Family history of premature cardiovascular disease as a sole and independent risk factor for increased carotid intima–media thickness

2009 ◽  
Vol 27 (4) ◽  
pp. 822-828 ◽  
Author(s):  
Tommaso de Giorgis ◽  
Cosimo Giannini ◽  
Antonino Scarinci ◽  
Ebe DʼAdamo ◽  
Sergio Agostinelli ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Family History ◽  
Independent Risk Factor ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Premature Cardiovascular Disease ◽  
History Of

Correlation of Waist to Calf Circumference Ratio and Carotid Intima Media Thickness in Diabetes Mellitus

2020 ◽  
Vol 16 ◽  
Author(s):  
Harish A Rao ◽  
Prakash Harischandra ◽  
Srikanth Yadav
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Calf Circumference ◽  
Media Thickness

Introduction: Diabetes mellitus is a well-known risk factor for cardiovascular disease, because of the accelerated process of atherosclerosis. Obesity is an established risk factor and has gained immense importance in recent studies as an important risk factor for clinical cardiovascular disease, yet the fundamental component stays unclear. Calf circumference is another form for lean mass and peripheral subcutaneous fat and is inversely associated with occurrence of carotid plaques (CP). Multiplicative and opposite effects of both Calf Circumference (CC) and Waist Circumference (WC) in event of CP suggest that the two measures should be taken into account commonly while assessing vascular risk profile. Aim & Objective: To ascertain if waist to calf circumference ratio (WCR) is a marker of Carotid atherosclerosis in patients with type 2 diabetes mellitus. To asses s the correlation between waist to calf circumference ratio and carotid intima media thickness (CIMT ) in patients with Type 2 diabetes. Materials and methods: A cross sectional study at Hospital affiliated to Kasturba Medical college Mangalore from Sept 2016 to Sept 2018 . Method of study: Patients with type 2 DM as per ADA criteria, age >18years are recruited for the study. Results and discussion: In our study with 150 population 25 patients had carotid atherosclerosis and 20 patients had CIMT>1.1. The waist circumference in patients with CA is in the range of 93.07 and 99.85 & the CC in patients with CA is in the range of 29.49 to 31.25. The WCR in patients with CA is in the range of 3.12 to 3.26. The difference was statistically significant with a p value of <0.05. In our study it was found that WC and WCR correlated well with carotid atherosclerosis, and surprisingly calf circumference also correlated with carotid atherosclerosis but not as significant as both WC and WCR. Conclusion: To conclude, in our population based study of 150 subjects we found that carotid atherosclerosis is significantly more in people with increased waist calf circumference ratio. WCR may be a new, useful and practical anthropometric index that facilitates the early identification of diabetic subjects with high risk for cardiovascular disease. Validation of this finding in individual populations is required. Future studies should test the association of calf circumference with carotid intima media thickness and carotid plaques using better measures than ultrasound such as magnetic resonance imaging. Further research focusing on underlying mechanisms in the role of lean mass and peripheral fat mass is required.

A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middle-aged women

2003 ◽  
Vol 167 (1) ◽  
pp. 141-148 ◽  
Author(s):  
Giuliana Fortunato ◽  
Paolo Rubba ◽  
Salvatore Panico ◽  
Daniela Trono ◽  
Nadia Tinto ◽  
...  
Keyword(s):  
Risk Factor ◽  
Gene Polymorphism ◽  
Independent Risk Factor ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Middle Aged ◽  
Media Thickness

Hyperlipidemia Screening Is Worthwhile

PEDIATRICS ◽  
1980 ◽  
Vol 65 (3) ◽  
pp. 674-674
Author(s):  
Peter C. Freis
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Family History ◽  
Pediatric Patients ◽  
Coronary Risk Factors ◽  
Coronary Risk ◽  
Primary Physician ◽  
Premature Cardiovascular Disease ◽  
History Of

Neil A. Holtzman, MD (Hyperlipidemia screening: A search for heffalumps. Pediatrics 64:270, 1979) writes persuasively discouraging hypercholesterolemia screening and therapy in childhood. His commentary would easily dissuade the primary physician from appropriate intervention on his pediatric patients' behalf to minimize every coronary risk factor. The author unfortunately pays little attention to the children who would benefit most from hypercholesterol screening, those with a family history of premature cardiovascular disease. This is misleading. We must redirect our thinking to a continued effort to seek and minimize more appropriately coronary risk factors.

scholarly journals Comparison of Carotid Intima Media Thickness between Women with History of Preeclampsia and Normal Pregnancy: A Meta-Analysis of Systematic Review

2021 ◽  
Author(s):  
Budi Susetyo Pikir ◽  
Agus Subagjo ◽  
Deasy Eka Wardhani ◽  
Andrianto ◽  
Yudi Her Oktaviono ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Meta Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Normal Pregnancy ◽  
Mean Difference ◽  
Atherosclerotic Cardiovascular Disease ◽  
Media Thickness ◽  
History Of ◽  
Standardized Mean Difference

ABSTRACTBackgroundWomen with a history of preeclampsia are twice as likely to experience long term cardiovascular disease (CVD) compared to women with unaffected pregnancy. The pathophysiology of preeclampsia is not well understood, however there is general agreement that, similar to cardiovascular disease, endothelial dysfunction plays a crucial role. On a clinical level, preeclampsia and atherosclerotic cardiovascular disease share common risk factors. Carotid intima media thickness (CIMT) is ultrasound-based imaging, non-invasive, simple and reproducible method of subclinical atherosclerosis evaluation. Nowadays, there were studies concerning of CIMT among preeclamptic women, although the results were different.ObjectiveTo prove that CIMT among women with histories of preeclampsia was greater compared to normal pregnancy.MethodsWe conducted a meta-analysis of studies that reported CIMT, in women who had preeclampsia and had normal pregnancy. Studies were identified through three databases: PubMed, Google Scholar dan SAGE Journals with publication year of 2010- 2020. Heterogeneity was assessed using the I2 statistic. Standardized mean difference was used as measured of effect size.ResultsNine eligible studies were included in the meta-analysis. This meta-analysis consisted of 439 women with preeclampsia histories and 526 women with normal pregnancy histories. Women who had preeclampsia had significantly higher CIMT compared to those with normal pregnancy with standardized mean difference −0.38 and 95% confidence interval (CI) −0.68 to −0.07 (p=0.02).ConclusionCIMT was greater among women with histories of preeclampsia compared to normal pregnancy.Prospero registration numberID 228825.

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