scholarly journals The Sexual Dimorphic Relationship Between Dietary Fiber Intake and Visceral Adipose Tissue

2016 ◽  
Vol 30 (S1) ◽  
Author(s):  
Alicia R Covello ◽  
Nicholas W Baumgartner ◽  
Morgan R Curran ◽  
Ginger E Reeser ◽  
Neal J Cohen ◽  
...  
2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 759-759
Author(s):  
Holly Hull ◽  
Amy Herman ◽  
Lauren Hand ◽  
Susan Carlson

Abstract Objectives Greater maternal fructose intake is linked to greater offspring fat accrual, while dietary fiber intake is related to lower weight gain and a more favorable adipose tissue distribution. However, data are lacking investigating these relationships in the especially critical time of pregnancy and early infancy. We explored the relationships between maternal fructose and fiber intake on early offspring adipose tissue accrual. Methods This is a secondary analysis using data from a prenatal DHA supplementation trial (ADORE HD083292). At enrollment (12–16 wks), women completed the DHQ II food frequency questionnaire. ADORE mothers were invited to enroll in the GAINS infant follow up study (DK118220). Infant skinfolds were assessed two weeks and six months at three central sites (suprailiac, subscapular, flank) and three peripheral sites (biceps, triceps, thigh). Median splits were calculated for maternal fructose and total dietary fiber intake (< 50th percentile, ≥50th percentile). An ANCOVA assessed the main effects of maternal fructose and fiber intake on infant fat accrual (central and peripheral). Results Data were available on n = 61 infants. For the change in infant central FM, a significant interaction (p = 0.034) was found between maternal fructose intake and dietary fiber intake. No effect of fiber was found in offspring exposed to low fructose intake. However, in offspring exposed to high fructose intake during pregnancy, exposure to high maternal dietary fiber intake was related to lower central FM accrual (high fiber intake: 4.2 mm vs. low fiber intake 6.9 mm; p = 0.016). No significant main effects or interaction was detected for the change in peripheral FM. Conclusions In offspring exposed to greater maternal fructose consumption during pregnancy, greater maternal intake of dietary fiber was related to lower early offspring central fat accretion. Interventions targeting to decrease maternal fructose consumption and increase maternal dietary fiber intake may positively impact offspring fat accretion. Funding Sources NIH Awards R01 HD083292 and R01 DK118220.


2012 ◽  
Vol 97 (9) ◽  
pp. 3326-3332 ◽  
Author(s):  
M. Denise Robertson ◽  
John W. Wright ◽  
Emmanuelle Loizon ◽  
Cyrille Debard ◽  
Hubert Vidal ◽  
...  

2001 ◽  
Vol 120 (5) ◽  
pp. A254-A254
Author(s):  
D SASS ◽  
R SCHOEN ◽  
J WEISSFELD ◽  
L KULLER ◽  
F THAETE ◽  
...  

Author(s):  
Ю.И. Шрамко ◽  
А.В. Кубышкин ◽  
А.А. Давыдова ◽  
И.И. Фомочкина ◽  
Л.Л. Алиев ◽  
...  

Цель работы состояла в изучении влияния полифенолов винограда на органы-мишени при экспериментальном метаболическом синдроме у крыс. Методы. В течение 12 недель полифенолы винограда применялись у крыс линии Вистар. Все крысы находились на стандартном рационе. Животные были разделены на 6 групп: 1-я контрольная получала питьевую воду; 2-я контрольная и все 4 экспериментальные - 2,5% раствор фруктозы в качестве питья. 1-я экспериментальная группа дополнительно получала препарат «Фэнокор» с суммарным содержанием полифенолов 181,53 г/дм, 2-я экспериментальная - виноматериал с суммарным содержанием полифенолов 1,73 г/дм; 3-я экспериментальная - виноматериал с суммарным содержанием полифенолов 4,33 г/дм и 4-я экспериментальная - виноматериал с суммарным содержанием полифенолов 8,58 г/дм. После окончания опыта у крыс проводили морфологические исследования висцеральной жировой ткани, тканей миокарда и печени. Результаты. Анализ результатов показал, что применение полифенольных продуктов переработки винограда в концентрациях 181,53 г/дм при моделировании метаболического синдрома приводило к минимизации морфофункциональных нарушений в висцеральной жировой ткани (уменьшение интенсивности лимфоплазмоцитарной инфильтрации), миокарде (мышечные волокна имели типичное строение и адипоциты между ними встречались лишь очагово) и печени (имелись лишь слабые очаговые дистрофические изменения гепатоцитов). Заключение. Результаты работы свидетельствуют о возможности применения виноматериалов с наибольшей концентрацией полифенолов и препарата «Фэнокор» в коррекции и профилактике поражений при метаболическом синдроме. The aim of this work was to study the effect of grape polyphenols on target organs in rats with experimental metabolic syndrome. Methods. Grape polyphenols were used in Wistar rats for 12 weeks. All rats received a standard diet. The animals were divided into 6 groups: group 1, control, received drinking water; group 2, the second control, and four experimental groups received a 2.5% fructose solution for drinking. The first experimental group additionally received a drug, Fenocor, containing polyphenols at 181.53 g/dm; the second experimental group - wine material containing polyphenols at 1,73 g/dm; the third experimental group - wine material containing polyphenols at 4,33 g/dm; and the fourth experimental group - wine material containing polyphenols at 8,58 g/dm. At the end of experiment, morphological studies of visceral adipose tissue, myocardial tissue, and hepatic tissue were performed. Results. The treatment of rats with experimental metabolic syndrome with grape polyphenolic products at a concentration of 181.53 g/dm minimized morphological and functional disorders in visceral adipose tissue (intensity of lymphoplasmocytic infiltration was decreased), myocardium (muscle fibers had normal structure with only occasional adipocytes between them), and liver (only slight focal degenerative changes were observed in hepatocytes). Conclusion. The study indicated a possibility of using wine materials with the highest concentration of polyphenols and the drug Fenocor for correction and prevention of damages in metabolic syndrome.


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