scholarly journals Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature

SLEEP ◽  
2019 ◽  
Vol 43 (4) ◽  
Author(s):  
Isabelle Guisle ◽  
Maud Gratuze ◽  
Séréna Petry ◽  
Françoise Morin ◽  
Rémi Keraudren ◽  
...  
Keyword(s):  
Body Temperature ◽  
Sleep Deprivation ◽  
Tau Protein ◽  
Sleep Disturbances ◽  
Tau Phosphorylation ◽  
Physiological Basis ◽  
Physiological Regulation ◽  
Hyperphosphorylated Tau Protein ◽  
Phosphatase 2A ◽  
Acute Sleep Deprivation

Abstract Study Objectives Aggregates of hyperphosphorylated tau protein are a hallmark of Alzheimer’s disease (AD) and other tauopathies. Sleep disturbances are common in AD patients, and insufficient sleep may be a risk factor for AD. Recent evidence suggests that tau phosphorylation is dysregulated by sleep disturbances in mice. However, the physiological regulation of tau phosphorylation during the sleep–wake cycle is currently unknown. We thus aimed to determine whether tau phosphorylation is regulated by circadian rhythms, inherently linked to the sleep–wake cycle. Methods To answer these questions, we analyzed by Western blotting tau protein and associated kinases and phosphatases in the brains of awake, sleeping, and sleep-deprived B6 mice. We also recorded their temperature. Results We found that tau phosphorylation undergoes sleep-driven circadian variations as it is hyperphosphorylated during sleep but not during acute sleep deprivation. Moreover, we demonstrate that the mechanism behind these changes involves temperature, as tau phosphorylation was inversely correlated with circadian- and sleep deprivation-induced variations in body temperature, and prevented by housing the animals at a warmer temperature. Notably, similar changes in tau phosphorylation were reproduced in neuronal cells exposed to temperatures recorded during the sleep–wake cycle. Our results also suggest that inhibition of protein phosphatase 2A (PP2A) may explain the hyperphosphorylation of tau during sleep-induced hypothermia. Conclusion Taken together, our results demonstrate that tau phosphorylation follows a circadian rhythm driven mostly by body temperature and sleep, and provide the physiological basis for further understanding how sleep deregulation can affect tau and ultimately AD pathology.

Acute sleep deprivation elevates brain and body temperature in rats

2020 ◽  
Author(s):  
Lal Chandra Vishwakarma ◽  
Binney Sharma ◽  
Vishwajeet Singh ◽  
Ashok Kumar Jaryal ◽  
Hruda Nanda Mallick
Keyword(s):  
Body Temperature ◽  
Sleep Deprivation ◽  
Acute Sleep Deprivation

scholarly journals Sleep deprivation suppresses aggression in Drosophila

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Matthew S Kayser ◽  
Benjamin Mainwaring ◽  
Zhifeng Yue ◽  
Amita Sehgal
Keyword(s):  
Sleep Deprivation ◽  
Sleep Disturbances ◽  
Social Behaviors ◽  
Fruit Fly ◽  
Reproductive Fitness ◽  
Sleep Loss ◽  
Aggressive Behaviors ◽  
Clear Effect ◽  
Competitive Disadvantage ◽  
Acute Sleep Deprivation

Sleep disturbances negatively impact numerous functions and have been linked to aggression and violence. However, a clear effect of sleep deprivation on aggressive behaviors remains unclear. We find that acute sleep deprivation profoundly suppresses aggressive behaviors in the fruit fly, while other social behaviors are unaffected. This suppression is recovered following post-deprivation sleep rebound, and occurs regardless of the approach to achieve sleep loss. Genetic and pharmacologic approaches suggest octopamine signaling transmits changes in aggression upon sleep deprivation, and reduced aggression places sleep-deprived flies at a competitive disadvantage for obtaining a reproductive partner. These findings demonstrate an interaction between two phylogenetically conserved behaviors, and suggest that previous sleep experiences strongly modulate aggression with consequences for reproductive fitness.

Sleep, health, and society

2018 ◽  
Author(s):  
Francesco P. Cappuccio ◽  
Michelle A. Miller ◽  
Steven W. Lockley ◽  
Shantha M. W. Rajaratnam
Keyword(s):  
Sleep Deprivation ◽  
Sleep Duration ◽  
Sleep Disturbances ◽  
Modern Society ◽  
Social Conditions ◽  
Sleep Health ◽  
Health And Wellbeing

Sleep disturbances are common in modern society. Since the beginning of the century, populations have shown a decline in sleep duration, owing to changes in environmental and social conditions. Industry was the first to appreciate the detrimental effects of sleep disturbances on health and wellbeing. It has taken, however, many decades to understand the implications for individuals and populations of sustained sleep deprivation.

S1911 Ghrelin Secretion is Altered in Sleep and Enforced Sleep Deprivation in Cirrhosis Compared to Controls: Association With Sleep Disturbances?

2010 ◽  
Vol 138 (5) ◽  
pp. S-815
Author(s):  
Jasmohan S. Bajaj ◽  
Christine Schubert ◽  
Muhammad Hafeezullah ◽  
Joan A. Pleuss ◽  
Glenn Krakower ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Sleep Disturbances ◽  
Ghrelin Secretion

TEMPERATURE REGULATION IN EXERCISE

PEDIATRICS ◽  
1963 ◽  
Vol 32 (4) ◽  
pp. 691-702
Author(s):  
Sid Robinson
Keyword(s):  
Blood Flow ◽  
Body Temperature ◽  
Heat Stroke ◽  
The Body ◽  
Physiological Regulation ◽  
Temperature Changes ◽  
Metabolic Heat ◽  
Warm Blood ◽  
Hot Environments ◽  
Large Increments

The central body temperature of a man rises gradually during the first half hour of a period of work to a higher level and this level is precisely maintained until the work is stopped; body temperature then slowly declines to the usual resting level. During prolonged work the temperature regulatory center in the hypothalamus appears to be reset at a level which is proportional to the intensity of the work and this setting is independent of environmental temperature changes ranging from cold to moderately warm. In hot environments the resistance to heat loss may be so great that all of the increased metabolic heat of work cannot be dissipated and the man's central temperature will rise above the thermostatic setting. If this condition of imbalance is continued long enough heat stroke will ensue. We have found that in a 3 mile race lasting only 14 minutes on a hot summer day a runner's rectal temperature may rise to 41.1°C., with heat stroke imminent. The physiological regulation of body temperature of men in warm environments and during the increased metabolic heat production of work is dependent on sweating to provide evaporative cooling of the skin, and on adjustments of cutaneous blood flow which determine the conductance of heat from the deeper tissues to the skin. The mechanisms of regulating these responses during work are complex and not entirely understood. Recent experiments carried out in this laboratory indicate that during work, sweating may be regulated by reflexes originating from thermal receptors in the veins draining warm blood from the muscles, summated with reflexes from the cutaneous thermal receptors, both acting through the hypothalamic center, the activity of which is increased in proportion to its own temperature. At the beginning of work the demand for blood flow to the muscles results in reflex vasoconstriction in the skin. As the body temperature rises the thermal demand predominates and the cutaneous vessels dilate, increasing heat conductance to the skin. Large increments in cardiac output and compensatory vasoconstriction in the abdominal viscera make these vascular adjustments in work possible without circulatory embarrassment.

Could BDNF be involved in compensatory mechanisms to maintain cognitive performance despite acute sleep deprivation? An exploratory study

2016 ◽  
Vol 99 ◽  
pp. 96-102 ◽  
Author(s):  
Bruno Lima Giacobbo ◽  
Márcio Silveira Corrêa ◽  
Kelem Vedovelli ◽  
Carlos Eduardo Bruhn de Souza ◽  
Letícia Martins Spitza ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Exploratory Study ◽  
Compensatory Mechanisms ◽  
Acute Sleep Deprivation
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