scholarly journals Human adipose‐derived stem cells attenuate cigarette smoke induced bone marrow hypoplasia via secretion of anti‐inflammatory cytokine TSG‐6

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Jie Xie ◽  
Kelly Schweitzer ◽  
Brian Johnstone ◽  
Todd Cook ◽  
Dongni Feng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Cigarette Smoke ◽  
Inflammatory Cytokine ◽  
Adipose Derived Stem Cells ◽  
Bone Marrow Hypoplasia ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

Spleen-Derived Anti-Inflammatory Cytokine IL-10 Stimulated by Adipose Tissue-Derived Stem Cells Protects Against Type 2 Diabetes

2017 ◽  
Vol 26 (24) ◽  
pp. 1749-1758 ◽  
Author(s):  
Jinying Zhang ◽  
Zihui Deng ◽  
Liyuan Jin ◽  
Chen Yang ◽  
Jiejie Liu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Stem Cells ◽  
Adipose Tissue ◽  
Inflammatory Cytokine ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

scholarly journals Genetically Modified Bone Marrow-Derived Vehicle Cells Site Specifically Deliver an Anti-Inflammatory Cytokine to Inflamed Interstitium of Obstructive Nephropathy

2001 ◽  
Vol 166 (1) ◽  
pp. 609-616 ◽  
Author(s):  
Hiroko Yamagishi ◽  
Takashi Yokoo ◽  
Toshiyuki Imasawa ◽  
Tetsuya Mitarai ◽  
Tetsuya Kawamura ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Inflammatory Cytokine ◽  
Genetically Modified ◽  
Obstructive Nephropathy ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

scholarly journals Dental Follicle Stem Cells Ameliorate Lipopolysaccharide-Induced Inflammation by Secreting TGF-β3 and TSP-1 to Elicit Macrophage M2 Polarization

2018 ◽  
Vol 51 (5) ◽  
pp. 2290-2308 ◽  
Author(s):  
Xiaochuan Chen ◽  
Bo Yang ◽  
Jun Tian ◽  
Hong Hong ◽  
Yu Du ◽  
...  
Keyword(s):  
Stem Cells ◽  
Inflammatory Cytokines ◽  
Inflammatory Cytokine ◽  
Paracrine Factors ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Follicle Stem Cells ◽  
Anti Inflammatory Cytokine ◽  
Pro Inflammatory Cytokines

Background/Aims: Increasing evidence has demonstrated the novel roles of mesenchymal stem cells (MSCs) in immunotherapy. However, difficulty in acquiring these cells and possible ethical issues limited their application. Recently, we have isolated a unique MSC population from dental follicles with potent stem cell-like properties. This study focused on the effects of dental follicle stem cells (DFSCs) on macrophage activation and polarization to determine their role in immunomodulation and to test if DFSCs are a promising cell source for MSC-based immunotherapy. Methods: Rat acute lung injury (ALI) models induced by Lipopolysaccharide (LPS) were applied to test the immune-modulatory effects of DFSC/DFSC-CM in vivo. The pulmonary permeability was determined by the dry / wet weight ratios of the left upper lung lobe. The lung histopathological damage was graded on a 0 to 4+ scale. And the inflammatory cytokines in bronchoalveolar lavage fluid (BALF) were tested by ELISA. Then we established LPS-induced inflamed macrophage models in vitro. Inflammatory cytokine production and polarization marker expression were measured by RT-qPCR, ELISA, western blot and flow cytometric analysis in macrophages following DFSC-CM treatment. The paracrine factors in DFSC-CM were revealed by a RayBiotech Protein Array. Thereafter, neutralization studies were performed to confirm the potential immune regulators in DFSC-CM. Results: The DFSC/DFSC-CM not only attenuated histopathological damage and pulmonary permeability, but also downregulated pro-inflammatory cytokines MCP-1, IL-1, IL-6 and TNF-α, and upregulated anti-inflammatory cytokine IL-10 in BALF. Immunofluorescence staining revealed the increased expression of macrophage M2 marker Arg-1. Further in vitro study revealed that macrophages switched to an anti-inflammatory M2 phenotype when co-cultured with DFSC-CM, characterized by suppressed production of pro-inflammatory cytokines MCP-1, IL-1, IL-6, TNF-α and M1-polarizing markers iNOS and CD86; and increased expression of the anti-inflammatory cytokine IL-10 and the M2-polarizing markers Arg-1 and CD163. A RayBiotech Protein Array revealed 42 differentially expressed (> 2-fold) paracrine factors in DFSC-CM compared with the serum-free Ham’s F-12K medium, among which TGF-β3 and Thrombospondin-1 (TSP-1) were upregulated by 18- and 105-fold, respectively. Neutralization studies confirmed the immunoregulatory roles of TGF-β3 and TSP-1 in macrophage activation and polarization. Conclusion: These results indicated that DFSCs can reprogram macrophages into the anti-inflammatory M2 phenotype, the paracrine factors TGF-β3 and TSP-1 may be one of the underlying mechanisms. This study supports the hypothesis that DFSCs are promising for MSC-based immunotherapy.

Anti-inflammatory cytokine profile and mortality in febrile patients

The Lancet ◽  
1998 ◽  
Vol 351 (9107) ◽  
pp. 950-953 ◽  
Author(s):  
J VANDISSEL ◽  
P VANLANGEVELDE ◽  
R WESTENDORP ◽  
K KWAPPENBERG ◽  
M FROLICH
Keyword(s):  
Inflammatory Cytokine ◽  
Cytokine Profile ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

Why does anti-inflammatory cytokine levels increase during memory acquisition?

Neuroscience ◽  
2021 ◽  
Author(s):  
Sergei G. Levin ◽  
Ekaterina V. Pershina ◽  
Nickolay A. Bugaev-Makarovskiy ◽  
Irina Yu. Chernomorets ◽  
Maxim V. Konakov ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Cytokine Levels ◽  
Memory Acquisition ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine
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