Higher preconceptional maternal body mass index is associated with faster early preimplantation embryonic development: the Rotterdam periconception cohort

Abstract Background Overweight and obesity affect millions of people globally, which has also serious implications for reproduction. For example, treatment outcomes after in vitro fertilisation (IVF) are worse in women with a high body mass index (BMI). However, the impact of maternal BMI on embryo quality is inconclusive. Our main aim is to study associations between preconceptional maternal BMI and morphokinetic parameters of preimplantation embryos and predicted implantation potential. In addition, associations with clinical IVF outcomes are investigated. Methods From a tertiary hospital, 268 women undergoing IVF or IVF with intracytoplasmic sperm injection (ICSI) were included; 143 normal weight, 79 overweight and 46 obese women. The embryos of these women were cultured in the EmbryoScope, a time-lapse incubator. The morphokinetic parameters of preimplantation embryos and predicted implantation potential, assessed by the KIDScore algorithm were longitudinally evaluated as primary and secondary outcomes, respectively. The tertiary outcomes included clinical outcomes, i.e., fertilization, implantation and live birth rate. Results After adjustment for patient- and treatment-related factors, we demonstrated in 938 embryos that maternal BMI is negatively associated with the moment of pronuclear appearance (βtPNa -0.070 h (95%CI -0.139, -0.001), p = 0.048), pronuclear fading (βtPNf -0.091 h (95%CI -0.180, -0.003), p = 0.043 and the first cell cleavage (βt2 -0.111 h (95%CI -0.205, -0.016), p = 0.022). Maternal BMI was not significantly associated with the KIDScore and tertiary clinical treatment outcomes. In embryos from couples with female or combined factor subfertility, the impact of maternal BMI was even larger (βtPNf -0.170 h (95%CI -0.293, -0.047), p = 0.007; βt2 -0.199 h (95%CI -0.330, -0.067), p = 0.003). Additionally, a detrimental impact of BMI per point increase was observed on the KIDScore (β -0.073 (se 0.028), p = 0.010). Conclusions Higher maternal BMI is associated with faster early preimplantation development. In couples with female or combined factor subfertility, a higher BMI is associated with a lower implantation potential as predicted by the KIDScore. Likely due to power issues, we did not observe an impact on clinical treatment outcomes. However, an effect of faster preimplantation development on post-implantation development is conceivable, especially since the impact of maternal BMI on pregnancy outcomes has been widely demonstrated.

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P078 Oral Appliance Fabrication Settings Impact Treatment Efficacy

SLEEP Advances ◽

10.1093/sleepadvances/zpab014.122 ◽

2021 ◽

Vol 2 (Supplement_1) ◽

pp. A46-A46

Author(s):

D Levendowski ◽

E Sall ◽

W Odom ◽

B Beine ◽

D Cruz Arista ◽

...

Keyword(s):

Body Mass Index ◽

Sleep Apnea ◽

Treatment Outcomes ◽

Body Mass ◽

Treatment Efficacy ◽

Oral Appliance ◽

Chi Squared ◽

Pre Treatment ◽

The Impact

Abstract Purpose Assess the impact of custom oral appliance (CA) fabrication settings on treatment outcomes. Methods CPAP-intolerant patients completed a two-night home-sleep-apnea study (HSAT); Night1=baseline, Night2=Apnea Guard® trial appliance (AG). The AG vertical-dimension-of-occlusion (VDO) selection was based on tongue-scallop (women=5.5/6.5 mm, men= 6.5/8.0 mm), with a target protrusion of 70% from neutral-maximum while in situ. Study1 CA VDO was dependent on sex (women=2.5 mm, men=5 mm), with protrusion set using a George-Gauge measured 70% from maximum retrusion-protrusion with dentist-directed titration. Study2 CA was fabricated to the AG VDO and target protrusion bite-registration. Efficacy HSATs were conducted after completion of Study1 CA titration with vertical-elastics optional, and at the AG target protrusion with vertical-elastics mandatory in Study2. Statistics included Mann-Whitney, Chi-squared, and Bland-Altman analyses. Results The Study1 (n=84) and Study2 (n=46) distributions were equivalent for tongue-scallop (64/63%) and sex (women=45/41%), however, noted differences in age (53.8±11.9 vs. 58.4±12.2; P=0.052), body-mass-index (29.4±5.7 vs. 27.8±4.0; P=0.128) and pre-treatment AHI severities (24.6±14.4 vs. 29.2±17.4 events/h; P=0.155) were observed. The Bland-Altman biases were significant different (Study1=4.2±7.8 vs. Study2=1.3±7.0 events/h, P=0.035). The significant Study1 differences between the CA vs. AG AHIs (12.3±9.2 vs. 8.2±5.9 events/h, P<0.0002) were not apparent in Study2 (11.7±8.0 vs. 10.4±6.7 events/h, P=0.362), however, the Study2 AG AHI values were higher (P=0.055). Discussion Despite the trend toward greater Study2 pre-treatment and AG AHI severities, CA treatment efficacy was equivalent to the AG once VMO was controlled and fabricated using the AG VDO and protrusion bite-registration. These findings confirmed CA fabrication settings impact treatment outcomes.

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Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study

Thorax ◽

10.1136/thoraxjnl-2017-210716 ◽

2018 ◽

Vol 73 (6) ◽

pp. 538-545 ◽

Cited By ~ 12

Author(s):

Sandra Ekström ◽

Jenny Hallberg ◽

Inger Kull ◽

Jennifer L P Protudjer ◽

Per Thunqvist ◽

...

Keyword(s):

Body Mass Index ◽

Lung Function ◽

Airway Obstruction ◽

Body Mass ◽

Overweight And Obesity ◽

School Age Children ◽

Childhood And Adolescence ◽

Small Airways ◽

Cross Sectional ◽

The Impact

BackgroundFew large prospective studies have investigated the impact of body mass index (BMI) on lung function during childhood.MethodsUsing data collected between 2002 and 2013, we analysed associations between BMI status and lung function (assessed by spirometry) from 8 to 16 years, as well as cross-sectional associations with small airway function (impulse oscillometry) at 16 years in the BAMSE cohort (n=2889). At 16 years, cross-sectional associations with local and systemic inflammation were investigated by analysing FENO, blood eosinophils and neutrophils.ResultsOverweight and obesity at 8 years were associated with higher FVC, but lower FEV1/FVC ratio at 8 and 16 years. In boys, but not girls, obesity at 8 years was associated with a further reduction in FEV1/FVC between 8 and 16 years. In cross-sectional analyses, overweight and obesity were associated with higher frequency dependence of resistance (R5–20) and larger area under the reactance curve (AX0.5) at 16 years. Increased blood neutrophil counts were seen in overweight and obese girls, but not in boys. No association was found between BMI status and FENO. Persistent, but not transient, overweight/obesity between 8 and 16 years was associated with higher R5–20 and AX0.5 and lower FEV1/FVC (−2.8% (95% CI −4.1 to −1.2) in girls and −2.7% (95% CI −4.4 to −1.1) in boys) at 16 years, compared with persistent normal weight.ConclusionIn childhood and adolescence, overweight and obesity, particularly persistent overweight, were associated with evidence of airway obstruction, including the small airways.

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SAT0058 AGE DEPENDENT EFFECTS OF BODY MASS INDEX AND SMOKING ON THE RISK OF RHEUMATOID ARTHRITIS IN MEN – RESULTS FROM A NESTED CASE CONTROL STUDY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.4846 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 961-961

Author(s):

C. Turesson ◽

U. Bergström ◽

M. Linnerud Keshavarz ◽

J. Å. Nilsson ◽

L. T. H. Jacobsson

Keyword(s):

Rheumatoid Arthritis ◽

Body Mass Index ◽

Body Mass ◽

Health Survey ◽

Conditional Logistic Regression ◽

Statistical Significance ◽

Overweight And Obesity ◽

Acr Criteria ◽

The Impact ◽

Reduced Risk

Background:As rheumatoid arthritis (RA) is more common in women compared to men, most studies of disease predictors have mainly included women, and data on risk factors in men are limited. Smoking is an established predictor of RA. A negative association between body mass index (BMI) and the risk of RA in men has been reported from several studies of Scandinavian populations.Objectives:To investigate whether the impact of smoking and BMI on the risk of subsequent development of RA in men differs by age.Methods:A total of 22 444 men from a defined catchment area were included in a Preventive Medicine Program (PMP). Height and weight were measured as part of the health survey, and BMI was calculated as weight (in kg)/height (in m2). Information on smoking was obtained using a structured self-administered questionnaire. Normal BMI, overweight and obesity was defined according to the WHO criteria. From this population, we identified individuals who developed RA after inclusion by linking the PMP register to the local community based RA register and to local and national patient administrative databases. In a structured review of the medical records, patients were classified according to the 1987 ACR criteria for RA. Four controls for each validated case, matched for sex, year of birth and year of screening, who were alive and free of RA when the index person was diagnosed with RA, were selected from the PMP register. The impact of BMI category and smoking on the risk of RA was examined in multivariable conditional logistic regression models, stratified by age at inclusion in the health survey (above vs below the median).Results:A total of 151 men were diagnosed with RA and fulfilled the ACR criteria after inclusion in the PMP (median time to diagnosis 13 years, interquartile range 9-19; 76 % rheumatoid factor positive at diagnosis). These pre-RA cases were compared to 604 matched controls. Among men aged >46 years, overweight/obesity was associated with a significantly reduced risk of subsequent RA (odds ratio (OR) 0.40; 95 % confidence interval (CI) 0.21-0.76, adjusted for smoking), whereas there was no such association in younger men (adjusted OR 0.75 (95% CI 0.42-1.36). Smoking was a significant predictor of RA in men aged >46 years (Table 1). There was a similar trend in those aged ≤46 years, but it did not reach statistical significance (Table 1).Conclusion:Overweight/obesity was associated with a reduced risk of subsequent RA in men aged >46 years. The relative importance of life style factors for the risk of RA may be greater in older men compared to younger.Disclosure of Interests:Carl Turesson Grant/research support from: Unrestricted grant from Bristol-Myers Squibb, Consultant of: Roche, Speakers bureau: Abbvie, Bristol Myers-Squibb, Pfizer, Roche, Ulf Bergström: None declared, Mitra Linnerud Keshavarz: None declared, Jan-Åke Nilsson: None declared, Lennart T.H. Jacobsson Consultant of: AbbVie, Eli Lilly, Janssen, Novartis and Pfizer

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The impact of body mass index on treatment outcomes for patients with low-intermediate risk prostate cancer

BMC Cancer ◽

10.1186/s12885-016-2572-y ◽

2016 ◽

Vol 16 (1) ◽

Cited By ~ 9

Author(s):

Kosj Yamoah ◽

Charnita M. Zeigler-Johnson ◽

Abra Jeffers ◽

Bruce Malkowicz ◽

Elaine Spangler ◽

...

Keyword(s):

Prostate Cancer ◽

Body Mass Index ◽

Treatment Outcomes ◽

Body Mass ◽

Intermediate Risk ◽

Risk Prostate Cancer ◽

The Impact

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The Impact of Obesity on Periodontal Health Status in Adolescent Iraqi Students

Brazilian Dental Science ◽

10.14295/bds.2021.v24i2.2095 ◽

2021 ◽

Vol 24 (2) ◽

Author(s):

Sarah Ihsan Al-Karawi ◽

Athraa Ali Mahmood ◽

Ban Karem Hassan

Keyword(s):

Body Mass Index ◽

Health Status ◽

Oral Health ◽

Body Mass ◽

Oral Hygiene ◽

Overweight And Obesity ◽

School Students ◽

Periodontal Health ◽

Periodontal Condition ◽

The Impact

Objetive: The aim of this study was to estimate the effect and association of obesity on the periodontal health status of middle school students. Materials and Methods: This study included 180 secondary school students aged 12- 15 years from Baghdad City in the survey. BMIfor-age (body mass index for age) was utilized to detect overweight and obesity. Furthermore, periodontal screening records (PSR) index was performed to evaluate the oral hygiene and periodontal condition of the subjects. Chisquare tests and two-way ANOVA were used for statistical analyses. Results: A highly significant association of BMI-for-age with periodontal health (codes 0, 1, 2, and 3) was observed. The association of gender and periodontal health was highly significant in code 3, significant in codes 0 and 1, and it was not significant in code 2. Additionally, the ANOVA test revealed that the effects of gender and BMI-for-age on periodontal health were significant. In contrast, the effect of the interaction between gender and BMI-for-age on periodontal health was not it was not significant. Conclusions: In adolescents, bad oral hygiene was correlated with extra body fat indicators. Therefore, oral health preventive schedules should take into consideration the relationship between periodontal condition and overweight/obesity in teenagers. Keywords Obesity; Body mass index; Periodontal disease; Oral health status.

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The Reality of Lung Cancer Paradox: The Impact of Body Mass Index on Long-Term Survival of Resected Lung Cancer. A French Nationwide Analysis from the Epithor Database

Cancers ◽

10.3390/cancers13184574 ◽

2021 ◽

Vol 13 (18) ◽

pp. 4574

Author(s):

Marco Alifano ◽

Elisa Daffré ◽

Antonio Iannelli ◽

Laurent Brouchet ◽

Pierre Emmanuel Falcoz ◽

...

Keyword(s):

Lung Cancer ◽

Body Mass Index ◽

Body Mass ◽

Performance Status ◽

Lung Resection ◽

Normal Weight ◽

Overweight And Obesity ◽

French Society ◽

Term Survival ◽

The Impact

Obesity could have a protective effect in patients with lung cancer. We assessed the prognostic role of preoperative BMI on survival in patients who underwent lung resection for NSCLC. A total of 54,631 consecutive patients with resectable lung cancer within a 15-year period were extracted from Epithor (the French Society of Thoracic and Cardiovascular Surgery database). Patient subgroups were defined according to body mass index (BMI): underweight (BMI < 18.5 kg/m2), normal weight (18.5 ≤ BMI < 25 kg/m2), overweight (25 ≤ BMI < 30 kg/m2), and obese (BMI ≥ 30 kg/m2). Underweight was associated with lower survival (unadjusted HRs 1.24 (1.16–1.33)) compared to normal weight, whereas overweight and obesity were associated with improved survival (0.95 (0.92–0.98) and 0.88 (0.84–0.92), respectively). The impact of BMI was confirmed when stratifying for sex or Charlson comorbidities index (CCI). Among patients with obesity, a higher BMI was associated with improved survival. After adjusting for period of study, age, sex, WHO performance status, CCI, side of tumor, extent of resection, histologic type, and stage of disease, the HRs for underweight, overweight, and obesity were 1.51 (1.41–1.63), 0.84 (0.81–0.87), and 0.80 (0.76–0.84), respectively. BMI is a strong and independent predictor of survival in patients undergoing surgery for NSCLC.

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The impact of body mass index on treatment outcomes among traumatic brain injury patients in intensive care units

European Journal of Trauma and Emergency Surgery ◽

10.1007/s00068-013-0314-2 ◽

2013 ◽

Vol 40 (1) ◽

pp. 51-55 ◽

Cited By ~ 10

Author(s):

S. Y. Chabok ◽

H. Yazdanshenas ◽

A. F. Naeeni ◽

A. Ziabakhsh ◽

S. S. Bidar ◽

...

Keyword(s):

Body Mass Index ◽

Traumatic Brain Injury ◽

Intensive Care ◽

Brain Injury ◽

Treatment Outcomes ◽

Intensive Care Units ◽

Body Mass ◽

The Impact

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Relationship of Body Mass Index with Diet, Physical Activities, and Lifestyles of Dental Students

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-2146 ◽

2017 ◽

Vol 18 (10) ◽

pp. 899-904 ◽

Cited By ~ 1

Author(s):

Kamran Habib Awan ◽

Syed R Habib ◽

Sakhar Alghofaily ◽

Hussam Alshamrani ◽

Abdullah Alhammad

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Dietary Habits ◽

Dental Students ◽

Overweight And Obesity ◽

Physical Activities ◽

Male Students ◽

Significant Difference ◽

Relationship Of ◽

The Impact

ABSTRACT Introduction The objective of the study was to investigate the prevalence of overweight issues and obesity by recording the body mass index (BMI) and explore the dietary habits, physical activities (PAs), and lifestyles of male students at the College of Dentistry, King Saud University. Materials and methods A custom-designed self-administrative form and questionnaire were used in this study for data collection. The first part of the form was used to record the participants’ height and weight for the BMI. The participants were grouped as underweight (BMI < 18.5), normal weight (BMI = 18.5–24.9), overweight (BMI = 25–29.9), and obese (BMI > 30.0). The second part comprised questions related to the dietary habits, PAs, and lifestyles of the male dental students. Chi-squared test was used to generate the significance of each question at significance <0.05. Results A total of 211 male students (mean age 22.31 ± 2.10 years) participated in the study (response rate 78.1%). The findings revealed that 29 and 28% of the dental students were overweight and obese respectively. A statistically significant difference (p < 0.05) between the groups was found for the questions asked about time spent exercising per day (p = 0.003), time spent sporting per week (p = 0.003), and time spent watching television and internet surfing per day (p = 0.012). Conclusion The prevalence of overweight issues and obesity is high among the dental students compared with the general population of Saudi Arabia, and there is a need for intervention programs to combat obesity among the dental students. The awareness about PA, healthy diet/lifestyle, consequences of overweight and obesity on their health and profession must be increased among the dental students to avoid future complications. Clinical significance The impact of obesity on individuals’ oral health and its influence on dental treatment protocols and postoperative procedures has been well documented. Dental students are more prone to obesity due to their lifestyle with less PA and disordered eating habits and, thereby, are prone to obesity-related health hazards. How to cite this article Habib SR, Alghofaily S, Alshamrani H, Alhammad A, Awan KH. Relationship of Body Mass Index with Diet, Physical Activities, and Lifestyles of Dental Students. J Contemp Dent Pract 2017;18(10):899-904.

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Maternal body mass index: how much it affects mother and baby

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20200873 ◽

2020 ◽

Vol 9 (3) ◽

pp. 1050

Author(s):

Chaitanya A. Shembekar ◽

Shantanu C. Shembekar ◽

Manisha C. Shembekar ◽

Parul Sharma Saoji ◽

Jayshree J. Upadhye

Keyword(s):

Body Mass Index ◽

Weight Gain ◽

Cesarean Section ◽

Pregnant Women ◽

Body Mass ◽

Maternal Obesity ◽

Overweight And Obesity ◽

Maternal Body Mass Index ◽

Normal Delivery ◽

The Impact

Background: Overweight, obesity, and morbid obesity in the mother are associated with adverse obstetrics well as neonatal outcome. Aim of this study was to assess the prevalence of overweight and obesity, and the impact of body mass index (BMI) on maternal and neonatal outcome.Methods: This is a retrospective study from January 2018 to September 2018 on 180 women with singleton term pregnancies. Maternal and neonatal outcomes at delivery were noted.Results: In present study, 3 (1.66%) pregnant women were underweight, 57 (31.66%) pregnant women had normal BMI, 71 (39.44%) pregnant women were overweight while 49 (27.22%) pregnant women were obese. Gestational weight gain was less than 8 kgs in 40 (22.22%) pregnant women, weight gain was 8-15.9 kgs in 132 (73.33%) pregnant women while weight gain was more than 16 kgs in 8 (4.44%) pregnant women. Out of 3 underweight women, 1 delivered by cesarean section and 2 had normal delivery, out of 57 women with normal BMI, 21 delivered by cesarean section and 36 had normal delivery, out of 71 overweight women, 47 delivered by cesarean section and 34 had normal delivery while out of 49 obese women, 38 delivered by cesarean section and 11 had normal delivery. PET and GDM was seen in 9 (7.5%) women each while macrosomia were seen in 5 (4.16%) women.Conclusions: Increased association was seen with maternal obesity and adverse outcome of pregnancy like PIH, GDM, cesarean section.

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Body Mass Index and Pregnancy Outcome after Assisted Reproduction Treatment

International Journal of Reproductive Medicine ◽

10.1155/2014/257974 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Khaled Kasim ◽

Ahmed Roshdy

Keyword(s):

Body Mass Index ◽

Pregnancy Outcome ◽

Body Mass ◽

Regression Models ◽

Overweight And Obesity ◽

Obese Women ◽

Logistic Regression Models ◽

Overweight Women ◽

The Impact ◽

Assisted Reproduction Treatment

The present study aimed to evaluate the impact of body mass index (BMI) on pregnancy outcome after intracytoplasmic sperm injection (ICSI). The study analyzed pregnancy outcome of 349 women who underwent ICSI by their BMI: <25, 25–<30, and ≥30 kg/m2. The associations were generated by applying logistic regression models. A significant reduction in positive pregnancy outcome was observed among overweight and obese women (odds ratio (OR) = 0.50; 95% confidence interval (CI) = 0.25–0.99 for overweight women and OR = 0.45; 95% CI = 0.20–0.89 for obese women). These estimates show that the pregnancy rates are reduced with increasing BMI. The effect of obesity on pregnancy outcome was absent when three and more embryos were transferred. Our study contributes to the reports linking overweight and obesity with decreased positive pregnancy outcome after ICSI and suggests women’s age, infertility type, and number of embryos transferred to modify this reducing effect.

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