Characterization of Chromosomal Rearrangements in Hematological Diseases Using Spectral Karyotyping

2004 ◽  
Vol 13 (3) ◽  
pp. 190-195 ◽  
Author(s):  
Joëlle Tchinda ◽  
Thomas E Neumann ◽  
Sarah Volpert ◽  
Wolfgang E Berdel ◽  
Thomas Büchner ◽  
...  
Keyword(s):  
Chromosomal Rearrangements ◽  
Spectral Karyotyping ◽  
Hematological Diseases

The characterization of chromosomal rearrangements by a combined micro-FISH approach in a patient with myelodysplastic syndrome

1995 ◽  
Vol 83 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Jia Xu ◽  
Edward Cedrone ◽  
Michele Roberts ◽  
Guan Wu ◽  
Sten Gershagen ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Chromosomal Rearrangements

Abstract 5605: Spectral karyotyping characterization of ovarian adenocarcinomas and corresponding cell lines and xenografts

2014 ◽  
Author(s):  
Marileila Varella-Garcia ◽  
Isabel M. Bernal ◽  
Sakshi Mahale ◽  
Evelyn M. Musselwhite ◽  
Victor Stastny ◽  
...  
Keyword(s):  
Cell Lines ◽  
Spectral Karyotyping ◽  
Ovarian Adenocarcinomas

scholarly journals Chromosomal Rearrangements in Post-Chernobyl Papillary Thyroid Carcinomas: Evaluation by Spectral Karyotyping and Automated Interphase FISH

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Ludwig Hieber ◽  
Reinhard Huber ◽  
Verena Bauer ◽  
Quirin Schäffner ◽  
Herbert Braselmann ◽  
...  
Keyword(s):  
Chromosomal Rearrangements ◽  
Primary Cultures ◽  
Genomic Rearrangements ◽  
Fish Analysis ◽  
Spectral Karyotyping ◽  
Papillary Thyroid ◽  
Chromosome 11 ◽  
Structural Genomic ◽  
Interphase Cell ◽  
Thyroid Carcinomas

Structural genomic rearrangements are frequent findings in human cancers. Therefore, papillary thyroid carcinomas (PTCs) were investigated for chromosomal aberrations and rearrangements of the RET proto-oncogene. For this purpose, primary cultures from 23 PTC have been established and metaphase preparations were analysed by spectral karyotyping (SKY). In addition, interphase cell preparations of the same cases were investigated by fluorescencein situhybridisation (FISH) for the presence of RET/PTC rearrangements using RET-specific DNA probes. SKY analysis of PTC revealed structural aberrations of chromosome 11 and several numerical aberrations with frequent loss of chromosomes 20, 21, and 22. FISH analysis for RET/PTC rearrangements showed prevalence of this rearrangement in 72% (16 out of 22) of cases. However, only subpopulations of tumour cells exhibited this rearrangement indicating genetic heterogeneity. The comparison of visual and automated scoring of FISH signals revealed concordant results in 19 out of 22 cases (87%) indicating reliable scoring results using the optimised scoring parameter for RET/PTC with the automated Metafer4 system. It can be concluded from this study that genomic rearrangements are frequent in PTC and therefore important events in thyroid carcinogenesis.

scholarly journals Characterization of complex chromosomal rearrangements by targeted capture and next-generation sequencing

2011 ◽  
Vol 21 (10) ◽  
pp. 1720-1727 ◽  
Author(s):  
N. L. M. Sobreira ◽  
V. Gnanakkan ◽  
M. Walsh ◽  
B. Marosy ◽  
E. Wohler ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Chromosomal Rearrangements ◽  
Next Generation ◽  
Complex Chromosomal Rearrangements ◽  
Targeted Capture ◽  
Generation Sequencing

scholarly journals Characterization of Chromosomal Changes in 17 Children with Acute Lymphoblastic Leukemia and Hyperdiploidy Using Spectral Karyotyping (SKY)

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 144A-144A
Author(s):  
Elisabeth Blennow ◽  
Ann Nordgren ◽  
Filip Farnebo ◽  
Stefan Soderhall ◽  
Magnus Nordenskjold
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Spectral Karyotyping ◽  
Chromosomal Changes

Cytogenetic characterization of NCI-H69 and NCI-H69AR small cell lung cancer cell lines by spectral karyotyping

2009 ◽  
Vol 191 (2) ◽  
pp. 97-101 ◽  
Author(s):  
Marta Salido ◽  
Edurne Arriola ◽  
Alma Carracedo ◽  
Israel Cañadas ◽  
Ana Rovira ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Small Cell ◽  
Spectral Karyotyping ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Cytogenetic Characterization
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