scholarly journals Inhibitory effects of caffeic acid phenethyl ester (CAPE) derivatives on multiple myeloma cell growth

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
My Lien Jackson ◽  
Xinyu Wang
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Caffeic Acid ◽  
Myeloma Cell ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effects ◽  
Multiple Myeloma Cell

scholarly journals Preparation of caffeic acid phenethyl ester‐incorporated nanoparticles and their inhibitory effects on multiple myeloma cell growth

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Barkley Smith ◽  
Xinyu Wang ◽  
Michael Tucker ◽  
Travis Fields ◽  
Yuancheng Li ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Caffeic Acid ◽  
Myeloma Cell ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effects ◽  
Multiple Myeloma Cell

scholarly journals A Peculiar Molecular Profile of Umbilical Cord-Mesenchymal Stromal Cells Drives Their Inhibitory Effects on Multiple Myeloma Cell Growth and Tumor Progression

2015 ◽  
Vol 24 (12) ◽  
pp. 1457-1470 ◽  
Author(s):  
Sabino Ciavarella ◽  
Anna Caselli ◽  
Antonella Valentina Tamma ◽  
Annalisa Savonarola ◽  
Giuseppe Loverro ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Tumor Progression ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Myeloma Cell ◽  
Molecular Profile ◽  
Inhibitory Effects ◽  
Multiple Myeloma Cell

scholarly journals KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival

Leukemia ◽  
2017 ◽  
Vol 31 (12) ◽  
pp. 2661-2669 ◽  
Author(s):  
H Ohguchi ◽  
T Harada ◽  
M Sagawa ◽  
S Kikuchi ◽  
Y-T Tai ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Mapk Pathway ◽  
Myeloma Cell ◽  
Growth And Survival ◽  
Multiple Myeloma Cell ◽  
Cell Growth And Survival

scholarly journals Toll-Like Receptor 4 Activation Promotes Multiple Myeloma Cell Growth and Survival Via Suppression of The Endoplasmic Reticulum Stress Factor Chop

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Tina Bagratuni ◽  
Aimilia D. Sklirou ◽  
Efstathios Kastritis ◽  
Christine Ivy Liacos ◽  
Christina Spilioti ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Endoplasmic Reticulum ◽  
Cell Growth ◽  
Endoplasmic Reticulum Stress ◽  
Myeloma Cell ◽  
Stress Factor ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Growth And Survival ◽  
Multiple Myeloma Cell

scholarly journals Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo

2014 ◽  
Vol 33 (1) ◽  
pp. 448-456 ◽  
Author(s):  
QI ZHANG ◽  
WEIQUN YAN ◽  
YANG BAI ◽  
HAO XU ◽  
CHANGHAO FU ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Myeloma Cell ◽  
Multiple Myeloma Cell

Aptamer TY04 Inhibits Multiple Myeloma Cell Growth Via Cell Cycle Arrest

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 5390-5390
Author(s):  
Jing Liu ◽  
Hong-Juan Dai ◽  
Bian-Ying Ma ◽  
Jian-Hui Song ◽  
Hui-yong Chen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Multiple Myeloma ◽  
Flow Cytometry ◽  
Cell Growth ◽  
Cell Lines ◽  
Myeloma Cell ◽  
Multiple Myeloma Cell ◽  
Cycle Arrest ◽  
M Phase ◽  
Target Molecules

Abstract Multiple myeloma (MM), also known as plasma cell myeloma, is characterized by accumulation of clonal plasma cells in the bone marrow and overproduction of monoclonal immunoglobulin (Ig) in the blood or urine. MM accounts for approximately 10% of all hematologic malignancies. Despite recent advances in the understanding and treatment of this disease, MM remains an incurable disease in the vast majority. With conventional chemotherapy, the 5-year median survival rate for MM patients is approximately 25%. Aptamers are single-stranded RNA or DNA sequences that bind to target molecules with high affinity and specificity. Compared with antibodies, aptamers have unique advantages including easy chemical synthesis and modification, low toxicity, lack of immunogenicity, and rapid tissue penetration, Based on these advantages, aptamers show great potential for therapeutic application. The aptamer TY04 is a single-stranded DNA (ssDNA) generated by a method named cell-based systematic evolution of ligands by exponential enrichment (cell-SELEX), We found TY04 strongly inhibited the growth of multiple myeloma cell lines including MM1.S, NCI-H929, KM3 and OPM2,The concentration of TY04 to inhibit 50% cell growth (IC50) on MM1.S was 3.89 μM. In contrast, TY04 had no effect on the growth of non-tumor cell lines — immortal B lymphoblastoid cell lines. Next, we used MM1.S cell line as the model to study the mechanism of TY04 anti- multiple myeloma. Flow cytometry analysis showed that TY04 with the sequence specifically bind to MM1.S cells when compared with unselected ssDNA library control. To investigate whether the target molecules of TY04 are membrane proteins on cell surface, MM1.S cells were treated with trypsin and proteinase k for 2 or 10 minutes before incubation with TY04. The result revealed that TY04 lost partly recognition ability on treated cells, indicating that the target molecules were most likely membrane proteins. Furthermore, we evaluated the cell cycle distribution of MM1.S after TY04 treatment. We found that TY04 significantly caused cell-cycle arrest in G2/M phase. The percentage of G2/M phase cells increased from 30.1±1.56 to 53.2±6.36. To identify the underlying molecular mechanism, G2/M-related proteins were assayed by flow cytometry. Following TY04 treatment, a concomitant inhibition of ERK1/2, cyclin B, CDK1 and γ-tubulin expression occurred. Meanwhile, human cell cycle PCR array was used to analyze the expression of 84 genes key to cell cycle regulation in TY04-treated MM1.S cells. Our results indicated that aptamer TY04 decreased the genes expression of CCNB1, CCNB2, BIRC5, BRCA1 and CCNH, which were involved in the progress of G2/M phase. All these results are significant in that they provide a framework for further exploring the use of TY04 as a novel anti-multiple myeloma agent. Disclosures: No relevant conflicts of interest to declare.

scholarly journals MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo

2006 ◽  
Vol 12 (19) ◽  
pp. 5887-5894 ◽  
Author(s):  
Teru Hideshima ◽  
Paola Neri ◽  
Pierfranchesco Tassone ◽  
Hiroshi Yasui ◽  
Kenji Ishitsuka ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Myeloma Cell ◽  
Multiple Myeloma Cell ◽  
Iκb Kinase

Targeting JNK and p27 to inhibit multiple myeloma cell growth

2003 ◽  
Vol 70 (4) ◽  
pp. 269-270
Author(s):  
K. Chan ◽  
M. Boluro-Ajayi ◽  
L. Corral ◽  
B. Ennis ◽  
F. Mercurio ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Myeloma Cell ◽  
Multiple Myeloma Cell

scholarly journals [Retracted] Synthetic miR‑145 mimic inhibits multiple myeloma cell growth in vitro and in vivo

2021 ◽  
Vol 46 (2) ◽  
Author(s):  
Qi Zhang ◽  
Weiqun Yan ◽  
Yang Bai ◽  
Hao Xu ◽  
Changhao Fu ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Myeloma Cell ◽  
Multiple Myeloma Cell
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