scholarly journals Protective Association of Serum Uric Acid on Hip Fracture Risk among Older Men But Not Women

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Shivani Sahni ◽  
Kelsey Mangano ◽  
Katherine Tucker ◽  
Caroline Fox ◽  
Douglas Kiel ◽  
...  
Keyword(s):  
Uric Acid ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Serum Uric Acid ◽  
Older Men ◽  
Hip Fracture Risk ◽  
Protective Association

scholarly journals Association of 3D Geometric Measures Derived From Quantitative Computed Tomography With Hip Fracture Risk in Older Men

2016 ◽  
Vol 31 (8) ◽  
pp. 1550-1558 ◽  
Author(s):  
Jan Borggrefe ◽  
Timm de Buhr ◽  
Smriti Shrestha ◽  
Lynn M Marshall ◽  
Eric Orwoll ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Quantitative Computed Tomography ◽  
Older Men ◽  
Hip Fracture Risk

Finite Element Analysis of Proximal Femur QCT Scans for the Assessment of Hip Fracture Risk In Older Men

2008 ◽  
Vol 11 (3) ◽  
pp. 467-468 ◽  
Author(s):  
Tony M. Keaveny ◽  
Lynn M. Marshall ◽  
Carrie M. Nielson ◽  
Steven R. Cummings ◽  
Paul F. Hoffmann ◽  
...  
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Proximal Femur ◽  
Older Men ◽  
Element Analysis ◽  
Hip Fracture Risk

scholarly journals Distribution of bone density in the proximal femur and its association with hip fracture risk in older men: The osteoporotic fractures in men (MrOS) study

2012 ◽  
Vol 27 (11) ◽  
pp. 2314-2324 ◽  
Author(s):  
Lang Yang ◽  
Annabel C Burton ◽  
Mike Bradburn ◽  
Carrie M Nielson ◽  
Eric S Orwoll ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Bone Density ◽  
Fracture Risk ◽  
Proximal Femur ◽  
Osteoporotic Fractures ◽  
Older Men ◽  
Hip Fracture Risk

scholarly journals Finite Element Analysis of the Proximal Femur and Hip Fracture Risk in Older Men

2009 ◽  
Vol 24 (3) ◽  
pp. 475-483 ◽  
Author(s):  
Eric S Orwoll ◽  
Lynn M Marshall ◽  
Carrie M Nielson ◽  
Steven R Cummings ◽  
Jodi Lapidus ◽  
...  
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Proximal Femur ◽  
Older Men ◽  
Element Analysis ◽  
Hip Fracture Risk

Suboptimal osteoporosis evaluation and treatment in older men with and without additional high-risk factors for fractures

2019 ◽  
Vol 67 (4) ◽  
pp. 743-749 ◽  
Author(s):  
Radhika Rao Narla ◽  
Lianne A Hirano ◽  
Serena H Y Lo ◽  
Bradley D Anawalt ◽  
Elizabeth A Phelan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hip Fracture ◽  
High Risk ◽  
Fracture Risk ◽  
Older Women ◽  
Significant Risk ◽  
Older Men ◽  
Risk Category ◽  
Mineral Density ◽  
Hip Fracture Risk

We compared osteoporosis case-finding, evaluation and treatment in groups of Older Men and Older Women with age alone as a significant risk for fracture and Older Men with Higher Risk (older men additionally having previous hip fracture, corticosteroid use or androgen deprivation therapy). We studied 13,704 older men and women (≥70 years old) receiving care at a Veterans Affairs medical center from January 2000 to August 2010 whose 10-year hip fracture risk was assessed by limited FRAX score. The main outcome measures were the proportion of patients who had bone mineral density (by dual-energy X-ray absorptiometry [DXA]) and serum 25-hydroxy vitamin D (25-OH D) measurements performed, and calcium/vitamin D or bisphosphonates prescribed. The proportion of men with a 10-year hip fracture risk ≥3% with age alone as a risk was 48% and 88% in men aged 75–79 and ≥80 years, respectively. Compared with Older Women, fewer Older Men underwent DXA (12% vs 63%, respectively) and 25-OH D measurements (18% vs 39%), and fewer received calcium/vitamin D (20% vs 63%) and bisphosphonate (5% vs 44%) prescriptions. In Older Men with Higher Risk category, the proportion of men with 10-year hip fracture risk ≥3% ranged from 69% to 95%. Despite a higher risk and expectation that this group would have greater case detection and screening, few Older Men with Higher risk underwent DXA screening (27%–36%) and 25-OH D measurements (23%–28%), and received fewer calcium/vitamin D (40%–50%) and bisphosphonate (13%–24%) prescriptions. Considering the known morbidity and mortality, our findings underscore the need for improved evaluation and management of osteoporosis in older men at high risk for fracture.

scholarly journals Biomechanical Computed Tomography Captures Older Men at High Risk of Hip Fracture Despite Low Fracture Risk Calculation by FRAX

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A242-A243
Author(s):  
Polly Fu ◽  
Janet Chiang ◽  
Tony M Keaveny ◽  
Daniel D Bikle
Keyword(s):  
Hip Fracture ◽  
Fracture Risk ◽  
Bone Strength ◽  
Older Men ◽  
Ct Scans ◽  
Hip Fracture Risk ◽  
T Score ◽  
Increased Risk ◽  
Fragile Bone ◽  
Fracture Risks

Abstract Background: Biomechanical computed tomography (BCT) can be applied to hip-containing CT scans to estimate femoral bone strength using finite-element analysis and to measure DXA-equivalent femoral neck (FN) BMD. Current guidelines recommend osteoporosis pharmacotherapy initiation in men with BMD T-score ≤ -2.5 or T-score between -1.0 and -2.5 with 10-year hip fracture risk ≥ 3% by FRAX.1 Estimated femoral strength by BCT is associated with incident hip fractures in men, independent of BMD,2 and can be used in conjunction with clinical risk factors for consideration of therapy initiation per the International Society of Clinical Dosimetry.3 Aim: To determine how many men are at increased risk of fractures with fragile bone strength (≤ 3500N) despite normal-to-low BMD (T-score > -2.5) and low 10-year hip fracture risk (< 3%). Methods: 625 men age ≥ 65 with hip-containing CT scans were randomly selected for BCT analysis out of 4209 scans performed from 2017 to 2019 at a single academic hospital. Scans were excluded if an intact femur was not imaged. BCT was performed for 557 men after accounting for un-processable scans. Electronic health records were retrospectively reviewed by investigators blinded to BCT results. 10-year hip fracture risks were calculated by FRAX based on available clinical data and FN BMD T-score from BCT. Chi-squared and t-test were used to investigate differences in clinical parameters between men with and without fragile bone strength. Results: The mean age was 77 (± 7.6 years), and 69% of men were white. Out of 102 men (18.3%) who met criteria for fragile bone strength by BCT, 42 (7.5%) had low FN BMD (T-score between -1.0 and -2.5) and 2 (0.4%) had normal FN BMD (T-score ≥ -1.0). The percentage of men with fragile bone strength and discrepant BMD increased with age (5.4% in age 65–74; 8.2% in age 75–84; 13.0% in age ≥ 85). The average 10-year hip fracture risk by FRAX of men with fragile bone strength was 6.5% (± 4.0%). However, 13 out of 44 men with normal-to-low BMD had 10-year hip fracture risks < 3% despite fragile bone strength presence and did not meet recommendation for osteoporosis pharmacotherapy. Examining men with normal-to-low BMD (n=493), those with fragile bone strength tended to be older, have lower BMI, and of Hispanic ethnicity compared to those with normal-to-low bone strength (p<0.05). Conclusions: Our study showed that fragile bone strength is present in older men with normal-to-low BMD, and that inclusion of 10-year hip fracture risk by FRAX may capture some, but not all, men at increased risk of hip fractures. Skeletal fragility measured by BCT may serve as additional data to assist with clinical decision making for men with osteoporosis, though further prospective research is needed. Reference: 1. Watts et al, J Clin Endocrinol Metab. 2012 Jun;97(6):1802–22. 2. Adams et al, J Bone Miner Res 2018 Jul;33(7):1291–1301. 3. Shuhart et al, J Clin Densitom. 2019 Oct-Dec;22(4):453–471.

Testosterone, dihydrotestosterone, bone density, and hip fracture risk among older men: The Cardiovascular Health Study

Metabolism ◽  
2021 ◽  
Vol 114 ◽  
pp. 154399
Author(s):  
Emily A. Rosenberg ◽  
Petra Bůžková ◽  
Howard A. Fink ◽  
John A. Robbins ◽  
Molly M. Shores ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Bone Density ◽  
Fracture Risk ◽  
Cardiovascular Health ◽  
Older Men ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Hip Fracture Risk

Socio-economic status and hip fracture risk: a region-wide ecological study

2014 ◽  
Author(s):  
Carlen Reyes ◽  
M Kassim Javaid ◽  
Cyrus Cooper ◽  
Adolfo Diez-Perez ◽  
Daniel Prieto-Alhambra
Keyword(s):  
Hip Fracture ◽  
Fracture Risk ◽  
Ecological Study ◽  
Economic Status ◽  
Hip Fracture Risk ◽  
Socio Economic Status
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