scholarly journals P078 Oral Appliance Fabrication Settings Impact Treatment Efficacy

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A46-A46
Author(s):  
D Levendowski ◽  
E Sall ◽  
W Odom ◽  
B Beine ◽  
D Cruz Arista ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Sleep Apnea ◽  
Treatment Outcomes ◽  
Body Mass ◽  
Treatment Efficacy ◽  
Oral Appliance ◽  
Chi Squared ◽  
Pre Treatment ◽  
The Impact

Abstract Purpose Assess the impact of custom oral appliance (CA) fabrication settings on treatment outcomes. Methods CPAP-intolerant patients completed a two-night home-sleep-apnea study (HSAT); Night1=baseline, Night2=Apnea Guard® trial appliance (AG). The AG vertical-dimension-of-occlusion (VDO) selection was based on tongue-scallop (women=5.5/6.5 mm, men= 6.5/8.0 mm), with a target protrusion of 70% from neutral-maximum while in situ. Study1 CA VDO was dependent on sex (women=2.5 mm, men=5 mm), with protrusion set using a George-Gauge measured 70% from maximum retrusion-protrusion with dentist-directed titration. Study2 CA was fabricated to the AG VDO and target protrusion bite-registration. Efficacy HSATs were conducted after completion of Study1 CA titration with vertical-elastics optional, and at the AG target protrusion with vertical-elastics mandatory in Study2. Statistics included Mann-Whitney, Chi-squared, and Bland-Altman analyses. Results The Study1 (n=84) and Study2 (n=46) distributions were equivalent for tongue-scallop (64/63%) and sex (women=45/41%), however, noted differences in age (53.8±11.9 vs. 58.4±12.2; P=0.052), body-mass-index (29.4±5.7 vs. 27.8±4.0; P=0.128) and pre-treatment AHI severities (24.6±14.4 vs. 29.2±17.4 events/h; P=0.155) were observed. The Bland-Altman biases were significant different (Study1=4.2±7.8 vs. Study2=1.3±7.0 events/h, P=0.035). The significant Study1 differences between the CA vs. AG AHIs (12.3±9.2 vs. 8.2±5.9 events/h, P<0.0002) were not apparent in Study2 (11.7±8.0 vs. 10.4±6.7 events/h, P=0.362), however, the Study2 AG AHI values were higher (P=0.055). Discussion Despite the trend toward greater Study2 pre-treatment and AG AHI severities, CA treatment efficacy was equivalent to the AG once VMO was controlled and fabricated using the AG VDO and protrusion bite-registration. These findings confirmed CA fabrication settings impact treatment outcomes.

scholarly journals The impact of body mass index on treatment outcomes for patients with low-intermediate risk prostate cancer

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Kosj Yamoah ◽  
Charnita M. Zeigler-Johnson ◽  
Abra Jeffers ◽  
Bruce Malkowicz ◽  
Elaine Spangler ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Treatment Outcomes ◽  
Body Mass ◽  
Intermediate Risk ◽  
Risk Prostate Cancer ◽  
The Impact

The Impact of Body Mass Index (BMI) on Outcome among Patients with Ductal Carcinoma In Situ (DCIS)

2011 ◽  
Vol 81 (2) ◽  
pp. S219-S220
Author(s):  
M. Chadha ◽  
S. Boolbol ◽  
K. Boachie-Adjei ◽  
L. Kirstein ◽  
J. Portenoy ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
The Impact

scholarly journals Validating pre-treatment body mass index as moderator of antidepressant treatment outcomes: Findings from CO-MED trial

2018 ◽  
Vol 234 ◽  
pp. 34-37 ◽  
Author(s):  
Manish K. Jha ◽  
Shereen Wakhlu ◽  
Neha Dronamraju ◽  
Abu Minhajuddin ◽  
Tracy L. Greer ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Treatment Outcomes ◽  
Body Mass ◽  
Antidepressant Treatment ◽  
Pre Treatment

The impact of body mass index on treatment outcomes among traumatic brain injury patients in intensive care units

2013 ◽  
Vol 40 (1) ◽  
pp. 51-55 ◽  
Author(s):  
S. Y. Chabok ◽  
H. Yazdanshenas ◽  
A. F. Naeeni ◽  
A. Ziabakhsh ◽  
S. S. Bidar ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Traumatic Brain Injury ◽  
Intensive Care ◽  
Brain Injury ◽  
Treatment Outcomes ◽  
Intensive Care Units ◽  
Body Mass ◽  
The Impact

scholarly journals Higher preconceptional maternal body mass index is associated with faster early preimplantation embryonic development: the Rotterdam periconception cohort

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Linette van Duijn ◽  
Melek Rousian ◽  
Jeffrey Hoek ◽  
Sten P. Willemsen ◽  
Eva S. van Marion ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Treatment Outcomes ◽  
Body Mass ◽  
Overweight And Obesity ◽  
Clinical Treatment ◽  
Preimplantation Development ◽  
Preimplantation Embryos ◽  
Morphokinetic Parameters ◽  
The Impact ◽  
Maternal Bmi

Abstract Background Overweight and obesity affect millions of people globally, which has also serious implications for reproduction. For example, treatment outcomes after in vitro fertilisation (IVF) are worse in women with a high body mass index (BMI). However, the impact of maternal BMI on embryo quality is inconclusive. Our main aim is to study associations between preconceptional maternal BMI and morphokinetic parameters of preimplantation embryos and predicted implantation potential. In addition, associations with clinical IVF outcomes are investigated. Methods From a tertiary hospital, 268 women undergoing IVF or IVF with intracytoplasmic sperm injection (ICSI) were included; 143 normal weight, 79 overweight and 46 obese women. The embryos of these women were cultured in the EmbryoScope, a time-lapse incubator. The morphokinetic parameters of preimplantation embryos and predicted implantation potential, assessed by the KIDScore algorithm were longitudinally evaluated as primary and secondary outcomes, respectively. The tertiary outcomes included clinical outcomes, i.e., fertilization, implantation and live birth rate. Results After adjustment for patient- and treatment-related factors, we demonstrated in 938 embryos that maternal BMI is negatively associated with the moment of pronuclear appearance (βtPNa -0.070 h (95%CI -0.139, -0.001), p = 0.048), pronuclear fading (βtPNf -0.091 h (95%CI -0.180, -0.003), p = 0.043 and the first cell cleavage (βt2 -0.111 h (95%CI -0.205, -0.016), p = 0.022). Maternal BMI was not significantly associated with the KIDScore and tertiary clinical treatment outcomes. In embryos from couples with female or combined factor subfertility, the impact of maternal BMI was even larger (βtPNf -0.170 h (95%CI -0.293, -0.047), p = 0.007; βt2 -0.199 h (95%CI -0.330, -0.067), p = 0.003). Additionally, a detrimental impact of BMI per point increase was observed on the KIDScore (β -0.073 (se 0.028), p = 0.010). Conclusions Higher maternal BMI is associated with faster early preimplantation development. In couples with female or combined factor subfertility, a higher BMI is associated with a lower implantation potential as predicted by the KIDScore. Likely due to power issues, we did not observe an impact on clinical treatment outcomes. However, an effect of faster preimplantation development on post-implantation development is conceivable, especially since the impact of maternal BMI on pregnancy outcomes has been widely demonstrated.

Correlation of body mass index with toxicity and survival in locoregionally advanced head and neck cancer patients treated with induction chemotherapy and concurrent chemoradiotherapy

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 6074-6074
Author(s):  
A. K. Jain ◽  
J. K. Salama ◽  
K. M. Stenson ◽  
E. Blair ◽  
E. E. Cohen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Body Mass ◽  
Neck Cancer ◽  
Concurrent Chemoradiotherapy ◽  
Advanced Head ◽  
Pre Treatment ◽  
The Impact

6074 Background: Concurrent chemoradiotherapy (CRT) offers high functional organ preservation rates for locoregionally advanced head and neck cancer (LRAHNC) patients, but is associated with significant acute and chronic speech and swallowing toxicity. Recently, body mass index (BMI) has been suggested as a predictor of head and neck cancer patient outcome. In this analysis we sought to determine the impact of BMI on survival and toxicity outcomes in LRAHNC patients treated with CRT. Methods: 220 LRAHNC patients were treated on a multiinstitutional protocol consisting of induction carboplatin and paclitaxel followed by CRT. CRT was delivered for 4–5 cycles; each 14-day cycle consisted of 5 days concurrent paclitaxel, continuous infusion 5-FU, hydroxyurea, and 1.5 Gy twice daily radiation followed by 9 days without any treatment. Each patient's pre-treatment BMI was classified as overweight (BMI >= 25) or non-overweight (BMI < 25). As an independent variable, BMI was analyzed as a predictor of IndCT or CRT toxicity, locoregional control, and overall survival. BMI was analyzed as categorical variable, and also a continuous variable in a multivariate proportional hazards model. Results: There was no association between BMI and IndCT toxicity. During CRT overweight patients had significantly lower rates (24/103 vs 42/112) of grade 3 or higher neutropenia (p = 0.027), mucositis (p = 0.05), dermatitis (p = 0.028) and higher rates of anorexia (p = 0.05). Overweight patients had 12% long term PEG tube rate, compared to 34% of non-overweight patients (p < 0.001). On pooled survival analysis, patients with BMI > 25 had significantly better overall survival outcomes (mean 81.2 months, 95% CI 75.1–87.3 months) than patients with BMI < 25 (median 58.2 months; mean 56.5 months, 95% CI 49.6–63.3 months) (log-rank p < 0.001). Conclusions: Our data suggest patients with pre-treatment BMI > 25 experience lower rates of toxicity commonly associated with chemoradiation, and have a significantly better prognosis than patients with BMI < 25. Although the mechanism of BMI as an independent predictor of outcomes is unclear, we are continuing to explore mechanisms underlying this association. No significant financial relationships to disclose.

P416 Predicting treatment outcomes for oral appliance therapy for sleep apnea using pre-treatment in-home sleep studies

2006 ◽  
Vol 7 ◽  
pp. S96
Author(s):  
Philip Westbrook ◽  
Daniel Levendowski ◽  
Todd Morgan ◽  
John Patrickus ◽  
Chris Berka ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Treatment Outcomes ◽  
Oral Appliance ◽  
Oral Appliance Therapy ◽  
Sleep Studies ◽  
Pre Treatment

scholarly journals Do Body Mass Index Levels Correlate with Tinnitus Among Teachers?

2021 ◽  
Author(s):  
Luciana Lozza de Moraes Marchiori ◽  
Glória de Moraes Marchiori ◽  
Priscila Carlos ◽  
Samuel Lopes Benites ◽  
Marina Stephany Bobroff Mendes ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Age Group ◽  
Moderate Correlation ◽  
Cross Sectional ◽  
Significance Level ◽  
Significant Difference ◽  
Chi Squared ◽  
The Impact

Abstract Introduction Working conditions can contribute to the development of lifestyle-related diseases among teachers, including obesity and tinnitus. Describing tinnitus in relation to characteristics and comorbidities can help the treatment and prognosis of teachers affected by this symptom. Objective To verify a possible association between tinnitus complaint and body mass index (BMI) in teachers. Methods Cross-sectional study with a sample of teachers who responded to the Visual Analog Scale (VAS) and to the Tinnitus Handicap Inventory (THI). The BMI (kg/m2) was calculated based on self-reported body weight (in kilograms) divided by height (in meters squared). Nonparametric statistics were applied adopting a significance level < 0.05 Results A total of 83 teachers were assessed, with a mean age 48 ± 9.7 years old; 63.9% (n= 53) were females; 44.6% were eutrophic (n = 37), and 16.9% (n = 14) were obese. Of the total, 19.3% (n = 16) reported tinnitus. No differences were found between the groups and BMI (p > 0.05), although there was a significant difference between the Tinnitus and No Tinnitus groups for age (p < 0.001). The chi-squared test showed an association between age group and tinnitus (p < 0.028); those with tinnitus were in the 49 to 65 years old age group. In addition, there was a moderate correlation between tinnitus parameters (VAS; THI-Functional; THI-Total) and BMI. Conclusion There was a moderate correlation between tinnitus parameters and BMI indicating that, as the BMI increased, so did the impact of tinnitus in the lives of the teachers. Body mass index should be considered a factor in tinnitus assessment and rehabilitation process.

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