Enhancement of LAK-like activity and cytokine induction in regional lymph nodes and spleen cells of mice after intralymphnodal injection of OK-432, a killed streptococcal preparation

The relation between serum antibody and resistance to tumor homografts in the mouse has been investigated. Production of serum antibody in response to homografts of a transplantable sarcoma (Sarcoma 1) was demonstrated, by cytotoxic action on the cells of the tumor, and also by a hemagglutinin test. The simpler and more repeatable hemagglutinin test was further investigated. Peak hemagglutinin titres were reached after the immunizing homografts underwent breakdown. Following transfer of lymph node cells from immunized mice into hosts of the same strain, hemagglutinin could be detected in the host serum. The course of its production showed that this secondary antibody was not elicited by transferred antigen, nor could it be due to transfer of preformed antibody. The cells developed the capacity to transfer hemagglutinin production later than the power to transfer heightened graft resistance. Spleen cells also transferred hemagglutinin production, at a later stage after immunization and to a lesser extent than cells from the regional lymph nodes. Implantation of the sarcoma in mice pretreated with certain preparations of lyophilized or frozen tissue stimulated hemagglutinin production, although the tumor grew progressively. The regional lymph nodes participated in the response: they could transfer hemagglutinin production into secondary hosts, but not graft resistance, and indeed appeared to diminish resistance. Lymph node cells from immunized donors conferred protection against the tumor on pretreated mice. Lymph nodes from normal donors also appeared in some experiments to confer protection although the effect was obscured by the rapidity with which the growing tumor became immunologically invulnerable. The fate of lymph node cells stained with acriflavine was followed after transfer. No effect of the staining on the power of the cells to confer immunity could be detected. Cells transferred to the peritoneal cavity passed into various host tissues, but were not found in test homografts. The conclusion is drawn that the hemagglutinating antibody is distinct from the antibody effective in combating homografts. The similarity in this respect between the homograft reaction and sensitization is emphasized in discussion.

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Breast Cancer Clinical Regional Lymph Nodes TNM Finding v8

10.32388/akyy54 ◽

2020 ◽

Author(s):

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Regional Lymph Nodes

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A case of primary biliary cirrhosis with sarcoid reaction in the regional lymph nodes after surgery of early gastric cancer

Kanzo ◽

10.2957/kanzo.46.437 ◽

2005 ◽

Vol 46 (7) ◽

pp. 437-442 ◽

Cited By ~ 2

Author(s):

Tadashi YOSHIDA ◽

Atsushi NAGASAKA ◽

Yayoi OGAWA ◽

Syuji NISHIKAWA ◽

Akifumi HIGUCHI

Keyword(s):

Gastric Cancer ◽

Early Gastric Cancer ◽

Primary Biliary Cirrhosis ◽

Lymph Nodes ◽

Biliary Cirrhosis ◽

Regional Lymph Nodes ◽

Sarcoid Reaction

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Faculty Opinions recommendation of Isolated tumor cells in regional lymph nodes as relapse predictors in stage I and II colorectal cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14264074.15779078 ◽

2012 ◽

Author(s):

Daniel Vorobiof ◽

Keo Tabane

Keyword(s):

Colorectal Cancer ◽

Lymph Nodes ◽

Tumor Cells ◽

Stage I ◽

Isolated Tumor Cells ◽

Regional Lymph Nodes

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BIOPSY OF THE SIGNALING LYMPH NODES IN GASTRIC CANCER - CURRENT STATUS OF THE PROBLEM AND PROSPECTS

Problems in oncology ◽

10.37469/0507-3758-2018-64-3-335-344 ◽

2018 ◽

Vol 64 (3) ◽

pp. 335-344

Author(s):

Aleksey Karachun ◽

Yuriy Pelipas ◽

Oleg Tkachenko ◽

D. Asadchaya

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Lymph Nodes ◽

Stomach Cancer ◽

Current Status ◽

Regional Lymph Nodes ◽

Systematic Analysis ◽

Tumor Spread ◽

Special Value

The concept of biopsy of sentinel lymph node as the first lymph node in the pathway of lymphogenous tumor spread has been actively discussed over the past decades and has already taken its rightful place in breast and melanoma surgery. The goal of this method is to exclude vain lymphadenectomy in patients without solid tumor metastases in regional lymph nodes. In the era of minimally invasive and organ-saving operations interventions it seems obvious an idea to introduce a biopsy of sentinel lymph node in surgery of early gastric cancer. Meanwhile the complexity of lymphatic system of the stomach and the presence of so-called skip metastases are factors limiting the introduction of a biopsy of sentinel lymph node in stomach cancer. This article presents a systematic analysis of biopsy technology of signaling lymph node as well as its safety and oncological adequacy. Based on literature data it seems to us that the special value of biopsy of sentinel lymph nodes in the future will be in the selection of personalized surgical tactics for stomach cancer.

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QUANTITATIVE AND QUALITATIVE CHARACTERISTICS OF METASTASES IN REGIONAL LYMPH NODES - RISK FACTORS FOR THE RECURRENCE OF PAPILLARY THYROID CANCER IN CHILDREN AND ADOLESCENTS

Problems in oncology ◽

10.37469/0507-3758-2018-64-2-159-165 ◽

2018 ◽

Vol 64 (2) ◽

pp. 159-165

Author(s):

Mikhail Fridman ◽

Svetlana Mankovskaya ◽

Olga Krasko

Keyword(s):

Risk Factors ◽

Thyroid Cancer ◽

Lymph Nodes ◽

Children And Adolescents ◽

Papillary Thyroid Cancer ◽

Papillary Thyroid ◽

Regional Lymph Nodes ◽

Cancer In Children ◽

Qualitative Characteristics

Among the factors determining the relapse/persistence of papillary thyroid cancer in children and adolescents the most important are the age of the patient (p= 0.003), the presence of concomitant background pathology (p

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THE ROLE OF SURGICAL STAGE IN COMBINATION THERAPY FOR PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER

Problems in oncology ◽

10.37469/0507-3758-2019-65-5-749-755 ◽

2019 ◽

Vol 65 (5) ◽

pp. 749-755

Author(s):

D. Reyes Santyago ◽

Anzhella Khadzhimba ◽

M. Smirnova ◽

Sergey Maksimov

Keyword(s):

Cervical Cancer ◽

Radiation Therapy ◽

Combination Therapy ◽

Lymph Nodes ◽

Locally Advanced ◽

Advanced Cervical Cancer ◽

Relapse Free Survival ◽

Regional Lymph Nodes ◽

Free Survival ◽

Locally Advanced Cervical Cancer

Objective: to justify the expediency of the surgical stage as a part of the combination treatment for stage IIA-IIIB cervical cancer. Materials and methods. The study included 343 women with stage IIA-IIIB cervical cancer treated from 2013 to 2016 with mandatory follow-up for at least 2 years. Patients were divided into 2 groups. The first group included 214 patients who received a combination treatment. At the first stage, neoadjuvant chemoradiation therapy was performed (remote radiation therapy 5 days a week with radio modification with Cisplatin once a week at a dose of 40 mg/m2). After evaluating the effect, patients were subjected to surgical treatment or continued chemoradiotherapy. The second group (n = 129) received standard combined radiation therapy. Various schemes of combination and complex treatment and standard combined radiation therapy were evaluated using the indices of general and relapse-free survival. Results. The proposed scheme for the combination therapy for patients with locally advanced cervical cancer showed significantly higher survival rates at all the analyzed stages. For the combined treatment group with complete cytoreduction, the two-year overall and relapse-free survival with stage IIA is 94.1% vs. 82.4%, with IIB 90.8% vs. 80.3%, with IIB 87.5% vs. 75%, with IIB with metastatic lesion of regional lymph nodes 85% vs. 70%. For the second group, two-year overall and relapse-free survival with stage IIA 75% vs. 50%, with IIB 70.9% vs. 56.3%, with IIB 59.1% vs. 40.9%, with IIB with metastatic lesion of regional lymph nodes 62.2% and 40.5%. The advantages of this approach are most clearly seen within patients with metastatic lesions of regional lymph nodes (85% vs. 62% accordingly). Conclusion. Cytoreductive surgery in combination with the combination therapy allows to achieve a significant increase in overall and relapse-free survival for patients with locally advanced cervical cancer compared with standard treatment programs.

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