◽

2018 ◽

Vol 58 (5) ◽

pp. 798-802 ◽

Cited By ~ 2

Author(s):

Alexandre Sepriano ◽

Sofia Ramiro ◽

Robert Landewé ◽

Maxime Dougados ◽

Désirée van der Heijde ◽

...

Keyword(s):

Bone Marrow ◽

Odds Ratio ◽

Structural Damage ◽

Axial Spondyloarthritis ◽

Multivariable Analysis ◽

Real Life ◽

Daily Practice ◽

Bone Marrow Oedema ◽

Number Of Patients ◽

Structural Progression

Abstract Objective To assess any association between bone marrow oedema on MRI of the sacroiliac joints (MRI-SIJ) according to local readings in daily practice and the development of structural damage on radiographs of the SIJ (X-SIJ) in axial spondyloarthritis (axSpA). Methods Patients with axSpA from the Assessment of the SpondyloArthritis international Society (ASAS) and DEvenir des Spondylarthopathies Indifférenciées Récentes (DESIR) multicentre cohorts were included. MRI-SIJ and X-SIJ were obtained at baseline, and X-SIJ at follow-up after a mean 4.6 years (ASAS) and 5.1 years (DESIR). All images were scored by local readers. Structural damage in the X-SIJ was defined according to the modified New York criteria. The percentage of structural net progression (number of ‘progressors’ minus the number of ‘regressors’ divided by the total number of patients) was assessed and the effect of bone marrow oedema on MRI-SIJ on X-SIJ damage evaluated by multivariable logistic regression. Results In total, 125 (ASAS-cohort) and 415 (DESIR-cohort) patients had baseline MRI-SIJ and complete X-SIJ data available. According to local readings, progression and ‘improvement’ in X-SIJ was seen in both the ASAS- and DESIR-cohort, yielding a net progression that was higher in the former than in the latter (19.2% and 6.3%). In multivariable analysis, baseline bone marrow oedema on MRI-SIJ was strongly associated with X-SIJ structural progression in both ASAS (odds ratio = 3.2 [95% CI: 1.3; 7.9]), and DESIR (odds ratio = 7.6 [95% CI: 4.3; 13.2]). Conclusion Inflammation on MRI-SIJ is associated with future radiographic progression according to local readings despite an expected increased imprecision invoked by local readings.

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Clinical Experience With Minocycline and Rifampin-Impregnated Central Venous Catheters in Bone Marrow Transplantation Recipients: Efficacy and Low Risk of Developing Staphylococcal Resistance

Infection Control and Hospital Epidemiology ◽

10.1086/502167 ◽

2003 ◽

Vol 24 (12) ◽

pp. 961-963 ◽

Cited By ~ 45

Author(s):

Ioannis Chatzinikolaou ◽

Hend Hanna ◽

Linda Graviss ◽

Gassan Chaiban ◽

Cheryl Perego ◽

...

Keyword(s):

Bone Marrow ◽

Bone Marrow Transplantation ◽

Clinical Experience ◽

Marrow Transplantation ◽

Bloodstream Infections ◽

Central Venous Catheters ◽

Low Risk ◽

Clinical Use ◽

Retrospective Evaluation ◽

Central Venous

AbstractIn this retrospective evaluation of the 4-year clinical use of minocycline and rifampin-impregnated catheters in bone marrow transplantation (BMT) patients, we report low risk of development of staphylococcal resistance to the antibiotics coating the catheters and efficacy in preventing primary staphylococcal bloodstream infections.

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Assessment of bone marrow Oedema-like lesions using MRI in patellofemoral knee osteoarthritis: Comparison of different MRI pulse sequences

British Journal of Radiology ◽

10.1259/bjr.20201367 ◽

2021 ◽

pp. 20201367

Author(s):

Henry Noorveriandi ◽

Matthew J Parkes ◽

Michael J Callaghan ◽

David T Felson ◽

Terence W O'Neill ◽

...

Keyword(s):

Bone Marrow ◽

Knee Pain ◽

Intraclass Correlation ◽

Pulse Sequences ◽

Correlation Coefficients ◽

Bone Marrow Oedema ◽

Volume Distribution ◽

Data Set ◽

Knee Oa ◽

Contrast Enhanced

Objective: To compare bone marrow oedema-like lesion (BML) volume in subjects with symptomatic patellofemoral (PF) knee OA using four different MRI sequences and to determine reliability of BML volume assessment using these sequences and their correlation with pain. Methods: Seventy-six males and females (mean age 55.8 years) with symptomatic patellofemoral knee OA had 1.5 T MRI scans. PD fat suppressed (FS), STIR, contrast-enhanced (CE) T1-w FS, and 3D T1-w FFE sequences were obtained. All sequences were assessed by one reader, including repeat assessment of 15 knees using manual segmentation and the measurements were compared. We used random-effects panel linear regression to look for differences in the log-transformed BML volume (due to positive skew in the BML volume distribution) between sequences and to determine associations between BML volumes and knee pain. Results: Fifty-eight subjects had PF BMLs present on at least one sequence. Median BML volume measured using T1-w FFE sequence was significantly smaller (224.7 mm3, interquartile range [IQR] 82.50–607.95) than the other three sequences. BML volume was greatest on the CE sequence (1129.8 mm3, IQR 467.28–3166.02). Compared to CE sequence, BML volumes were slightly lower when assessed using PDFS (proportional difference = 0.79; 95% confidence interval [CI] 0.62, 1.01) and STIR sequences (proportional difference = 0.85; 95% CI 0.67, 1.08). There were strong correlations between BML volume on PDFS, STIR, and CE T1-w FS sequences (ρs = 0.98). Correlations were lower between these three sequences and T1-w FFE (ρs = 0.80–0.81). Intraclass correlation coefficients were excellent for PDFS, STIR, and CE T1-w FS sequences (0.991 to 0.995), while the ICC for T1-w FFE was good at 0.88. We found no significant association between BML volumes assessed using any of the sequences and knee pain. Conclusion: T1-w FFE sequences were less reliable and measured considerably smaller BML volume compared to other sequences. BML volume was larger when assessed using the contrast enhanced T1-w FS although not statistically significantly different from BMLs when assessed using PDFS and STIR sequences. Advances in knowledge: This is the first study to assess BMLs by four different MRI pulse sequences on the same data set, including different fluid sensitive sequences and gradient echo type sequence.

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