The Association Between Risk of Coronary Heart Disease Death and Hospitalizations for Cardiovascular Disease and Ambient Air Pollutants: The AHSMOG Study

Epidemiology ◽  
2006 ◽  
Vol 17 (Suppl) ◽  
pp. S69
Author(s):  
Synnove F. Knutsen ◽  
Larry Beeson ◽  
Lie Hong Chen ◽  
Medora Rodriques ◽  
Mark Ghamsary ◽  
...  
2011 ◽  
Vol 58 (4) ◽  
pp. 608-616 ◽  
Author(s):  
Rhonda Spencer-Hwang ◽  
Synnove Fonnebo Knutsen ◽  
Sam Soret ◽  
Mark Ghamsary ◽  
W. Lawrence Beeson ◽  
...  

2019 ◽  
Vol 2 (3) ◽  
pp. e190318 ◽  
Author(s):  
Bo-Yi Yang ◽  
Yuming Guo ◽  
Iana Markevych ◽  
Zhengmin (Min) Qian ◽  
Michael S. Bloom ◽  
...  

2018 ◽  
Vol 41 (3) ◽  
pp. 494-501 ◽  
Author(s):  
Lingling Wang ◽  
Xiaomei Xiang ◽  
Baibing Mi ◽  
Hui Song ◽  
Min Dong ◽  
...  

Abstract Background The aim of this study was to investigate an association between birth defects and exposure to sulfur dioxide (SO2), nitrogen dioxide (NO2) and particles ≤10 μm in an aerodynamic diameter (PM10) during early pregnancy in Xi’an, China. Methods Birth defect data were from the Birth Defects Monitoring System of Xi’an, and data on ambient air pollutants during 2010–15 were from the Xi’an Environmental Protection Bureau. A generalized additive model (GAM) was used to investigate the relationship between birth defects and ambient air pollutants. Results Among the 8865 cases with birth defects analyzed, the overall incidence of birth defects was 117.33 per 10 000 infants. Ambient air pollutant exposure during the first trimester increased the risk of birth defects by 10.3% per 10 μg/m3 increment of NO2 and 3.4% per 10 μg/m3 increment of PM10. No significant association was found between birth defects and SO2. Moreover, NO2 increased risk of neural tube defects, congenital heart disease, congenital polydactyly, cleft palate, digestive system abnormalities and gastroschisis, and PM10 was associated with congenital heart disease and cleft lip with or without cleft palate. Conclusions Chinese women should avoid exposure to high levels of NO2 and PM10 during the first 3 months of pregnancy.


Author(s):  
Theo Pezel ◽  
Bharath Ambale Venkatesh ◽  
Henrique Doria De Vasconcellos ◽  
Yoko Kato ◽  
Mahsima Shabani ◽  
...  

Both left atrial and left ventricular functional parameters influence the prognosis of patients with cardiovascular diseases. This study aimed to investigate the prognostic value of a novel left atrioventricular coupling index (LACI) in a population without history of cardiovascular diseases at baseline. Participants of the Multi-Ethnic Study of Atherosclerosis who underwent a baseline cardiovascular magnetic resonance study were analyzed. LACI was defined by the ratio of the left atrial end-diastolic volume divided by the left ventricular end-diastolic volume. Cox proportional hazard models were used to evaluate the association between LACI and atrial fibrillation, heart failure, coronary heart disease death, and hard cardiovascular disease defined by myocardial infarction, resuscitated cardiac arrest, fatal and nonfatal stroke, or coronary heart disease death. Among the 4124 participants (61.5±10.1 years, 47.4% men), 1074 cardiovascular events were observed (mean follow-up, 13.0±3.2 years). Greater LACI was independently associated with atrial fibrillation (hazard ratio, 1.86 [95% CI, 1.69–2.04]), heart failure (hazard ratio, 1.50 [95% CI, 1.38–1.62]), hard cardiovascular disease (1.23 [95% CI, 1.13–1.34]), and coronary heart disease death (hazard ratio, 1.29 [95% CI, 1.15–1.45]; all P <0.0001). After adjustment for traditional cardiovascular risk factors, LACI showed significant improvement in model discrimination and reclassification compared with currently used standard models to predict outcomes. LACI is a strong predictor for the incidence of heart failure, atrial fibrillation, hard cardiovascular disease, and coronary heart disease death. LACI has incremental prognostic value to predict cardiovascular events over traditional risk factors and better discrimination and reclassification power compared with individual left atrial or left ventricular parameters.


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