scholarly journals O044 PROMISing questionnaires to measure sleep disturbance and impairment

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A19-A20
Author(s):  
A Antonov ◽  
G Hamilton
Keyword(s):  
Sleep Disturbance ◽  
Depression Scale ◽  
Symptom Burden ◽  
Sleep Apnoea ◽  
Adult Patients ◽  
Surrogate Markers ◽  
Sleep Impairment ◽  
Obstructive Sleep ◽  
Patient Reported ◽  
The Relationship

Abstract Background Obstructive sleep apnoea (OSA) is highly prevalent in Australia with significant health and economic impacts. OSA severity as measured by Apnoea Hypopnoea Index (AHI) does not reliably predict symptom burden as measured by questionnaires such as the Epworth Sleepiness Scale (ESS) or Functional Outcomes of Sleep Questionnaire (FOSQ). Our hypothesis is that utilising the standardised, scenario-agnostic, evidence-based Patient-Reported Outcomes Information System (PROMIS) questionnaires would yield better clinical utility. The primary aim was to validate PROMIS questionnaires in detecting symptom burden of OSA and its relationship to AHI. Secondary outcomes were to investigate the relationship between PROMIS questionnaires and other commonly used measures of sleep impairment and disturbance, and the relationship between PROMIS questionnaires and surrogate markers of sleep impairment on a Polysomnogram. Methods Analysis of prospectively collected data from 122 adult patients referred to an Australian University and Tertiary Hospital associated sleep apnoea clinic. All adult patients who completed extensive pre-assessment questionnaires and subsequently underwent polysomnography following clinician review were included in this study. Questionnaires included: PROMIS Sleep Disturbance, Sleep Related Impairment and Cognitive Function-Abilities questionnaires, FOSQ, ESS, Insomnia Severity Index (ISI) and Hospital Anxiety and Depression Scale (HADS). Progress to date Data collected for all 122 participants. Preliminary analysis currently underway. Intended outcome and impact: Examine utility of the novel PROMIS scales in measuring symptom burden in patients referred for suspected OSA and its relationship to AHI. Investigate the relationship between PROMIS scales, surrogate markers of sleep impairment and other validated sleep disorder questionnaires.

scholarly journals P061 The effect of anxiety on symptom burden in patients with obstructive sleep apnoea

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A41-A41
Author(s):  
L Kelley ◽  
G Hamilton
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Functional Outcomes ◽  
Depression Scale ◽  
Symptom Burden ◽  
Severity Index ◽  
Sleep Apnoea ◽  
Common Symptom ◽  
Fatigue Score ◽  
Obstructive Sleep ◽  
History Of

Abstract Background There is a high prevalence of anxiety in patients with obstructive sleep apnoea and such patients often describe fatigue in addition to sleepiness. We currently use the Epworth Sleepiness Scale (ESS) to quantify sleepiness in our patients, but we do not have useful tools for assessing fatigue. Fatigue is a common symptom in patients with many medical conditions but has not been well studied in patients presenting to sleep services. Our hypothesis is that patients with obstructive sleep apnoea who have a comorbid anxiety disorder, as measured by the Hospital Anxiety and Depression Scale (HADS) are likely to have increased symptom burden such as fatigue or poorer functional outcomes of sleep. Methods Analysis of prospectively collected data from 128 adult patients referred for suspected obstructive sleep apnea to Monash University Health Sleep Clinic. All patients have completed a comprehensive questionnaire prior to their first clinical review assessing their symptom burden at baseline. Questionnaires completed include extensive symptom and medical history assessment, the Fatigue Severity Scale (FSS), ESS, HADS, Functional Outcomes of Sleep Questionnaire (FOSQ), Insomnia Severity Index (ISI) and Global Fatigue Score. All patients were subsequently reviewed by a clinician and have overnight polysomnography data available. Progress to date; Data collected for all 128 participants. Preliminary analysis currently underway. Intended outcome & impact; We intend to examine whether the comorbidity of anxiety results in an increased or different symptom burden in patients referred for suspected obstructive sleep apnoea when compared to patients without a history of anxiety.

The Triad Nocturia, Smoking and Obstructive Sleep APnea

2019 ◽  
Vol 70 (5) ◽  
pp. 1839-1842 ◽  
Author(s):  
Mihaela Trenchea ◽  
Ioan Anton Arghir ◽  
Gilda Georgeta Popescu ◽  
Stefan Rascu ◽  
Edwin Sever Bechir ◽  
...  
Keyword(s):  
Multidisciplinary Approach ◽  
Sleep Apnoea ◽  
Obstructive Pulmonary Disease ◽  
Sleep Breathing Disorders ◽  
Smoking Exposure ◽  
Obstructive Sleep ◽  
Spss Software ◽  
The Relationship ◽  
Transversal Study

In patients with obstructive sleep apnoea (OSA), a consequence of the intermittent hypoxia is nocturia. The frequency of nocturia related OSA is increased because many pathological pathways are present simultaneously. The aim was to assess the prevalence of nocturia among OSA patients and to identify the relationship with OSA and its comorbidities. A transversal study determining the prevalence of OSA�s comorbidities and nocturia related OSA and smoking was assessed, from 2011 to 2015, in 2 Romanian centres of Somnology, in Constanta county. All patients suspected of sleep breathing disorders were investigated by polygraphy and all patients diagnosed with OSA were recruited. Demographic and clinical characteristics were assessed, including the onset of nocturia. The comparison between groups with and without nocturia was performed using SPSS software, using Anova for numerical outcomes and c2 test for the categorical ones. Nocturia was highly prevalent (62.75 %) among 204 OSA patients, especially in elderly (p [ 0.00001). High blood pressure (hypertension), obstructive pulmonary disease (COPD), smoking exposure were more frequently reported in the OSA patients presenting nocturia (p[0.05). Type 2 diabetes and cardiac failure were also frequent, but did not reach a significant threshold of 95%. In conclusion, the nocturia is a frequent symptom and it is influenced by the OSA severity and comorbidities as hypertension and COPD. A further multidisciplinary approach in these patients is justified, especially in smokers.

THE RELATIONSHIP BETWEEN OBSTRUCTIVE SLEEP APNOEA AND TASK-1 GENETIC VARIANTS

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e205
Author(s):  
N. Li ◽  
T. Shi ◽  
X. Yao ◽  
Y. Wang ◽  
M. Heizhati ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Genetic Variants ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
The Relationship ◽  
And Task

scholarly journals Longitudinal study of symptom burden in outpatients with advanced cancers based on electronic Patient-Reported Outcome (ePRO) platform: a single institution, prospective study protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e038223
Author(s):  
Lili Tang ◽  
Ying Pang ◽  
Yi He ◽  
Qiuling Shi ◽  
Xinkun Han ◽  
...  
Keyword(s):  
Study Protocol ◽  
Symptom Management ◽  
Depression Scale ◽  
Symptom Burden ◽  
Patient Reported Outcome ◽  
Critical Parameters ◽  
Advanced Lung Cancer ◽  
Optimal Time ◽  
Patient Reported

IntroductionAn electronic Patient-Reported Outcome (ePRO) platform is needed for implementing evidence-based symptom management in outpatients with advanced cancer. We describe the overall protocol and the methodology for measuring symptom burden, to provide critical parameters needed to implement symptom management on the ePRO platform.Methods and analysisThe study focusses on patients with advanced lung cancer, stomach cancer, oesophagus cancer, liver cancer, colorectal cancer or breast cancer. The primary outcome is the change of symptom burden. MD Anderson Symptom Inventory, and other PRO instruments (Insomnia Severity Index, Hospital Anxiety and Depression Scale, 9-item Patient Health Questionnaire and EuroQol-5 dimensions-5 levels version) were used. The secondary outcomes include feasibility of using ePRO, symptom-related quality of life, reasons for no improvement of symptoms, defining frequency of PRO assessments and cut-points, items for screening and management of comorbidity and satisfaction with ePRO platform in patients and health providers. After initial outpatient visit for baseline assessment, ePRO system will automatically send follow-up notification seven times over 4 weeks to patients. The characteristics and changing trajectory of symptoms of patients will be described. Parameters for using PROs, such as optimal time points for follow-up and cut-off point for alert will be determined. The feasibility of ePRO platform to track the changes of target symptoms in outpatients will be evaluated.Ethics and disseminationThe study protocol and related documents were approved by the Institutional Research Board (IRB) of Peking University Cancer Hospital on 13 February 2019 (2019YJZ07). The results of this study will be disseminated through academic workshops, peer-reviewed publications and conferences.Trial registration numberChiCTR1900023560.

scholarly journals Effects of the presence of hypertension on the relationship between obstructive sleep apnoea and sleepiness

2011 ◽  
Vol 20 (4) ◽  
pp. 538-543 ◽  
Author(s):  
YUKA HARADA ◽  
TORU OGA ◽  
KAZUO CHIN ◽  
MISA TAKEGAMI ◽  
KEN-ICHI TAKAHASHI ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
The Relationship

scholarly journals Structural brain correlates of obstructive sleep apnoea in older adults at risk for dementia

2018 ◽  
Vol 52 (1) ◽  
pp. 1800740 ◽  
Author(s):  
Nathan E. Cross ◽  
Negar Memarian ◽  
Shantel L. Duffy ◽  
Casey Paquola ◽  
Haley LaMonica ◽  
...  
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Sleep Disturbance ◽  
Obstructive Sleep Apnoea ◽  
Cortical Thickness ◽  
Neuropsychological Testing ◽  
Sleep Apnoea ◽  
Oxygen Desaturation ◽  
Obstructive Sleep ◽  
Brain Correlates

This study aimed to investigate associations between obstructive sleep apnoea (OSA) and cortical thickness in older adults with subjective and objective cognitive difficulties, who are considered “at-risk” for dementia.83 middle-aged to older adults (51–88 years) underwent neuropsychological testing, polysomnography assessment of OSA and a structural magnetic resonance imaging brain scan. A principal components analysis was performed on OSA measures. Cortical thickness and subcortical volumes were compared to extracted components of “oxygen desaturation” and “sleep disturbance”.Oxygen desaturation was significantly related to reduced cortical thickness in the bilateral temporal lobes (left: r=−0.44, p<0.001; right: r=−0.39, p=0.003). Conversely, sleep disturbance was associated with increased thickness in the right postcentral gyrus (r=0.48, p<0.001), pericalcarine (r=0.50, p=0.005) and pars opercularis (r=0.46, p=0.009) and increased volume of the hippocampus and amygdala. Decreased thickness in the bilateral temporal regions was associated with reduced verbal encoding (r=0.28, p=0.010).Given the clinical significance of this sample in terms of dementia prevention, these changes in grey matter reveal how OSA might contribute to neurodegenerative processes in older adults.

Obstructive Sleep Apnoea in Adult Patients Post-tonsillectomy

2020 ◽  
Author(s):  
Renata L. Riha ◽  
Serafeim – Chrysovalantis Kotoulas ◽  
Athanasia Pataka ◽  
John Arthur Kvamme ◽  
Pavel Joppa ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Adult Patients ◽  
Obstructive Sleep

scholarly journals Relationship of Obstructive Sleep Apnoea with Diabetic Retinopathy: A Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Zhenliu Zhu ◽  
Fengying Zhang ◽  
Yunxia Liu ◽  
Shuqin Yang ◽  
Chunting Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Sensitivity Analysis ◽  
Diabetic Retinopathy ◽  
Publication Bias ◽  
Meta Analysis ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
Increased Risk ◽  
Relationship Of ◽  
The Relationship

Until now, the relationship of obstructive sleep apnoea (OSA) with diabetic retinopathy (DR) was controversial. This meta-analysis was performed to obtain definitive conclusion on this topic. Relevant articles were searched on databases of Pubmed, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI). The articles were selected according to inclusion and exclusion criteria. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the relationship of OSA with risk of DR.I2andPvalue were used to assess the presence of heterogeneity.I2≥ 50% orP<0.05indicated significant heterogeneity. Sensitivity analysis was performed to evaluate the robustness of pooled results. Begg’s funnel plot and Egger’s regression analysis were adopted to assess publication bias. 6 eligible studies were selected in the present meta-analysis. The pooled results indicated that OSA was significantly associated with increased risk of DR (OR = 2.01, 95% CI = 1.49–2.72). Subgroup analysis based on type of diabetes mellitus suggested that OSA was related to DR in both Type 1 and Type 2 diabetes mellitus. Sensitivity analysis demonstrated that pooled results were robust. No significant publication bias was observed (P=0.128). The results indicate that OSA is related to increased risk of DR.

Sign in / Sign up

Export Citation Format

Share Document