“Smart Bandage” May Accelerate Treatment of Chronic Wounds

2022 ◽  
Vol 52 (2) ◽  
pp. 15-16
Keyword(s):  
Author(s):  
Debby A. Jennings ◽  
Michael J. Morykwas ◽  
Louis C. Argenta

Grafts of cultured allogenic or autogenic keratlnocytes have proven to be an effective treatment of chronic wounds and burns. This study utilized a collagen substrate for keratinocyte and fibroblast attachment. The substrate provided mechanical stability and augmented graft manipulation onto the wound bed. Graft integrity was confirmed by light and transmission electron microscopy.Bovine Type I dermal collagen sheets (100 μm thick) were crosslinked with 254 nm UV light (13.5 Joules/cm2) to improve mechanical properties and reduce degradation. A single cell suspension of third passage neonatal foreskin fibroblasts were plated onto the collagen. Five days later, a single cell suspension of first passage neonatal foreskin keratinocytes were plated on the opposite side of the collagen. The grafts were cultured for one month.The grafts were fixed in phosphate buffered 4% formaldehyde/1% glutaraldehyde for 24 hours. Graft pieces were then washed in 0.13 M phosphate buffer, post-fixed in 1% osmium tetroxide, dehydrated, and embedded in Polybed 812.


2007 ◽  
Vol 40 (14) ◽  
pp. 13
Author(s):  
SHARON WORCESTER
Keyword(s):  

1985 ◽  
Vol 1 (2) ◽  
pp. 407-416
Author(s):  
Raleigh R. White ◽  
Charles N. Verheyden ◽  
Dennis J. Lynch
Keyword(s):  

2020 ◽  
Vol 99 (4) ◽  
pp. 183-188

Modern medicine offers a wide spectrum of wound healing resources for acute or chronic wounds. Negative pressure wound therapy (NPWT) is a very effective method, allowing complicated defects and wounds to heal. The basic set is usually provided with various special accessories to facilitate the use and support safe application of NPWT to high-risk tissue. Selected case reports are presented herein to document the special use and combinations of materials in negative pressure wound therapy.


2020 ◽  
pp. 43-57
Author(s):  
Anna Tabuika

The article reflects the results of a retrospective non-comparative study, the objects of which were 34 outpatient comorbid patients (15 of which are over 60 years old) with chronic wounds of the lower limbs developed against the background of varicosity, post-thrombotic disease, chronic arterial insufficiency of the lower limbs, diabetes mellitus or their combination. Their local treatment was carried out using atraumatic ointment dressing «Branolind N» containing Peruvian balsam. There were 23 women (67.6 %) and 11 men (32.4 %). In microbiological study prior to the beginning of treatment in 31 patients the growth of a pathogen of wound infection was revealed; in 19 patients — Staphylococcus aureus in monoculture and in various associations, in 6 patients — Pseudomonas aeruginosa in monoculture, in other cases — other pathogens. In 3 patients the pathogen was not detected. The average wound size was 34 cm2 . The phase of the wound process was additionally confirmed by cytological studies. After treatment the average area of the wound defect decreased by 10 cm2 and made 24 cm2 on average. Full healing of the wound defect occurred in 11 patients, the others had granulation and active marginal epithelization. There was also a decrease in bacterial semination of wounds, a change in composition of infection agents to less aggressive monoflora, and cytologically — a decrease in signs of inflammation against the background of significant activation of reparative processes.


2017 ◽  
Vol 68 (9) ◽  
pp. 2112-2113
Author(s):  
Laura Raducu ◽  
Andra Elena Balcangiu Stroescu ◽  
Iulia Ioana Stanescu ◽  
Maria Daniela Tanasescu ◽  
Cristina Nicoleta Cozma ◽  
...  

Chronic wounds have a long period of healing, being impeded by numerous factors, as infections. Polyhexanidine is a new broad spectrum antiseptic with non-toxic action which is used lately in wound cleaning solutions. A case control study was realized with two groups of patients treated with silver sulfodiazine and with polyhexanidine, the last group having an accelerated healing evolution. Besides the bactericide action, polyhexanidine has also no cytotoxicity, good tolerability and anti-inflammatory proprieties.


2018 ◽  
Vol 69 (3) ◽  
pp. 585-586 ◽  
Author(s):  
Laura Raducu ◽  
Cristina Nicoleta Cozma ◽  
Andra Elena Balcangiu Stroescu ◽  
Adelaida Avino ◽  
Maria Daniela Tanasescu ◽  
...  

Polyurethane foam has numerous applications, from furniture to medical field. As a wound dressing creates a moisture environment that promotes epithelialization and diminishes pain. A prospective study was realized to evaluate polyurethane foam efficacy in treating chronic wounds due to venous, arterial or diabetic causes. Our evaluation showed good results with an accelerated epithelialization.


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