REGULAR PHYSICAL ACTIVITY PREVENTS AGE-RELATED DECLINE IN PLASMA ANTIOXIDANT CAPACITY AND ENDOTHELIUM-DEPENDENT VASODILATION OF CONDUIT ARTERY

Muscles of old adults respond to stress with heightened inflammatory signaling that disrupts the regenerative process. This muscle inflammation susceptibility could contribute to the age-related decline in muscle mass, as anti-inflammatory medications taken concurrently with exercise training, have proven beneficial in attenuating age-related loss of muscle mass. With antioxidants and anti-inflammatory potential, blueberries (BB) are a natural alternative that might regulate aged muscle inflammation susceptibility. Objectives: The purpose of this study was to determine the effects of BB consumption on the muscle inflammatory profile of older adults, and to determine the subsequent muscle inflammatory response to exercise. We hypothesized that BB would lower the inflammatory profile of muscle and attenuate the inflammatory response after resistance exercise. Design: Subjects were randomized to receive daily BB or placebo supplements, which were blind to subjects and researchers. All subjects underwent baseline functional testing, post-supplementation testing, and testing post-muscle stress stimulus. Setting: Volunteers were recruited from Western North Carolina region, USA. Participants: Healthy, non-resistance trained adults over 60 years old (n=22) were recruited. Measurements: Profiles of inflammation pathways known to affect muscle mass were established prior to and after 6-weeks of daily consumption of BB. Post-supplementation, subjects performed an exercise protocol to induce inflammation and returned 24 hours post-exercise to determine the muscle inflammatory profiles. Results: Muscle cytokine and soluble cytokine receptor levels were similar between groups and within groups before and after BB consumption. Cytokine and cytokine receptor levels post-muscle stress changed similarly in the BB and placebo group, indicating BB had no effect on the muscle’s inflammatory response. Total plasma antioxidant capacity was 22% higher in the BB group 24-hours post-muscle stress, however, plasma oxidative stress was not different between groups or within groups. Conclusion: While BB consumption did not affect inflammatory signaling pathways within the muscle nor affect inflammation after a regenerative stimulus, a higher plasma antioxidant capacity could contribute to a better long-term regenerative response.

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Effects of Dietary Strawberry Supplementation on Antioxidant Biomarkers in Obese Adults with Above Optimal Serum Lipids

Journal of Nutrition and Metabolism ◽

10.1155/2016/3910630 ◽

2016 ◽

Vol 2016 ◽

pp. 1-9 ◽

Cited By ~ 9

Author(s):

Arpita Basu ◽

Stacy Morris ◽

Angel Nguyen ◽

Nancy M. Betts ◽

Dongxu Fu ◽

...

Keyword(s):

Trace Elements ◽

Enzyme Activity ◽

Antioxidant Capacity ◽

Serum Lipids ◽

Low Dose ◽

High Dose ◽

Obese Adults ◽

Plasma Antioxidant Capacity ◽

Dose Control ◽

Plasma Antioxidant

Berries have shown several cardiovascular health benefits and have been associated with antioxidant functions in experimental models. Clinical studies are limited. We examined the antioxidant effects of freeze-dried strawberries (FDS) in adults [n=60; age:49±10years; BMI:36±5 kg/m2(mean ± SD)] with abdominal adiposity and elevated serum lipids. Participants were randomized to one of the following arms: low dose strawberry (25 g/day FDS), low dose control beverage (LD-C), high dose strawberry (50 g/d FDS), and high dose control beverage (HD-C) for 12 weeks. Control beverages were matched for calories and total fiber. Plasma antioxidant capacity, trace elements (copper, iron, selenium, and zinc), whole blood glutathione (GSH), and enzyme activity (catalase, glutathione peroxidase, and glutathione reductase) were examined at screening (0 week) and after 12 weeks’ intervention. At 12 weeks, plasma antioxidant capacity and glutathione levels were higher in the strawberry versus control groups (low and high dose FDS: 45% and 42% for plasma antioxidant capacity and 28% and 36% for glutathione, resp.); glutathione was higher in the high versus low dose strawberry group (allp<0.05). Serum catalase activity was higher in the low dose strawberry (43%) versus control group (p<0.01). No differences were noted in plasma trace elements and glutathione enzyme activity. Dietary strawberries may selectively increase plasma antioxidant biomarkers in obese adults with elevated lipids.

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Erratum to “Folic acid and Vitamin E supplementation effects on homocysteinemia, endothelial function and plasma antioxidant capacity in young myocardial-infarction patients”

Pharmacological Research ◽

10.1016/j.phrs.2003.12.008 ◽

2004 ◽

Vol 49 (5) ◽

pp. 501

Author(s):

F Visioli

Keyword(s):

Myocardial Infarction ◽

Folic Acid ◽

Vitamin E ◽

Endothelial Function ◽

Antioxidant Capacity ◽

Plasma Antioxidant Capacity ◽

Plasma Antioxidant ◽

Vitamin E Supplementation

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Plasma Antioxidant Capacity Of Olympic Sailors Prior To The Olympic Games

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000354569.04582.9b ◽

2009 ◽

Vol 41 ◽

pp. 2

Author(s):

Nathan A. Lewis ◽

Brian Moore ◽

Pete Cunningham ◽

Lindy Castell ◽

Jan Knight

Keyword(s):

Antioxidant Capacity ◽

Olympic Games ◽

Plasma Antioxidant Capacity ◽

Plasma Antioxidant ◽

The Olympic Games

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Effects of Korean black raspberry supplementation on oxidative stress and plasma antioxidant capacity in healthy male smokers

Journal of Functional Foods ◽

10.1016/j.jff.2015.04.047 ◽

2015 ◽

Vol 16 ◽

pp. 393-402 ◽

Cited By ~ 5

Author(s):

Eunkyo Park ◽

SooMuk Cho ◽

Jung eun Lee ◽

Seung Min Lee ◽

Yesl Kim ◽

...

Keyword(s):

Oxidative Stress ◽

Antioxidant Capacity ◽

Black Raspberry ◽

Healthy Male ◽

Plasma Antioxidant Capacity ◽

Plasma Antioxidant

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Amino acids and plasma antioxidant capacity

Amino Acids ◽

10.1007/bf01373017 ◽

1997 ◽

Vol 12 (3-4) ◽

pp. 373-377 ◽

Cited By ~ 45

Author(s):

E. Meucci ◽

M. C. Mele

Keyword(s):

Amino Acids ◽

Antioxidant Capacity ◽

Plasma Antioxidant Capacity ◽

Plasma Antioxidant

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Effect of Propofol, Sevoflurane and Desflurane on Systemic Redox Balance

International Journal of Immunopathology and Pharmacology ◽

10.1177/039463200702000316 ◽

2007 ◽

Vol 20 (3) ◽

pp. 585-593 ◽

Cited By ~ 15

Author(s):

G. Cinnella ◽

G. Vendemiale ◽

M. Dambrosio ◽

G. Serviddio ◽

P.L. Pugliese ◽

...

Keyword(s):

Antioxidant Capacity ◽

Antioxidant Properties ◽

Redox Balance ◽

Trolox Equivalent Antioxidant Capacity ◽

Sodium Thiopental ◽

Blood Samples ◽

Plasma Antioxidant Capacity ◽

Trolox Equivalent ◽

Plasma Antioxidant ◽

Group D

We studied the effects of Propofol, Desflurane, and Sevoflurane on the systemic redox balance in patients undergoing laparohysterectomy. We measured blood concentration of glutathione (GSH), plasma antioxidant capacity (Trolox Equivalent Antioxidant Capacity-TEAC), and lipid peroxidation products (malondialdehyde (aMDA) and 4-hydroxynonenal (aHNE) protein adducts). Sixty patients were randomly placed into three groups of twenty people each. In Group P anesthesia was induced with Propofol 2 mg/kg and maintained with 12–10–8 mg/kg/min; in Groups S and D anesthesia was induced with 3 mg/kg Sodium Thiopental and maintained with 2% Sevoflurane and 6% Desflurane, respectively. Blood samples were collected prior to induction (T0bas), 60min and 24h postoperatively (T160' and T224 h). In Group P, GSH increased on T160' (p<0.02) and returned to baseline on T24h, while TEAC remained unmodified; in Groups S, GSH and TEAC decreased on T160' (p<0.01 vs. T0bas, p<0.03 vs. T0bas, respectively); in Group D, on T160' there was a slight decrease of GSH and TEAC. The levels of aMDA slightly decreased throughout the study periods in Group P, increased in Group D, and remained stable in Group S. Propofol showed antioxidant properties, while Sevoflurane and Desflurane seemed to shift the redox balance towards oxidation, yet without inducing overt oxidative damage.

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