scholarly journals Impact of heat therapy on body composition and skeletal muscle function in a model of peripheral artery disease

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Kyoungrae Kim ◽  
Bruno T. Roseguini
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Peripheral Artery Disease ◽  
Muscle Function ◽  
Peripheral Artery ◽  
Skeletal Muscle Function ◽  
Heat Therapy ◽  
Artery Disease

scholarly journals Heat therapy improves body composition and muscle function, but does not affect capillary or collateral growth in a model of obesity and hindlimb ischemia

2020 ◽  
Author(s):  
Kyoungrae Kim ◽  
Bohyun Ro ◽  
Frederick W. Damen ◽  
Daniel P. Gramling ◽  
Trevor D. Lehr ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Body Mass ◽  
Muscle Function ◽  
Exercise Intolerance ◽  
Contractile Dysfunction ◽  
Skeletal Muscle Function ◽  
Positive Effects ◽  
Collateral Growth ◽  
Heat Therapy

Heat therapy (HT) has emerged as a potential adjunctive therapy to alleviate the symptoms of peripheral artery disease (PAD), but the mechanisms underlying the positive effects of this treatment modality remain undefined. Using a model of diet-induced obesity (DIO) and ischemia-induced muscle damage, we tested the hypothesis that HT would alter body composition, promote vascular growth and mitochondrial biogenesis, and improve skeletal muscle function. Male DIO C57Bl/6J mice underwent bilateral ligation of the femoral artery and were randomly allocated to receive HT or a control intervention for 30 min daily over 3 weeks. When compared to a group of lean, sham-operated animals, ligated DIO mice exhibited increases in body and fat masses, exercise intolerance and contractile dysfunction of the isolated soleus (SOL) and extensor digitorum longus (EDL) muscles. Repeated HT averted an increase in body mass induced by high-fat feeding due to reduced fat accrual. Fat mass was ~25% and 29% lower in the HT group relative to controls after 2 and 3 weeks of treatment, respectively. Muscle mass relative to body mass and maximal absolute force of the EDL, but not SOL, were higher in animals exposed to HT. There were no group differences in skeletal muscle capillarization, the expression of angiogenic factors, mitochondrial content and the diameter of the gracilis arteries. These findings indicate that HT reduces diet-induced fat accumulation and rescues skeletal muscle contractile dysfunction. This practical treatment may prove useful for diabetic and obese PAD patients who are unable to undergo conventional exercise regimens.

scholarly journals Heat therapy improves soleus muscle force in a model of ischemia-induced muscle damage

2019 ◽  
Vol 127 (1) ◽  
pp. 215-228 ◽  
Author(s):  
Kyoungrae Kim ◽  
Blake A. Reid ◽  
Bohyun Ro ◽  
Caitlin A. Casey ◽  
Qifan Song ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Muscle Mass ◽  
Peripheral Artery Disease ◽  
Soleus Muscle ◽  
Peripheral Artery ◽  
Muscle Morphology ◽  
Heat Therapy ◽  
Artery Disease ◽  
The Impact

Leg muscle ischemia in patients with peripheral artery disease (PAD) leads to alterations in skeletal muscle morphology and reduced leg strength. We tested the hypothesis that exposure to heat therapy (HT) would improve skeletal muscle function in a mouse model of ischemia-induced muscle damage. Male 42-wk-old C57Bl/6 mice underwent ligation of the femoral artery and were randomly assigned to receive HT (immersion in a water bath at 37°C, 39°C, or 41°C for 30 min) or a control intervention for 3 wk. At the end of the treatment, the animals were anesthetized and the soleus and extensor digitorum longus (EDL) muscles were harvested for the assessment of contractile function and examination of muscle morphology. A subset of animals was used to examine the impact of a single HT session on the expression of genes involved in myogenesis and the regulation of muscle mass. Relative soleus muscle mass was significantly higher in animals exposed to HT at 39°C compared with the control group (control: 0.36 ± 0.01 mg/g versus 39°C: 0.40 ± 0.01 mg/g, P = 0.024). Maximal absolute force of the soleus was also significantly higher in animals treated with HT at 37°C and 39°C (control: 274.7 ± 6.6 mN; 37°C: 300.1 ± 7.7 mN; 39°C: 299.5 ± 10 mN, P < 0.05). In the soleus, but not the EDL muscle, a single session of HT enhanced the mRNA expression of myogenic factors as well as of both positive and negative regulators of muscle mass. These findings suggest that the beneficial effects of HT are muscle specific and dependent on the treatment temperature in a model of PAD. NEW & NOTEWORTHY This is the first study to comprehensively examine the impact of temperature and muscle fiber type composition on the adaptations to repeated heat stress in a model of ischemia-induced muscle damage. Exposure to heat therapy (HT) at 37°C and 39°C, but not at 41°C, improved force development of the isolated soleus muscle. These results suggest that HT may be a practical therapeutic tool to restore muscle mass and strength in patients with peripheral artery disease.

scholarly journals Leg heat therapy improves perceived physical function but does not enhance walking capacity or vascular function in patients with peripheral artery disease

2020 ◽  
Vol 129 (6) ◽  
pp. 1279-1289
Author(s):  
Jacob C. Monroe ◽  
Chen Lin ◽  
Susan M. Perkins ◽  
Yan Han ◽  
Brett J. Wong ◽  
...  
Keyword(s):  
Physical Function ◽  
Peripheral Artery Disease ◽  
Vascular Function ◽  
Controlled Study ◽  
Peripheral Artery ◽  
Walking Capacity ◽  
Heat Therapy ◽  
Walking Performance ◽  
Artery Disease ◽  
Potent Vasoconstrictor

This is the first sham-controlled study to investigate the effects of leg heat therapy (HT) on walking performance, vascular function, and quality of life in patients with peripheral artery disease (PAD). Adherence to HT was high, and the treatment was well tolerated. Our findings revealed that HT applied with water-circulating trousers evokes a clinically meaningful increase in perceived physical function and reduces the serum concentration of the potent vasoconstrictor endothelin-1 in patients with PAD.

scholarly journals Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease

2020 ◽  
Vol 25 (5) ◽  
pp. 411-418
Author(s):  
Brian D Duscha ◽  
William E Kraus ◽  
William S Jones ◽  
Jennifer L Robbins ◽  
Lucy W Piner ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Peripheral Artery Disease ◽  
Anaerobic Threshold ◽  
Cardiopulmonary Exercise Testing ◽  
Capillary Density ◽  
Exercise Intolerance ◽  
Peripheral Artery ◽  
Cross Sectional ◽  
Control Subjects ◽  
Artery Disease

Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Exercise intolerance may result from reduced skeletal muscle capillary density and impaired muscle oxygen delivery. This cross-sectional study tested the hypothesis that capillary density is related to claudication times and anaerobic threshold (AT) in patients with PAD. A total of 37 patients with PAD and 29 control subjects performed cardiopulmonary exercise testing on a treadmill for AT and gastrocnemius muscle biopsies. Skeletal muscle capillary density was measured using immunofluorescence staining. PAD had decreased capillary density (278 ± 87 vs 331 ± 86 endothelial cells/mm2, p = 0.05), peak VO2 (15.7 ± 3.9 vs 24.3 ± 5.2 mL/kg/min, p ⩽ 0.001), and VO2 at AT (11.5 ± 2.6 vs 16.1 ± 2.8 mL/kg/min, p ⩽ 0.001) compared to control subjects. In patients with PAD, but not control subjects, capillary density was related to VO2 at AT ( r = 0.343; p = 0.038), time to AT ( r = 0.381; p = 0.020), and time after AT to test termination ( r = 0.610; p ⩽ 0.001). Capillary density was also related to time to claudication ( r = 0.332; p = 0.038) and time after claudication to test termination ( r = 0.584; p ⩽ 0.001). In conclusion, relationships between capillary density, AT, and claudication symptoms indicate that, in PAD, exercise limitations are likely partially dependent on limited skeletal muscle capillary density and oxidative metabolism.

Mitochondrial DNA damage in calf skeletal muscle and walking performance in people with peripheral artery disease

2020 ◽  
Vol 160 ◽  
pp. 680-689 ◽  
Author(s):  
Sunil K. Saini ◽  
Mary M. McDermott ◽  
Anna Picca ◽  
Lingyu Li ◽  
Stephanie E. Wohlgemuth ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Mitochondrial Dna Damage ◽  
Walking Performance ◽  
Artery Disease

Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e13002-e13002
Author(s):  
L. Jones ◽  
A. Friedman ◽  
M. West ◽  
S. Mabe ◽  
J. Fraser ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Muscle Strength ◽  
Malignant Glioma ◽  
Exercise Capacity ◽  
Muscle Function ◽  
Isokinetic Strength ◽  
Safe Procedure ◽  
Skeletal Muscle Function ◽  
Cross Sectional

e13002 Background: The neuropsychological impact of malignant glioma is well documented; the physiological and functional effects are not known. We conducted a pilot study to quantitatively assess cardiorespiratiory fitness, skeletal muscle function, and body composition of patients with primary malignant glioma. Methods: Using a cross-sectional design, patients with clinically stable postsurgical (10 ± 7 days post surgery) high-grade glioma (HGG; n=25) and low-grade glioma (LGG) were studied. Participants performed a cardiopulmonary exercise test (CPET) with expired gas analysis to assess peak exercise capacity (VO2peak) and other parameters of cardiovascular function. Other physiological outcomes included skeletal muscle cross-sectional area (CSA; magnetic resonance imaging), isokinetic muscle strength (isokinetic dynamometer), and body composition (air displacement plethysmography). QOL was assessed by the Functional Assessment of Cancer Therapy-Brain scale (FACT-BR). Results: CPET was a feasible and safe procedure for malignant glioma patients with no serious adverse events. Peak VO2 indexed to total body weight and lean body mass for both groups was 13.0 mL.min-1 and 19 mL.min-1; the equivalent to 59% and 38% below age and sex-predicted normative values, respectively. Skeletal muscle isokinetic strength was significantly lower in HGG relative to LGG patients (83 vs. 125 Nm, p=.025) and predicted peak VO2 (r = 0.44, p<0.05). In patients with HGG, only self-reported exercise behavior was correlated with QOL (r = 0.42; p=.046) while sex (male) (r = 0.44; p=.037), lean mass (r = -0.41; p=.049), and VO2peak (r = -0.40; p=.052) were associated with fatigue. Conclusions: CPET is a safe and feasible tool to evaluate physical functioning in select patients with malignant glioma. Postsurgical glioma patients have markedly reduced exercise capacity, isokinetic strength and CSA. Muscle strength is an important contributor to poor VO2peak in this population. Prospective studies are now required to determine whether such abnormalities influence prognosis as well as test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction. No significant financial relationships to disclose.

Abstract 282: Biomarkers of Muscle Damage in Patients with Peripheral Artery Disease

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Kim Cluff ◽  
Hootan Mehraein ◽  
Kaitlyn Howard ◽  
Panagiotis Koutakis ◽  
George P Casale ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Ftir Spectroscopy ◽  
Muscle Damage ◽  
Clinical Diagnosis ◽  
Peripheral Artery Disease ◽  
The United States ◽  
Least Squares Regression ◽  
Peripheral Artery ◽  
Spectral Peaks ◽  
Artery Disease

Introduction: Peripheral artery disease (PAD), a manifestation of systemic atherosclerosis (fat, plaque deposition and hardening of arterial walls), characterized by blockages of the arteries supplying the legs affects approximately 8 million lives in the United States. The classic symptom of PAD is intermittent claudication (IC), de[[Unable to Display Character: &#64257;]]ned as walking-induced calf pain and gait dysfunction relieved by rest. At the level of the skeletal muscle ischemic injury is manifested as a gradual and characteristic degradation of muscle histology. This injury includes altered metabolic processes, damaged organelles, and compromised bioenergetics in the affected muscle. In this study, we evaluated the hypothesis that Fourier Transform Infrared (FTIR) spectroscopy of human biopsy samples (gastrocnemius muscle) can be used to identify biochemical alterations in PAD muscle and characterize severity of muscle damage. Method: FTIR spectral profiles were collected from muscle biopsies of the gastrocnemius from 13 patients consisting of 4 controls, 5 claudicating patients, and 4 critical limb ischemia (CLI) patients. Statistical analysis of the data included an analysis of variance, and partial least squares regression (PLRS) to identify significant differences in spectral peaks and correlate them with clinical diagnosis. Results: When comparing spectral peaks between controls, claudicants, and CLI patients, significant differences (p<.05) were found in the fingerprint region at spectral peaks between wavenumbers 1200-1250 cm-1. These spectral peaks have been attributed to alterations in protein content, lipids, and DNA or phospholipid groups. FTIR spectral biomarkers, of the muscle, also correlated (r=0.91) with clinical diagnosis of PAD. Conclusion: FTIR spectroscopy was able to characterize the secondary effects of PAD on the gastrocnemius by identifying unique biochemical signatures of diseased PAD skeletal muscle. These signatures can discriminate control from PAD muscle and correlate with the clinical presentation of the PAD patient. FTIR spectroscopy provides novel spectral biomarkers that may complement existing diagnosis and treatment monitoring methods for PAD.

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