Developmental Course of Nighttime Sleep-Wake Patterns in Full-Term and Premature Infants During the First Year of Life. I.

The early life gut microbiota has been reported to be involved in neonatal weight gain and later infant growth. Therefore, this early microbiota may constitute a target for the promotion of healthy neonatal growth and development with potential consequences for later life. Unfortunately, we are still far from understanding the association between neonatal microbiota and weight gain and growth. In this context, we evaluated the relationship between early microbiota and weight in a cohort of full-term infants. The absolute levels of specific fecal microorganisms were determined in 88 vaginally delivered and 36 C-section-delivered full-term newborns at 1 month of age and their growth up to 12 months of age. We observed statistically significant associations between the levels of some early life gut microbes and infant weight gain during the first year of life. Classifying the infants into tertiles according to their Staphylococcus levels at 1 month of age allowed us to observe a significantly lower weight at 12 months of life in the C-section-delivered infants from the highest tertile. Univariate and multivariate models pointed out associations between the levels of some fecal microorganisms at 1 month of age and weight gain at 6 and 12 months. Interestingly, these associations were different in vaginally and C-section-delivered babies. A significant direct association between Staphylococcus and weight gain at 1 month of life was observed in vaginally delivered babies, whereas in C-section-delivered infants, lower Bacteroides levels at 1 month were associated with higher later weight gain (at 6 and 12 months). Our results indicate an association between the gut microbiota and weight gain in early life and highlight potential microbial predictors for later weight gain.

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Abnormal Shoulder Girdle Muscle Tone in Premature Infants During Their First 18 Months of Life

PEDIATRICS ◽

10.1542/peds.77.5.664 ◽

1986 ◽

Vol 77 (5) ◽

pp. 664-669

Author(s):

Michael K. Georgieff ◽

Judy C. Bernbaum

Keyword(s):

Premature Infants ◽

Motor Development ◽

Muscle Tone ◽

Birth Asphyxia ◽

Shoulder Girdle ◽

First Year ◽

First Year Of Life ◽

Girdle Muscle ◽

Shoulder Girdle Muscle

To document the incidence of and neonatal factors associated with abnormal shoulder girdle muscle tone in premature infants at follow-up, we studied 125 consecutively admitted infants weighing < 1,750 g treated in The Children's Hospital of Philadelphia intensive care nursery and subsequently seen in the Neonatal Follow-up Program up to 18 months of age. Fifty-seven infants (46%) displayed abnormal shoulder girdle muscle tone which presented clinically as scapular retractions. These infants had significantly lower birth weights (P < .001) and gestational age (P < .001) as well as a higher incidence of acute and chronic pulmonary disease (P < 0.01) and CNS insults (P < .05) when compared with infants without scapular retractions. The 57 infants with scapular retractions were further divided into two groups: 42 infants (74%) in whom scapular retractions were associated with generalized mild hypertonicity and 15 infants (26%) in whom scapular retractions compensated for trunk and neck hypotonicity. The infants with scapular retractions and hypotonicity had a significantly higher incidence of neonatal neurologic morbidity including seizures, major resuscitations, and birth asphyxia (P < .01) when compared with the infants with scapular retractions and hypertonicity. Shoulder girdle tone abnormalities in the first year of life inhibit crawling, sitting, and object manipulation and, therefore, may manifest as delays in motor development. Identification of infants with significant neonatal risk factors for tone abnormalities is important to allow for earlier therapeutic intervention.

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THE EFFECT OF MONTHLY GAMMA-GLOBULIN ADMINISTRATION ON MORBIDITY AND MORTALITY FROM INFECTION IN PREMATURE INFANTS DURING THE FIRST YEAR OF LIFE

PEDIATRICS ◽

10.1542/peds.32.1.4 ◽

1963 ◽

Vol 32 (1) ◽

pp. 4-9 ◽

Cited By ~ 1

Author(s):

Jules Amer ◽

Esther Ott ◽

Frank A. Ibbott ◽

Donough O'Brien ◽

C. Henry Kempe

Keyword(s):

Premature Infants ◽

Gamma Globulin ◽

Repeated Administration ◽

Morbidity And Mortality ◽

Controlled Study ◽

First Year ◽

Double Blind ◽

First Year Of Life

A double-blind controlled study to determine the effect on infections of repeated administration of large doses of gamma-globulin to premature infants revealed that significantly more of these infants had no infections and fewer had mild infections during the first year of life. The data also suggests that gamma-globulin afforded some amelioration of serious but nonfatal infections. Deaths from infection showed a similar trend in favor of the gamma-globulin group, but this difference on its own was not significant.

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HEMATOPOIESIS IN PREMATURE INFANTS WITH SPECIAL CONSIDERATION OF THE EFFECT OF IRON AND OF ANIMAL-PROTEIN FACTOR

PEDIATRICS ◽

10.1542/peds.16.6.753 ◽

1955 ◽

Vol 16 (6) ◽

pp. 753-762

Author(s):

James A. Wolff ◽

Alice M. Goodfellow

Keyword(s):

Premature Infants ◽

Animal Protein ◽

Iron Therapy ◽

First Year ◽

Protein Factor ◽

Anemia Of Prematurity ◽

Significant Difference ◽

One Year ◽

First Year Of Life ◽

Weight Groups

Normal values in the first 3 months of life have been determined for hemoglobin, erythrocytes, reticulocytes, platelets, leukocytes and differential counts for premature infants with birth weights less than 1200 gm., and for those between 1200 and 1500 gm. at birth. No significant difference was found in the degree of depression of levels of hemoglobin and erythrocytes when values in the 2 weight groups were compared. Two reticulocyte peaks occur during the first 3 months of life. The first peak is present immediately after birth. The second peak, at about the eighth week, coincides with the occurrence of the greatest degree of anemia. Neither iron therapy nor treatment with animal-protein factor containing vitamin B12 and Aureomycin®, started before the end of the third week of life, had a statistically significant effect on the early phase of the anemia of prematurity. Untreated premature infants and those given animal-protein factor were anemic at the end of the first year of life. Subjects given iron therapy had normal hemoglobin values at one year of age. Blood transfusion is rarely necessary in the treatment of the anemia of prematurity.

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Successful Use of Propranolol in a Symptomatic Giant Congenital Hepatic Hemangioma

Journal of Neonatology ◽

10.1177/0973217920928645 ◽

2020 ◽

Vol 34 (1-2) ◽

pp. 99-102

Author(s):

Luis S. Florian-Tutaya ◽

Lizet Cuba-Valencia ◽

Sandra F. Bustamante-Encinas ◽

Fernando M. Vela-Alfaro

Keyword(s):

Corticosteroid Therapy ◽

Full Term ◽

Vascular Tumors ◽

First Year ◽

Hepatic Hemangioma ◽

Tumor Characteristics ◽

Term Newborn ◽

First Year Of Life ◽

Complications And Mortality ◽

Hepatic Hemangiomas

Congenital hepatic hemangiomas are rare benign vascular tumors present at birth. They often are asymptomatic but can have significant complications and mortality that directly correlate with the tumor characteristics and size. Congenital hemangiomas generally regress during the first year of life and are managed medically or surgically depending on its course. We present a case of a full-term newborn with a symptomatic giant congenital hepatic hemangioma that received propranolol and corticosteroid therapy.

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PRS23 COST AND RESOURCE UTILIZATION OF RESPIRATORY SYNCYTIAL VIRUS (RSV) OR WINTER UNSPECIFIED BRONCHIOLITIS OR PNEUMONIA (UBP) HOSPITALIZATIONS DURING THE FIRST YEAR OF LIFE AMONG LATE PRETERM AND FULL-TERM INFANTS

Value in Health ◽

10.1016/s1098-3015(10)73686-x ◽

2009 ◽

Vol 12 (3) ◽

pp. A125

Author(s):

ML Forbes ◽

CB Hall ◽

A Jackson ◽

A Masaquel ◽

PJ Mahadevia

Keyword(s):

Respiratory Syncytial Virus ◽

Resource Utilization ◽

Full Term ◽

Late Preterm ◽

First Year ◽

Term Infants ◽

Syncytial Virus ◽

First Year Of Life

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Magnocellular and parvocellular developmental course in infants during the first year of life

Documenta Ophthalmologica ◽

10.1023/b:doop.0000005331.66114.05 ◽

2003 ◽

Vol 107 (3) ◽

pp. 225-233 ◽

Cited By ~ 30

Author(s):

Benoit Hammarrenger ◽

Franco Leporé ◽

Sarah Lippé ◽

...

Keyword(s):

First Year ◽

Developmental Course ◽

First Year Of Life

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Neonatal gut and respiratory microbiota: coordinated development through time and space

10.1101/247122 ◽

2018 ◽

Author(s):

Alex Grier ◽

Andrew McDavid ◽

Bokai Wang ◽

Xing Qiu ◽

James Java ◽

...

Keyword(s):

Infant Health ◽

Term Infant ◽

Full Term ◽

First Year ◽

Body Site ◽

Clinical Practices ◽

Dynamic Interactions ◽

Term Infants ◽

First Year Of Life ◽

Respiratory Microbiota

ABSTRACTBackground: Postnatal development of the microbiota in early life influences immunity, metabolism, neurodevelopment and long-term infant health. Microbiome development occurs at multiple body sites, each with distinct community compositions and functions. Associations between microbiota at multiple sites represent an unexplored influence on the infant microbiome. Here, we examined co-occurrence patterns of gut and respiratory microbiota in pre- and full-term infants over the first year of life, a period critical to neonatal development and risk of respiratory diseases.Results: Gut and respiratory microbiota collected as longitudinal rectal, throat and nasal samples from 38 pre-term and 44 full-term infants were first clustered into community state types (CSTs) on the basis of their composition. Multiple methods were used to relate the occurrence of CSTs to several measures of infant maturity, including gestational age (GA) at birth, week of life (WOL), and post menstrual age (PMA: equal to GA plus WOL). Manifestation of CSTs followed one of three patterns with respect to infant maturity. First, chronological: independent of infant maturity (GA) at birth, and strongly associated with post-natal age (WOL). Second, idiosyncratic: primarily dependent on maturity (GA) at birth, with persistent differences in CST occurrence between pre- and full-term infants through the first year of life. Third, convergent: CSTs appear earlier in infants with greater maturity (GA) at birth, but after a sufficient post-natal interval their occurrence in pre-term infants reaches parity with full-term infants. The composition of CSTs was highly dissimilar between different body sites, but the CST of any one body site was highly predictive of the CSTs at other body sites. There were significant associations between the abundance of individual taxa at each body site and the CSTs of the other body sites, which persisted after stringent control for the non-linear effects of infant maturity. Significant canonical correlations exist between the microbiota composition at each pair of body sites, with the strongest correlations between more proximal locations.Conclusion: Cross-body site associations of developing infant microbiota suggest the importance of research and clinical practices that focus on dynamic interactions between multiple microbial communities to elucidate and promote systemic microbiota development.

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