scholarly journals Impact of the Mediterranean diet and weight loss on plasma cell adhesion molecule concentrations in men with the metabolic syndrome

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Caroline Richard ◽  
Charles Couillard ◽  
Marie‐Michelle Royer ◽  
Sophie Desroches ◽  
Patrick Couture ◽  
...  
2011 ◽  
Vol 107 (5) ◽  
pp. 705-711 ◽  
Author(s):  
Caroline Richard ◽  
Patrick Couture ◽  
Sophie Desroches ◽  
Suzanne Benjannet ◽  
Nabil G. Seidah ◽  
...  

The mechanisms implicated in the LDL-cholesterol (LDL-C)-lowering effects of the Mediterranean-type diet (MedDiet) are unknown. The present study assessed the impact of the MedDiet consumed under controlled feeding conditions, with and without weight loss, on surrogate markers of cholesterol absorption, synthesis and clearance using plasma phytosterols, lathosterol and proprotein convertase subtilisin/kexin-9 (PCSK9) concentrations, respectively, in men with the metabolic syndrome. The subjects' diet (n19, 24–62 years) was first standardised to a baseline North American control diet (5 weeks) followed by a MedDiet (5 weeks), both under weight-maintaining isoenergetic feeding conditions. The participants then underwent a 20-week free-living energy restriction period (10 (sd3) % reduction in body weight,P < 0·01), followed by the consumption of the MedDiet (5 weeks) under controlled isoenergetic feeding conditions. The LDL-C-lowering effect of the MedDiet in the absence of weight loss ( − 9·9 %) was accompanied by significant reductions in plasma PCSK9 concentrations ( − 11·7 %,P < 0·01) and in the phytosterol:cholesterol ratio ( − 9·7 %,P < 0·01) compared with the control diet. The addition of weight loss to the MedDiet had no further impact on plasma LDL-C concentrations and on these surrogate markers of LDL clearance and cholesterol absorption. The present results suggest that the MedDiet reduces plasma LDL-C concentrations primarily by increasing LDL clearance and reducing cholesterol absorption, with no synergistic effect of body weight loss in this process.


2021 ◽  
Vol 14 (3) ◽  
Author(s):  
Danilo Everton Cunha Cavalcante ◽  
Alexandre Carli Pinto ◽  
Etianne Andrade Araújo ◽  
Francione Moreira Cabral ◽  
Jhonatas Mota Santos ◽  
...  

Metabolic syndrome is the association of chronic diseases related to diet and physical activity. Also recognized as a complex entity that associates well-established cardiovascular risk factors, such as high blood pressure, hypercholesterolemia, and diabetes, among others, such as central fat deposition and insulin resistance. Currently, Metabolic Syndrome has gained worrisome dimensions within clinical practice, becoming one of the greatest challenges at the beginning of this century. In contrast, the Mediterranean diet recognized for its combination of tasty taste and nutritional benefits, in addition to its culture of the link between health and longevity, is a strategy in the treatment of the metabolic syndrome. Although there is no consensus on the most adequate nutritional strategy to treat Metabolic Syndrome (MS), in such a way that there is a reduction in cardiovascular risk, recent studies show the effectiveness of adopting healthy lifestyles capable of reversing this trend. To address the role of diet in MS treatment, with the main focus on the interaction of benefits of different nutritional interventions in MS remission, contributing to the integration of current evidence in the pre-existing context. In view of the studies carried out in this research, it was found that the Mediterranean diet has shown benefits in the secondary prevention of this syndrome, although the underlying mechanisms are not completely clear. In this sense, it is important to revitalize and apply this diet in the future in terms of preventive and therapeutic guidelines.


Nutrients ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 305 ◽  
Author(s):  
Élise Carbonneau ◽  
Marie-Michelle Royer ◽  
Caroline Richard ◽  
Patrick Couture ◽  
Sophie Desroches ◽  
...  

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