scholarly journals The root extract of Angelica gigas Nakai promotes adipogenic differentiation via activation of the insulin signaling pathway in 3T3‐L1 cells (854.6)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Joseph Cruz ◽  
Song‐Ee Jeong ◽  
Hee Ok Hong ◽  
Seong Gu Hwang
Keyword(s):  
Signaling Pathway ◽  
Insulin Signaling ◽  
Adipogenic Differentiation ◽  
Insulin Signaling Pathway ◽  
Root Extract ◽  
Angelica Gigas ◽  
Angelica Gigas Nakai

scholarly journals Metallothioneins regulate the adipogenic differentiation of 3T3-L1 cells via the insulin signaling pathway

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0176070 ◽  
Author(s):  
Yoshito Kadota ◽  
Yuriko Toriuchi ◽  
Yuka Aki ◽  
Yuto Mizuno ◽  
Takashige Kawakami ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Insulin Signaling ◽  
Adipogenic Differentiation ◽  
Insulin Signaling Pathway

scholarly journals Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2268
Author(s):  
Dina Medina-Vera ◽  
Juan Antonio Navarro ◽  
Rubén Tovar ◽  
Cristina Rosell-Valle ◽  
Alfonso Gutiérrez-Adan ◽  
...  
Keyword(s):  
Oral Administration ◽  
Signaling Pathway ◽  
Insulin Signaling ◽  
Insulin Response ◽  
Pharmacological Action ◽  
Akt Signaling ◽  
Insulin Signaling Pathway ◽  
Acute Administration ◽  
Insulin Sensitizer ◽  
Peripheral Tissues

D-Pinitol (DPIN) is a natural occurring inositol capable of activating the insulin pathway in peripheral tissues, whereas this has not been thoroughly studied in the central nervous system. The present study assessed the potential regulatory effects of DPIN on the hypothalamic insulin signaling pathway. To this end we investigated the Phosphatidylinositol-3-kinase (PI3K)/Protein Kinase B (Akt) signaling cascade in a rat model following oral administration of DPIN. The PI3K/Akt-associated proteins were quantified by Western blot in terms of phosphorylation and total expression. Results indicate that the acute administration of DPIN induced time-dependent phosphorylation of PI3K/Akt and its related substrates within the hypothalamus, indicating an activation of the insulin signaling pathway. This profile is consistent with DPIN as an insulin sensitizer since we also found a decrease in the circulating concentration of this hormone. Overall, the present study shows the pharmacological action of DPIN in the hypothalamus through the PI3K/Akt pathway when giving in fasted animals. These findings suggest that DPIN might be a candidate to treat brain insulin-resistance associated disorders by activating insulin response beyond the insulin receptor.

scholarly journals Effects of resveratrol on the insulin signaling pathway of obese mice

2014 ◽  
Vol 15 (2) ◽  
pp. 179 ◽  
Author(s):  
Hyun Ju Hong ◽  
Wonyoung Kang ◽  
Dong Geon Kim ◽  
Dae Ho Lee ◽  
Youngjae Lee ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Insulin Signaling ◽  
Insulin Signaling Pathway ◽  
Obese Mice
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