scholarly journals Shen-Cao granules formulated based on traditional Chinese medicine alleviates bone marrow suppression caused by platinum-based anticancer reagents

Medicine ◽  
2017 ◽  
Vol 96 (19) ◽  
pp. e6818 ◽  
Author(s):  
Chunfeng Yu ◽  
Zhonghua Jiang ◽  
Aihua Hou ◽  
Yuejun Mu ◽  
Wei Liu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Bone Marrow Suppression

scholarly journals The progress of traditional Chinese medicine in the treatment of aplastic anemia

2018 ◽  
Vol 6 (4) ◽  
pp. 159-164 ◽  
Author(s):  
Ningning Zhu ◽  
Dijiong Wu ◽  
Baodong Ye
Keyword(s):  
Bone Marrow ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Aplastic Anemia ◽  
Peripheral Blood ◽  
Clinical Course ◽  
Hematologic Disease ◽  
Therapeutic Principle ◽  
The Past ◽  
Severity Of The Disease

Abstract Aplastic anemia (AA) is a common hematologic disease that is characterized by hematopoietic failure of the bone marrow and pancytopenia of the peripheral blood, which can be divided into severe and non-severe aplastic ane-mia, or acute and chronic aplastic anemia according to the severity of the disease and the progress of the clinical course. During the past years, the advantages of Traditional Chinese Medicine (TCM) on the treatment of AA have been well clarified and its theory system has been improved as well. This review is mainly on representing the pathogenesis, therapeutic principle and method, research progression, and advantages of TCM on AA.

scholarly journals A Data Mining-Based Analysis of Medication Rules in Treating Bone Marrow Suppression by Kidney-Tonifying Method

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Xing You ◽  
Yinkun Xu ◽  
Jin Huang ◽  
Yaofeng Zhi ◽  
Fengzhen Wu ◽  
...  
Keyword(s):  
Data Mining ◽  
Bone Marrow ◽  
Chinese Medicine ◽  
High Frequency ◽  
Bone Marrow Suppression ◽  
Biomedical Literature ◽  
Astragali Radix ◽  
Knowledge Infrastructure ◽  
Pathogenic Factors ◽  
Chinese National Knowledge Infrastructure

Objective. To investigate the rule of kidney-tonifying method in Chinese medicine for the treatment of bone marrow suppression (BMS), in order to provide evidence and references for the clinical application of herbs and formulae. Design. Collecting and sorting the information about the treatment of BMS related to kidney-tonifying (Bushen) method in Chinese medicine literatures on databases including Chinese National Knowledge Infrastructure (CNKI), and Chinese Biomedical Literature Database (CBM), establishing a database of BMS treating formulae after radiotherapy and chemotherapy with traditional Chinese medicine (TCM) kidney-tonifying method, and finally applying the relevant theories and techniques of data mining to analyze the medication rules of it. Results. A total of 239 formulae and 202 herbs were included in this database, in which the herbs occurred 2,602 times in general. The high frequency herbs included Astragali Radix (Huangqi), Atractylodis Macrocephalae Rhizoma (Baizhu), and Ligustri Lucidi Fructus (Nvzhenzi). The main herb categories were deficiency-tonifying herbs, blood-activating herbs, dampness-draining diuretic herbs, heat-clearing herbs, and digestant herbs. Deficiency-tonifying herbs accounted for 64.60% of the total number. A total of 8 clustering formulae are summarized according to cluster analysis and 26 herb suits association rules are identified by Apriori algorithm. Conclusion. The treatment of BMS is mainly based on the method of invigorating the spleen and tonifying the kidney and liver to strengthen healthy qi, supplementing with blood-activating herbs, and dampness-draining diuretic herbs to eliminate pathogenic factors.

scholarly journals Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine

2014 ◽  
Vol 2014 ◽  
pp. 1-21 ◽  
Author(s):  
Ya-Li Hsiao ◽  
Pei-Chun Chang ◽  
Hung-Jin Huang ◽  
Chia-Chen Kuo ◽  
Calvin Yu-Chian Chen
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Lymphoblastic Leukemia ◽  
White Blood Cells ◽  
Multiple Organ ◽  
Organ Injury ◽  
Qsar Models ◽  
All Treatment

Acute lymphoblastic leukemia (ALL) is a cancer that immature white blood cells continuously overproduce in the bone marrow. These cells crowd out normal cells in the bone marrow bringing damage and death. Methotrexate (MTX) is a drug used in the treatment of various cancer and autoimmune diseases. In particular, for the treatment of childhood acute lymphoblastic leukemia, it had significant effect. MTX competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis so as to inhibit purine synthesis. In addition, its downstream metabolite methotrexate polyglutamates (MTX-PGs) inhibit the thymidylate synthase (TS). Therefore, MTX can inhibit the synthesis of DNA. However, MTX has cytotoxicity and neurotoxin may cause multiple organ injury and is potentially lethal. Thus, the lower toxicity drugs are necessary to be developed. Recently, diseases treatments with Traditional Chinese Medicine (TCM) as complements are getting more and more attention. In this study, we attempted to discover the compounds with drug-like potential for ALL treatment from the components in TCM. We applied virtual screen and QSAR models based on structure-based and ligand-based studies to identify the potential TCM component compounds. Our results show that the TCM compounds adenosine triphosphate, manninotriose, raffinose, and stachyose could have potential to improve the side effects of MTX for ALL treatment.

scholarly journals Progress of Interference of Traditional Chinese Medicine on Cirrhosis Treated with Bone Marrow Mesenchymal Stem Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yaxin Wang ◽  
Huicun Zhang ◽  
Hongbing Wang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Specific Mechanism ◽  
Improve Liver Function ◽  
Marrow Mesenchymal Stem Cells ◽  
Stem Cells Transplantation

Transplantation of bone marrow mesenchymal stem cells has attracted more and more attention as a regenerative therapy for the treatment of liver diseases. A large number of studies have shown that this kind of cells can inhibit the activation of hepatic stellate cells and regulate tissue homeostasis and immune system via a variety of ways. Meanwhile, bone marrow mesenchymal stem cells can inhibit apoptosis of hepatocyte, improve liver function, and reduce inflammation through multiple pathways. These cells have a broad prospect in the treatment of liver cirrhosis. At present, there are many studies on the specific mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis. This paper reviews the pathogenesis of liver cirrhosis and the mechanism of bone marrow mesenchymal stem cells transplantation in the treatment of liver cirrhosis, discusses the effectiveness of traditional Chinese medicine method in enhancing the efficacy of bone marrow mesenchymal stem cells transplantation, and looks forward to its application prospect in the future.

scholarly journals Study on the Inhibitory Effects of Ephedra Aconite Asarum Decoction on LPS-Induced Dendritic Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Wenting Ji ◽  
Jinghong Hu ◽  
Xue Yu ◽  
Lanlan Zhang ◽  
Min Liu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Inflammatory Responses ◽  
Inhibitory Effects ◽  
Chinese Medicine Formula ◽  
Th1 Polarization ◽  
Anti Inflammation

Dendritic cells (DCs) can secrete cytokines stimulated by lipopolysaccharide (LPS), which leads to not just acute inflammatory responses but also Th1 polarization. Furtherly, chronic inflammation or autoimmune diseases could be triggered. As a classic Traditional Chinese Medicine formula, Ephedra Aconite Asarum Decoction with the main ingredients of ephedrine and hypaconitine can show effect on anti-inflammation and immunoregulation. But it remains unclear whether Ephedra Aconite Asarum Decoction controls DCs. In this study, we investigated the effects of Ephedra Aconite Asarum Decoction on LPS-induced bone marrow-derived DCs (BMDCs) in vitro. We found that Ephedra Aconite Asarum Decoction lowered surface costimulators on DCs and reduced the expression of Th1 type cytokines. Yet it is slightly beneficial for shifting to Th2. Our work reveals that the Ephedra Aconite Asarum Decoction can regulate Th1 inflammation through intervening DCs.

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