scholarly journals Thin-Section CT Characteristics and Longitudinal CT Follow-up of Chemotherapy Induced Interstitial Pneumonitis

Medicine ◽  
2016 ◽  
Vol 95 (2) ◽  
pp. e2460 ◽  
Author(s):  
Han Na Lee ◽  
Mi Young Kim ◽  
Hyun Jung Koo ◽  
Sung-Soo Kim ◽  
Dok Hyun Yoon ◽  
...  
Keyword(s):  
Thin Section ◽  
Interstitial Pneumonitis

Diagnosis of Usual Interstitial Pneumonitis in the Absence of Honeycombing: Evaluation of Specific CT Criteria With Clinical Follow-Up in 38 Patients

2016 ◽  
Vol 206 (3) ◽  
pp. 472-480 ◽  
Author(s):  
James F. Gruden ◽  
Prasad M. Panse ◽  
Michael B. Gotway ◽  
Eric A. Jensen ◽  
Clinton V. Wellnitz ◽  
...  
Keyword(s):  
Interstitial Pneumonitis ◽  
Usual Interstitial Pneumonitis

Machine learning for lung texture analysis on thin-section CT: Capability for assessments of disease severity and therapeutic effect for connective tissue disease patients in comparison with expert panel evaluations

2021 ◽  
pp. 028418512110449
Author(s):  
Yoshiharu Ohno ◽  
Kota Aoyagi ◽  
Daisuke Takenaka ◽  
Takeshi Yoshikawa ◽  
Yasuko Fujisawa ◽  
...  
Keyword(s):  
Machine Learning ◽  
Texture Analysis ◽  
Disease Severity ◽  
Thin Section ◽  
Ct Scans ◽  
Normal Lung ◽  
Quantitative Index ◽  
Serial Ct ◽  
Ct Texture Analysis

Background The need for quantitative assessment of interstitial lung involvement on thin-section computed tomography (CT) has arisen in interstitial lung diseases including connective tissue disease (CTD). Purpose To evaluate the capability of machine learning (ML)-based CT texture analysis for disease severity and treatment response assessments in comparison with qualitatively assessed thin-section CT for patients with CTD. Material and Methods A total of 149 patients with CTD-related ILD (CTD-ILD) underwent initial and follow-up CT scans (total 364 paired serial CT examinations), pulmonary function tests, and serum KL-6 level tests. Based on all follow-up examination results, all paired serial CT examinations were assessed as “Stable” (n = 188), “Worse” (n = 98) and “Improved” (n = 78). Next, quantitative index changes were determined by software, and qualitative disease severity scores were assessed by consensus of two radiologists. To evaluate differences in each quantitative index as well as in disease severity score between paired serial CT examinations, Tukey's honestly significant difference (HSD) test was performed among the three statuses. Stepwise regression analyses were performed to determine changes in each pulmonary functional parameter and all quantitative indexes between paired serial CT scans. Results Δ% normal lung, Δ% consolidation, Δ% ground glass opacity, Δ% reticulation, and Δdisease severity score showed significant differences among the three statuses ( P < 0.05). All differences in pulmonary functional parameters were significantly affected by Δ% normal lung, Δ% reticulation, and Δ% honeycomb (0.16 ≤r2 ≤0.42; P < 0.05). Conclusion ML-based CT texture analysis has better potential than qualitatively assessed thin-section CT for disease severity assessment and treatment response evaluation for CTD-ILD.

scholarly journals Incidental finding of bronchial diverticula in a non-smoker population: evaluation on thin-section CT

2016 ◽  
Vol 81 (1-2) ◽  
Author(s):  
Federica Ciccarese ◽  
Giorgio Garzillo ◽  
Anna Maria Chiesa ◽  
Antonio Poerio ◽  
Serena Baroncini ◽  
...  
Keyword(s):  
Thin Section ◽  
Healthy Subjects ◽  
Respiratory Symptoms ◽  
Incidental Finding ◽  
Radiological Finding ◽  
Chest Ct ◽  
Lobe Bronchus ◽  
Significant Difference ◽  
The Right

<p>Bronchial diverticula have been described as a common radiological finding in smoker patients with COPD, but the specificity of this sign should be further investigated. Thus, the aim of our study was to evaluate the prevalence of diverticula in a cohort of non-smoker subjects. Between February and July 2012, 2438 patients were admitted to our Radiology Unit to undergo a chest CT. Among them, we enrolled 121 non-smoking patients (78/121-64.5% females, 43/121-35.5% males), of different age (57.0±20.7 years-range: 12-88), without any respiratory symptoms, submitted to chest CT for several reasons (oncologic evaluation: 59/121-48.8%; follow up of lung nodules: 27/121-22.3%; screening in connectivitis: 12/121-9.9%; others: 23/121-19.0%). We considered thin-section CT scan on axial, coronal and sagittal plans to evaluate prevalence, numbers and level of bronchial diverticula. Diverticula were found in 41/121-33.9% patients, with a slight major prevalence in males (p=0.048), but no significant difference on age. In 31/41-75.6% the number was &lt;3, whereof 17/31-54.8% with just one diverticulum assessed. Regarding the level, in 30/41-73.2% they were subcarinal, but they were also detected in mainstem (2/41-4.9%) and lobar bronchi (with the right upper lobe bronchus most frequently involved- 12/41-29.3%). Bronchial diverticula can be observed in non-smokers, as well as in smoker patients with COPD. However, their prevalence seems to be lower than in smokers and they tend to be isolated and subcarinal. The age of patients does not influence their finding. More studies should be proposed to better define a cut-off between smokers and healthy subjects.</p>

scholarly journals Nodular Ground-Glass Opacities on Thin-section CT: Size Change during Follow-up and Pathological Results

2007 ◽  
Vol 8 (1) ◽  
pp. 22 ◽  
Author(s):  
Hyun Ju Lee ◽  
Jin Mo Goo ◽  
Chang Hyun Lee ◽  
Chul-Gyu Yoo ◽  
Young Tae Kim ◽  
...  
Keyword(s):  
Thin Section ◽  
Ground Glass ◽  
Size Change

scholarly journals Interstitial pneumonitis after acetylene welding: A case report

2014 ◽  
Vol 27 (1) ◽  
Author(s):  
Miran Brvar
Keyword(s):  
Corticosteroid Therapy ◽  
Interstitial Pneumonitis ◽  
Ground Glass Opacity ◽  
Airway Disease ◽  
Gas Diffusion ◽  
High Dose ◽  
Aluminum Electrode ◽  
Small Airway Disease ◽  
Chest X Ray

AbstractAcetylene is a colorless gas commonly used for welding. It acts mainly as a simple asphyxiant. In this paper, however, we present a patient who developed a severe interstitial pneumonitis after acetylene exposure during aluminum welding. A 44-year old man was welding with acetylene, argon and aluminum electrode sticks in a non-ventilated aluminum tank for 2 h. Four hours after welding dyspnea appeared and 22 h later he was admitted at the Emergency Department due to severe respiratory insufficiency with pO2 = 6.7 kPa. Chest X-ray showed diffuse interstitial infiltration. Pulmonary function and gas diffusion tests revealed a severe restriction (55% of predictive volume) and impaired diffusion capacity (47% of predicted capacity). Toxic interstitial pneumonitis was diagnosed and high-dose systemic corticosteroid methylprednisolone and inhalatory corticosteroid fluticasone therapy was started. Computed Tomography (CT) of the lungs showed a diffuse patchy ground-glass opacity with no signs of small airway disease associated with interstitial pneumonitis. Corticosteroid therapy was continued for the next 8 weeks gradually reducing the doses. The patient’s follow-up did not show any deterioration of respiratory function. In conclusion, acetylene welding might result in severe toxic interstitial pneumonitis that improves after an early systemic and inhalatory corticosteroid therapy.

Thin-section CT follow-up of metastatic ovarian carcinoma correlation with levels of CA-125 marker and clinical history

1998 ◽  
Vol 22 (5) ◽  
pp. 364-370 ◽  
Author(s):  
Francesco Ferrozzi ◽  
Davide Bova ◽  
Flavia De Chiara ◽  
Giacomo Garlaschi ◽  
Ferdinando Draghi ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Thin Section ◽  
Clinical History ◽  
Ca 125

scholarly journals Bevacizumab-Induced Pneumonitis in a Patient With Metastatic Colon Cancer: A Case Report

2020 ◽  
Vol 14 ◽  
pp. 117954842092928
Author(s):  
Sami Pervaiz ◽  
Sylvester Homsy ◽  
Naureen Narula ◽  
Sam Ngu ◽  
Dany Elsayegh
Keyword(s):  
Colon Cancer ◽  
Interstitial Pneumonitis ◽  
High Dose ◽  
Vascular Endothelial ◽  
Metastatic Colon Cancer ◽  
Nasal Septal Perforation ◽  
Humanized Monoclonal Antibody ◽  
Inhibition Of Angiogenesis ◽  
Endothelial Growth Factor

Bevacizumab is a vascular endothelial growth factor–directed humanized monoclonal antibody used to treat many types of cancer and some eye diseases. Due to inhibition of angiogenesis, many adverse reactions such as bowel necrosis, nasal septal perforation, and renal thrombotic microangiopathy have been described. However, its association with interstitial pneumonitis is scarcely reported in the literature. We report a case of a 79-year-old woman with metastatic colon cancer who presented with cough and dyspnea on exertion the day after initiation of bevacizumab. She was found to have bilateral airspace opacities on imaging. Infectious and cardiogenic etiologies of dyspnea were ruled out. Due to the temporal relationship with the initiation of chemotherapy, she was suspected to have developed bevacizumab-induced interstitial pneumonitis. She improved rapidly with high-dose steroids. Follow-up imaging showed resolution of infiltrates. This is the first reported case in the literature that directly links bevacizumab to interstitial pneumonitis.

scholarly journals Temporal lung changes on thin-section CT in patients with COVID-19 pneumonia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Zhiyan Zhang ◽  
Runhui Tang ◽  
Heyang Sun ◽  
Haiyang Dai ◽  
Kangyin Chen ◽  
...  
Keyword(s):  
Thin Section ◽  
Chest Ct ◽  
Illness Onset ◽  
Group 4 ◽  
Lung Abnormalities ◽  
Group 3 ◽  
Time Periods ◽  
Group 2 ◽  
Discharge From Hospital

AbstractWe examined characteristics of chest CT across different time periods for patients with COVID-19 pneumonia in Huizhou, China. This study included 56 COVID-19 patients with abnormal CT acquired between January 22 and March 3, 2020. The 141 scans of 56 patients were classified into four groups (Groups 1–4) based on dates on which scans were obtained at the 1st, 2nd, 3rd week or longer than three weeks after illness onset. Forty-five patients with follow-up scans were categorized into four groups (Groups A–D) according to extent that lesions reduced (≥ 75%, 50–75%, 25–50% and < 25%). Ground-glass opacities (GGO) was prevalent in Groups 1–4 (58.1–82.6%), while percentages of consolidation ranged between 9.7% in Group 4 and 26.2% in Group 2. The highest frequency of fibrous stripes occurred in Group 3 (46.7%). Total CT scores were on average higher in Groups 2–3. Among 45 follow-up patients, 11 (24.4%) of them recovered with lesions reducing ≥ 75%, with the lowest median age and total CT scores on admission. There are temporal patterns of lung abnormalities in COVID-19 patients, with higher extent of lesion involvement occurring in the 2nd and 3rd week. Persisting lung changes indicate some patients may need isolation after discharge from hospital.

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