PS 14-62 FLUVOXAMINE INFLUENCE ON DISTURBING - DEPRESSIVE DISORDER AT PATIENTS WITH ESSENTIAL HYPERTENSION HYPERTENSIVE, COMPLICATED BY CHRONIC HEART FAILURE.

2016 ◽  
Vol 34 (Supplement 1) ◽  
pp. e451
Author(s):  
Sojida Djalilova ◽  
Nodira Makhamatjanova ◽  
Zarifboy Ibodullayev ◽  
Saida Sadikova ◽  
Dilshoda Abdullayeva
Keyword(s):  
Heart Failure ◽  
Essential Hypertension ◽  
Chronic Heart Failure ◽  
Depressive Disorder

scholarly journals Dermatoglyphic pattern in the men with essential hypertension, who are carriers of the polymorphic genes of angiotensin II type 1 receptors

2018 ◽  
pp. 29-36
Author(s):  
V. O. Ruzhanska
Keyword(s):  
Heart Failure ◽  
Essential Hypertension ◽  
Angiotensin Ii ◽  
Cardiovascular Diseases ◽  
Chronic Heart Failure ◽  
Left Hand ◽  
The Third ◽  
Polymorphic Genes ◽  
Ulnar Loop

Essential hypertension and its common complication - chronic heart failure, is one of the most significant medical, economic and social problems in the XXI century. At the same time, this pathology is 30-40% genetically predisposed. One of significant pathogenic factors is the inheritance of definite variants of genes, coding the receptors to angiotensin II type 1. For this reason, the effective and inexpensive researches for screening of the mentioned genetic phenomenon are being carried out. Objective: to improve the screening diagnostic methods for carriers of polymorphic genes of angiotensin II type 1 receptors with essential hypertension and essential hypertension complicated by chronic heart failure. There were studied dermatoglyphic prints of men 40-60 years, who are carriers of polymorphic gene variants of angiotensin II type 1 receptor with no cardiovascular diseases (n=79), male patients with essential hypertension and hypertrophy of the myocardium (stage II), II-III stages (n=62) and essential hypertension (n=50) complicated by chronic heart failure, residents of Podillya region of Ukraine. Genotyping of the gene of angiotensin II type 1 receptor was performed using polymerase chain reaction. All patients included in the control group and those with essential hypertension underwent dermatoglyphic examination of fingers on both hands using modern portable rolling scanner Futronic FS50 (Korea). Interpretation and decoding of dermatoglyphic prints was conducted by T. D. Gladkova’s method. Statistical analysis was done on personal computer using standard statistical package “STATISTICA 10.0”. The found ulnar loop was dominant dermatoglyphic print regardless of the presence or absence of essential hypertension and chronic heart failure in 40-60 year old men. Besides, positive correlation relationship was revealed between the inheritance gene of angiotensin II type 1 receptors and fingerprint patterns: the third finger on the left hand in males with no cardiovascular pathology (weak strength) and the second finger on the right hand in patients with essential hypertension (medium strength). In individuals with no cardiovascular diseases, carriers of genotype A1166A, prevalence of ulnar loop on the third finger of left hand is higher than in carriers of C allele gene of angiotensin II type 1 receptors. In males with essential hypertension, carriers of C allele, degree of incidence of the whorl on the second finger of right hand is significantly higher than in carriers of genotype А1166А, offering the possibility to determine the carriership of a particular gene of angiotensin II type 1 receptors. Carrying out dermatoglyphic examination in patients with an increase in blood pressure and determining the variant of carrier of the gene of the receptor to angiotensin II type 1 will make it possible to facilitate the selection of those individuals who in the future need to spend all the necessary amount of research to confirm the diagnosis of essential hypertension and the possible development of complications of the course of this cardiovascular disease.

scholarly journals Modern biomarker cardiotrophin-1 in the diagnosis of myocardial diastolic function in men with essential hypertension

2020 ◽  
Vol 24 (3) ◽  
pp. 460-464
Author(s):  
M. O. Matokhniuk ◽  
V. M. Zhebel ◽  
L. V. Kulchevich ◽  
O. K. Shevchuk
Keyword(s):  
Heart Failure ◽  
Essential Hypertension ◽  
Chronic Heart Failure ◽  
Diastolic Function ◽  
Enzyme Linked Immunosorbent Assay ◽  
Chain Reaction ◽  
Standard Statistical Package ◽  
Polymerase Chain ◽  
Mathematical Processing

Annotation. The aim of the study was to improve the diagnosis of myocardial diastolic function in men with essential hypertension and chronic heart failure with different variants of the cardiotrophin-1 gene. 100 people aged 40–60 were examined: 50 men with asymptomatic essential hypertension and 50 men with essential hypertension complicated by chronic heart failure. Genotyping of the cardiotrophin-1 gene was performed by polymerase chain reaction. Determination of the concentration of cardiotrophin-1 was performed by enzyme-linked immunosorbent assay. Structural and functional parameters of the myocardium were evaluated using ultrasound of the heart. Mathematical processing of the material was performed on a personal computer using the standard statistical package SPSS 10. It was found that in persons with essential hypertension and chronic heart failure, carriers of the GA + AA variant of the cardiotrophin-1 gene (rs8046707) have significantly higher plasma peptide levels with diastolic dysfunction (p <0.05).

scholarly journals Inflammation Markers and Major Depressive Disorder in Patients With Chronic Heart Failure

2015 ◽  
Vol 77 (7) ◽  
pp. 808-815 ◽  
Author(s):  
Glen L. Xiong ◽  
Kevin Prybol ◽  
Stephen H. Boyle ◽  
Russell Hall ◽  
Robert D. Streilein ◽  
...  
Keyword(s):  
Heart Failure ◽  
Major Depressive Disorder ◽  
Chronic Heart Failure ◽  
Depressive Disorder ◽  
Inflammation Markers ◽  
Major Depressive

scholarly journals Systemic Action of Inflammatory Mediators in Patients with Essential Hypertension and Diastolic Chronic Heart Failure: A Clinical Pathophysiological Study

2020 ◽  
Vol 27 (1) ◽  
pp. 30-43
Author(s):  
Anton V. Barsukov ◽  
Alla Yu. Seidova ◽  
Ksenia A. Shcherbakova ◽  
Marina S. Black ◽  
Alexander E. Korovin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Essential Hypertension ◽  
Chronic Heart Failure ◽  
Left Ventricular ◽  
Volume Index ◽  
Left Ventricular Ejection ◽  
Female Patients ◽  
Tnf Α ◽  
Α Level ◽  
Second Degree

The aim of this research was to correlate indicators of proinflammatory status and the structural/functional characteristics of the cardiovascular system comparatively in male and female patients with essential hypertension (EH) complicated by diastolic chronic heart failure (CHF) with preserved left ventricular ejection fraction (LVEF). The study included 104 middle-aged patients (55 males (M) and 49 females (F)) with first- or second-degree EH complicated by CHF with preserved LVEF. They all belonged to the low functional class of CHF, with LVEF ≥50%, first- or second-degree of LV diastolic dysfunction (LVDD), LV hypertrophy (LVH), and dilatation of the left atrium (LA) with a sinus rhythm and N-terminal brain natriuretic peptide >125 pg/mL. Serum levels of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) were measured. To identify the relationship between the proinflammatory pattern and cardiovascular parameters, Spearman’s rank correlation coefficients were determined. M had markedly higher levels of CRP, TNF-α, and IL-6 compared to F. However, all the mean values corresponded to the reference range. Significant direct associations of CRP level with the LV mass index (LVMI), relative wall thickness (RWT), LA volume index (LAVI), E/e’ ratio, and systolic and diastolic blood pressure (SBP, DBP) existed in both M and F, as well as negative correlations of CRP with LVDD parameter e’ and distance covered in a 6 min walk test. M and F had a positive association between IL-6 and LVMI, LAVI, E/e’ ratio, SBP, RWT, and DBP, as well as strong negative associations between IL-6 and e’ and distance passed in 6 min in each group. Significant direct correlations existed between serum TNF-α level and LVMI, RWT, LAVI, E/e’, SBP, and DBP both in M and F. Furthermore, there were negative relationships of TNF-α level with e’ and the distance covered for the 6 min walk. This study demonstrated a close relationship between the blood levels of proinflammatory autacoids and indicators of EH, exercise tolerance, LVH, LVDD, and LA enlargement, regardless of the patient’s sex. Compared to female patients, male patients had stronger correlations of CRP, TNF-α, and IL-6 levels with indicators of LVDD degree.

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