Conjugated linoleic acid metabolism

2002 ◽  
Vol 13 (3) ◽  
pp. 261-266 ◽  
Author(s):  
Sebastiano Banni
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Acid Metabolism ◽  
Linoleic Acid Metabolism

Florfenicol Enhances Colonization of Salmonella enterica serovar Enteritidis floR mutant with Major Alterations to the Intestinal Microbiota and Metabolome in Neonatal Chickens

2021 ◽  
Author(s):  
Xueran Mei ◽  
Boheng Ma ◽  
Xiwen Zhai ◽  
Anyun Zhang ◽  
Changwei Lei ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Intestinal Microbiota ◽  
Salmonella Enterica ◽  
Acid Metabolism ◽  
Intestinal Inflammation ◽  
Poultry Production ◽  
Intestinal Colonization ◽  
Gut Colonization ◽  
Linoleic Acid Metabolism

Florfenicol is an important antibiotic commonly used in poultry production to prevent and treat Salmonella infection. However, oral administration of florfenicol may alter the animals’ natural microbiota and metabolome, thereby reducing the intestinal colonization resistance and increasing the susceptibility to Salmonella infection. In this study, we determined the effect of florfenicol (30 mg/kg) on gut colonization of neonatal chickens challenged with Salmonella enterica subsp. enterica serovar Enteritidis ( S. Enteritidis ). We then analyzed the microbial community structure and metabolic profiling of cecal contents using microbial 16S amplicon sequencing and LC-MS untargeted metabolomics, respectively. We also screened the marker metabolites using a multi-omics technique and assessed the effect of these markers on the intestinal colonization S. Enteritidis . Florfenicol administration significantly increased the loads of S. Enteritidis in cecal contents, spleen, and liver, and prolonged the residence of S. Enteritidis . Moreover, florfenicol significantly affected the cecal colony structures, with reduced the abundance of Lactobacillus and Bacteroidetes , and increased the levels of Clostridia , Clostridium and Dorea . The metabolome was greatly influenced by florfenicol administration, and perturbation in metabolic pathways related to linoleic acid metabolism (linoleic acid, conjugated linoleic acid, 12,13-EpOME and 12,13-diHOME) was most prominently detected. We screened conjugated linoleic acid (CLA) and 12,13-diHOME as the marker metabolites, which were highly associated with Lactobacillus , Clostridium and Dorea . Supplementation with CLA maintained intestinal integrity, reduced intestinal inflammation, and accelerated Salmonella clearance from the gut and remission of enteropathy. Whereas, treatment with 12,13-diHOME promoted intestinal inflammation and disrupted the intestinal barrier function to sustain Salmonella infection. Thus, these results highlight that florfenicol alters the intestinal microbiota and metabolism of neonatal chickens, and promotes Salmonella infection mainly by affecting linoleic acid metabolism.

scholarly journals Effects of Conjugated Linoleic Acid. 1. Fatty Acid Modification of Yolks and Neonatal Fatty Acid Metabolism

2000 ◽  
Vol 79 (6) ◽  
pp. 817-821 ◽  
Author(s):  
M.A. Latour ◽  
A.A. Devitt ◽  
R.A. Meunier ◽  
J.J. Stewart ◽  
B.A. Watkins
Keyword(s):  
Fatty Acid ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Acid Modification ◽  
Fatty Acid Modification

scholarly journals Combined Metabolome and Transcriptome Analyses of Young, Mature, and Old Rhizome Tissues of Zingiber officinale Roscoe

2021 ◽  
Vol 12 ◽  
Author(s):  
Huanfang Liu ◽  
Honghua Yang ◽  
Tong Zhao ◽  
Canjia Lin ◽  
Yongqing Li ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Acid Metabolism ◽  
Zingiber Officinale ◽  
Sucrose Metabolism ◽  
Gene Expressions ◽  
Zingiber Officinale Roscoe ◽  
Ginger Rhizome ◽  
Linoleic Acid Metabolism ◽  
Phenylpropanoid Biosynthesis ◽  
Metabolome Profiling

Ginger (Zingiber officinale Roscoe) is known for its unique pungent taste and useability in traditional Chinese medicine. The main compounds in ginger rhizome can be classified as gingerols, diarylheptanoids, and volatile oils. The composition and concentrations of the bioactive compounds in ginger rhizome might vary according to the age of the rhizome. In this regard, the knowledge on the transcriptomic signatures and accumulation of metabolites in young (Y), mature (M), and old (O) ginger rhizomes is scarce. This study used HiSeq Illumina Sequencing and UPLC-MS/MS analyses to delineate how the expression of key genes changes in Y, M, and O ginger rhizome tissues and how it affects the accumulation of metabolites in key pathways. The transcriptome sequencing identified 238,157 genes of which 13,976, 11,243, and 24,498 were differentially expressed (DEGs) in Y vs. M, M vs. O, and Y vs. O, respectively. These DEGs were significantly enriched in stilbenoid, diarylheptanoid, and gingerol biosynthesis, phenylpropanoid biosynthesis, plant-hormone signal transduction, starch and sucrose metabolism, linoleic acid metabolism, and α-linoleic acid metabolism pathways. The metabolome profiling identified 661 metabolites of which 311, 386, and 296 metabolites were differentially accumulated in Y vs. M, Y vs. O, and M vs. O, respectively. These metabolites were also enriched in the pathways mentioned above. The DEGs and DAMs enrichment showed that the gingerol content is higher in Y rhizome, whereas the Y, M, and O tissues differ in linoleic and α-linoleic acid accumulation. Similarly, the starch and sucrose metabolism pathway is variably regulated in Y, M, and O rhizome tissues. Our results showed that ginger rhizome growth slows down (Y > M > O) probably due to changes in phytohormone signaling. Young ginger rhizome is the most transcriptionally and metabolically active tissue as compared to M and O. The transitioning from Y to M and O affects the gingerol, sugars, linoleic acid, and α-linoleic acid concentrations and related gene expressions.

scholarly journals Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides

2002 ◽  
Vol 44 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Maria Rodriguez ◽  
Simone Funke ◽  
Maria Fink ◽  
Hans Demmelmair ◽  
Marco Turini ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Preterm Infants ◽  
Acid Metabolism ◽  
Medium Chain Triglycerides ◽  
Plasma Fatty Acids ◽  
Medium Chain ◽  
Linoleic Acid Metabolism
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