Age and Sex Analysis on the Relationship between Serum 25‐Hydroxyvitamin D and Hypertension in General Korean Population

This retrospective study aimed to determine the levels of 25- hydroxyvitamin D [25-(OH) D] in the individuals that have been referred to two laboratories (Bio Lab and King Lab) and to around 50 private side laboratories that use both Bio Lab and King Lab as a referral lab for their tests, in Erbil city, Iraq. Then show the range of deficiency and its relation with sunlight exposure, sex and age. Out of the total number of cases (N=10823), large percentage (nearly 78%) referred to both clinical laboratory based in Erbil city were found to have a deficiency in vitamin D levels, which means they had 25-(OH) D levels lower than 20 μg/L. This study found the percentage of vitamin D level in the serum of groups insufficient, deficient, adequate, optimal; intoxication were 52.8, 24.1, 11, 12 and 0.2% respectively. When the records have been compared according to gender, the results suggested that there was no difference between male and female within the study population (P>0.05), while there was difference in the grouped ages (P<0.05). Our results indicate that although Erbil is located in a Mediterranean country, people living there should periodically check their 25-(OH) D levels, in order to get appropriate supplements of vitamin D, which eventually prevents secondary chronic disease due to vitamin D deficiency.

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Age- and sex-dependent hormonal modulation of the expression of vitamin D receptor and 25-hydroxyvitamin D 1α hydroxylase in human bone cells

Expert Review of Endocrinology & Metabolism ◽

10.1586/17446651.2014.899897 ◽

2014 ◽

Vol 9 (3) ◽

pp. 283-292

Author(s):

Dalia Somjen ◽

Sara Katzburg ◽

David Hendel ◽

Orli Sharon ◽

Gary H Posner

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Bone Cells ◽

Human Bone ◽

Hydroxyvitamin D ◽

Hormonal Modulation ◽

25 Hydroxyvitamin D ◽

Age And Sex

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Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population

Dermatology Practical & Conceptual ◽

10.5826/dpc.0904a06 ◽

2019 ◽

pp. 278-282

Author(s):

Mahboobeh-Sadat Hosseini ◽

Fereshteh Salarvand ◽

Amir Houshang Ehsani ◽

Pedram Noormohammadpour ◽

Shadi Azizzadeh ◽

...

Keyword(s):

Vitamin D ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Outdoor Environment ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

History Of ◽

25 Hydroxyvitamin D ◽

The Relationship

Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined. Objective: To investigate the relationship between vitamin D levels and the incidence of skin SCC for the first time in Iran. Methods and Study Design: In this case-control study, 126 subjects were enrolled (63 in each group) out of referents to Razi Skin Hospital in Tehran in 2014. The risk factors for cancer gathered by self-reported questionnaires and blood samples were obtained to measure the level of 25-hydroxyvitamin D. Multivariate logistic regression was used to neutralize the effect of confounding factors. Results: Cases of SCC were more likely to be in men, older than 49 years and working in an outdoor environment, and with longtime exposure to sunlight and a personal history of skin cancers. Family history of skin cancer and of cigarette smoking were not significantly related to SCC. In the SCC and control groups, 69.8% and 31.7%, respectively, had sufficient levels of vitamin D (P < 0.001). Mean level of 25-hydroxyvitamin D was 40.99 ng/mL in the SCC group and 26.34 ng/mL in the control group (P < 0.05). In the unadjusted model, the level of vitamin D as a continuous variable was positively related to SCC risk. In the adjusted model, vitamin D did not independently predict the likelihood of SCC. Conclusion: Vitamin D level and SCC risk are directly related, although not in an independent fashion. Indeed, this relation is severely confounded by exposure to sunlight, which was evidenced by an increased vitamin D level in the people working outside and the higher prevalence of SCC in the same population.

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Serum Parathyroid Hormone in Healthy Japanese Women in Relation to Serum 25-Hydroxyvitamin D

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.70.6.287 ◽

2000 ◽

Vol 70 (6) ◽

pp. 287-292 ◽

Cited By ~ 10

Author(s):

Kazutoshi Nakamura ◽

Mitsue Nashimoto ◽

Yasushi Hori ◽

Masaharu Yamamoto

Keyword(s):

Parathyroid Hormone ◽

Healthy Adult ◽

Japanese Women ◽

Normal Serum ◽

Adult Women ◽

Serum Parathyroid Hormone ◽

Intact Pth ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

The Relationship

The aim of this work was to clarify levels of serum parathyroid hormone (PTH) in healthy adult women and to study the relationship between PTH and 25-hydroxyvitamin D [25(OH)D]. One hundred sixty-nine healthy women aged 40 years or older in a community were studied. The average age of the subjects was 65.3 years (SD 8.2). All subjects had normal serum creatinine levels. Serum intact PTH and 25(OH)D were measured in these subjects. The mean intact PTH concentration was 2.19 pmol/A (SD 1.02). High intact PTH levels above the reference range were observed in four women (2.4%), all of whom were aged 70 years or older. Intact PTH increased with age with a correlation coefficient of 0.192 (p = 0.013). However, there was no correlation (r = –0.125, p = 0.105) between intact PTH and 25(OH)D whose concentrations were more than 37.5 nmol/l. In conclusion, PTH levels of healthy adult Japanese women are lower than previous reports from Western countries, which may be due to the high 25(OH)D levels of the present subjects and/or an ethnic difference. In addition, there is no association between serum 25(OH)D and PTH levels in this Japanese population, supporting a cutoff level of 25(OH)D less than 37.5 nmol/l for the elevated PTH level.

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LB026-MON THE RELATIONSHIP BETWEEN 25-HYDROXYVITAMIN D AND HbA1c IN TYPE 2 DIABETES

Clinical Nutrition Supplements ◽

10.1016/s1744-1161(12)70684-1 ◽

2012 ◽

Vol 7 (1) ◽

pp. 275

Author(s):

J.Y. Nam ◽

S.Y. Nam ◽

E. Kang

Keyword(s):

Type 2 Diabetes ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

The Relationship

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The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy

Medicine ◽

10.1097/md.0000000000018118 ◽

2019 ◽

Vol 98 (48) ◽

pp. e18118 ◽

Cited By ~ 2

Author(s):

Binjie Zhang ◽

Wenli Zhao ◽

Jinli Tu ◽

Xueying Wang ◽

Yu Hao ◽

...

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

The Relationship ◽

Type 2 Diabetic

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Role of vitamin D and sFlt-1/PlGF ratio in the development of early- and late-onset preeclampsia

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2014-1039 ◽

2015 ◽

Vol 53 (7) ◽

Cited By ~ 8

Author(s):

Indira Álvarez-Fernández ◽

Belén Prieto ◽

Verónica Rodríguez ◽

Yolanda Ruano ◽

Ana I. Escudero ◽

...

Keyword(s):

Vitamin D ◽

Late Onset ◽

Tertiary Care ◽

Care Hospital ◽

Hydroxyvitamin D ◽

Increased Risk ◽

25 Hydroxyvitamin D ◽

The Relationship ◽

Plgf Ratio

AbstractThe imbalanced production of placental biomarkers and vitamin D deficiency have been proposed as risk factors for the development of preeclampsia (PE). However, little is known about the relationship between them and their role in early- versus late-onset PE. The objectives were to assess the role of 25-hydroxyvitamin D [25(OH)D] concentrations and the soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) ratio in the development of early- and late-onset PE; and to evaluate the relationship between 25(OH)D and the biomarkers.A retrospective, full-blinded cohort study was conducted at the Obstetric Emergency Service of a tertiary care hospital. Pregnant women (n=257) attending obstetric triage with suspicion of PE were included. sFlt-1, PlGF and 25(OH)D concentrations were measured by electrochemoluminescence (ECLIA) immunoassay and pregnancy outcome (development of PE) was registered from patients records.PE women showed lower 25(OH)D concentrations at clinical presentation than non-PE women (median: 35.0 nmol/L and 39.6 nmol/L, respectively; p=0.027). Women with 25(OH)D levels <50 nmol/L experienced an increased risk of developing late-onset PE [odds ratio (OR) 4.6, 95% confidence interval (CI) 1.4–15], but no association was found for early-onset PE. However, a sFlt-1/PlGF ratio above the corresponding cutpoints increased the risk of developing both early- and late-onset PE [ORs 58 (95% CI 11–312) and 12 (95% CI 5.0–27), respectively]. No association was found between 25(OH)D levels and sFlt-1/PlGF ratio.Low vitamin D status in women with suspected late-onset PE increases the risk of imminent development of the disease.

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Age-Related Changes in the 25-Hydroxyvitamin D Versus Parathyroid Hormone Relationship Suggest a Different Reason Why Older Adults Require More Vitamin D

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2002-021064 ◽

2003 ◽

Vol 88 (1) ◽

pp. 185-191 ◽

Cited By ~ 298

Author(s):

Reinhold Vieth ◽

Yasmin Ladak ◽

Paul G. Walfish

Keyword(s):

Older Adults ◽

Vitamin D ◽

Secondary Hyperparathyroidism ◽

Age Groups ◽

The Elderly ◽

Age Group ◽

Hydroxyvitamin D ◽

Age Related ◽

25 Hydroxyvitamin D ◽

The Relationship

Vitamin D requirements are thought to vary with age, but there is little comparative evidence for this. One goal in establishing a vitamin D requirement is to avoid secondary hyperparathyroidism. We studied 1741 euthyroid, thyroid clinic outpatients without evidence of calcium abnormalities, ranging in age from 19 to 97 yr, whose serum and urine had been analyzed for calcium, vitamin D, and parathyroid status. We found no effect of age on the 25-hydroxyvitamin D [25(OH)D] concentration associated with specific vitamin D intakes, and there was no relationship between 25(OH)D and 1,25hydroxyvitamin D [1,25(OH)2D]. In every age group, serum 1,25(OH)2D declined with increasing creatinine (P < 0.001). What changed with age included creatinine, which correlated with 25(OH)D (r = 0.146, P < 0.001) only in the youngest age group (19–50 yr) but not in the older age groups (P > 0.1). Creatinine did not correlate with PTH in the youngest age group, but the relationship became significant as age increased (e.g. for the elderly, r = 0.365, P < 0.001). Linear regression of log PTH vs. log 25(OH)D agreed with the natural shape of the relationship observed with scatterplot smoothing, and this showed no plateau in PTH as 25(OH)D increased. We compared PTH concentrations among age groups, based on 20 nmol/liter increments in 25(OH)D. Mean PTH in adults older than 70 yr was consistently higher than in adults younger than 50 yr (P < 0.05 by ANOVA and Dunnett’s t test). PTH levels of the elderly who had 25(OH)D concentrations greater than 100 nmol/liter matched PTH of younger adults having 25(OH)D concentrations near 70 nmol/liter. This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function.

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