Antenatal thalassaemia screening – determining the appropriate mean corpuscular volume (MCV) cut-off for excluding alpha thalassaemia

Pathology ◽  
2015 ◽  
Vol 47 ◽  
pp. S57
Author(s):  
Koon Lee ◽  
Carol Cheung
Keyword(s):  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Alpha Thalassaemia

scholarly journals Thalassaemia genes in Baghdad, Iraq

2021 ◽  
Vol 2 (2) ◽  
pp. 315-319
Author(s):  
Hassan I. Yahya ◽  
Khalid J. Khalel ◽  
Nasir A. S. Al AlIawi ◽  
Ferial Helmi
Keyword(s):  
Maternity Care ◽  
Screening Test ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Prevalence Rates ◽  
Care Clinic ◽  
Beta Thalassaemia ◽  
Thalassaemia Trait ◽  
Alpha Thalassaemia ◽  
The City

To estimate the prevalence of thalassaemia genes in Baghdad, a study was made of 502 randomly selected pregnant women attending a major maternity care clinic in the city. A reduced mean corpuscular volume [MCV] of < 80 fl was used as a screening test for thalassaemia in this population, followed by a battery of tests, including haemoglobin analysis and iron studies, to confirm the diagnosis. Using this approach, 22 cases were diagnosed of beta-thalassaemia trait, five cases of alpha-thalassaemia trait and one case of delta beta-thalassaemia trait. Based on these figures the estimated prevalence rates of beta-, alpha- and delta beta-thalassaemia traits in Baghdad, would be 4.4%, 1.0% and 0.2%, respectively. The study also includes a discussion of the above findings in the context of those reported in other neighbouring countries

Prevalence of anaemia and it's associated risk factors among under five children at Mukinge Missions Hospital in Kasempa District: Retrospective Study (Preprint)

2019 ◽  
Author(s):  
Lloyd Sampa
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Mean Corpuscular Volume ◽  
Sub Saharan Africa ◽  
Corpuscular Volume ◽  
Under Five ◽  
Under Five Children ◽  
Mission Hospital ◽  
Associated Risk Factors ◽  
Prevalence Of Anemia

BACKGROUND Anemia is a worldwide major problem known to affect people throughout the world. It has an adverse effect on both the social and economic development. The worldwide prevalence of anemia is 9% in developed nations. The global estimate indicates that 293.1 million of children under five years, approximately 43%, are anaemic worldwide and 28.5% of these children are found in sub Saharan Africa. In Zambia specifically Kasempa, no documented studies on prevalence have been done. Despite iron supplementation being given to pregnant women and the availability of blood transfusion. The burden of the disease remains high as determined by high mortality and morbidity. This study aims at determining the prevalence of anemia and the associated risk factors among under-five children at Mukinge Mission Hospital in Kasempa District. Knowledge of prevalence and the associated risk factors of anaemia will enhance early detection and timely management. OBJECTIVE 1.To determine the hemoglobin status of anaemia by its severity among anaemic under-five children admitted at Mukinge Mission Hospital. 2.To assess the association of anaemia with Malaria among under-five children admitted at Mukinge Mission Hospital. METHODS This was a retrospective study review of under-five children that were diagnosed and managed of Anemia at Mukinge Missions Hospital, over the period of period of 2015, 2017 and 2018. .Data of the variables of interest was extracted and analyzed using SPSS. RESULTS A sample population of 52 children was included in our study. The majority of the children were females 28 (53.8 %) and 24 (46.2 %) were Males. It was found that moderate and severe anaemia was 17.3% and 82.7 % respectively. Additionally, Majority of the anaemic children (75%) had Normocytic anaemia. The Pearson Chi square test revealed no statistical relationship between the variables; Malaria (p=0.58), Age (P=0.82), Gender (P=0.91). CONCLUSIONS According to our study, 39 (75%) had normal mean corpuscular volume which could suggest chronic diseases and sickle cell anemia. 11 (21.2%) had a low mean corpuscular volume indicating Microcytic anemia which could suggest diseases such as iron deficiency and thalassemia among many other causes. However, we were unable to determine the specific cause of anemia.

scholarly journals Vitamin D and Blood Parameters

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1017
Author(s):  
Thomas Müller ◽  
Lutz Lohse ◽  
Andreas Blodau ◽  
Katja Frommholz
Keyword(s):  
Vitamin D ◽  
Mean Corpuscular Volume ◽  
Plasma Concentrations ◽  
Blood Parameters ◽  
Vitamin D Supplementation ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Volume ◽  
Corpuscular Haemoglobin ◽  
Mean Corpuscular Haemoglobin ◽  
The Impact

Background: Vitamin D has a steroid- and an anabolic-resembling chemical structure. Vitamin D is essential for many processes in the human body after hydroxylation. Aims of the Study: To investigate the impact of 25-hydroxy-vitamin D plasma concentrations on the blood parameters number of erythrocytes, hematocrit, mean corpuscular hemoglobin and mean corpuscular volume. Methods: Serial assessments were done in 290 patients with multiple sclerosis and repeated after a mean interval of 245 days. A recommendation for vitamin D supplementation was given in case of a concentration lower than 20 ng/mL combined with a prescription of a formulation containing vitamin D but not vitamin K. Results: There was a fall of vitamin D in 119 subjects and a rise in 164, while no change appeared in 7 participants. When vitamin D values went down between both assessments moments, the computed increase of mean corpuscular haemoglobin was significantly lower compared with the rise of mean corpuscular haemoglobin associated with a vitamin D elevation. When vitamin D declined, the computed fall of mean corpuscular volume fall was significantly lower compared with the decrease of mean corpuscular volume, when vitamin D rose. Positive correlations were found between differences of vitamin D and mean corpuscular haemoglobin, respectively mean corpuscular volume. Inverse relations appeared between disparities of vitamin D and erythrocytes, respectively haematocrit. Conclusions: The elevation of vitamin D plasma levels provides enhanced preconditions for a better tissue oxygenation on a cellular level.

scholarly journals Inaccuracy in automated measurement of hematocrit and corpuscular indices in the presence of severe hyperglycemia

Blood ◽  
1981 ◽  
Vol 57 (6) ◽  
pp. 1065-1067 ◽  
Author(s):  
JA Strauchen ◽  
W Alston ◽  
J Anderson ◽  
Z Gustafson ◽  
LF Fajardo
Keyword(s):  
Blood Glucose ◽  
Mean Corpuscular Volume ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Volume ◽  
Automated Measurement ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin ◽  
Hyperosmolar Glucose

Abstract Because we recently observed two patients with severe diabetic hyperglycemia and spuriously elevated electronically determined hematocrit and mean corpuscular volume (MCV), we investigated the effect of hyperglycemia on two popular automated hematology systems, the Coulter S and Ortho ELT-8. Marked hyperglycemia (blood glucose 800-- 2000 mg/dl) caused consistent overestimation of the electronically determined MCV compared to that derived from a simultaneous spun microhematocrit. The resultant overestimation and underestimation, respectively, of the derived values for hematocrit and mean corpuscular hemoglobin concentration may be clinically misleading. The mechanism of MCV elevation in hyperglycemia appears to be swelling of hyperosmolar glucose “loaded” erythrocytes when diluted into “isotonic” counting medium. This effect is readily circumvented by determination of a spun microhematocrit.

Etanercept-induced leukemia: could increased mean corpuscular volume be a predictor of hematologic malignancy?

2017 ◽  
Vol 37 (8) ◽  
pp. 1381-1385 ◽  
Author(s):  
Döndü Üsküdar Cansu ◽  
Hava Üsküdar Teke ◽  
Cengiz Korkmaz
Keyword(s):  
Mean Corpuscular Volume ◽  
Hematologic Malignancy ◽  
Corpuscular Volume

scholarly journals Erythrocyte mean corpuscular volume during cytotoxic therapy is a predictive parameter of secondary leukemia in Hodgkin's disease

Cancer ◽  
1987 ◽  
Vol 59 (2) ◽  
pp. 301-304 ◽  
Author(s):  
Aimery De Gramont ◽  
Christophe Louvet ◽  
Marcel Krulik ◽  
Nicole Smadja ◽  
Daniel Donadio ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Mean Corpuscular Volume ◽  
Hodgkin’S Disease ◽  
Corpuscular Volume ◽  
Secondary Leukemia ◽  
Cytotoxic Therapy

scholarly journals Hematologic differences between African-Americans and whites: the roles of iron deficiency and α-thalassemia on hemoglobin levels and mean corpuscular volume

Blood ◽  
2005 ◽  
Vol 106 (2) ◽  
pp. 740-745 ◽  
Author(s):  
Ernest Beutler ◽  
Carol West
Keyword(s):  
African American ◽  
African Americans ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Blood Cell Count ◽  
Iron Deficient ◽  
The Difference

Abstract The average results of some laboratory measurements, including the hemoglobin, mean corpuscular volume (MCV), serum transferrin saturation (TS), serum ferritin, and white blood cell count of African-Americans differ from those of whites. Anonymized samples and laboratory data from 1491 African-American and 31 005 white subjects, approximately equally divided between men and women, were analyzed. The hematocrit, hemoglobin, MCV, TS, and white blood cell counts of African-Americans were lower than those of whites; serum ferritin levels were higher. When iron-deficient patients were eliminated from consideration the differences in hematocrit, hemoglobin, and MCV among women were slightly less. The -3.7-kilobase α-thalassemia deletion accounted for about one third of the difference in the hemoglobin levels of African-Americans and whites and neither sickle trait nor elevated creatinine levels had an effect. Among all subjects, 19.8% of African-American women would have been classified as “anemic” compared with 5.3% of whites. Among men, the figures were 17.7% and 7.6%. Without iron-deficient or thalassemic subjects, the difference had narrowed to 6.1% and 2.77% and to 4.29% and 3.6%, respectively. Physicians need to take into account that the same reference standards for hemoglobin, hematocrit, MCV, and TS and the white blood cell count do not apply to all ethnic groups. (Blood. 2005;106:740-745)

scholarly journals Influence of seasonality and pollution on the hematological parameters of the estuarine fish Centropomus parallelus

2013 ◽  
Vol 61 (2) ◽  
pp. 105-111 ◽  
Author(s):  
Robson Seriani ◽  
Denis Moledo de Souza Abessa ◽  
Camilo D. S. Pereira ◽  
Aline A. Kirschbaum ◽  
Andrea Assunção ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Mean Corpuscular Volume ◽  
Hematological Parameters ◽  
Absolute Number ◽  
Aquatic Pollution ◽  
Estuarine Fish ◽  
Corpuscular Volume ◽  
Tropical Estuarine ◽  
Non Destructive

This study investigated the hematological parameters of the tropical estuarine fish Centropomus parallelus and their use as a non-destructive biomarker for aquatic pollution. Individuals were collected, in summer and winter, at two estuaries, Cananéia (CAN) and São Vicente (SVE), and blood was extracted by caudal puncture. The evaluated parameters were hematocrit (Ht), red blood cells (RBC), Mean Corpuscular Volume (MCV), and the leukocyte (WBC) and thrombocyte counts. Fishes from CAN showed higher values of absolute number of thrombocytes in the summer. The fishes from SVE presented lower values of Ht and MCV in winter. Comparing the hematological parameters of fishes from these two sites, Ht, MCV, WBC and RBC were higher in fishes from SVE in the summer, whereas during the winter, Ht and thrombocytes were higher in animals from SVE. The results allow attributing the changes in the blood of fishes to seasonality and the presence of contaminants.

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