Epithelioid Hemangioendothelioma of Skin and Soft Tissues: Clinicopathologic and Immunohistochemical Study of 30 Cases

1997 ◽  
Vol 21 (4) ◽  
pp. 363-374 ◽  
Author(s):  
Thomas Mentzel ◽  
Alfred Beham ◽  
Eduardo Calonje ◽  
Detlef Katenkamp ◽  
Christopher D.M. Fletcher
Keyword(s):  
Soft Tissues ◽  
Immunohistochemical Study ◽  
Epithelioid Hemangioendothelioma

scholarly journals Living-related liver transplant to treat epithelioid hemangioendothelioma – a case report

2005 ◽  
Vol 8 (4) ◽  
pp. 449-451
Author(s):  
Marcelo A. F. Ribeiro Jr ◽  
Christian Evangelista Garcia ◽  
Telma Eugênio dos Santos ◽  
Adavio de Oliveira e Silva ◽  
Regina Leitão ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Case Report ◽  
Liver Transplant ◽  
Soft Tissues ◽  
Liver Tumors ◽  
Epithelioid Hemangioendothelioma ◽  
Low Grade ◽  
Living Related Liver Transplant ◽  
Transplantation Technique ◽  
Living Related

Introduction: Epithelioid hemangioendothelioma of liver is a rare, low-grade neoplasm of vascular origin that has an unpredictable malignant potential. It preferentially arises in soft tissues and bones, and seldom in the liver. Biologically, it trends to be multi-focal and often unresectable. Objective: The outcome of a patient submitted to a living-related liver transplant to treat epithelioid hemangioendothelioma of the liver. Case report: The reported case involves a 39-year old female patient with an immense epithelioid hemangioendothelioma of the liver, involving segments III, IV, V, VII, and VIIl. The prognostic to any kind of treatment was considered unfavorable, and the decision of submitting her to a liver transplant was made. It was suggested a living-related liver transplant. The donor was the patient’s 36-year old brother, who donated his right liver lobe (segments V, VI, VII, VIII). The recipient´s original liver was large, presenting very solid consistence and no node evidence. The transplant itself was performed using the conventional living-related liver transplantation technique. The recovery was good, and she was discharged from hospital on the 15th postoperative day using micophenolate mofetil, tacrolimus, and corticoid. Conclusion: Liver transplantation for epithelioid hemangioendothelioma of the liver can be performed with acceptable survival rate. The living related liver transplant opens a great perspective to that group of patients presenting liver tumors and who are unfeasible to wait for an organ on a waiting list.

Pediatric Angiosarcoma of Soft Tissue: A Rare Clinicopathologic Entity

2010 ◽  
Vol 134 (3) ◽  
pp. 481-485 ◽  
Author(s):  
Lobna Ayadi ◽  
Abdelmajid Khabir
Keyword(s):  
Spindle Cell ◽  
Immunohistochemical Study ◽  
Kaposi Sarcoma ◽  
Neck Region ◽  
Epithelioid Hemangioendothelioma ◽  
Vascular Tumors ◽  
Clinical Settings ◽  
Vascular Differentiation ◽  
Head And Neck Region ◽  
Poorly Differentiated

Abstract Angiosarcomas are rare tumors that predominantly affect adults and elderly patients. Although angiosarcomas are well described in a variety of clinical settings, they have been poorly studied in children and little is known about their biology, natural history, or optimal treatment. Childhood angiosarcomas are exceedingly rare. The head and neck region and mediastinum seem to be the preferred locations. Most tumors are high-grade tumors. Vasoformative architecture is not always obvious on light microscopy requiring the benefit of immunohistochemical study. The differential diagnosis includes Kaposi sarcoma, epithelioid hemangioendothelioma, hemangiopericytoma, and spindle cell hemangioendothelioma whose prognosis is different. Complete resection is required for patients with localized tumors. Malignant vascular tumors are rare in children in the first 2 decades of life and when they do occur they seem to be more aggressive than in adults. Pathologic diagnosis is difficult particularly in poorly differentiated angiosarcomas requiring immunohistochemical study to confirm vascular differentiation.

scholarly journals A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid Hemangioendothelioma

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
J. K. Ma ◽  
J. Barr ◽  
S. Vijayakumar
Keyword(s):  
Multidisciplinary Approach ◽  
Pathological Fracture ◽  
Soft Tissues ◽  
Intensity Modulated Radiation Therapy ◽  
Vascular Tumor ◽  
Epithelioid Hemangioendothelioma ◽  
Histopathological Study ◽  
Incisional Biopsy ◽  
Multidisciplinary Intervention ◽  
Imaging Characteristics

Hemangioendothelioma is a rare vascular tumor of intermediate malignant potential. Though epithelioid hemangioendothelioma (EH) is commonly found in soft tissues, it has been known to be present in skeletal tissues. The authors present a case of a 50-year-old woman diagnosed with EH of the iliac bone and acetabulum, who experienced pathological fracture at presentation. This report describes a multidisciplinary approach to the management that includes initial incisional biopsy, curettage, and bone grafting, followed by Intensity Modulated Radiation Therapy. The patient finally underwent hemipelvic resection with allograft reconstruction after recurrence. Histopathological study revealed osseous EH of low mitotic activity that stained positively for CD31, CD34, vimentin, and Factor VIII. Herein, the authors discuss the imaging characteristics, histopathological aspects, cytogenetic findings, and the radiobiological behavior of osseous EH. After an aggressive multidisciplinary intervention, the patient is able to achieve local control with no evidence of distal metastatic disease.

scholarly journals Metastatic cutaneous epithelioid hemangioendothelioma involving right atrium - a case report

2016 ◽  
Vol 3 (3) ◽  
pp. 47
Author(s):  
Sandy Mpho Mosenye ◽  
Rahul Daimari ◽  
Neha Sharma ◽  
Princess Lelani Chikanda ◽  
Feng Zhou ◽  
...  
Keyword(s):  
Right Atrium ◽  
Cardiac Involvement ◽  
Soft Tissues ◽  
Vascular Tumor ◽  
Epithelioid Hemangioendothelioma ◽  
Malignant Potential ◽  
Vascular Endothelial ◽  
Rare Occurrence ◽  
Scalp Lesion ◽  
The Common

Epithelioid hemangioendothelioma (EHE) is a rare vascular endothelial tumour with unpredictable malignant potential. The common sites involved are the lung, liver and soft tissues; with cardiac involvement being a very rare occurrence. The diagnosis of this rare vascular tumor is made by typical histopathological findings and confirmed by specific immunohistochemistry. We present a case of a patient with a long standing painless scalp lesion who presented with pulmonary symptoms and ultimately diagnosed to have metastatic cutaneous EHE involving the lungs, pericardium and right atrium.

scholarly journals Multifocal cutaneous epithelioid hemangiodothelioma on the same lower limb

2021 ◽  
Vol 7 (4) ◽  
pp. 578
Author(s):  
Mehdi Khallaayoune ◽  
Elgaitibi Fatima Azzahra ◽  
Meziane Mariame ◽  
Senouci Karima
Keyword(s):  
Young Patient ◽  
Lower Limb ◽  
Soft Tissues ◽  
Epithelioid Hemangioendothelioma ◽  
Low Grade ◽  
Vascular Tumour ◽  
Cutaneous Involvement

<p class="abstract">Epithelioid hemangioendothelioma (EHE) is a rare low-grade vascular tumour mainly affecting bones, deep soft tissues and exceptionally the skin. Multifocal cutaneous involvement is uncommon and should raise suspicion for metastasizing extracutaneous epithelioid hemangiodothelioma. Hereby we report the case of a young patient with multifocal cutaneous EHE involving the same lower limb. We emphasize the necessity for dermatologists to evoke the diagnosis of EHE in patients presenting with nonspecific tumours of the extremities. Prompt management and diagnosis are essential in this potential aggressive tumour.</p>

CD117 expression in peri-implantitis soft tissues: An immunohistochemical study

2010 ◽  
Vol 26 ◽  
pp. e44
Author(s):  
S.D. Aspriello ◽  
A. Zizzi ◽  
F. Bambini ◽  
M. Lorenzi ◽  
C. Rubini ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Immunohistochemical Study

Comparison of peri-implant soft tissues in submerged versus transmucosal healing: A split mouth prospective immunohistochemical study

2018 ◽  
Vol 90 ◽  
pp. 61-66
Author(s):  
José María Martínez-González ◽  
María Martín-Ares ◽  
Natalia Martínez-Rodríguez ◽  
Cristina Barona-Dorado ◽  
Javier Sanz-Alonso ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Immunohistochemical Study

scholarly journals Triple whammy: a rare case of epithelioid hemangioendothelioma with synchronous angiomyomatous hamartoma complicated by Actinomyces meyeri

2021 ◽  
Vol 8 (3) ◽  
pp. 56-61
Author(s):  
Nariman Khan ◽  
◽  
Saadia Waheed ◽  
Rahaf Alkhateb ◽  
◽  
...  
Keyword(s):  
Groin Pain ◽  
Soft Tissues ◽  
Treatment Guidelines ◽  
Epithelioid Hemangioendothelioma ◽  
The Body ◽  
Vascular Endothelial ◽  
Imaging Studies ◽  
One Year ◽  
The Right ◽  
Hispanic Male

Epithelioid hemangioendothelioma is a rare vascular malignancy that originates from vascular endothelial or pre-endothelial cells and is composed of epithelioid or histiocytoid cells. This malignancy has an incidence of approximately one per one million individuals and can occur in various regions of the body including the lungs, liver, bones, and soft tissues. The behavior of this cancer can range from indolent to aggressive and diagnosis and treatment are often delayed due to variable presentations and lack of established treatment guidelines. Here we present the case of a 27-year-old Hispanic male that presented with right groin pain, abdominal pain, and a fifty-pound weight loss over one year. The patient had a complex hospital course during which he was found to have an angiomyomatous hamartoma of his right groin area, postsurgical right inguinal wound infection with Actinomyces meyeri, and epithelioid hemangioendothelioma distal to the right iliac bifurcation. The patient is currently pending further imaging studies to evaluate candidacy for surgical resection and following with oncology for chemotherapeutic options.

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