scholarly journals Exosomes in intercellular communication and implications for osteoarthritis

Rheumatology ◽  
2019 ◽  
Author(s):  
Sabha Asghar ◽  
Gary J Litherland ◽  
John C Lockhart ◽  
Carl S Goodyear ◽  
Anne Crilly
Keyword(s):  
Public Health ◽  
Significant Proportion ◽  
Cell Communication ◽  
Regulatory Mechanisms ◽  
Target Cells ◽  
Public Health Burden ◽  
Health Burden ◽  
Significant Public Health ◽  
Secretory Tissue ◽  
Review Current

Abstract Osteoarthritis (OA) is the most prevalent of the musculoskeletal conditions and represents a significant public health burden. While degeneration of articular cartilage is a key feature, it is now increasingly recognized as a complex condition affecting the whole joint, with synovial inflammation present in a significant proportion of patients. As a secretory tissue, the OA synovium is a rich source of both soluble inflammatory mediators and extracellular vesicles, including exosomes, which have been implicated in cell–cell communication. Exosome cargo has been found to include proteins, lipids and various RNA subtypes such as mRNA and miRNA, potentially capable of regulating gene expression in target cells and tissues. Profiling of exosome cargo and understanding effects on cartilage could elucidate novel regulatory mechanisms within the joint, providing insight for targeted treatment. The aim of this article is to review current literature on exosome biology, highlighting the relevance and application for OA pathogenesis.

scholarly journals Asthma and stroke: a narrative review

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
A. Corlateanu ◽  
Iu Stratan ◽  
S. Covantev ◽  
V. Botnaru ◽  
O. Corlateanu ◽  
...  
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Airway Inflammation ◽  
Severe Disease ◽  
Complex Relationship ◽  
Confounding Effect ◽  
Public Health Burden ◽  
Health Burden ◽  
Asthma Patients ◽  
Significant Public Health

AbstractAsthma is a heterogeneous disease, usually characterized by chronic airway inflammation, bronchial reversible obstruction and hyperresponsiveness to direct or indirect stimuli. It is a severe disease causing approximately half a million deaths every year and thus possessing a significant public health burden. Stroke is the second leading cause of death and a major cause of disability worldwide. Asthma and asthma medications may be a risk factors for developing stroke. Nevertheless, since asthma is associated with a variety of comorbidities, such as cardiovascular, metabolic and respiratory, the increased incidence of stroke in asthma patients may be due to a confounding effect. The purpose of this review is to analyze the complex relationship between asthma and stroke.

Violence

2013 ◽  
Author(s):  
Sheara A. Williams
Keyword(s):  
Public Health ◽  
Violent Behavior ◽  
The United States ◽  
Intervention Strategies ◽  
Prevalence Rates ◽  
Public Health Burden ◽  
Socioeconomic Groups ◽  
Factors Associated ◽  
Health Burden ◽  
Significant Public Health

Violence is a serious social issue that affects millions of individuals, families, and communities every year. It transcends across racial, age, gender, and socioeconomic groups, and is considered a significant public health burden in the United States. The purpose of this entry is to provide an overview of violence as a broad yet complicated concept. Definitional issues are discussed. Additional prevalence rates of select types of violence are presented in addition to risk and protective factors associated with violent behavior. The entry concludes with a summary of approaches to address violence in the context of prevention and intervention strategies.

The genomic epidemiology of SARS-CoV-2 in Palestine

2020 ◽  
Author(s):  
Nouar Qutob ◽  
Zaidoun Salah ◽  
Damien Richard ◽  
Hisham Darwish ◽  
Husam Sallam ◽  
...  
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
The Novel ◽  
Public Health Burden ◽  
Genomic Epidemiology ◽  
Health Burden ◽  
The World ◽  
Significant Public Health ◽  
Novel Coronavirus ◽  
The Uk

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus responsible for the COVID-19 pandemic, continues to cause significant public health burden and disruption globally. Genomic epidemiology approaches point to most countries in the world having experienced many independent introductions of SARS-CoV-2 during the early stages of the pandemic. However, this situation may change with local lockdown policies and restrictions on travel leading to the emergence of more geographically structured viral populations and lineages transmitting locally. Here, we report the first SARS-CoV-2 genomes from Palestine sampled from early March, when the first cases were observed, through to August of 2020. SARS-CoV-2 genomes from Palestine fall across the diversity of the global phylogeny, consistent with at least nine independent introductions into the region. We identify one locally predominant lineage in circulation represented by 50 Palestinian SARS-CoV-2, grouping with isolated viral samples from patients in Israel and the UK. We estimate the age of introduction of this lineage to 05/02/2020 (16/01/2020 - 19/02/2020), suggesting SARS-CoV-2 was already in circulation in Palestine predating its first detection in Bethlehem in early March. Our work highlights the value of ongoing genomic surveillance and monitoring to reconstruct the epidemiology of COVID-19 at both local and global scales.

scholarly journals Rabies epidemiology, prevention and control in Nigeria: Scoping progress towards elimination

2021 ◽  
Vol 15 (8) ◽  
pp. e0009617
Author(s):  
Philip P. Mshelbwala ◽  
J. Scott Weese ◽  
Olufunmilayo A. Sanni-Adeniyi ◽  
Shovon Chakma ◽  
Stephen S. Okeme ◽  
...  
Keyword(s):  
Public Health ◽  
Rabies Virus ◽  
Prevention And Control ◽  
Significant Proportion ◽  
Public Health Problem ◽  
Human Rabies ◽  
Public Health Burden ◽  
Attitudes And Practices ◽  
Significant Public Health ◽  
And Control

Background Human rabies remains a significant public health problem in Africa with outbreaks reported in most countries. In Nigeria–the most populous country in Africa–rabies causes a significant public health burden partly due to perennial obstacles to implementing a national prevention and control program. Methods We conducted a scoping review using standard Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify and select published articles from Nigeria during 1978–2020 reporting on rabies virus infections (human, canine, livestock, and wildlife), canine bites, knowledge, attitudes and practices (KAP) surveys on rabies and canine ecology studies. We extracted information on study location, year and additional details of each study such as rabies prevalence, general characteristics of offending dogs, dog vaccination status and health-seeking behaviours. Findings Between 1978 and 2020, 90 published articles met our inclusion criteria. The prevalence of rabies virus antigen detection varied between 3% and 28%, with more studies in the north. Most bites were unprovoked from dog bite studies (36.4%-97%), by dogs with low vaccination rates (12–38%). A more significant proportion of biting dogs were owned (31–90%). Laboratory confirmation for biting was available for only a small proportion of studies (6%; n = 2/32). Of the dogs surveyed during ecology studies, indigenous dogs accounted for the majority (62–98%), used mostly for security purposes (52–98%), with the vaccination rate between 15% and 38% in most states. Studies conducted in areas distant from rabies diagnostic facilities accounted for more human rabies cases and fewer dog rabies cases. Conclusion Significant improvements are necessary to achieve the elimination of human rabies mediated via dogs by 2030.

Detection of Flaviviral-Like DNA Sequences in Aedes aegypti (Diptera: Culicidae) Collected From Argentina

2021 ◽  
Author(s):  
Melisa B Bonica ◽  
Dario E Balcazar ◽  
Ailen Chuchuy ◽  
Jorge A Barneche ◽  
Carolina Torres ◽  
...  
Keyword(s):  
Public Health ◽  
Aedes Aegypti ◽  
Dna Sequences ◽  
Immature Stages ◽  
Public Health Burden ◽  
The Past ◽  
Health Burden ◽  
The World ◽  
Aegypti Genome ◽  
Dengue Epidemics

Abstract Diseases caused by flaviviruses are a major public health burden across the world. In the past decades, South America has suffered dengue epidemics, the re-emergence of yellow fever and St. Louis encephalitis viruses, and the introduction of West Nile and Zika viruses. Many insect-specific flaviviruses (ISFs) that cannot replicate in vertebrate cells have recently been described. In this study, we analyzed field-collected mosquito samples from six different ecoregions of Argentina to detect flaviviruses. We did not find any RNA belonging to pathogenic flaviviruses or ISFs in adults or immature stages. However, flaviviral-like DNA similar to flavivirus NS5 region was detected in 83–100% of Aedes aegypti (L.). Despite being previously described as an ancient element in the Ae. aegypti genome, the flaviviral-like DNA sequence was not detected in all Ae. aegypti samples and sequences obtained did not form a monophyletic group, possibly reflecting the genetic diversity of mosquito populations in Argentina.

Tuberculosis and notifiable skin diseases amongst a representative cohort of refugees in Germany (2014–16)

2020 ◽  
Author(s):  
Patrick D Dissmann ◽  
Felix Koehring ◽  
Florian Fischer
Keyword(s):  
Public Health ◽  
Infectious Diseases ◽  
Skin Diseases ◽  
Absolute Number ◽  
Federal State ◽  
Head Lice ◽  
Public Health Burden ◽  
Health Burden ◽  
Representative Cohort ◽  
Screening Result

Abstract Until now, systematic surveillance for infectious diseases in refugees is still missing. For that reason, this study aims at illustrating the prevalence of tuberculosis (TB) and notifiable skin diseases in a representative cohort of refugees in Lippe, a district of the federal state of North Rhine-Westphalia, Germany. We collected data on notifiable communicable diseases (TB, scabies, and head lice) from refugees (n = 8946) based on a medical screening after their arrival from October 2014 until May 2016. Data were analysed using descriptive and bivariate methods. Overall, we found 63 of 8764 screened refugees to have an abnormal TB screening result (0.72%). Of 8946 screened refugees, only 51 individuals were found to have scabies (0.57%) and a further 49 were tested positive for head lice (0.55%). The absolute number of TB cases indicate only a moderate public health burden. However, communicable skin diseases can become a problem in crowded holding camps, where they can cause local outbreaks.

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