1785: CHROMOBACTERIUM VIOLACEUM SEPTIC SHOCK IN A HEALTHY TEENAGER

Chromobacterium violaceumis a facultative anaerobic, Gram-negative rod, prevalent in tropical and subtropical regions. It enters through the skin injury and is capable of causing severe systemic infections leading to septic shock and multiorgan failure. It has been reported by few authors across the world but this is probably the first case ofChromobacterium violaceumisolated from wound sepsis from Nepal. In this study, a pus sample from the infection of a prick injury in the left middle finger was collected from the patient admitted to the intensive care unit. Bacteriological investigations of the pus sample revealed the causative organism to beChromobacterium violaceum. This case study indicates thatChromobacterium violaceumcan act as a potential cause of wound sepsis that may lead to the septic shock and if not treated timely, the mortality rate can be high as was in this study. Although this organism is very rare, the infection caused requires prompt treatment to minimize the mortality rate. Therefore, we recommend the timely diagnosis and antimicrobial therapy of this infection to combat the consequences led.

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Review on Chromobacterium violaceum, a Rare but Fatal Bacteria Needs Special Clinical Attention

Anwer Khan Modern Medical College Journal ◽

10.3329/akmmcj.v10i2.44131 ◽

2019 ◽

Vol 10 (2) ◽

pp. 169-175

Author(s):

Sadia Sharmin ◽

SM Mostofa Kamal

Keyword(s):

Septic Shock ◽

High Frequency ◽

Distress Syndrome ◽

Opportunistic Pathogen ◽

Chromobacterium Violaceum ◽

Gram Negative ◽

Medical College ◽

Tract Infections ◽

Prompt Diagnosis ◽

Soil And Water

Chromobacterium violaceum is isolated from soil and water in tropical and subtropical areas. This Gram negative, capsulated, motile bacillus is considered as a saprophyte but occasionally it can act as an opportunistic pathogen for animals and human. It causes skin lesion with liver and lung abscesses, pneumonia, gastrointestinal tract infections, urinary tract infections, osteomyelitis, meningitis, peritonitis, endocarditis, respiratory distress syndrome and septic shock. Increasing reported cases with Chrombacterium violaceum infection has been noticed in recent decades. It should be considered for its difficult-to-treat entity characterized by a high frequency of sepsis, distantant metastasis, multidrug resistance and relapse. High mortality rate associated with this infection necessitate prompt diagnosis and appropriate antimicrobial therapy Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 169-175

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Fatal septicemia caused by Chromobacterium violaceum in a child from Colombia

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652007000600011 ◽

2007 ◽

Vol 49 (6) ◽

pp. 391-393 ◽

Cited By ~ 5

Author(s):

Pedro Martinez ◽

Salim Mattar

Keyword(s):

Septic Shock ◽

Abdominal Pain ◽

Multiple Organ Failure ◽

Organ Failure ◽

Multiple Organ ◽

Blood Cultures ◽

Severe Abdominal Pain ◽

Chromobacterium Violaceum ◽

History Of ◽

Fatal Septicemia

A 4-year old child living in Colombia presented with a history of fever and severe abdominal pain for four days. The patient developed pneumonia, septic shock, multiple organ failure and died on the fifth day of hospitalization. Chromobacterium violaceum was isolated from admission blood cultures and was resistant to ampicillin, cephalosporins, carbapenems and aminoglycosides.

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‘The Violet Killer’—Successful Treatment of an Infant with Chromobacterium violaceum Sepsis

Journal of Tropical Pediatrics ◽

10.1093/tropej/fmab076 ◽

2021 ◽

Vol 67 (4) ◽

Author(s):

Jawad M Mohammed ◽

T M Sajana ◽

Reshma Raj ◽

Babu A Rachana ◽

George Paul ◽

...

Keyword(s):

Septic Shock ◽

Soft Tissue ◽

Mortality Rate ◽

Chromobacterium Violaceum ◽

Soft Tissue Infections ◽

Unique Case ◽

Facultative Anaerobic ◽

Tropical Areas ◽

Reduced Activity ◽

Very High

Abstract Chromobacterium violaceum, a facultative anaerobic proteobacterium, is isolated from water and soil in tropical areas and has been implicated in infections like septicemia, visceral abscesses, skin and soft tissue infections, meningitis and diarrhea. Chromobacterium violaceum sepsis, a rarely reported phenomenon has a very high mortality rate. Here, we report a unique case of Chromobacterium sepsis in an infant. A 48-day-old baby boy was referred to our institution with h/o fever, loose stools and reduced activity. He was intubated and referred to us in septic shock. Radiological investigations revealed multiple abscesses in the liver, spleen and kidneys. The infant was successfully treated with trimethoprim-sulfamethoxazole and ciprofloxacin.

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Low-Dose Steroids Cut Mortality in Septic Shock

Family Practice News ◽

10.1016/s0300-7073(06)73943-3 ◽

2006 ◽

Vol 36 (19) ◽

pp. 24

Author(s):

BRUCE JANCIN

Keyword(s):

Septic Shock ◽

Low Dose

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Septic shock patient and ultrasound in the emergency room

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/s-0036-1587960 ◽

2016 ◽

Vol 37 (S 01) ◽

Author(s):

M Algaba Montes ◽

AÁ Oviedo García ◽

M Patricio Bordomás

Keyword(s):

Septic Shock ◽

Emergency Room ◽

Septic Shock Patient

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Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1642520 ◽

1994 ◽

Vol 71 (06) ◽

pp. 768-772 ◽

Cited By ~ 14

Author(s):

Gerhard Dickneite ◽

Jörg Czech

Keyword(s):

Septic Shock ◽

Klebsiella Pneumoniae ◽

Organ Failure ◽

Therapeutic Effect ◽

Disseminated Intravascular Coagulation ◽

Post Infection ◽

Thrombin Inhibitor ◽

Bolus Administration ◽

Bacterial Burden ◽

Recombinant Hirudin

SummaryRats which were infected with the gramnegative pathogen Klebsiella pneumoniae develop disseminated intravascular coagulation (DIC), multi-organ failure (MOF) and finally die in a septic shock. We investigated the therapeutic effect of antibiotic (tobramycin) treatment combined with the infusion of the highly specific thrombin inhibitor rec. hirudin. Although administration of 2 mg/kg tobramycin alone leads to a decrease of the bacterial burden, DIC could not be prevented. Infusion of rec. hirudin (0.25 mg/kg x h) for 4 h (start of treatment 1 h post infection), in addition to a bolus administration of tobramycin, led to an amelioration of DIC parameters as fibrinogen, thrombin-antithrombin complex (TAT) and platelets. Serum transaminase levels (GOT, GPT) as a marker of MOF were significantly improved by rec. hirudin, the T50 value increased from 17 h in the tobramycin group to 42 h in the tobramycin + rec. hirudin giuup, muilality rates were 90% or 60%, respectively. Combination of heparin (10011/kg x h) and tobramycin was not effective on survival.

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