Xuezhikang, An Extract of Cholestin, Reduces Cardiovascular Events in Type 2 Diabetes Patients With Coronary Heart Disease: Subgroup Analysis of Patients With Type 2 Diabetes From China Coronary Secondary Prevention Study (CCSPS)

Objective To examine the utility of repeated computed tomography (CT) coronary artery calcium (CAC) testing, we assessed risks of detectable CAC and its cardiovascular consequences in individuals with and without type 2 diabetes from ages 45 to 85 years. Research Design and Methods We included 5836 individuals (618 with type 2 diabetes, 2972 without baseline CAC) from the Multi-Ethnic Study of Atherosclerosis. Logistic and Cox regression evaluated the impact of type 2 diabetes, diabetes treatment duration and other predictors on prevalent and incident CAC. We used time-dependent Cox modeling of follow-up data (median 15.9 years) for two repeat CT exams and cardiovascular events to assess the association of CAC at follow-up CT with cardiovascular events. Results For 45-year-olds with type 2 diabetes, the likelihood of CAC at baseline was 23% versus 17% for those without. Median age at incident CAC was 52.2 versus 62.3 years for those with and without diabetes. Each 5 years of diabetes treatment increased the odds and hazard rate of CAC by 19% (95% confidence interval [CI] 8-33%) and 22% (95% CI 6-41%). Male gender, white ethnicity/race, hypertension, hypercholesterolemia, obesity, and low serum creatinine also increased CAC. CAC at follow-up CT independently increased coronary heart disease rates. Conclusions We estimated cumulative CAC incidence to age 85. Patients with type 2 diabetes develop CAC at a younger age than those without diabetes. Because incident CAC is associated with increased coronary heart disease risk, the value of periodic CAC-based risk assessment in type 2 diabetes should be evaluated.

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M.481 Oxidized LDL in middle-aged type 2 diabetes patients without coronary heart disease

Atherosclerosis ◽

10.1016/s0021-9150(04)90479-0 ◽

2004 ◽

Vol 5 (1) ◽

pp. 111-112

Author(s):

Z CAPAREVIC

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

Oxidized Ldl ◽

Middle Aged ◽

Diabetes Patients

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Abstract 17257: The Association Between Diet Quality After Diabetes Diagnosis and Major Cardiovascular Events in Women With Type 2 Diabetes Mellitus

Circulation ◽

10.1161/circ.130.suppl_2.17257 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Hyun J Shin ◽

Peter A McCullough ◽

Shanshan Li ◽

Eunyoung Cho ◽

Eric Rimm ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

Cardiovascular Events ◽

Dietary Habits ◽

Healthy Eating Index ◽

Diabetes Diagnosis ◽

Relative Risks ◽

Major Cardiovascular Events

Introduction: The role of dietary choices in the prevention of cardiovascular hard-outcome among type 2 diabetes patients has not been studied well. We examined whether there is an association between dietary quality after diagnosis of type 2 diabetes and major cardiovascular events among women using long-term prospective cohort study. Hypothesis: Healthy dietary pattern after type 2 diabetes diagnosis is associated with decreased risk for major cardiovascular events among women. Methods: The women with type 2 diabetes (n=6,895, mean age 64 years old) from the Nurses’ Health Study with no baseline cancer or cardiovascular disease were selected. Cox proportional hazard model was used to assess the multivariate association between the alternate Healthy Eating Index (aHEI) and the first episode of major cardiovascular events (coronary heart disease (CHD) or stroke). Results: During 26 years of follow-up (75, 276 person-years), a total of the 705 major cardiovascular events (432 cases of CHD, 314 cases of stroke, 41 cases of both CHD and stroke) were documented. The age-adjusted relative risks of major cardiovascular events across quintiles of aHEI score (Q1, Q2, Q3, Q4, Q5) were 1, 0.99 (95% CI, 0.80 to 1.22), 0.84 (CI, 0.67 to 1.05), 0.57 (CI, 0.44 to 0.72), and 0.66 (CI, 0.52 to 0.84) (P < 0.0001 for trend). These figures did not change materially after adjustment for body mass index, physical activity, smoking and other cardiovascular risk factors (1, 1.00, 0.91, 0.63, and 0.80, respectively; P = 0.008 for trend). The multivariate relative risks for stroke and CHD across quintiles of aHEI score were 1, 0.72, 0.80, 0.46, and 0.72 (P = 0.028 for trend) and 1, 1.21, 0.96, 0.72, and 0.73 (p=0.014 for trend), respectively. Conclusions: Healthier dietary habits after the diagnosis of diabetes are associated with a reduced risk of cardiovascular events including stroke and coronary heart disease.

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