HEMATOPOIESIS IN PREMATURE INFANTS WITH SPECIAL CONSIDERATION OF THE EFFECT OF IRON AND OF ANIMAL-PROTEIN FACTOR

PEDIATRICS ◽  
1955 ◽  
Vol 16 (6) ◽  
pp. 753-762
Author(s):  
James A. Wolff ◽  
Alice M. Goodfellow
Keyword(s):  
Premature Infants ◽  
Animal Protein ◽  
Iron Therapy ◽  
First Year ◽  
Protein Factor ◽  
Anemia Of Prematurity ◽  
Significant Difference ◽  
One Year ◽  
First Year Of Life ◽  
Weight Groups

Normal values in the first 3 months of life have been determined for hemoglobin, erythrocytes, reticulocytes, platelets, leukocytes and differential counts for premature infants with birth weights less than 1200 gm., and for those between 1200 and 1500 gm. at birth. No significant difference was found in the degree of depression of levels of hemoglobin and erythrocytes when values in the 2 weight groups were compared. Two reticulocyte peaks occur during the first 3 months of life. The first peak is present immediately after birth. The second peak, at about the eighth week, coincides with the occurrence of the greatest degree of anemia. Neither iron therapy nor treatment with animal-protein factor containing vitamin B12 and Aureomycin®, started before the end of the third week of life, had a statistically significant effect on the early phase of the anemia of prematurity. Untreated premature infants and those given animal-protein factor were anemic at the end of the first year of life. Subjects given iron therapy had normal hemoglobin values at one year of age. Blood transfusion is rarely necessary in the treatment of the anemia of prematurity.

scholarly journals Factors That Influence Refractive Changes in the First Year of Myopia Development in Premature Infants

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Jianbo Mao ◽  
Jimeng Lao ◽  
Chenyi Liu ◽  
Mingyuan Wu ◽  
Xueting Yu ◽  
...  
Keyword(s):  
Birth Weight ◽  
Premature Infants ◽  
Gestational Age ◽  
First Year ◽  
Myopia Progression ◽  
Significant Difference ◽  
Refractive Status ◽  
Postmenstrual Age ◽  
Hyperopic Shift ◽  
One Year

Purpose. To study the development of refractive status from 36 weeks to one year of postmenstrual age and to identify factors that contribute to development of myopia, including gender, birth weight, gestational age, and retinopathy of prematurity (ROP).Methods. Premature infants underwent full cycloplegic retinoscopy at 36 weeks, 38 weeks, 40 weeks, 42 weeks, 44 weeks, 46 weeks, 48 weeks, 3 months, 6 months, 9 months, and 12 months of postmenstrual age. The infants were grouped by gender, birth weight, gestational age, and the severity of ROP to evaluate the correlation with refractive status at each postmenstrual age.Results. A total of 942 infants were recruited in this study. A total of 2716 readings were obtained. Refractive state had a hyperopic shift until 46 weeks of postmenstrual age (r = 0.42,P<0.0001). After that, the mean spherical equivalent (SE) gradually declined (r = −0.30,P<0.0001). Boys had lower hyperopia than girls at nine months (t = 3.10,P=0.003) and one year (t = 3.34,P=0.001) of postmenstrual age. Premature infants with ROP had a lower average SE at most of the postmenstrual ages; however, this value did not vary significantly (P>0.05). Premature infants with severe ROP were less hyperopic than those without it at every postmenstrual age, and the average SE differed significantly at one year of postmenstrual age (t = 2.60,P=0.011). There was no significant difference between each birth weight and gestational age (P>0.05).Conclusions. The dioptric value of premature infants within one year was generally hyperopic. Different gender, birth weight, gestational age, and ROP did not affect the overall development of refractive status. Females may have higher hyperopia at nine months of postmenstrual age. Birth weight and gestational age had little effect on change of refractive status. Severe ROP was an important contributing factor in myopia progression, which may be related to the treatment required. Further study may be carried out to understand the mechanism behind myopia progression in premature infants, including changes in refractive system parameters and emmetropization process.

Teething Symptoms in the First Year of Life and Associated Factors: A Cohort Study

2010 ◽  
Vol 34 (3) ◽  
pp. 201-206 ◽  
Author(s):  
Carlos Alberto Feldens ◽  
Italo Medeiros Faraco Junior ◽  
Andréia Bertani Ottoni ◽  
Eliane Gerson Feldens ◽  
Márcia Regina Vítolo
Keyword(s):  
Associated Factors ◽  
Primary Outcome ◽  
First Year ◽  
Structured Interviews ◽  
Self Medication ◽  
Nuclear Families ◽  
Dental Examination ◽  
Pediatric Dentists ◽  
One Year ◽  
First Year Of Life

Objective: To investigate the occurrence and management of teething symptoms during the first year of life and associated factors. Study design: 500 children were recruited at birth. Research assessments including structured interviews, anthropometric measurements and dental examination were carried out after birth, at 6 months and at one-year of age. The primary outcome of this study was defined as the occurrence of one or more teething symptoms within the first year of life, as reported by the mother. Results: Teething symptoms were reported in 73% of the children analyzed (273/375). The symptoms most frequently reported were irritability (40.5%), fever (38.9%), diarrhoea (36.0%) and itching (33.6%). Dentists had little influence on the management of symptoms and self-medication to relieve them was a common practice. The risk of reporting teething symptoms was higher for children from nuclear families (p=0.040) and for children from families with higher income (p=0.040). Conclusions: Teething symptoms were highly reported in this population. Pediatric dentists should be accessible and provide adequate orientation when symptoms can be managed at home or immediate referral to health services when more serious diseases are suspected.

Abnormal Shoulder Girdle Muscle Tone in Premature Infants During Their First 18 Months of Life

PEDIATRICS ◽  
1986 ◽  
Vol 77 (5) ◽  
pp. 664-669
Author(s):  
Michael K. Georgieff ◽  
Judy C. Bernbaum
Keyword(s):  
Premature Infants ◽  
Motor Development ◽  
Muscle Tone ◽  
Birth Asphyxia ◽  
Shoulder Girdle ◽  
First Year ◽  
First Year Of Life ◽  
Girdle Muscle ◽  
Shoulder Girdle Muscle

To document the incidence of and neonatal factors associated with abnormal shoulder girdle muscle tone in premature infants at follow-up, we studied 125 consecutively admitted infants weighing &lt; 1,750 g treated in The Children's Hospital of Philadelphia intensive care nursery and subsequently seen in the Neonatal Follow-up Program up to 18 months of age. Fifty-seven infants (46%) displayed abnormal shoulder girdle muscle tone which presented clinically as scapular retractions. These infants had significantly lower birth weights (P &lt; .001) and gestational age (P &lt; .001) as well as a higher incidence of acute and chronic pulmonary disease (P &lt; 0.01) and CNS insults (P &lt; .05) when compared with infants without scapular retractions. The 57 infants with scapular retractions were further divided into two groups: 42 infants (74%) in whom scapular retractions were associated with generalized mild hypertonicity and 15 infants (26%) in whom scapular retractions compensated for trunk and neck hypotonicity. The infants with scapular retractions and hypotonicity had a significantly higher incidence of neonatal neurologic morbidity including seizures, major resuscitations, and birth asphyxia (P &lt; .01) when compared with the infants with scapular retractions and hypertonicity. Shoulder girdle tone abnormalities in the first year of life inhibit crawling, sitting, and object manipulation and, therefore, may manifest as delays in motor development. Identification of infants with significant neonatal risk factors for tone abnormalities is important to allow for earlier therapeutic intervention.

ADENOVIRUS COMPLEMENT-FIXING ANTIBODY TITERS FROM BIRTH THROUGH THE FIRST YEAR OF LIFE

PEDIATRICS ◽  
1963 ◽  
Vol 32 (4) ◽  
pp. 497-500
Author(s):  
Rosa Lee Nemir ◽  
Donna O'Hare ◽  
Stanley Goldstein ◽  
Charles B. Hilton
Keyword(s):  
Cytopathic Effect ◽  
Gradual Increase ◽  
Newborn Infants ◽  
First Year ◽  
Placental Barrier ◽  
Culture Studies ◽  
Antibody Titers ◽  
Level 1 ◽  
One Year ◽  
First Year Of Life

Complement fixing antibody titers to the adenoviruses were determined in 251 newborn infants, using cord blood. Approximately 95% of these were found to have CF titers of 1:16 or over, the majority (75%) were 1:32 or more. Material from the pharyngeal and rectal swabs of these infants on tissue culture studies (542) on HeLa and amnion cells showed no cytopathic effect in oven 96% of these infants. A longitudinal study of 114 of these infants was made at 3 months intervals; 67 have been observed for one year. At 3 months, only 12% still showed CF antibody titers, and these were chiefly at a low level, 1:16. At the subsequent 3-month interval observations, a gradual rise in CF antibodies were found. At one year of age, approximately 37% had titers of 1:32 on over. The findings of this report support the statement that CF antibodies to adenovirus pass the placental barrier. There is a gradual increase in the percentage of infants with positive CF antibodies after 3 months.

scholarly journals In congenital hypothyroidism bone maturation at birth may be a predictive factor of psychomotor development during the first Year of life irrespective of other variables related to treatment

2003 ◽  
pp. 1-6 ◽  
Author(s):  
M Wasniewska ◽  
F De Luca ◽  
A Cassio ◽  
N Oggiaro ◽  
P Gianino ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Psychomotor Development ◽  
First Year ◽  
X Rays ◽  
Bone Maturation ◽  
Gestation Age ◽  
Group A ◽  
One Year ◽  
First Year Of Life ◽  
Tsh Levels

OBJECTIVE: To evaluate in a cohort of infants with congenital hypothyroidism (CH): (a) the frequency of bone maturation (BM) retardation at birth and (b) whether BM delay at birth may be considered as a tool to make a prognosis of psychomotor status at the age of 1 Year, irrespective of other variables related to treatment. DESIGN: BM at birth, CH severity and developmental quotient (DQ) at the age of 1 Year were retrospectively evaluated in 192 CH infants selected by the following inclusion criteria: (a) gestation age ranging between 38 and 42 weeks; (b) onset of therapy within the first Month of life; (c) initial thyroxine (l-T(4)) dosage ranging from 10 to 12 microg/kg/day; (d) normalization of serum thyrotropin (TSH) levels before the age of 3 Months; (e) Monthly adjustments of l-T(4) dose during the first Year of life with serum TSH levels ranging from 0.5 to 4 mIU/l; (f) no major diseases and/or physical handicaps associated with CH; (g) availability of both thyroid scanning and knee X-rays at the time of treatment initiation; (h) availability of DQ assessment at an average age of 12 Months. METHODS: BM was considered normal if the distal femur bony nucleus diameter exceeded 3 mm (group A) or retarded if either this nucleus was absent (subgroup B1) or its diameter was <3 mm (subgroup B2). DQ was evaluated with the Brunet-Lezine test. RESULTS: In 44.3% of cases BM was either delayed (23.5%) or severely delayed (20.8%). The risk of BM retardation was higher in the patients with athyreosis than in the remaining patients (41/57 vs 44/135, chi(2)=25.13, P<0.005). BM-retarded infants showed a more severe biochemical picture of CH at birth and a lower DQ at the age of one Year compared with the group A patients. If compared with infants of subgroup B2 those of subgroup B1 exhibited significantly lower T(4) levels at birth and a more frequent association with athyreosis (70.0 vs 30.0%; chi(2)=7.49, P<0.01), whereas DQ was superimposable in both subgroups. CONCLUSIONS: (a) BM at birth is delayed in almost half of CH patients and (b) CH severity per se can affect DQ at the age of 1 Year irrespective of other variables related to therapy.

THE EFFECT OF MONTHLY GAMMA-GLOBULIN ADMINISTRATION ON MORBIDITY AND MORTALITY FROM INFECTION IN PREMATURE INFANTS DURING THE FIRST YEAR OF LIFE

PEDIATRICS ◽  
1963 ◽  
Vol 32 (1) ◽  
pp. 4-9 ◽  
Author(s):  
Jules Amer ◽  
Esther Ott ◽  
Frank A. Ibbott ◽  
Donough O'Brien ◽  
C. Henry Kempe
Keyword(s):  
Premature Infants ◽  
Gamma Globulin ◽  
Repeated Administration ◽  
Morbidity And Mortality ◽  
Controlled Study ◽  
First Year ◽  
Double Blind ◽  
First Year Of Life

A double-blind controlled study to determine the effect on infections of repeated administration of large doses of gamma-globulin to premature infants revealed that significantly more of these infants had no infections and fewer had mild infections during the first year of life. The data also suggests that gamma-globulin afforded some amelioration of serious but nonfatal infections. Deaths from infection showed a similar trend in favor of the gamma-globulin group, but this difference on its own was not significant.

scholarly journals Being born to a single mother in France: trajectories of father’s involvement over the first year of life

2020 ◽  
Vol 11 (1) ◽  
pp. 123-149
Author(s):  
Ariane Pailhé ◽  
Lidia Panico ◽  
Marieke Heers
Keyword(s):  
Father Involvement ◽  
Single Mother ◽  
First Year ◽  
Parental Relationships ◽  
Father Engagement ◽  
Child Involvement ◽  
Nationally Representative ◽  
One Year ◽  
First Year Of Life ◽  
Representative Cohort

This paper characterises families where the father is not living (or not living permanently) with the child from around birth, and identifies the drivers of the evolution of father contact over the first year of life across different types of household. We use a recent, nationally representative cohort of children born in France in 2011, Elfe (the Etude longitudinale française depuis l’enfance), and latent clustering techniques to identify different groups of households characterised by non-residential fatherhood. We show that non-residential fatherhood from around birth is not a marginal phenomenon in France, and it corresponds to a heterogeneity of situations, describing both advantaged and low involvement fathers, as well less disadvantaged but involved groups. Over the first year of life, most non-resident fathers managed to keep in contact with their child, including relatively disadvantaged groups such as migrant and young parents, although groups characterised by low father involvement shortly after birth lost contact. On the other hand, among a group of very involved non-resident fathers who were in a relationship with the mother, we observed high levels of contact and indeed co-residence when the child was one year of age. A number of channels emerged to explain the correlations between our latent groups and father contact at one year: notably, father engagement around birth, especially whether the father formally recognised the child. Trajectories of father–child involvement and of parental relationships are therefore at least as important as socio-economic conditions to understand future father contact.

scholarly journals Complementary feeding patterns in the first year of life in the city of Rio de Janeiro, Brazil: time trends from 1998 to 2008

2014 ◽  
Vol 30 (8) ◽  
pp. 1755-1764 ◽  
Author(s):  
Daniel Alves de Oliveira ◽  
Inês Rugani Ribeiro de Castro ◽  
Patricia Constante Jaime
Keyword(s):  
Time Trends ◽  
Rio De Janeiro ◽  
Complementary Feeding ◽  
Linear Trend ◽  
Feeding Practices ◽  
First Year ◽  
Significant Downward Trend ◽  
One Year ◽  
First Year Of Life ◽  
The City

This study aimed to analyze time trends in complementary feeding practices among children under one year of age in the city of Rio de Janeiro, Brazil, from 1998 to 2008. Based on comparable questions on food consumption in five surveys conducted in representative randomized samples of children in 1998 (n = 3,762), 2000 (n = 3,670), 2003 (n = 4,305), 2006 (n = 3,686), and 2008 (n = 2,621), 16 complementary feeding indicators were constructed. The percentage frequency of all indicators was estimated for each year of the study. Linear trend analyses were also conducted by means of multivariate regression models. All indicators of early complementary feeding decreased from 1998 to 2008. In the 6-11.9 month age group, there was a significant downward trend in the proportion of children receiving food with adequate consistency for their age, consumption of iron-rich foods, and overall adequacy of the diet. A significant upward trend in fruit consumption was observed. There was a decrease in the early complementary feeding, and generally a worsening of complementary feeding practices in children aged 6-11.9 months in Rio de Janeiro during the period studied.

scholarly journals Age-Related Changes in Peripheral Nerves of the Dog. II. A Morphologic and Morphometric Study of Cross-Sectional Nerve

1982 ◽  
Vol 19 (4) ◽  
pp. 379-398 ◽  
Author(s):  
K. G. Braund ◽  
J. A. McGuire ◽  
C. E. Lincoln
Keyword(s):  
Fold Increase ◽  
Morphometric Study ◽  
First Year ◽  
Fiber Density ◽  
Cross Sectional ◽  
Quantitative Measurements ◽  
Age Related ◽  
Large Fiber ◽  
One Year ◽  
First Year Of Life

Qualitative histologic studies and quantitative measurements were made on cross-sectional preparations of common peroneal and ulnar nerves of 32 neuromuscular disease-free dogs from birth to 15 years of age, to provide normative data not available previously. Minimal lesions were seen in nerves of dogs from birth to seven years; however, in older dogs, the incidence of axonal degeneration and segmental demyelination and remyelination increased. Total fiber density of both nerves was over 40,000 fibers/mm2 at birth and declined rapidly during the first six to nine months to level off at about 10,000 fibers/mm2 by one year of age. Density of small (< 5 μm) and large (≥ 5 μm) diameter fibers attained adult values by one year of age. The frequency distribution of the myelinated fibers was unimodal at birth and became bimodal between three and six months of age. The peaks of the small and large fiber groups occurred at 3 μm and 6 μm, respectively. Larger diameter fibers (10 μm to 12 μm) reached adult values between nine months and one year of age. A 2.5 fold increase in mean fiber diameter occurred during the first year of life. There was no statistically significant change in any histometric parameter after maturity (approximately one year of age).

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