Inflammation Markers and Major Depressive Disorder in Patients With Chronic Heart Failure

Major depressive disorder is one of the leading causes of disability in the world since depression is highly frequent and causes a strong burden. In order to reduce the duration of depressive episodes, clinicians would need to choose the most effective therapy for each individual right away. A prerequisite for this would be to have biomarkers at hand that would predict which individual would benefit from which kind of therapy (for example, pharmacotherapy or psychotherapy) or even from which kind of antidepressant class. In the past, neuroimaging, electroencephalogram, genetic, proteomic, and inflammation markers have been under investigation for their utility to predict targeted therapies. The present overview demonstrates recent advances in all of these different methodological areas and concludes that these approaches are promising but also that the aim to have such a marker available has not yet been reached. For example, the integration of markers from different systems needs to be achieved. With ongoing advances in the accuracy of sensing techniques and improvement of modelling approaches, this challenge might be achievable.

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Prevalence and Correlates of Major Depressive Disorder in Nigerian Outpatients With Heart Failure

Psychosomatics ◽

10.1176/appi.psy.47.6.479 ◽

2006 ◽

Vol 47 (6) ◽

pp. 479-485 ◽

Cited By ~ 12

Author(s):

Abiodun O. Adewuya ◽

Bola A. Ola ◽

Olufemi E. Ajayi ◽

Adebayo O. Oyedeji ◽

Michael O. Balogun ◽

...

Keyword(s):

Heart Failure ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Major Depressive

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Depression and one-year survival of patients with heart failure in China: analysis from the China-PEACE Prospective Heart Failure study

European Heart Journal ◽

10.1093/ehjci/ehaa946.1166 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

M Gao ◽

F Xing ◽

D Hu ◽

X Huang ◽

S Hu ◽

...

Keyword(s):

Heart Failure ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Hospitalized Patients ◽

Public Institution ◽

Funding Source ◽

Minor Depression ◽

Major Depressive ◽

Patients With Heart Failure ◽

All Cause Mortality

Abstract Background Depression is prevalent among patients with heart failure (HF), but data exploring association of depression with risk of death in patients with HF is scarce in China. We investigated the relationship between depression and all-cause mortality of heart failure in China. Methods In China PEACE 5p-HF Study, we prospectively enrolled patients primarily hospitalized with HF from 52 diverse hospitals throughout China during 2016–2018. All the patients were followed up for 1 year. About 10% patients in the cohort from 41 hospitals was included for the measurement of depression state at convenience. Depression was measured by the Patient Health Questionnaire-8 depression scale (PHQ-8) at baseline. Depression state was categorized into major depressive disorder (10–24 points), minor depression (5–10 points) and no depression (0–5 points). Cox proportional hazards regression analyses, controlling for established risk factors as age, gender, LVEF, NYHA, medication use and medical history, were used to evaluate how depression were related to end point of death from any cause. Results Total 584 patients were included in our analysis, with median age 69 (IQR 60–77) years, and 40.8% female. Among these patients, 36.0% had major depressive disorder (n=210), 33.9% had minor depression (n=198). There were 70 (12%) patients died within 1 year after discharge. Major depressive disorder was associated with higher all-cause mortality compared with no depression (hazard ratio=2.18, 95% confidence interval 1.36–3.50, p=0.001). While minor depression was not significantly associated with all-cause mortality. Conclusions Major depression is an independent risk factor for all-cause mortality in hospitalized patients with HF in China. It is necessary to screen for psychological health in hospitalized patients to targeting intervention. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): National Key Research and Development Program from the Ministry of Science and Technology of China

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Association of Major Depressive Disorder on Heart Failure With Reduced and Preserved Ejection Fraction: Analysis of National Readmission Database 2018

Cureus ◽

10.7759/cureus.15107 ◽

2021 ◽

Author(s):

Harshith S Thyagaturu ◽

Sittinun Thangjui ◽

Kashyap Shah ◽

Riddhima V Naik ◽

Gayatri Bondi

Keyword(s):

Heart Failure ◽

Major Depressive Disorder ◽

Ejection Fraction ◽

Depressive Disorder ◽

Preserved Ejection Fraction ◽

Major Depressive ◽

National Readmission Database

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Abstract P230: Antidepressant Use and Incident Heart Failure among Veterans with and without HIV Infection and Major Depressive Disorder

Circulation ◽

10.1161/circ.131.suppl_1.p230 ◽

2015 ◽

Vol 131 (suppl_1) ◽

Author(s):

Jessica R White ◽

Chung-Chou H Chang ◽

Kaku A Armah ◽

Jesse C Stewart ◽

Samir K Gupta ◽

...

Keyword(s):

Heart Failure ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Hiv Infection ◽

Lower Risk ◽

Tricyclic Antidepressant ◽

Cox Proportional Hazards ◽

Major Depressive ◽

Increased Risk ◽

Antidepressant Use

Depression is associated with an increased risk of heart failure (HF) among HIV infected (HIV+) and uninfected (HIV-) veterans. Antidepressants are commonly prescribed to mitigate psychosocial symptoms related to major depressive disorder (MDD). The purpose of this study was to determine whether antidepressant use was associated with lower HF risk among a large cohort of HIV+ and HIV- veterans with MDD. We analyzed data on 13,849 veterans (36.5% HIV+) from the Veterans Aging Cohort Study (VACS), a prospective study of HIV+ and matched HIV- veterans who had a diagnosis of MDD (ICD-9 codes 296.2x & 296.3x) and were free of cardiovascular disease (CVD) at baseline. Antidepressant use was defined as documentation of selective serotonin reuptake inhibitor (SSRIs), tricyclic antidepressant (TCAs), and non-SSRI, non-TCA antidepressant use from the VA pharmacy records during the baseline period (1998 - 2003). Incident HF was identified using ICD-9 codes and defined as first HF event on or after 4/1/2003 until 12/31/2009. We used Cox proportional hazards regression to assess the association between HIV infection, antidepressant use and incident HF, adjusting for covariates (Table). Most participants were on antidepressant therapy [90.2% (12,498 of 13,849)]. In the total sample, baseline antidepressant use was associated with a lower risk of HF, adjusting for all covariates including HIV (adjusted HR = 0.76, 95% CI = 0.58 - 0.99). The rates of incident HF were highest among HIV+ participants who did not use antidepressants (Table). Among the HIV+ participants, the association between antidepressant use and lower HF risk neared significance (p = 0.053). Antidepressant use was common among this cohort of veterans with MDD and was associated with a lower risk of incident HF. Our study lends support to further investigations to determine the importance of antidepressants as additional therapy for CVD prevention among MDD patients with and without HIV.

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