Prosthetic joint infection in culture-negative and alpha-defensin-positive patients versus culture-positive and alpha-defensin-negative patients: a retrospective cohort study of the differences in clinical characteristics and outcomes

Aims: This studied aimed to compare rates of reoperation for patients who received primary ankle arthrodesis (AA) versus total ankle replacement (TAR) for posttraumatic indications between 2010 and 2016 Q2 using a nationwide claims database. Methods: A retrospective cohort study analyzing patients who received primary AA or TAR for posttraumatic indications was performed using PearlDiver. Reoperations assessed included prosthetic joint infection (PJI), hardware removal, adjacent joint fusion, and local open reduction internal fixation (ORIF). Multivariable logistic regression was used to compare rates of reoperations at 1 and 2 years postdischarge. Results: A total of 862 (74%) patients received AA and 318 (26%) patients underwent TAR for a posttraumatic indication. At 1 year, 305 (35.4%) AA patients had at least 1 reoperation compared with 55 (17.3%) TAR patients (OR 2.32; 95% CI, 1.68-3.26). At 2 years, 364 (42.2%) AA patients and 66 (20.8%) TAR patients had at least 1 reoperation (OR 2.51; 95% CI, 1.84-3.45). ORIF, hardware removal, and adjacent joint fusions were more likely for AA patients at both time intervals (all Ps < .05). Conclusion: Patients who received primary AA for posttraumatic indications exhibited higher rates of major reoperations in the short to medium term compared with patients who underwent TAR. Levels of Evidence: Level III: Retrospective cohort study

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Tu1788 CLINICAL CHARACTERISTICS AND TREATMENT DIFFERENCES BETWEEN YOUNGER AND OLDER ONSET MICROSCOPIC COLITIS: A MULTICENTER RETROSPECTIVE COHORT STUDY

Gastroenterology ◽

10.1016/s0016-5085(20)33576-9 ◽

2020 ◽

Vol 158 (6) ◽

pp. S-1161

Author(s):

Amrit K. Kamboj ◽

Amandeep Gujral ◽

Elida Voth ◽

Daniel Penrice ◽

Jessica McGoldrick ◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Clinical Characteristics ◽

Microscopic Colitis

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Clinical Characteristics, Risk Factor and Transmission of the COVID-19 Discharged Cases with Positive Retest in Guangzhou, China: A Retrospective Cohort Study

SSRN Electronic Journal ◽

10.2139/ssrn.3732143 ◽

2020 ◽

Author(s):

Lei Luo ◽

Dan Liu ◽

Zhou-Bin Zhang ◽

Zhi-Hao Li ◽

Chaojun Xie ◽

...

Keyword(s):

Risk Factor ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Clinical Characteristics

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Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection

Antibiotics ◽

10.3390/antibiotics10040446 ◽

2021 ◽

Vol 10 (4) ◽

pp. 446

Author(s):

Laura Soldevila-Boixader ◽

Bernat Villanueva ◽

Marta Ulldemolins ◽

Eva Benavent ◽

Ariadna Padulles ◽

...

Keyword(s):

Risk Factors ◽

Adverse Effect ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Older Patients ◽

Retrospective Cohort ◽

Joint Infection ◽

Eosinophilic Pneumonia ◽

Severe Adverse Effect ◽

Osteoarticular Infection

Background: Daptomycin-induced eosinophilic pneumonia (DEP) is a rare but severe adverse effect and the risk factors are unknown. The aim of this study was to determine risk factors for DEP. Methods: A retrospective cohort study was performed at the Bone and Joint Infection Unit of the Hospital Universitari Bellvitge (January 2014–December 2018). To identify risk factors for DEP, cases were divided into two groups: those who developed DEP and those without DEP. Results: Among the whole cohort (n = 229) we identified 11 DEP cases (4.8%) and this percentage almost doubled in the subgroup of patients ≥70 years (8.1%). The risk factors for DEP were age ≥70 years (HR 10.19, 95%CI 1.28–80.93), therapy >14 days (7.71, 1.98–30.09) and total cumulative dose of daptomycin ≥10 g (5.30, 1.14–24.66). Conclusions: Clinicians should monitor cumulative daptomycin dosage to minimize DEP risk, and be cautious particularly in older patients when the total dose of daptomycin exceeds 10 g.

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The change of coagulation profile in two-staged arthroplasty for periprosthetic joint infection patients: a retrospective cohort study

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-021-02477-4 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Hao Li ◽

Rui Li ◽

L. L. Li ◽

Wei Chai ◽

Chi Xu ◽

...

Keyword(s):

Cohort Study ◽

Periprosthetic Joint Infection ◽

Retrospective Cohort Study ◽

Persistent Infection ◽

Retrospective Cohort ◽

Joint Infection ◽

Diagnostic Study ◽

Level Of Evidence ◽

Coagulation Profile ◽

Significant Difference

Abstract Aims Periprosthetic joint infection (PJI) is a serious complication of total joint arthroplasty. We performed a retrospective cohort study to evaluate (1) the change of coagulation profile in two-staged arthroplasty patients and (2) the relationship between coagulation profile and the outcomes of reimplantation. Method Between January 2011 and December 2018, a total of 202 PJI patients who were operated on with two-staged arthroplasty were included in this study initially. This study continued for 2 years and the corresponding medical records were scrutinized to establish the diagnosis of PJI based on the 2014 MSIS criteria. The coagulation profile was recorded at two designed points, (1) preresection and (2) preimplantation. The difference of coagulation profile between preresection and preimplantation was evaluated. Receiver operating characteristic curves (ROC) were used to evaluate the diagnostic efficiency of the coagulation profile and change of coagulation profile for predicting persistent infection before reimplantation. Results The levels of APTT, INR, platelet count, PT, TT, and plasma fibrinogen before spacer implantation were significantly higher than before reimplantation. No significant difference was detected in the levels of D-dimer, ACT, and AT3 between the two groups. The AUC of the combined coagulation profile and the change of combined coagulation profile for predicting persistent infection before reimplantation was 0.667 (95% CI 0.511, 0.823) and 0.667 (95% CI 0.526, 0.808), respectively. Conclusion The coagulation profile before preresection is different from before preimplantation in two-staged arthroplasty and the coagulation markers may play a role in predicting infection eradication before reimplantation when two-stage arthroplasty is performed. Level of evidence Level III, diagnostic study.

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