Long-Term (2???4 Year) Weight Reduction With Metformin Plus Carbohydrate-Modified Diet in Euglycemic, Hyperinsulinemic, Midlife Women (Syndrome W)

Heart Disease ◽  
2003 ◽  
Vol 5 (6) ◽  
pp. 384-392 ◽  
Author(s):  
Harriette R. Mogul ◽  
Stephen J. Peterson ◽  
Bernard I. Weinstein ◽  
Jianyu Li ◽  
A Louis Southren
Keyword(s):  
Weight Reduction ◽  
Midlife Women ◽  
Modified Diet

Two Weight-Reduction Programs among Southwestern Indians: Long-Term Results

1972 ◽  
Vol 87 (6) ◽  
pp. 530 ◽  
Author(s):  
Maurice L. Sievers ◽  
Margaret E. Hendrikx
Keyword(s):  
Weight Reduction ◽  
Long Term Results ◽  
Weight Reduction Programs

Weight Reduction with a Novel Carbohydrate Modified Diet in 52 Study Subjects in the EMPOWIR Trial.

2010 ◽  
pp. P3-424-P3-424
Author(s):  
HR Mogul ◽  
R Freeman ◽  
LA Klein ◽  
B Williams-Cleaves ◽  
GD Cruikshank ◽  
...  
Keyword(s):  
Weight Reduction ◽  
Modified Diet

scholarly journals A Special, Strict, Fat-Reduced, and Carbohydrate-Modified Diet Leads to Marked Weight Reduction even in Overweight Adolescents with Prader-Willi Syndrome (PWS)

2009 ◽  
Vol 9 ◽  
pp. 934-939 ◽  
Author(s):  
Walter Bonfig ◽  
Kathi Dokoupil ◽  
Heinrich Schmidt
Keyword(s):  
Weight Reduction ◽  
Cardiovascular Complications ◽  
Prader Willi Syndrome ◽  
Frequent Symptom ◽  
Special Diet ◽  
Long Run ◽  
Marked Weight ◽  
Overweight Adolescents ◽  
Modified Diet

Hyperphagia is a frequent symptom in patients with Prader-Willi Syndrome (PWS) and results in marked obesity with the risk of metabolic and cardiovascular complications. Previously, we reported that our special diet for PWS patients is effective in the long run, if started early at about 2 years of age. Our objective in this study was to investigate if our special diet is also effective in PWS adolescents who are already overweight. We provided a strict, fat-reduced, and carbohydrate-modified diet, consisting of 10 kcal/cm height, to five adolescents (two female, three male) with PWS. Patients were prospectively followed at our center for 2-6 years. BMI, BMI-SDS, and Weight-for-Height Index were recorded over that period. The special diet was started at a mean age of 16 years (range: 14.1-18.9 years) and initial BMI was 41.3 kg/m2(range: 32.4-55.5 kg/m2), corresponding to BMI-SDS +3.6 (range: +2.8 to +4.5 SDS). Weight-for-Height Index was 243% (range: 190-339%). After 2 years of the diet, BMI decreased to 33 kg/m2(range: 26.7-38 kg/m2), as well as BMI-SDS +2.7 (range: 1.7-3.4 SDS) and Weight-for-Height Index to 191% (range: 157-232%); p < 0.01. The special diet was still effective in reducing weight after 4–6 years, with a mean BMI of 30.5 kg/m2(range: 24.6–34.5 kg/m2) and a mean BMI-SDS of +2.1 (range: 0.7–2.9). We conclude that in a period of 2–6 years, our strict, fat-reduced, and carbohydrate-modified diet, with 10 kcal/cm height, is effective even in adolescents with PWS who are already overweight.

scholarly journals Weight Reduction by the Low-Insulin-Method—A Randomized Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3004
Author(s):  
Martin Röhling ◽  
Katharina Martin ◽  
Sabine Ellinger ◽  
Michael Schreiber ◽  
Stephan Martin ◽  
...  
Keyword(s):  
Weight Reduction ◽  
Controlled Trial ◽  
Fasting Blood Glucose ◽  
Group Analysis ◽  
Intervention Group ◽  
Eating Behaviour ◽  
Control Group ◽  
Insulin Levels ◽  
Overweight Or Obesity

Continuous high insulin levels are associated with weight gain and lead to cardiometabolic diseases. Therefore, we have developed the Low-Insulin-Method and integrated it into the multi-component, occupational healthcare program SHAPE-AND-MOTION-Medical-Accompanied-Slimming (SAMMAS) to reduce daily insulin levels for long-term weight reduction in overweight or obesity. Employees were randomized into a starting intervention group (SI, n = 15) or waiting list control group (WL, n = 15). SAMMAS consisted of group-based seminars, low-carbohydrate nutrition including formula diet, continuous glucose monitoring, telemetric monitoring, and telemedical coaching. Both groups received telemetric devices at baseline. Intention-to-treat analyses were performed after 12, 26, and 52 weeks. The estimated treatment difference in weight reduction after 12 weeks, which is the primary endpoint of the study, showed a pronounced effect in favour of SI (−6.3 kg with (95% confidence interval) (−7.4; −4.5) (p < 0.001)) after 12 weeks. Furthermore, SI improved fasting blood glucose, HbA1c, quality of life, fasting insulin, blood pressure, and eating behaviour (all p < 0.05) in the within-group analysis, while WL did not. After 26 and 52 weeks, weight reduction could be maintained in the whole group (both groups together) by −6.7 kg (−9.5; −3.8) (p < 0.001) and −6.1 kg (−9.2; −2.7) (p < 0.01). SAMMAS supports clinically relevant weight reduction and long-term weight loss maintenance in individuals with overweight or obesity.

scholarly journals Association between coarse particulate matter and inflammatory and hemostatic markers in a cohort of midlife women

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Emilie Davis ◽  
Brian Malig ◽  
Rachel Broadwin ◽  
Keita Ebisu ◽  
Rupa Basu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Monitoring Network ◽  
High Sensitivity ◽  
Midlife Women ◽  
Plasminogen Activator Inhibitor 1 ◽  
Cvd Risk ◽  
Coarse Particulate Matter ◽  
One Year ◽  
Pai 1

Abstract Background Exposure to particulate matter air pollution has been associated with cardiovascular disease (CVD) morbidity and mortality; however, most studies have focused on fine particulate matter (PM2.5) exposure and CVD. Coarse particulate matter (PM10–2.5) exposure has not been extensively studied, particularly for long-term exposure, and the biological mechanisms remain uncertain. Methods We examined the association between ambient concentrations of PM10–2.5 and inflammatory and hemostatic makers that have been linked to CVD. Annual questionnaire and clinical data were obtained from 1694 women (≥ 55 years old in 1999) enrolled in the longitudinal Study of Women’s Health Across the Nation (SWAN) at six study sites from 1999 to 2004. Residential locations and the USEPA air monitoring network measurements were used to assign exposure to one-year PM10–2.5, as well as co-pollutants. Linear mixed-effects regression models were used to describe the association between PM10–2.5 exposure and markers, including demographic, health and other covariates. Results Each interquartile (4 μg/m3) increase in one-year PM10–2.5 exposure was associated with a 5.5% (95% confidence interval [CI]: 1.8, 9.4%) increase in levels of plasminogen activator inhibitor-1 (PAI-1) and 4.1% (95% CI: − 0.1, 8.6%) increase in high-sensitivity C-creative Protein (hs-CRP). Stratified analyses suggested that the association with PAI-1 was particularly strong in some subgroups, including women who were peri-menopausal, were less educated, had a body mass index lower than 25, and reported low alcohol consumption. The association between PM10–2.5 and PAI-1 remained unchanged with adjustment for PM2.5, ozone, nitrogen dioxide, and carbon monoxide. Conclusions Long-term PM10–2.5 exposure may be associated with changes in coagulation independently from PM2.5, and thus, contribute to CVD risk in midlife women.

Body weight: reduction by long-term glycerol treatment

Science ◽  
1977 ◽  
Vol 198 (4323) ◽  
pp. 1271-1274 ◽  
Author(s):  
D Wirtshafter ◽  
J. Davis
Keyword(s):  
Body Weight ◽  
Weight Reduction ◽  
Body Weight Reduction ◽  
Glycerol Treatment

ESTIMATING THE EFFECTS OF LONG-TERM EXPOSURE TO AMBIENT PARTICULATE AIR POLLUTION ON BIOLOGICAL MARKERS OF CARDIOVASCULAR RISK IN A COHORT OF MIDLIFE WOMEN

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Rochelle Green ◽  
Rachel Broadwin ◽  
Brian Malig ◽  
Rupa Basu ◽  
Ellen B. Gold ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cardiovascular Risk ◽  
Biological Markers ◽  
Midlife Women ◽  
Particulate Air Pollution
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