Transfusion-transmissible dengue infections

2020 ◽  
Vol 114 (11) ◽  
pp. 866-882 ◽  
Author(s):  
Lakshika Perera ◽  
Nandrani De Zoysa ◽  
Umesh Jayarajah ◽  
Nilanthi Senanayake ◽  
Ishan De Zoysa ◽  
...  
Keyword(s):  
Global Health ◽  
Literature Search ◽  
Blood Donors ◽  
Developed Countries ◽  
Screening Tests ◽  
Safe Blood ◽  
Selection Stage ◽  
Global Health Problem ◽  
Developing And Developed Countries ◽  
Apparently Healthy

Abstract Dengue is an important global health problem and is endemic in many developing and developed countries. Transmission of dengue may occur in several ways and information on transfusion-transmitted dengue is limited. We conducted a literature search on transfusion-related dengue using the PubMed, Scopus, Embase and Google Scholar databases and have summarized the findings. A number of apparently healthy blood donors have been found to be infected with the dengue virus (DENV) and thus may transmit the virus onto recipients of this blood. It is not possible to identify and exclude such donors at the donor selection stage and thus reliable screening tests should be available in highly endemic areas to ensure a safe blood supply.

Idiopathic Ulcers as an Oral Manifestation in Pediatric Patients with AIDS: Multidisciplinary Management

2012 ◽  
Vol 37 (1) ◽  
pp. 65-69
Author(s):  
B Martinez-Sandoval ◽  
H Ceballos-Hernández ◽  
J Téllez-Rodríguez ◽  
L Xochihua-Díaz ◽  
G Durán-Ibarra ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Dental Health ◽  
Clinical Manifestations ◽  
Developed Countries ◽  
Oral Lesions ◽  
Multidisciplinary Management ◽  
Oral Manifestation ◽  
Preventive Methods ◽  
Global Health Problem ◽  
Developing And Developed Countries

HIV infection is a major global health problem affecting developing and developed countries alike. HIV infection is associated with multiple oral lesions, some of which are of value in diagnosing the disease. The aim of this report is to describe the clinical manifestations and their multidisciplinary management, in a 6- year-old girl with AIDS. The findings of this case report indicate that, it is essential to be familiar with the early oral manifestations of AIDS in order to understand the patient's dental health needs, apply preventive methods, control caries, and understand the value of oral lesions as diagnostic markers of disease progression in children with HIV infection. A multidisciplinary management is fundamental.

scholarly journals Prevalence of viral (HBV, HCV and HIV) co-infections among apparently healthy blood donors in Ranchi, Jharkhand, India

2017 ◽  
Vol 5 (6) ◽  
pp. 2674
Author(s):  
Sushma Kumari ◽  
Asha Kiran ◽  
Ritesh Kumar ◽  
Ramesh K. Shrivastava
Keyword(s):  
Blood Transfusion ◽  
Viral Infection ◽  
Blood Donors ◽  
Early Stage ◽  
Blood Samples ◽  
Life Threatening ◽  
Safe Blood ◽  
Apparently Healthy

Background: Apparently healthy blood donors may carry double viral co-infections that might be more fatal than viral mono-infection for the donor himself as well as recipient later on.Methods: All blood samples were screened for HIV-I and II (4th generation kit), HBV and HCV (3rd generation kit) by using chemiluminescence technique (Manufacturer- Abbott, Model-Architect i 1000SR).Results: On screening of 41307 blood units, 829 (2.0%) donors were found positive for one of the viral infection (HBV, HCV and HIV). Highest prevalence was for HBV (417 donors- 1.0%) followed by HCV (324 donors- 0.78 %) and HIV (88 donors- 0.21 %).Conclusions: Apparently healthy blood donors might carry, life threatening, double viral co-infections in their blood. Failure to diagnose and treat co-infection at an early stage results in serious complications and sequelae. For safe blood transfusion all blood units should be tested for compatibility and TTI’s with reduction in unnecessary blood transfusion.

Housing Inflation: Policy Guidelines from Shariah Perspective

2019 ◽  
Vol 16 (1) ◽  
pp. 70-81
Author(s):  
Azrul Azlan Iskandar Mirza ◽  
Asmaddy Haris ◽  
Ainulashikin Marzuki ◽  
Ummi Salwa Ahmad Bustamam ◽  
Hamdi Hakiem Mudasir ◽  
...  
Keyword(s):  
Content Analysis ◽  
Housing Prices ◽  
Construction Materials ◽  
Housing Price ◽  
Developed Countries ◽  
Control Element ◽  
Recent Issue ◽  
Analysis Methodology ◽  
The Government ◽  
Developing And Developed Countries

The soaring housing prices in Malaysia is not a recent issue. It is a global phenomenon especially in developing and developed countries, driven by factors including land price, location, construction materials cost, demand, and speculation. This issue demands immediate attention as it affects the younger generation, most of whom could not afford to buy their own house. The government has taken many initiatives and introduced regulations to ensure that housing prices are within the affordable range. This article aims to introduce a housing price control element from the Shariah perspective, as an alternative solution for all parties involved in this issue. It adopts content analysis methodology on policy from Shariah approved sources.

scholarly journals Osmium–arene complexes with high potency towards Mycobacterium tuberculosis

Metallomics ◽  
2021 ◽  
Vol 13 (4) ◽  
Author(s):  
James P C Coverdale ◽  
Collette S Guy ◽  
Hannah E Bridgewater ◽  
Russell J Needham ◽  
Elizabeth Fullam ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Global Health ◽  
Mechanism Of Action ◽  
Health Problem ◽  
Normal Lung ◽  
Lung Cells ◽  
Redox Mechanism ◽  
Human Lung Cells ◽  
Half Sandwich ◽  
Global Health Problem

Abstract The treatment of tuberculosis (TB) poses a major challenge as frontline therapeutic agents become increasingly ineffective with the emergence and spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). To combat this global health problem, new antitubercular agents with novel modes of action are needed. We have screened a close family of 17 organometallic half-sandwich Os(II) complexes [(arene)Os(phenyl-azo/imino-pyridine)(Cl/I)]+Y– containing various arenes (p-cymene, biphenyl, or terphenyl), and NMe2, F, Cl, or Br phenyl or pyridyl substituents, for activity towards Mtb in comparison with normal human lung cells (MRC5). In general, complexes with a monodentate iodido ligand were more potent than chlorido complexes, and the five most potent iodido complexes (MIC 1.25–2.5 µM) have an electron-donating Me2N or OH substituent on the phenyl ring. As expected, the counter anion Y (PF6–, Cl–, I–) had little effect on the activity. The pattern of potency of the complexes towards Mtb is similar to that towards human cells, perhaps because in both cases intracellular thiols are likely to be involved in their activation and their redox mechanism of action. The most active complex against Mtb is the p-cymene Os(II) NMe2-phenyl-azopyridine iodido complex (2), a relatively inert complex that also exhibits potent activity towards cancer cells. The uptake of Os from complex 2 by Mtb is rapid and peaks after 6 h, with temperature-dependence studies suggesting a major role for active transport. Significance to Metallomics Antimicrobial resistance is a global health problem. New advances are urgently needed in the discovery of new antibiotics with novel mechanisms of action. Half-sandwich organometallic complexes offer a versatile platform for drug design. We show that with an appropriate choice of the arene, an N,N-chelated ligand, and monodentate ligand, half-sandwich organo–osmium(II) complexes can exhibit potent activity towards Mycobacterium tuberculosis (Mtb), the leading cause of death from a single infectious agent. The patterns of activity of the 17 azo- and imino-pyridine complexes studied here towards Mtb and normal lung cells suggest a common redox mechanism of action involving intracellular thiols.

scholarly journals Income, wealth and use of personal protection equipment in the Mekong Delta

2021 ◽  
Author(s):  
Matteo Migheli
Keyword(s):  
Low Income ◽  
Mekong Delta ◽  
Developed Countries ◽  
Household Wealth ◽  
Protective Equipment ◽  
Personal Protection ◽  
Personal Protection Equipment ◽  
Management Techniques ◽  
Using Data ◽  
Developing And Developed Countries

AbstractBoth in developing and developed countries, farmers often do not protect themselves adequately, especially when applying agrochemicals that are dangerous for their health. The issue is relevant because insufficient protection is between the causes leading to intoxication of farmers and workers who handle these products. The literature suggests that both lack of training and information and low income may explain why, especially in developing countries, protective equipment is under-used. Using data from the Mekong Delta, this study addresses the issue of whether income and household wealth may help explaining the use of incomplete protections against pesticides. The results suggest that income, more than wealth, is a reason why Vietnamese farmers operating in the Mekong Delta fail in using adequate protections. In particular, the data suggest that they may prefer to divert resources to increasing the production of their fields or to buying goods that may be used both as protection and as everyday garments. This behaviour leads to underinvestment in some important protective goods. Possible public interventions to mitigate the problem are suggested; in particular, the promotion of integrated pest management techniques could be useful.

Investigation of therapeutic potential of three endemic Cirsium species for global health problem obesity

2021 ◽  
Vol 141 ◽  
pp. 243-254
Author(s):  
Sila Ozlem Sener ◽  
Ufuk Ozgen ◽  
Seyda Kanbolat ◽  
Nuriye Korkmaz ◽  
Merve Badem ◽  
...  
Keyword(s):  
Global Health ◽  
Health Problem ◽  
Therapeutic Potential ◽  
Global Health Problem

scholarly journals Strategies for reducing out of pocket payments in the health system: a scoping review

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Faride Sadat Jalali ◽  
Parisa Bikineh ◽  
Sajad Delavari
Keyword(s):  
Health System ◽  
Health Systems ◽  
Scoping Review ◽  
Health Financing ◽  
Developed Countries ◽  
Vulnerable Groups ◽  
System A ◽  
Out Of Pocket Payments ◽  
Review Study ◽  
Developing And Developed Countries

Abstract Background Direct out-of-pocket payments (OOP) are among the most important financing mechanisms in many health systems, especially in developing countries, adversely affecting equality and leading vulnerable groups to poverty. Therefore, this scoping review study was conducted to identify the strategies involving OOP reduction in health systems. Methods Articles published in English on strategies related to out-of-pocket payments were Searched and retrieved in the Web of Science, Scopus, PubMed, and Embase databases between January 2000 and November 2020, following PRISMA guidelines. As a result, 3710 papers were retrieved initially, and 40 were selected for full-text assessment. Results Out of 40 papers included, 22 (55%) and 18 (45%) of the study were conducted in developing and developed countries, respectively. The strategies were divided into four categories based on health system functions: health system stewardship, creating resources, health financing mechanisms, and delivering health services.As well, developing and developed countries applied different types of strategies to reduce OOP. Conclusion The present review identified some strategies that affect the OOP payments According to the health system functions framework. Considering the importance of stewardship, creating resources, the health financing mechanisms, and delivering health services in reducing OOP, this study could help policymakers make better decisions for reducing OOP expenditures.

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