scholarly journals Mechanoregulation of extracellular matrix dynamics by endothelial cell surface heparan sulfate

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Brian P. Helmke ◽  
Jessie J. Qian ◽  
Rosalind E. Mott
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cell ◽  
Cell Surface ◽  
Heparan Sulfate ◽  
Endothelial Cell Surface ◽  
Matrix Dynamics

scholarly journals High-resolution probing heparan sulfate–antithrombin interaction on a single endothelial cell surface: single-molecule AFM studies

2015 ◽  
Vol 17 (20) ◽  
pp. 13301-13306 ◽  
Author(s):  
Cunlan Guo ◽  
Xian Fan ◽  
Hong Qiu ◽  
Wenyuan Xiao ◽  
Lianchun Wang ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
High Resolution ◽  
Cell Surface ◽  
Heparan Sulfate ◽  
Single Molecule ◽  
Binding Sites ◽  
Specific Interactions ◽  
Endothelial Cell Surface ◽  
Afm Probe

Using an antithrombin functionalized AFM probe, the specific interactions between antithrombin and heparan sulfate on endothelial cell surface were determined, revealing previously unexpected diverse binding sites as well as critical roles of N-, 2-O- and 6-O-sulfation in the interactions.

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