scholarly journals Relationship of human paraoxonase-1 serum activity and genotype with atherosclerosis in individuals from the Deep South

2011 ◽  
Vol 21 (12) ◽  
pp. 867-875 ◽  
Author(s):  
R. Hunter Coombes ◽  
J. Allen Crow ◽  
Mary Beth Dail ◽  
Howard W. Chambers ◽  
Robert W. Wills ◽  
...  
Keyword(s):  
Paraoxonase 1 ◽  
Deep South ◽  
Serum Activity ◽  
Relationship Of

scholarly journals Using topographic map interpretation methods to determine Tookany (Tacony) Creek erosion history upstream from Philadelphia, Pennsylvania, USA

2016 ◽  
Vol 8 (4) ◽  
pp. 30
Author(s):  
Eric Clausen
Keyword(s):  
Drainage Basin ◽  
Walking Distance ◽  
Deep South ◽  
Topographic Map ◽  
Map Interpretation ◽  
Narrow Valley ◽  
Erosion History ◽  
Schuylkill River ◽  
Relationship Of ◽  
Flood Flow

Topographic map interpretation methods are used to determine erosional landform origins in and adjacent to the Tookany (Tacony) Creek drainage basin, located upstream from and adjacent to Philadelphia, PA. Five wind gaps notched into the Tookany-Wissahickon Creek drainage divide (which is also the Delaware-Schuylkill River drainage divide), a deep through valley crossing the Tookany-Pennypack Creek drainage divide, a Tookany Creek elbow of capture, orientations of Tookany Creek tributary valleys, a narrow valley carved in erosion resistant metamorphic bedrock, and the relationship of a major Tookany Creek direction change with a Pennypack Creek elbow of capture and a Pennypack Creek barbed tributary are used along with other evidence to reconstruct how a deep south oriented Tookany Creek valley eroded headward across massive southwest oriented flood flow. The flood flow origin cannot be determined from Tookany Creek drainage basin evidence, but may have been derived from a melting continental ice sheet, and originally flowed across the Tookany Creek drainage basin region on a low gradient topographic surface equivalent in elevation to or higher than the highest present day Tookany Creek drainage divide elevations with the water flowing in a complex of shallow diverging and converging channels that had formed by scouring of less resistant bedrock units and zones. William Morris Davis, sometimes referred to as the father of North American geomorphology, spent much of his boyhood and several years as a young man living in the Tookany Creek drainage basin and all landforms discussed here were within walking distance of his home and can be identified on a topographic map published while he was developing and promoting his erosion cycle ideas. Davis never published about Tookany Creek drainage basin erosion history, but he developed and promoted uniformitarian and erosion cycle models that failed to recognize the significance of Tookany Creek drainage basin erosional landform features providing evidence of the immense floods that once crossed present day drainage divides and eroded the Tookany Creek drainage basin.

NASA and the Long Civil Rights Movement

2019 ◽  
Keyword(s):  
Cold War ◽  
Civil Rights ◽  
Civil Rights Movement ◽  
Deep South ◽  
Apollo Program ◽  
Role Relationship ◽  
The Cold War ◽  
Relationship Of ◽  
The Impact ◽  
Long Civil Rights Movement

NASA and the Long Civil Rights Movement addresses the role/relationship of NASA and the Apollo program to the “long” civil rights movement in, particularly but not limited to, the Deep South (Huntsville, Florida, Houston, Mississippi, and New Orleans) and identifies the impact of NASA on the movement and the experiences of those who were directly affected by the space program and the impact of the movement on NASA’s development during the Cold War.

Relationship of adiponectin to serum paraoxonase 1

2008 ◽  
Vol 197 (1) ◽  
pp. 363-367 ◽  
Author(s):  
Laszlo Bajnok ◽  
Eva Csongradi ◽  
Ildiko Seres ◽  
Zsuzsa Varga ◽  
Sara Jeges ◽  
...  
Keyword(s):  
Paraoxonase 1 ◽  
Serum Paraoxonase ◽  
Relationship Of

scholarly journals Methods for Measuring Serum Activity Levels of the 192 Q and R Isoenzymes of Paraoxonase 1 in QR Heterozygous Individuals

2013 ◽  
Vol 59 (8) ◽  
pp. 1251-1259 ◽  
Author(s):  
John F Teiber ◽  
Gerald L Kramer ◽  
Robert W Haley
Keyword(s):  
Excellent Agreement ◽  
Intraclass Correlation ◽  
Hydrolytic Activity ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Accurate Estimation ◽  
Activity Levels ◽  
Protective Properties ◽  
Interpolation Methods ◽  
Serum Activity

BACKGROUND Paraoxonase 1 (PON1), an esterase that hydrolyzes toxic organophosphates and has antioxidative and antiatherogenic properties, contains a common polymorphism at position 192: glutamine (Q) or arginine (R). The Q and R isoenzymes exhibit different physical and protective properties. We describe 2 methods for quantifying their serum activity levels. METHODS We measured serum hydrolytic activity with paraoxon [paraoxonase (PXN) activity], phenylacetate [arylesterase (AE) activity], and diazoxon [diazoxonase (DZN) activity] with standard automated assays. We determined PON1 Q192R genotypes with PCR and Q192R phenotypes using the PXN/AE and PXN/DZN ratios. Interpolation equations were empirically derived to predict the percentage of total PON1 hydrolytic activity due to the Q isoenzyme (%Q) from the PXN/AE and PXN/DZN ratios; %R is 100 − %Q. We estimated Q and R isoenzyme activity levels in sera from 2095 veterans by multiplying AE activity, a measure of total PON1 hydrolytic activity, by %Q and %R. RESULTS In all 2095 samples, the PXN/AE and PXN/DZN ratios predicted Q192R phenotypes with nearly identical accuracy (κ = 0.997). In the 925 QR heterozygotes, the 2 interpolation methods predicted Q and R isoenzyme activity levels with excellent agreement (intraclass correlation 0.94). After excluding a few genotype/phenotype-discordant samples, the percentage of total PON1 activity due to the Q isoenzyme ranged from 22% to 70%. CONCLUSIONS These new interpolation methods allow accurate estimation of PON1 192 Q and R isoenzyme activity levels, increasing specificity and power for studying susceptibility to disease.

Relationship of paraoxonase-1 Q192R genotypes and in-stent restenosis and re-stenting in Chinese patients after coronary stenting

2016 ◽  
Vol 251 ◽  
pp. 305-310 ◽  
Author(s):  
Wenfang Ma ◽  
Yan Liang ◽  
Jun Zhu ◽  
Tao Chen ◽  
Guangxun Feng ◽  
...  
Keyword(s):  
Coronary Stenting ◽  
Paraoxonase 1 ◽  
Chinese Patients ◽  
Stent Restenosis ◽  
Relationship Of ◽  
In Stent Restenosis

scholarly journals Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus

2006 ◽  
Vol 54 (6) ◽  
pp. 1928-1939 ◽  
Author(s):  
Laura M. Tripi ◽  
Susan Manzi ◽  
Qi Chen ◽  
Margaret Kenney ◽  
Penny Shaw ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Paraoxonase 1 ◽  
Systemic Lupus ◽  
Serum Paraoxonase ◽  
Relationship Of
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