Humankind is on the move all the time, but in the past few decades this movement has become massive in different parts of the world. We are living in an era of unprecedented mobility of ideas, technology, money, and people. Globalization has changed the world and is continuing to change the relationships between nation-states, corporations, and international organizations. By 2030, 80% of the world’s poor will be living in an area defined as ‘fragile’—a status that may reflect any number of political, social, security, economic, or environmental causes, forcing millions who are suffering to flee their country and homes. The CAPE Vulnerability Index tool helps assess the causes of violent conflict, terrorism, climate change, poverty, inequality and injustice, migration and displacement through this new axis of geopolitical determinants of health rather than focusing disproportionately on the effects. Leaders across the globe have a moral imperative to provide security, economic prosperity, and well-being to their people, but the policy needs to be fit for the local environment, be it geographical, political, or cultural, to help people to function well.