Risk Factors for High-Risk Human Papillomavirus Infection and Cofactors for High-Grade Cervical Disease in Peru

2011 ◽  
Vol 21 (9) ◽  
pp. 1654-1663 ◽  
Author(s):  
Maribel Almonte ◽  
Catterina Ferreccio ◽  
Miguel Gonzales ◽  
Jose Manuel Delgado ◽  
C. Hilary Buckley ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
High Risk ◽  
Hpv Infection ◽  
High Grade ◽  
Papanicolaou Test ◽  
First Sexual Intercourse ◽  
Papillomavirus Infection ◽  
Cervical Disease ◽  
Potential Risk Factors

ObjectiveTo evaluate the association between potential risk factors for high-risk human papillomavirus (HR-HPV) infection and cofactors for cervical intraepithelial lesions grade 2 or worse (CIN2+) in women attending cervical screening in Amazonian Peru.Materials and MethodsParticipants completed a risk factor questionnaire before screening. High-risk human papillomavirus infection was determined by Hybrid Capture II. Logistic regression was used to evaluate associations between potential risk factors for HR-HPV infection and between cofactors and risk of CIN2+ among women with HR-HPV infection.ResultsScreening and questionnaires were completed by 5435 women aged 25 to 49 years. The prevalence of HR-HPV was 12.6% (95% confidence interval [CI], 11.8%–13.6%) and decreased by age. Early age at first sexual intercourse and several lifetime sexual partners increased the risk of having HR-HPV (age-adjusted odds ratio [AOR] of age at first sexual intercourse <18 vs ≥20, 1.5; 95% CI, 1.2–2.0; AOR of ≥5 lifetime sexual partners vs 1, 2.1; 95% CI, 1.4–3.2). Among women with HR-HPV infection, those with no schooling (AOR relative to 1–5 years of schooling, 3.2; 95% CI, 1.3–8.3) and those with parity ≥3 (AOR relative to parity <3, 2.6; 95% CI, 1.4–4.9) were at increased risk of CIN2+. The effect of parity was stronger for cancer (AOR of parity ≥3 vs <3, 8.3; 95% CI, 1.0–65.6). Further analysis showed that the association between parity and CIN2+ was restricted to women younger than 40. Most women (83%) had previously been screened. Sixty-four percent of CIN2+ cases detected in this study occurred in women who reported having had a Papanicolaou test in the previous 3 years. Only 4 of 20 cancers were detected in women never screened before. Having had a previous abnormal Papanicolaou test increased the risk of CIN2+ (OR, 16.1; 95% CI, 6.2–41.9).ConclusionAmong women with HR-HPV, high parity (in young women), no schooling, lack of good-quality screening and of adequate follow-up care are the main risk factors for high-grade cervical disease in Peru.

scholarly journals The Correlation Between Bacterial Vaginosis, High-Risk Human Papillomavirus Infection, and Cervical Intraepithelial Neoplasia Progression

2021 ◽  
Author(s):  
Xiaolin Xu ◽  
Yichan Zhang ◽  
Liqun Yu ◽  
Xingxian Shi ◽  
Min Min ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
High Risk ◽  
Bacterial Vaginosis ◽  
Cervical Intraepithelial Neoplasia ◽  
Protective Factor ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Vaginal Microbiota ◽  
Papillomavirus Infection

Abstract Persistent infection with high-risk human papillomavirus (HR-HPV) is an important reason for the progression of cervical intraepithelial neoplasia (CIN). Bacterial vaginosis (BV) is a genital infection that frequently presents in women infected with HPV, but the correlation between BV and HPV during CIN development is still elusive. In this study, we enrolled 624 participants and obtained 423 samples of vaginal secretions from them, including 193 HPV-negative samples and 230 HPV-positive samples. We used 16S rRNA sequencing to measure the vaginal microbiota diversity in women with or without BV and HPV co-infection and then calculated risk factors for CIN progression by logistic regression. We found that condom use (OR=3.480; 95% CI=1.069-11.325; P < .05) was a protective factor against CIN, whereas BV (OR=0.358; 95% CI=0.195-0.656; P < .05) and HR-HPV infection (OR= 0.016; 95% CI=0.004-0.072; P < .001) were risk factors for CIN. BV and HPV infection could trigger an increase in the diversity of vaginal microbiota and decrease Lactobacillus domination, which is conducive to CIN regression. The depletion of the carbohydrate metabolism pathway may induce Lactobacillus reduction. Treating BV in the clinical setting could block CIN development and L. iners may be a crucial species during this process.

scholarly journals Asociación entre infección por VPH, presencia de lesiones intraepiteliales en cuello uterino y factores de riesgo

2020 ◽  
Vol 80 (04) ◽  
pp. 322-331
Author(s):  
Ledyz Cuesta ◽  
◽  
Hugo Torres ◽  
Militza Quintero ◽  
Rafael Borges ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
High Risk ◽  
Sexual Partners ◽  
Low Risk ◽  
Cervical Cytology ◽  
Papanicolaou Test ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Intraepithelial Lesions

Objective: To establish associations between risk factors and the presence of intraepithelial lesions and human papillomavirus infection. Methods: Cross-sectional study with 1639 from the Santos Marquina municipality, Mérida, Venezuela. Cervical cytology and colposcopy, human papillomavirus detection and genotyping were analyzed using PCR and surveys to measure risk factors. Results: 477 women (31.8%) had human papillomavirus infection and 82 women (5.6%) had abnormalities in cervical cytology. Among the cases where human papillomavirus genotyping was performed, 135 (42%) correspond to low-risk types, while 177 (55%) correspond to high-risk types. A higher proportion of abnormal cytologies was found in cases with high-risk human papillomavirus with 21 cases (13.4%) compared to low-risk human papillomavirus with 9 cases (6.4%). The number of lifetime sexual partners greater than 1 (OR=2,303; p=0.001) and the history of pregnancy (OR=3,283; p=0.036) were significant independently associated with the presence of abnormal cytology. While the number of lifetime sexual partners greater than 1 (OR=1.304; p=0.026), the residence in rural area (OR=1.957; p <0.001) and the age under 35 years (OR=1,397; p=0.003) were significant independently associated with the presence of human papillomavirus infection. Conclusion: The type of human papillomavirus and other risk factors play an important role in the appearance of cervical intraepithelial lesions. Keywords: Squamous intraepithelial lesions of the cervix, Human papillomavirus, Papanicolaou Test, Risk factors.

The role of circumcision, tobacco, and alcohol use in genital human papillomavirus infection among men from Denmark

2021 ◽  
pp. 095646242110147
Author(s):  
Julie B Hebnes ◽  
Christian Munk ◽  
Kirsten Frederiksen ◽  
Hans O Joergensen ◽  
Thomas Iftner ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sexual Behavior ◽  
Human Papillomavirus ◽  
Alcohol Use ◽  
Potential Risk ◽  
Hpv Infection ◽  
Sex Partners ◽  
Current Cigarette Smoking ◽  
Hpv Dna ◽  
Potential Risk Factors

It is crucial to understand the natural history of genital human papillomavirus (HPV) infection in men to prevent the increasing male HPV-related disease burden. We evaluated the associations between HPV infection and circumcision, smoking, and alcohol use after accounting for sexual behavior. The study included 2331 male personnel from Danish barracks. Penile swabs were tested for HPV DNA with a polymerase chain reaction assay, INNO-LiPA. All men completed a self-administered questionnaire providing data on potential risk factors for HPV such as lifestyle and sexual habits. Using multivariable logistic regression, associations between potential risk factors and HPV infection were estimated and expressed as odds ratios (ORs) with 95% confidence intervals (CI). Current cigarette smoking was associated with increased odds of HPV detection (OR = 1.2; 95% CI: 1.0–1.4), but we found no association with alcohol use in the analysis adjusted for sexual behavior. Circumcision reduced the odds of a prevalent HPV infection (OR = 0.7; 95% CI: 0.5–1.0) although not statistically significantly. Strong associations with lifetime and recent number of female sex partners were observed, but in contrast to uncircumcised men, increasing number of sex partners was not associated with higher HPV prevalence in circumcised men. In conclusion, smoking was associated with increased odds of penile HPV in men from the general population in Denmark, whereas circumcision seemed to reduce the risk. Moreover, our results indicated that there might be differences in the viral susceptibility between circumcised and uncircumcised men.

Prevalence and risk factors for oral human papillomavirus infection in 129 women screened for cervical HPV infection

Oral Oncology ◽  
2014 ◽  
Vol 50 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Moritz F. Meyer ◽  
Christian U. Huebbers ◽  
Oliver G. Siefer ◽  
Julia Vent ◽  
Iris Engbert ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Hpv Infection ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection

Risk factors associated with human papillomavirus infection status in a Korean cohort

2013 ◽  
Vol 142 (8) ◽  
pp. 1579-1589 ◽  
Author(s):  
H. LEE ◽  
D.-H. LEE ◽  
Y.-M. SONG ◽  
K. LEE ◽  
J. SUNG ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Papillomavirus ◽  
Contraceptive Use ◽  
Transmitted Disease ◽  
Multivariate Regression Analysis ◽  
Hpv Infection ◽  
Sexually Transmitted ◽  
Papillomavirus Infection ◽  
Behavioural Factors ◽  
Epidemiological Characteristics

SUMMARYBy surveying extensive epidemiological behavioural and sexual risk factors in a Korean twin cohort, risk factors for human papillomavirus (HPV) infection were investigated in South Korea. A total of 912 vaginal specimens were collected from the Healthy Twin Study, consisting of twins and their families. A range of epidemiological, behavioural, and sexual activity characteristics were evaluated using multivariate logistic regression analyses of family and twin relationships, adjusted to elucidate the risk factors for HPV infection. Of the various epidemiological characteristics, the possibility of extramarital affairs [odds ratio (OR) 2·48, 95% confidence interval (CI) 1·02–6·02] significantly increased the prevalence of HPV infection. Our multivariate regression analysis indicated that oral contraceptive use (OR 40·64, 95% CI 0·99–1670·7) and history of sexually transmitted disease (OR 2·56, 95% CI 0·93–7·10) were strongly associated with an increase in HPV infection. On the other hand, more frequent vaginal douching (OR 0·32, 95% CI 0·13–0·77) significantly decreased the prevalence of HPV infection. Our results suggested that HPV infection is associated with both biological and behavioural factors.

scholarly journals Type-specific oncogenic human papillomavirus infection in high grade cervical disease in New Zealand

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Leonardo M Simonella ◽  
Hazel Lewis ◽  
Megan Smith ◽  
Harold Neal ◽  
Collette Bromhead ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
New Zealand ◽  
High Grade ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Cervical Disease

scholarly journals Coinfection of High-Risk Human Papillomavirus and Lower Genital Tract Pathogens in the Development of High-Grade Cervical Lesions

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Hui Zhong ◽  
Yao Tong ◽  
Haifeng Lin ◽  
Xiaodan Mao ◽  
Binhua Dong ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Genital Tract ◽  
Hpv Infection ◽  
High Grade ◽  
Infection Rates ◽  
Squamous Intraepithelial Lesions ◽  
Cervical Lesions ◽  
Lower Genital Tract ◽  
Intraepithelial Lesions

Purpose. This study investigated the infection status and relationship between other common lower genital tract infectious pathogens and high-risk human papillomavirus (HR-HPV) in the high-grade cervical lesions. Methods. Overall, 882 patients were enrolled in this retrospective study, of which 339 patients (≥HSIL group) were confirmed with high-grade squamous intraepithelial lesions (HSIL) or cervical squamous cell carcinoma (SCC), while 543 patients (≤LSIL group) were diagnosed with low-grade squamous intraepithelial lesions (LSIL) or normal cervical pathology diagnosis. Cervical swab specimens were tested for HPV, pathogenic bacteria (PB), U. urealyticum (UU), M. hominis (MH), and C. trachomatis (CT) in both groups. Results. The infection rates of HR-HPV, PB, UU (at high density), and CT were higher in the ≥HSIL group than in the ≤LSIL group (P<0.001); however, higher infection rates with MH were not observed (P>0.05). PB, UU, and CT were associated with HR-HPV infection (P<0.001). The PB and UU infection rates in the ≥HSIL group were significantly different from those in the ≤LSIL group, regardless of whether there was an HR-HPV infection at the same time (P<0.05). However, this was not the case for the CT (P>0.05). Furthermore, 259 pathogenic bacterial strains were detected in 882 cases. The difference in the distribution of pathogenic bacterial flora in the different grades of cervical lesions had no statistical significance, which was prioritized over Escherichia coli (P>0.05). Conclusion. PB, UU, and CT infection is associated with susceptibility to HR-HPV, HR-HPV coinfection with these pathogens might increase the risk of high-grade cervical lesions, and PB and UU might be independent risk factors for cervical lesions.

Sign in / Sign up

Export Citation Format

Share Document