Isolated uncontrolled hypertension at home and in the office among treated hypertensive patients from the J-HOME study

Abstract Background: - Uncontrolled hypertension is if SBP is ≥140 mm Hg and/or DBP ≥90 mm Hg for general hypertensive population or if SBP ≥130 mm Hg and/or DBP ≥80 mm Hg in patients with established diabetes mellitus or chronic kidney disease based on the average of two or more properly measured, seated, BP readings on each of two or more office visits. The aim of this study was to assess the magnitude of uncontrolled hypertension and associated factors among adult hypertensive patients in public hospitals of central zone, Tigray, Ethiopia, 2018. Methods:- A hospital based cross sectional study design was used. The study population was all sampled adult hypertensive patients who had follow up in public hospitals of central zone, Tigray and the data collection period was from March 01 to April 30, 2018. About 421 study participants were selected using systematic random sampling. Interviewer administered structured questionnaire, chart review checklist and measurements were used. The collected data was checked for its completeness manually and then entered and cleaned in to epi data version 3.1 and exported to Statistical packages for social science version 22 for analysis. Bivariate and multivariable analyses were done to identify factors of uncontrolled hypertension. Then those variables significant at p<0.25 with the outcome variable in bivariate analysis were selected for multivariable analysis and odds ratio with 95% confidence level was computed and p-value < 0.05 was described as a significant association in multivariable analysis. Result: - Among 421 respondents about 177(42%) had uncontrolled hypertension. Co-morbidity [AOR=0.36, (0.205, 0.631)], five to ten years duration of medication taken [AOR=0.398, (0.218, 0.725)], side effect of medication [AOR=0.542, (0.339, 0.866)] and medication adherence [AOR=4.092, (2.419, 6.924)] were significantly associated with uncontrolled hypertension. Conclusion: - In this study the magnitude of uncontrolled hypertension was high. Co-morbidity, antihypertensive medication taken for long duration, side effect of antihypertensive medication and non adherence to antihypertensive medication shows statistical association with uncontrolled hypertension.

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Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry

European Heart Journal ◽

10.1093/eurheartj/ehz118 ◽

2019 ◽

Vol 40 (42) ◽

pp. 3474-3482 ◽

Cited By ~ 45

Author(s):

Felix Mahfoud ◽

Michael Böhm ◽

Roland Schmieder ◽

Krzysztof Narkiewicz ◽

Sebastian Ewen ◽

...

Keyword(s):

Renal Function ◽

Real World ◽

Active Sites ◽

Renal Denervation ◽

Uncontrolled Hypertension ◽

Open Label ◽

Hypertensive Patients ◽

Safety And Efficacy

Abstract Aims Several studies and registries have demonstrated sustained reductions in blood pressure (BP) after renal denervation (RDN). The long-term safety and efficacy after RDN in real-world patients with uncontrolled hypertension, however, remains unknown. The objective of this study was to assess the long-term safety and efficacy of RDN, including its effects on renal function. Methods and results The Global SYMPLICITY Registry is a prospective, open-label registry conducted at 196 active sites worldwide in hypertensive patients receiving RDN treatment. Among 2237 patients enrolled and treated with the SYMPLICITY Flex catheter, 1742 were eligible for follow-up at 3 years. Baseline office and 24-h ambulatory systolic BP (SBP) were 166 ± 25 and 154 ± 18 mmHg, respectively. SBP reduction after RDN was sustained over 3 years, including decreases in both office (−16.5 ± 28.6 mmHg, P < 0.001) and 24-h ambulatory SBP (−8.0 ± 20.0 mmHg; P < 0.001). Twenty-one percent of patients had a baseline estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. Between baseline and 3 years, renal function declined by 7.1 mL/min/1.73 m2 in patients without chronic kidney disease (CKD; eGFR ≥60 mL/min/1.73 m2; baseline eGFR 87 ± 17 mL/min/1.73 m2) and by 3.7 mL/min/1.73 m2 in patients with CKD (eGFR <60 mL/min/1.73 m2; baseline eGFR 47 ± 11 mL/min/1.73 m2). No long-term safety concerns were observed following the RDN procedure. Conclusion Long-term data from the Global SYMPLICITY Registry representing the largest available cohort of hypertensive patients receiving RDN in a real-world clinical setting demonstrate both the safety and efficacy of the procedure with significant and sustained office and ambulatory BP reductions out to 3 years.

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The current status of home and office blood pressure control among hypertensive patients with diabetes mellitus: The Japan Home Versus Office Blood Pressure Measurement Evaluation (J-HOME) study

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2006.01.015 ◽

2006 ◽

Vol 73 (3) ◽

pp. 276-283 ◽

Cited By ~ 19

Author(s):

Taku Obara ◽

Takayoshi Ohkubo ◽

Masahiro Kikuya ◽

Kei Asayama ◽

Hirohito Metoki ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Blood Pressure Measurement ◽

Pressure Control ◽

Office Blood Pressure ◽

Current Status ◽

Hypertensive Patients ◽

Home Study ◽

Measurement Evaluation ◽

Patients With Diabetes

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Determining the Earliest Time within 30 Minutes to Erectogenic Effect after Tadalafil 10 and 20 mg: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled, At‐Home Study

Journal of Sexual Medicine ◽

10.1111/j.1743-6109.2004.04028.x ◽

2004 ◽

Vol 1 (2) ◽

pp. 193-200 ◽

Cited By ~ 26

Author(s):

Raymond C. Rosen ◽

Harin Padma‐Nathan ◽

Ridwan Shabsigh ◽

Khalil Saikali ◽

Vish Watkins ◽

...

Keyword(s):

Double Blind ◽

Double Blind Placebo ◽

Home Study ◽

At Home

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Characteristics of resistant hypertension determined by self-measured blood pressure at home and office blood pressure measurements: the J-HOME study

Journal of Hypertension ◽

10.1097/01.hjh.0000242397.53214.27 ◽

2006 ◽

Vol 24 (9) ◽

pp. 1737-1743 ◽

Cited By ~ 58

Author(s):

Takuya Oikawa ◽

Taku Obara ◽

Takayoshi Ohkubo ◽

Masahiro Kikuya ◽

Kei Asayama ◽

...

Keyword(s):

Blood Pressure ◽

Resistant Hypertension ◽

Office Blood Pressure ◽

Pressure Measurements ◽

Home Study ◽

At Home

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Prevalence of Controlled Systemic Hypertension and Its Associated Risk Factors among Hypertensive Patients at Mbeya Zonal Referral Hospital, Tanzania.

10.21203/rs.3.rs-571424/v1 ◽

2021 ◽

Author(s):

Samson Peter Mvandal ◽

Victor Jastin Mwinuka

Keyword(s):

Risk Factors ◽

Salt Intake ◽

Clinic Visit ◽

Referral Hospital ◽

Uncontrolled Hypertension ◽

Systemic Hypertension ◽

Cross Sectional ◽

Hypertensive Patients ◽

Financial Challenges ◽

Associated Risk Factors

Abstract Objectives To determine the prevalence of controlled systemic hypertension and its associated risk factors among the hypertensive patients who attended the clinic at Mbeya Zonal Referral Hospital in Tanzania. Methods A descriptive cross-sectional quantitative study was used determine the prevalence of co to 252 hypertensive patients were recruited during clinic visit from September to November 2020 and participant was randomly selected interviews using structured self-administered questionnaires. Data was analyzed using chi square test to find the risk factors associated with controlled hypertension. Results Among 252 participants, 94(39.7%) individuals with controlled hypertension giving the prevalence of controlled hypertension. The proportion of females with controlled hypertension was slightly higher than male (49 females to 45 males). The prevalence of uncontrolled hypertension was 152(60.3%) participants. The prevalence of controlled hypertension was higher among patients who have regular clinic visit (p < .05) and have daily adherence to their anti-hypertensive medication. A similar trend was observed among participants without financial challenges to attend clinic, short duration of illness, higher level of education and there was no association between age, sex, marital status, smoking, alcohol consumption, having health insurance and having chronic illness. Conclusion Prevalence of controlled hypertension is higher among patients who have regular clinic visit and have daily adherence to their anti-hypertensive medication. Also, it is higher among participants without financial challenges to attend clinic so they can have regular clinic visit and checkup. Reinforcement on regular drug intake and clinic visit, good nutrition and reduced salt intake and modifying lifestyles of patient with hypertension is important.

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